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Information on EC 5.1.1.14 - nocardicin A epimerase

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EC Tree
     5 Isomerases
         5.1 Racemases and epimerases
             5.1.1 Acting on amino acids and derivatives
                5.1.1.14 nocardicin A epimerase
IUBMB Comments
Requires pyridoxal 5'-phosphate. The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the monolactam antibiotic nocardicin A. It catalyses the epimerization of the amino group at position 9' from (S)- configuration to (R)-. The enzyme can act on both isonocardicin A and isonocardicin C, but the in vivo substrate appears to be the latter .
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The expected taxonomic range for this enzyme is: Nocardia uniformis
Synonyms
Epimerase, isonocardicin A, nocardicin C-9'epimerase, NocJ, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
isonocardicin A = nocardicin A
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(2)
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isonocardicin C = nocardicin C
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(1)
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