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Information on EC 4.8.1.1 - L-piperazate synthase

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EC Tree
     4 Lyases
         4.8 Nitrogen-oxygen lyases
             4.8.1 Hydro-lyases
                4.8.1.1 L-piperazate synthase
IUBMB Comments
Contains a heme b cofactor. The enzyme, characterized from the bacterium Kutzneria sp. 744, is one of very few enzymes known to result in the formation of an N-N bond. (3S)-1,2-diazinane-3-carboxylate (piperazate) is known to be incorporated into assorted secondary products that are produced by nonribosomal peptide synthetase or nonribosomal peptide synthetase/polyketide synthase hybrid pathways, such as the kutznerides, padanamides, himastatins, and sanglifehrins.
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The enzyme appears in viruses and cellular organisms
Synonyms
ktzT, sfaC, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N5-hydroxy-L-ornithine = (3S)-1,2-diazinane-3-carboxylate + H2O
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PATHWAY SOURCE
PATHWAYS
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