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Information on EC 4.6.1.2 - guanylate cyclase and Organism(s) Mus musculus and UniProt Accession Q6TL19
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4.6.1.2 guanylate cyclaseIUBMB Comments
Also acts on ITP and dGTP.
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Word Map
- 4.6.1.2
- cgmp
- artery
- guanosine
- nitroprusside
- monophosphate
- phosphodiesterase
-
methylene
-
vasodilation
- endothelium
-
cgmp-dependent
-
l-name
- l-arginine
- pkg
-
tone
-
endothelium-dependent
-
blocker
- aorta
- acetylcholine
-
vasorelaxation
-
endothelium-derived
- ng-nitro-l-arginine
- snap
- phenylephrine
- 8-br-cgmp
- ng-monomethyl-l-arginine
-
endothelium-denuded
- nnos
- nomega-nitro-l-arginine
-
apamin
-
no-dependent
- zaprinast
- tetraethylammonium
- 8-bromo-cgmp
- glibenclamide
- sin-1
- s-nitroso-n-acetylpenicillamine
-
no-mediated
- sildenafil
-
no-induced
-
precontracted
- nitroglycerin
- diagnostics
- trinitrate
- molecular biology
- analysis
-
iberiotoxin
- cavernosum
- 7-nitroindazole
-
no-donors
- pharmacology
- medicine
-
phototransduction
-
charybdotoxin
-
endothelium-intact
- drug development
-
nitrergic
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
guanylate cyclase, soluble guanylate cyclase, guanylyl cyclase, soluble guanylyl cyclase, npr-a, npr-b, particulate guanylate cyclase, h-nox, no receptor, guanylyl cyclase c, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ANPRA
-
-
-
-
ANPRB
-
-
-
-
Atrial natriuretic peptide A-type receptor
-
-
-
-
Atrial natriuretic peptide B-type receptor
-
-
-
-
GC-A
guanyl cyclase
-
-
-
-
Guanylate cyclase
-
-
-
-
Guanylate cyclase 2D, retinal
-
-
-
-
Guanylate cyclase 2E
-
-
-
-
Guanylate cyclase 2F, retinal
-
-
-
-
Guanylate cyclase, olfactory
-
-
-
-
guanylyl cyclase
-
-
-
-
guanylyl cyclase C
guanylyl cyclase-A receptor
hSTAR
-
-
-
-
Intestinal guanylate cyclase
-
-
-
-
KSGC
-
-
-
-
Rod outer segment membrane guanylate cyclase
-
-
-
-
ROS-GC
-
-
-
-
ROS-GC2
-
-
-
-
sGC
-
-
soluble guanylate cyclase
-
-
STA receptor
-
-
-
-
additional information
additional information
-
the enzyme is a member of the family of nucleotide cyclizing enzymes
additional information
GC-C is a member of the particulate guanylyl cyclase family
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
GTP = 3',5'-cyclic GMP + diphosphate
reaction mechanism, structure-function relationship
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
P-O bond cleavage
-
-
-
-
PATHWAY SOURCE
PATHWAYS
KEGG
SYSTEMATIC NAME
IUBMB Comments
GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Also acts on ITP and dGTP.
CAS REGISTRY NUMBER
COMMENTARY
9054-75-5
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GTP
3',5'-cyclic GMP + diphosphate
membrane forms of guanylyl cyclase serve as cell-surface receptors that synthesize the second messenger cGMP, which mediates diverse cellular processes. GC-G plays a role in mediating injury, GC-G may act as an early signaling molecule that promotes apoptotic and inflammatory responses in I/R-induced acute renal injury
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
-
679514, 690355, 690364, 690367, 690841, 691340, 691401, 691542, 691656, 691926, 692083, 692193, 692204, 692547, 692548, 692584, 693152, 693769, 693776, 693821, 693894, 694141, 694347, 694349, 694915
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
atrial natriuretic factor receptor guanylate cyclase GC-A is the receptor of the atrial natriuretic factor and the type B natriuretic peptide, overview
cyclic GMP is a second messenger in controlling blood pressure, cardiac vasculature, and fluid secretion
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
GC-A acts as receptor for atrial natriuretic peptide that regulates arterial blood pressure and volume, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
guanylyl cyclase receptors synthesize the second-messenger cyclic GMP
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
isozyme GC-A is a common receptor for atrial and brain natriuretic peptide
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
NO receptor isozymes NO-GC1 and NO-GC2 are required for long term potentiation in smooth muscle relaxation, they mediate vasorelaxation and platelet-inhibition of nitric oxide being the only NO receptor of the signalling pathway
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
NO-GC plays a role in neuropathic pain. cGMP produced by NO-GC may activate signaling pathways different from cGMP-dependent protein kinase I, cGKI, during spinal nociceptive processing, whereas cGKI can be activated by natriuretic peptide receptor-B dependent cGMP production, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
role of sGCalpha1beta1 in nitrergic regulation of jejunal smooth muscle activity in male and female mice, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in a mouse lung model, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice, enzyme inhibition in lung increases the filtration coefficient, regulation, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
the enzyme is involved in vasorelaxation, NO acts as a signalling molecule regulating sGC expression in a negative feedback loop, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
the homodimeric transmembrane guanylyl cyclase-A receptor produces cytoplasmic cyclic GMP from GTP on binding its extracellular ligands, atrial and B-type natriuretic peptides, which modulate blood pressure and volume through the stimulation of cyclic GMP production by their guanylyl cyclase-A receptor, overview. Alternative splicing can regulate endogenous ANP/GC-A signaling, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
the regulation of arterial vasodilatory and cardiac beta-adrenergic reserve by phosphodiesterase type 5-I targets cGMP from soluble GC stimulation
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
the retina-specific guanylyl cyclases, retGC1 and retGC2 support synthesis of cGMP in photoreceptors
cyclic GMP serves as the second messenger in visual transduction, linking photon absorption by rhodopsin to the activity of ion channels
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
the soluble guanylate cyclase isoforms alpha1beta1 and alpha2beta1 are involved in the relaxation of distal colon by exogenous NO and by NANC nerve stimulation, mechanism, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
von Willebrand factor/ristocetin-mediated activation of the sGC/cGMP signaling pathway may contribute to feedback platelet inhibition, regulation mechanisms, overview
-
-
?
GTP
3',5'-cyclic-GMP + diphosphate
-
isozyme RetGC1 contributes 23-28% to the maximal cGMP synthesis rate in mouse rod outer segments. The activity of isozyme RetGC2 is about 5times lower than isozyme RetGC1
-
-
?
additional information
?
-
-
ATP-dependent mode of ANF-RGC signal transduction mechanism, overview
-
-
?
additional information
?
-
-
inhibition of soluble guanylate cyclase abolishes the potentiating effect of Mn2+ on MAP kinase phosphorylation, NF-kappaB activation, and production of NO
-
-
?
additional information
?
-
-
isozyme GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic and antifibrotic actions in the heart. Isozyme GC-B, the specific receptor for C-type natriuretic peptide, has a critical role in endochondral ossification. Isozyme GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation. Isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Isozyme GC-D has chemosensory functions in the olfactory neuroepithelium
-
-
?
additional information
?
-
-
modeling of the intracellular signal transduction for CO2 detection by GC-D+ neurons and the molecular mechanism of bicarbonate sensing by GC-D, overview
-
-
?
additional information
?
-
-
sGC role in vascular system diseases and failures, overview
-
-
?
additional information
?
-
-
soluble guanylyl cyclase alpha1/alpha2 subunits are involved in the relaxant effect of CO and CORM-2, i.e. CO-releasing molecule-2, on enteric smooth muscle, overview
-
-
?
additional information
?
-
-
sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil, overview
-
-
?
additional information
?
-
-
the atrial natriuretic peptide/GC-A/cGMP-dependent protein kinase I system stimulates the phosphorylation of VASP in cultured microvascular endothelial cells
-
-
?
additional information
?
-
-
structure and functions of membrane guanylate cyclase isozymes, overview
-
-
?
additional information
?
-
-
the enzyme binds the human rod Galphat protein without altering cyclase activity, overview
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GTP
3',5'-cyclic GMP + diphosphate
membrane forms of guanylyl cyclase serve as cell-surface receptors that synthesize the second messenger cGMP, which mediates diverse cellular processes. GC-G plays a role in mediating injury, GC-G may act as an early signaling molecule that promotes apoptotic and inflammatory responses in I/R-induced acute renal injury
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
-
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
atrial natriuretic factor receptor guanylate cyclase GC-A is the receptor of the atrial natriuretic factor and the type B natriuretic peptide, overview
cyclic GMP is a second messenger in controlling blood pressure, cardiac vasculature, and fluid secretion
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
GC-A acts as receptor for atrial natriuretic peptide that regulates arterial blood pressure and volume, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
guanylyl cyclase receptors synthesize the second-messenger cyclic GMP
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
isozyme GC-A is a common receptor for atrial and brain natriuretic peptide
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
NO receptor isozymes NO-GC1 and NO-GC2 are required for long term potentiation in smooth muscle relaxation, they mediate vasorelaxation and platelet-inhibition of nitric oxide being the only NO receptor of the signalling pathway
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
NO-GC plays a role in neuropathic pain. cGMP produced by NO-GC may activate signaling pathways different from cGMP-dependent protein kinase I, cGKI, during spinal nociceptive processing, whereas cGKI can be activated by natriuretic peptide receptor-B dependent cGMP production, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
role of sGCalpha1beta1 in nitrergic regulation of jejunal smooth muscle activity in male and female mice, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
sGC contributes to the pathology of pulmonary arterial hypertension, its stimulation reverses right heart hypertrophy and structural lung vascular remodelling, hemodynamics and vascular remodelling in a mouse lung model, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice, enzyme inhibition in lung increases the filtration coefficient, regulation, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
the enzyme is involved in vasorelaxation, NO acts as a signalling molecule regulating sGC expression in a negative feedback loop, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
the homodimeric transmembrane guanylyl cyclase-A receptor produces cytoplasmic cyclic GMP from GTP on binding its extracellular ligands, atrial and B-type natriuretic peptides, which modulate blood pressure and volume through the stimulation of cyclic GMP production by their guanylyl cyclase-A receptor, overview. Alternative splicing can regulate endogenous ANP/GC-A signaling, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
the regulation of arterial vasodilatory and cardiac beta-adrenergic reserve by phosphodiesterase type 5-I targets cGMP from soluble GC stimulation
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
the retina-specific guanylyl cyclases, retGC1 and retGC2 support synthesis of cGMP in photoreceptors
cyclic GMP serves as the second messenger in visual transduction, linking photon absorption by rhodopsin to the activity of ion channels
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
the retinal isozyme retGC-1 influences transducin movement, not through its cyclase activity, but through direct interaction with Galphat protein, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
the soluble guanylate cyclase isoforms alpha1beta1 and alpha2beta1 are involved in the relaxation of distal colon by exogenous NO and by NANC nerve stimulation, mechanism, overview
-
-
?
GTP
3',5'-cyclic GMP + diphosphate
-
von Willebrand factor/ristocetin-mediated activation of the sGC/cGMP signaling pathway may contribute to feedback platelet inhibition, regulation mechanisms, overview
-
-
?
additional information
?
-
-
ATP-dependent mode of ANF-RGC signal transduction mechanism, overview
-
-
?
additional information
?
-
-
inhibition of soluble guanylate cyclase abolishes the potentiating effect of Mn2+ on MAP kinase phosphorylation, NF-kappaB activation, and production of NO
-
-
?
additional information
?
-
-
isozyme GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic and antifibrotic actions in the heart. Isozyme GC-B, the specific receptor for C-type natriuretic peptide, has a critical role in endochondral ossification. Isozyme GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation. Isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Isozyme GC-D has chemosensory functions in the olfactory neuroepithelium
-
-
?
additional information
?
-
-
modeling of the intracellular signal transduction for CO2 detection by GC-D+ neurons and the molecular mechanism of bicarbonate sensing by GC-D, overview
-
-
?
additional information
?
-
-
sGC role in vascular system diseases and failures, overview
-
-
?
additional information
?
-
-
soluble guanylyl cyclase alpha1/alpha2 subunits are involved in the relaxant effect of CO and CORM-2, i.e. CO-releasing molecule-2, on enteric smooth muscle, overview
-
-
?
additional information
?
-
-
sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil, overview
-
-
?
additional information
?
-
-
the atrial natriuretic peptide/GC-A/cGMP-dependent protein kinase I system stimulates the phosphorylation of VASP in cultured microvascular endothelial cells
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
-
the two neuronal calcium sensors, GCAP1 and GCAP2, confer Ca2+ sensitivity to guanylyl cyclase activity
Mg2+
Mn2+
Mn2+
-
Mn2+-stimulated synthesis of cGMP is independent of IFNgamma/TNFalpha in astrocytes
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
-
i.e. NS-2028, acts via the heme domain
atrial natriuretic peptide
-
elicits GC-A desensitization, can induce decreased GC-A activity in MA-10 Leydig cells, based on mechanisms directly affecting the hormone responsiveness of the receptor. Protein kinase A blocks homologous atrial natriuretic peptide induced desensitization, in which cGMP is generated as second messenger
-
lysophosphatidic acid
-
preincubations for 30 min before assessments of atrial natriuretic peptide-induced cGMP generation reveals inhibitory effects, exerted in a dose-dependent manner, elicits GC-A desensitization, protein kinase A does not block lysophosphatidic acid-induced heterologous desensitization. MEK inhibitor PD 98059 does not protect against the lysophosphatidic acid-mediated decrease in GC-A hormone sensitivity
NO
-
long acting NO donors pentaerythrityl tetranitrate and isosorbide mononitrate have a significant impact on the regulation of vascular sGC expression and activity, overview
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
-
a soluble guanylate cyclase inhibitor, maximal inhibition (70%) at 0.01 mM
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one
-
inhibits the enzyme and the enzyme activating effect of sodium nitroprusside
additional information
-
competitive GC-C isozyme inhibition by exogenous 18-residue heat-stable enterotoxins, STa, produced by diarrheagenic bacteria, Ki values of 1.5-57.6 nM, binding to GC-C by quantifying competitive displacement of [125I]STa from GC-C expressed in membranes, overview
-
additional information
-
effects of activators and inhibitors on enzyme regulation, overview
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
A-350619
-
a heme-dependent stimulator of sGC, structurally not related to YC-1, but synergistic to YC-1 and sodium nitroprusside for the binding site
A-778935
-
i.e. cis-3-[2-(2,2-dimethyl-propylsulfanyl)pyridin-3-yl]-N-(3-hydroxycyclohexyl-)acrylamide, derived from the YC-1 structure, activates the enzyme is a synergistic fashion with the NO donor sodium nitroprusside
ATP
-
ATP-binding pocket and second, the transduction region, structure modelling, overview. The binding pocket resides in the smaller, N-terminal lobe of the ARM and the transduction region in the larger, predominantly helical, C-terminal lobe, overview. ATP-dependent mode of ANF-RGC signal transduction mechanism
atrial natriuretic factor
-
binding the hormone to the GC-A extracellular domain activates its intracellular catalytic domain, overview
-
BaY 63-2521
-
i.e. methyl-4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimindin-5-ylmethylcarbamate, stimulates sGC directly and sensitizes it to NO, causes enzyme upregulation in pulmonary arterial hypertension lungs
bicarbonate
-
activates cGMP-producing ability of guanylyl cyclase-D, a membrane guanylate cyclase exclusively expressed in the CO2-responsive olfactory sensory neurons, by directly acting on the intracellular cyclase domain of GC-D. The molecular mechanism for pH-independent GC-D activation is distinct from the release-from-repression model for other membrane guanylate cyclases, overview
brain natriuretic peptide
-
highly effective in stimulating cGMP production in MA-10 cells
-
CORM-2
-
i.e. CO-releasing molecule-2, a tricarbonyldichlororuthenium(II) dimer
-
guanylyl cyclase activating protein
-
the native RetGC isozymes are accelerated 5-28fold at physiological concentrations of guanylyl cyclase activating proteins GCAP1 and GCAP2
-
H2O2
-
activates the enzyme, and reduces the cGMP formation activation by nitroprusside and BAY 41-2272 in smooth muscle cells, but enhances the response to HMR-1766, the activation by reactive oxigen species is heme-dependent
HMR-1766
-
stimulates the enzyme, especially heme-free sGC, identification of the interaction region and binding structure of the enzyme by computational modelling
neuronal calcium sensor GCAP1
-
confers Ca2+ sensitivity to guanylyl cyclase activity
-
neuronal calcium sensor GCAP2
-
confers Ca2+ sensitivity to guanylyl cyclase activity, absence of GCAP2 affected guanylyl cyclase activity in two ways: 1. the maximal rate of cGMP synthesis at low [Ca2] dropps 2fold and 2. the half-maximal rate of cGMP synthesis is attained at a higher than normal [Ca2+], phenotype of GCAP2 knockout mice, overview
-
von Willebrand factor/ristocetin
-
increase the enzyme activity in an NO-independent manner correlating with Src kinase-dependent phosphorylation of sGC beta1-subunit-Tyr192
-
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one
-
potentiates the activating effect of HMR-1766 on the wild-type enzyme
atrial natriuretic peptide
-
highly effective in stimulating cGMP production in MA-10 cells
-
BAY 41-8543
-
i.e. 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)pyrimidine-4,6-diamine, a sGC stimulator
natriuretic peptide
-
the transcription factor Ets-1 regulates the natriuretic peptide receptor-A gene expression and the stimulation of the guanylate cyclase GC-A isozyme
-
NO
-
activates the sGCalpha2beta1 enzyme and induces muscle relaxation after electric field stimulation
NO
-
NO, acting via isozyme sGCalpha1beta1, is the principal neurotransmitter in electrical field stimulation-evoked responses
YC-1
-
i.e. 1-benzyl-3-(5'-hydroxymethyl-2'-furyl-)-indazol, a sGC sensitizer, able to potentiate CO- and CORM-2-induced relaxations in wild-type mice
YC-1
-
synergistic with NO, blocked by 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one
additional information
-
C-type natriuretic peptide does not stimulate cGMP production
-
additional information
-
direct stimulation of cGMP synthesis and activation of mitogen-activated protein kinase signaling pathways underlies the capacity of Mn2+ to augment NF-kappaB-dependent gene expression in astrocytes
-
additional information
-
effects of activators and inhibitors on enzyme regulation, overview
-
additional information
-
NO-independent sGC activation is synergistic with NO-sGC stimulation
-
additional information
-
synthesis of STa, exogenous heat-stable enterotoxin, fragments peptide 3 and peptide 6, which behave as agonists in stimulating cGMP production, overview
-
additional information
treatment of mice with angiotensin II results in enhanced pulmonary mRNA expression of spliced GC-A, which is concomitant to diminished GC-A/cGMP responses to atrial natriuretic peptide, overview
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.63
GTP
-
isozyme RetGC2, stimulated by guanylyl cyclase activating protein 1,in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
0.64
GTP
-
isozyme RetGC1, stimulated by guanylyl cyclase activating protein 1, in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
0.7
GTP
-
isozyme RetGC1, stimulated by guanylyl cyclase activating protein 2, in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
0.79
GTP
-
isozyme RetGC2, stimulated by guanylyl cyclase activating protein 2,in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
1.55
GTP
-
nonstimulated isozyme RetGC1, in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
3.18
GTP
-
nonstimulated isozyme RetGC2, in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2.6
GTP
-
nonstimulated isozyme RetGC1, in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
20
GTP
-
nonstimulated isozyme RetGC2, in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
33
GTP
-
isozyme RetGC1, stimulated by guanylyl cyclase activating protein 2, in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
74
GTP
-
isozyme RetGC1, stimulated by guanylyl cyclase activating protein 1, in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
94
GTP
-
isozyme RetGC2, stimulated by guanylyl cyclase activating protein 2,in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
116
GTP
-
isozyme RetGC2, stimulated by guanylyl cyclase activating protein 1,in 30 mM MOPS-KOH (pH 7.2), 60 mM KCl, 4 mM NaCl, 1 mM dithiothreitol, 2 mM Ca2+/EGTA buffer, at 30°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.4
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
guanylyl cyclase C is a protein that is expressed in the cells that line the normal intestine and by metastatic colorectal cancer cells. Isozyme GCC is universally expressed by primary and metastatic colorectal tumors
-
retina and rod segements, retGC is a transmembrane protein localized in the outer segment
-
dorsal root ganglion, NO-GC is restricted to non-neuronal cells in dorsal root ganglia
-
guanylyl cyclase-C protein is expressed predominantly on the somata and dendrites of dopaminergic neurons in the the midbrain ventral tegmental area and substantia nigra compacta
-
isozyme GC-D is exclusively expressed in the olfactory neuroepithelium in rodents
-
the membrane guanylate cyclase is exclusively expressed in the CO2-responsive olfactory sensory neurons
-
isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina
-
detectable at day 18 of postnatal development and thereafter increasing progressively
additional information
guanylyl cyclase C is a protein that is expressed in the cells that line the normal intestine and by metastatic colorectal cancer cells
-
soluble guanylate cyclase accounts for nearly 20% of the total guanylate cyclase activity of the retina
-
isozymes GC-E and GC-F are colocalized within the same photoreceptor cells of the retina
-
predominantly expressed from round spermatids to spermatozoa in mouse testis at both the mRNA and protein levels
additional information
-
not detectable in spermatogonia, Sertoli cells, and spermatocytes
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
-
-
-
retGC is a transmembrane protein localized in the outer segment
-
overlying the acrosome and midpiece of the flagellum in mature sperm
-
several membrane guanylyl cyclase receptor isozymes, GC-A to GC-G
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
physiological function
malfunction
-
guanyl cyclase-C-knockout mice exhibit hyperactivity and attention deficits
physiological function
-
guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart
physiological function
-
guanyl cyclase-C activation potentiates the excitatory responses mediated by glutamate and acetylcholine receptors via the activity of GMP-dependent protein kinase
physiological function
-
isozyme RetGC1 is absolutely required for cone function and survival
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). GUC2G_MOUSE
1100
0
122546
Swiss-Prot
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
heterodimer
-
alphabeta heterodimer, the sGCalpha1 subunit harbors an essential part of the catalytic domain
homodimer
additional information
homodimer
-
functional enzyme form of atrial natriuretic factor receptor guanylate cyclases
additional information
-
isozymes GC-A to GC-G share a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic guanylate cyclase region, structure and functions of membrane guanylate cyclase isozymes, overview
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
-
activation by Src kinase-dependent phosphorylation of sGC beta1-subunit-Tyr192
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
H105F
-
the enzyme of heme-free alpha1-subunit/H105F beta1-subunit sGC mutant is not activated by sodium nitroprusside, but by HMR-1766, 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one does not potentiate the activating effect of HMR-1766 in mutant cells, while it does in wild-type cells, binding structure of H105F mutant with HMR-1766, overview
W669A
-
the mutant is only slightly responsive to the ATP/ANF signal, at about 29% compared to the wild-type enzyme
W669L
-
the mutant is only slightly responsive to the ATP/ANF signal, at about 29% compared to the wild-type enzyme
additional information
additional information
generation of a mutant mouse with a targeted disruption of the GC-G gene Gucy2g, which shows no histologic abnormalities at baseline, but after I/R injury, elevations in serum creatinine and urea are attenuated in GC-G knockout mice compared with wild-type controls, and this correlated with less tubular disruption, less tubular cell apoptosis, and less caspase-3 activation, phenotype, overview. Direct transfer of a GC-G expression plasmid to the kidneys of GC-G-deficient mice results in a dramatically higher mortality after renal I/R injury
additional information
-
generation of a mutant mouse with a targeted disruption of the GC-G gene Gucy2g, which shows no histologic abnormalities at baseline, but after I/R injury, elevations in serum creatinine and urea are attenuated in GC-G knockout mice compared with wild-type controls, and this correlated with less tubular disruption, less tubular cell apoptosis, and less caspase-3 activation, phenotype, overview. Direct transfer of a GC-G expression plasmid to the kidneys of GC-G-deficient mice results in a dramatically higher mortality after renal I/R injury
additional information
-
endothelial NO synthase and natriuretic peptide receptor-A knockout mice, sodium nitroprusside and atrial natriuretic peptide produce enhanced dose-dependent reductions in mean arterial blood pressure in endothelial NO synthase knockout mice. In natriuretic peptide receptor-A knockout mice, sodium nitroprusside produces a dose-dependent reduction in mean arterial blood pressure that is significantly higher than that in wild-type mice. Responsiveness to the cAMP-dependent vasodilator epoprostenol is similar in wild-type, endothelial NO synthase and natriuretic peptide receptor-A knockout animals. Atrial natriuretic peptide causes vasodilatation of the forearm resistance vasculature that is significantly higher in individuals lacking endothelium-derived NO
additional information
-
GC1-/-, GC2-/- and GC1/GC2 double knock-out mice, GC1 expression level is maintained in GC2-/- retina and GC2 expression level is maintained in GC1-/- retina. Deletion of GC1 and GC2 renders rod and cone photoreceptors nonfunctional and unstable. In the rod outer segments of guanylate cyclase double knock-out mice, guanylate cyclase-activating proteins 1 and 2, and cyclic GMP phosphodiesterase are undetectable, although rhodopsin and transducin alpha-subunit are mostly unaffected. Outer segment membranes of GC1-/- and GC double knock-out cones are destabilized and devoid of cone transducin (alpha- and gamma-subunits), cone phosphodiesterase, and G protein-coupled receptor kinase 1, whereas cone pigments are present at reduced levels. Down-regulated proteins show normal RNA transcript levels, indicating that down-regulation is posttranslational
additional information
-
basal cGMP levels are lower in sGCalpha1 knockout strips but NO still significantly increases cGMP levels versus basal. In conclusion, in the absence of sGCalpha1beta1, exogenous NO is able to partially act through sGCalpha2beta1, comparison of the soluble guanylate cyclase (sGC) isoforms ?1?1 and ?2?1, and of wild-type with sGCalpha1 knockout mice in the relaxation of distal colon by exogenous NO and by NANC nerve stimulation, overview
additional information
-
construction and phenotype of sGCalpha1 KO mice, expression levels of sGC subunits are altered in the mutant compared to the wild-type mice, the KO mice show reduced enzyme activation and induced muscle relaxation by CO, overview
additional information
-
construction of a deletion mutant of ANF-RGC lacking the 669WTAPELL675 motif
additional information
construction of a mutant GC-ADELTALys314-Gln330 and transfection into HEK-293 cells leading to complete inhibition of binding of atrial natriuretic peptide and atrial natriuretic peptide-induced cyclic GMP formation, overview. Alternative splicing does not affect membrane localization of GC-A, overview
additional information
construction of a truncated GCC 1-430 construct, GCC ECD, containing the extracellular ligand-binding domain and a C-terminus His6-tag in in colorectal cancer cells using a viral vector, overview
additional information
-
construction of a truncated GCC 1-430 construct, GCC ECD, containing the extracellular ligand-binding domain and a C-terminus His6-tag in in colorectal cancer cells using a viral vector, overview
additional information
-
construction of GC-A knockout mice that show significant chronic hypervolemic hypertension, phenotype, overview
additional information
-
construction of isozyme sGCalpha1-deficient mice, in contrast to wild-type mice, the neurologic and myocardial functions are reduced in cardiac arrest and cardiopulmonary resuscitation, CPR, the detrimental effects are associated with enhanced inflammation of heart and liver, and increased cell death in heart, liver, and brain, which can be prevented by overexpression of NO synthase 3, overview
additional information
-
construction of mice deficient in one of the two isozymes NO-GC1 and NO-GC2 or in both, phenotypes, overview
additional information
-
GC-C knckout in intestinal epithelial cells increases apoptosis following radiation-injury, supplementation with cGMP ameliorates radiation-induced apoptosis, overview
additional information
-
generation of sGCalpha1 subunit KO mice, that show abolished muscle relaxation after electric field stimulation more pronounced in female than in male KO mice
additional information
-
mice deficient in isozyme GC-A show marked cardiac hypertrophy and fibrosis, which can be inhibited by both genetic and pharmacological blockade of type 1 angiotensin II receptors. The mutant mice show increased expression of atrial and brain natriuretic peptides, and increased systemic blood pressure and heart weight to body weight ratios compared to the wild-type mice, overview
additional information
-
mouse line lacking retGC-1, GCE null, light-induced transducin redistribution occurs faster in mice lacking ret-GC1, phenotype, overview
additional information
-
nociceptive behavior of mice deficient in NO-sensitive guanylyl cyclase, GC-KO mice fail to develop pain sensitization induced by intrathecal administration of drugs releasing NO or carbon monoxide, NO-, CO-, and cGMP-induced pain behavior in GC-KO mice, overview
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant GC-D partially from HEK-293T cell membranes, recombinant His-tagged intracellular cyclase domain of GC-D consisting of GC-D residues 850-1110 in insect HiFive cells by nickel affinity chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of isozyme GC-A, DNA and amino acid sequence determination, analysis, and quantitative expression analysis, expression of FLAG-tagged or HA-tagged wild-type GC-A and of mutant GC-ADELTALys314-Gln330 and in HEK-293 cells
expression analysis of sGC subunits in pulmonary artery tissue from healthy and hypertensive lungs
-
expression of the heme-free alpha1-subunit/H105F beta1-subunit sGC mutant in COS-7 cells
-
expression of the His6-tagged truncated enzyme mutant in CT26 mouse colon cancer cells, subclining in 293T cells
functional transient expression of GC-D HEK-293T cell membranes, expression of His-tagged intracellular cyclase domain of GC-D consisting of GC-D residues 850-1110 in insect HiFive cells by using the baculovirus expression system
-
the sGCalpha1 gene encodes for an essential part of the catalytic domain. Quantitative expression analysis by RT-PCR and relative levels of alpha1, alpha2, and beta1 subunit mRNA in male KO tissues versus male wild-type tissues
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
pharmacology
alternative splicing can regulate endogenous ANP/GC-A signaling, thus, angiotensin II-induced alternative splicing of GC-A may represent a mechanism for reducing the sensitivity to atrial natriuretic peptide
additional information
medicine
-
crosstalk occurs between the NO-sGC and atrial natriuretic peptide-pGC pathways to regulate cGMP-dependent vasodilatation in vivo
medicine
-
inhibition of sGC is an approach to restore hypoxic pulmonary vasoconstriction during endotoxemia
additional information
-
coexistence of homologous and heterologous desensitization of GC-A in the same cell type, these reactions are mediated by different pathways, cross talk between phospholipid and natriuretic peptide signaling
additional information
-
intrinsic requirement of guanylate cyclases for stability and/or transport of a set of membrane-associated phototransduction proteins
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Durham, J.P.
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61
535-544
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Mus musculus
Sitaramayya, A.
Soluble guanylate cyclases in the retina
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Bos taurus, Mus musculus
Madhani, M.; Okorie, M.; Hobbs, A.J.; MacAllister, R.J.
Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo
Br. J. Pharmacol.
149
797-801
2006
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Mueller, D.; Cortes-Dericks, L.; Budnik, L.T.; Brunswig-Spickenheier, B.; Pancratius, M.; Speth, R.C.; Mukhopadhyay, A.K.; Middendorff, R.
Homologous and lysophosphatidic acid-induced desensitization of the atrial natriuretic peptide receptor, guanylyl cyclase-A, in MA-10 leydig cells
Endocrinology
147
2974-2985
2006
Mus musculus, Rattus norvegicus
Huang, Y.H.; Wei, C.C.; Su, Y.H.; Wu, B.T.; Ciou, Y.Y.; Tu, C.F.; Cooper, T.G.; Yeung, C.H.; Chu, S.T.; Tsai, M.T.; Yang, R.B.
Localization and characterization of an orphan receptor, guanylyl cyclase-G, in mouse testis and sperm
Endocrinology
147
4792-4800
2006
Mus musculus
Baehr, W.; Karan, S.; Maeda, T.; Luo, D.G.; Li, S.; Bronson, J.D.; Watt, C.B.; Yau, K.W.; Frederick, J.M.; Palczewski, K.
The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors
J. Biol. Chem.
282
8837-8847
2007
Mus musculus, Mus musculus C57/BL6J
Garin-Laflam, M.P.; Steinbrecher, K.A.; Rudolph, J.A.; Mao, J.; Cohen Md, M.B.
Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis
Am. J. Physiol. Gastrointest. Liver Physiol.
296
740-749
2009
Mus musculus, Mus musculus BALB/c
Zhou, Z.; Pyriochou, A.; Kotanidou, A.; Dalkas, G.; van Eickels, M.; Spyroulias, G.; Roussos, C.; Papapetropoulos, A.
Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress
Am. J. Physiol. Heart Circ. Physiol.
295
H1763-H1771
2008
Mus musculus
Schmidt, E.P.; Damarla, M.; Rentsendorj, O.; Servinsky, L.E.; Zhu, B.; Moldobaeva, A.; Gonzalez, A.; Hassoun, P.M.; Pearse, D.B.
Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice
Am. J. Physiol. Lung Cell Mol. Physiol.
295
L1056-L1065
2008
Mus musculus, Mus musculus C57BL/6
Rosenzweig, D.H.; Nair, K.S.; Levay, K.; Peshenko, I.V.; Crabb, J.W.; Dizhoor, A.M.; Slepak, V.Z.
Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization
Biochem. J.
417
803-812
2009
Bos taurus, Mus musculus, Homo sapiens (Q02846)
Tian, X.; Michal, A.M.; Li, P.; Wolfe, H.R.; Waldman, S.A.; Wickstrom, E.
STa peptide analogs for probing guanylyl cyclase C
Biopolymers
90
713-723
2008
Homo sapiens, Mus musculus
Kumar, P.; Bolden, G.; Arise, K.K.; Krazit, S.T.; Pandey, K.N.
Regulation of natriuretic peptide receptor-A gene expression and stimulation of its guanylate cyclase activity by transcription factor Ets-1
Biosci. Rep.
29
57-70
2009
Mus musculus
Oppermann, M.; Dao, V.T.; Suvorava, T.; Bas, M.; Kojda, G.
Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase
Br. J. Pharmacol.
155
335-342
2008
Oryctolagus cuniculus, Mus musculus, Mus musculus C57BL/6
Hoenicka, M.; Schmid, C.
Cardiovascular effects of modulators of soluble guanylyl cyclase activity
Cardiovasc. Hematol. Agents Med. Chem.
6
287-301
2008
Bos taurus, Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa, Ovis aries (Q8SPV3)
Nishida, T.; Yu, J.D.; Minamishima, S.; Sips, P.Y.; Searles, R.J.; Buys, E.S.; Janssens, S.; Brouckaert, P.; Bloch, K.D.; Ichinose, F.
Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice
Crit. Care Med.
37
256-262
2009
Mus musculus
Schreier, B.; Boerner, S.; Voelker, K.; Gambaryan, S.; Schaefer, S.C.; Kuhlencordt, P.; Gassner, B.; Kuhn, M.
The heart communicates with the endothelium through the guanylyl cyclase-A receptor: acute handling of intravascular volume in response to volume expansion
Endocrinology
149
4193-4199
2008
Mus musculus
Dhaese, I.; Vanneste, G.; Sips, P.; Buys, E.; Brouckaert, P.; Lefebvre, R.A.
Involvement of soluble guanylate cyclase alpha1 and alpha2, and SKCa channels in NANC relaxation of mouse distal colon
Eur. J. Pharmacol.
589
251-259
2008
Mus musculus
Schermuly, R.T.; Stasch, J.P.; Pullamsetti, S.S.; Middendorff, R.; Mueller, D.; Schlueter, K.D.; Dingendorf, A.; Hackemack, S.; Kolosionek, E.; Kaulen, C.; Dumitrascu, R.; Weissmann, N.; Mittendorf, J.; Klepetko, W.; Seeger, W.; Ghofrani, H.A.; Grimminger, F.
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
Eur. Respir. J.
32
881-891
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Mergia, E.; Koesling, D.; Friebe, A.
Genetic mouse models of the NO receptor soluble guanylyl cyclases
Handb. Exp. Pharmacol.
191
33-46
2009
Mus musculus
Kuhn, M.
Function and dysfunction of mammalian membrane guanylyl cyclase receptors: lessons from genetic mouse models and implications for human diseases
Handb. Exp. Pharmacol.
191
47-69
2009
Homo sapiens, Homo sapiens (P16066), Homo sapiens (P20594), Homo sapiens (P25092), Homo sapiens (P51841), Mus musculus
Zhang, Q.; Saito, Y.; Naya, N.; Imagawa, K.; Somekawa, S.; Kawata, H.; Takeda, Y.; Uemura, S.; Kishimoto, I.; Nakao, K.
The specific mineralocorticoid receptor blocker eplerenone attenuates left ventricular remodeling in mice lacking the gene encoding guanylyl cyclase-A
Hypertens. Res.
31
1251-1256
2008
Mus musculus
Lin, H.; Cheng, C.F.; Hou, H.H.; Lian, W.S.; Chao, Y.C.; Ciou, Y.Y.; Djoko, B.; Tsai, M.T.; Cheng, C.J.; Yang, R.B.
Disruption of guanylyl cyclase-G protects against acute renal injury
J. Am. Soc. Nephrol.
19
339-348
2008
Mus musculus (Q6TL19), Mus musculus
Hartmann, M.; Skryabin, B.V.; Mueller, T.; Gazinski, A.; Schroeter, J.; Gassner, B.; Nikolaev, V.O.; Buenemann, M.; Kuhn, M.
Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling
J. Biol. Chem.
283
28313-28320
2008
Mus musculus (P18293)
Makino, C.L.; Peshenko, I.V.; Wen, X.H.; Olshevskaya, E.V.; Barrett, R.; Dizhoor, A.M.
A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice
J. Biol. Chem.
283
29135-29143
2008
Mus musculus
Snook, A.E.; Stafford, B.J.; Li, P.; Tan, G.; Huang, L.; Birbe, R.; Schulz, S.; Schnell, M.J.; Thakur, M.; Rothstein, J.L.; Eisenlohr, L.C.; Waldman, S.A.
Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity
J. Natl. Cancer Inst.
100
950-961
2008
Mus musculus (Q3UWA6), Mus musculus, Mus musculus BALB/c (Q3UWA6)
Schmidtko, A.; Gao, W.; Koenig, P.; Heine, S.; Motterlini, R.; Ruth, P.; Schlossmann, J.; Koesling, D.; Niederberger, E.; Tegeder, I.; Friebe, A.; Geisslinger, G.
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I
J. Neurosci.
28
8568-8576
2008
Mus musculus
Moreno, J.A.; Sullivan, K.A.; Carbone, D.L.; Hanneman, W.H.; Tjalkens, R.B.
Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways
J. Neurosci. Res.
86
2028-2038
2008
Mus musculus, Mus musculus C57BL/6
Nagayama, T.; Zhang, M.; Hsu, S.; Takimoto, E.; Kass, D.A.
Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil
J. Pharmacol. Exp. Ther.
326
380-387
2008
Mus musculus
Gambaryan, S.; Kobsar, A.; Hartmann, S.; Birschmann, I.; Kuhlencordt, P.J.; Mueller-Esterl, W.; Lohmann, S.M.; Walter, U.
NO-synthase-/NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity
J. Thromb. Haemost.
6
1376-1384
2008
Homo sapiens, Mus musculus
Duda, T.; Bharill, S.; Wojtas, I.; Yadav, P.; Gryczynski, I.; Gryczynski, Z.; Sharma, R.K.
Atrial natriuretic factor receptor guanylate cyclase signaling: new ATP-regulated transduction motif
Mol. Cell. Biochem.
324
39-53
2009
Mus musculus
De Backer, O.; Elinck, E.; Sips, P.; Buys, E.; Brouckaert, P.; Lefebvre, R.A.
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus
Naunyn Schmiedebergs Arch. Pharmacol.
378
493-502
2008
Mus musculus
Dhaese, I.; Vanneste, G.; Sips, P.; Buys, E.S.; Brouckaert, P.; Lefebvre, R.A.
Small intestinal motility in soluble guanylate cyclase alpha1 knockout mice: (Jejunal phenotyping of sGCalpha1 knockout mice)
Naunyn Schmiedebergs Arch. Pharmacol.
379
473-487
2008
Mus musculus
Sun, L.; Wang, H.; Hu, J.; Han, J.; Matsunami, H.; Luo, M.
Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate
Proc. Natl. Acad. Sci. USA
106
2041-2046
2009
Mus musculus
Li, Y.; Saito, Y.; Kuwahara, K.; Rong, X.; Kishimoto, I.; Harada, M.; Adachi, Y.; Nakanishi, M.; Kinoshita, H.; Horiuchi, M.; Murray, M.; Nakao, K.
Guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart
Endocrinology
150
3759-3765
2009
Mus musculus
Hidaka, A.; Azuma, Y.T.; Nakajima, H.; Takeuchi, T.
Nitric oxide and carbon monoxide act as inhibitory neurotransmitters in the longitudinal muscle of C57BL/6J mouse distal colon
J. Pharmacol. Sci.
112
231-241
2010
Mus musculus
Spohr, F.; Busch, C.J.; Teschendorf, P.; Weimann, J.
Selective inhibition of guanylate cyclase prevents impairment of hypoxic pulmonary vasoconstriction in endotoxemic mice
J. Physiol. Pharmacol.
60(2)
107-112
2009
Mus musculus
Peshenko, I.V.; Olshevskaya, E.V.; Savchenko, A.B.; Karan, S.; Palczewski, K.; Baehr, W.; Dizhoor, A.M.
Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors
Biochemistry
50
5590-5600
2011
Mus musculus
EXTERNAL LINKS (specific for EC-Number 4.6.1.2)
Transporter Classification Database (TCDB): 1.A.87.2.9, 8.A.85.1.6, 8.A.85.1.2, 8.A.85.1.1, 8.A.85.1.3
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