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17beta-estradiol
-
decreases enzyme activity in immature rats, while the amount of sGC alpha subuit increases, estrogen receptor-dependent effects, overview
1H-(1,2,4)oxadiazole(4,3-a)quinoxalin-1-one
-
-
1H-[1,2,4]-oxadiazole[4,3-a]quinoxalin-1-one
i.e. ODQ, a highly selective sGC inhibitor
1H-[1,2,4]oxadiazolo [4,3,-a]quinoxalin-1-one
i.e. ODQ, in vivo treatment with the sGC inhibitors ODQ does not decrease plasmatic and jejunal cGMP levels, nor does it influence the change in electrical field-induced relaxation
1H-[1,2,4]oxadiazolo[4,3-a]-quinoxalin-1-one
-
specific sGC inhibitor, significantly blocks the capsaicin-induced reduction of mechanical threshold to noxious stimulation of the masseter
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
-
-
1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one
-
-
4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
-
i.e. NS-2028, acts via the heme domain
6-(ethoxymethyl)-1-methyl-1,4,5,6-tetrahydropyrrolo[2,3-g]indazole
-
-
6-(ethoxymethyl)-1-phenyl-1,4,5,6-tetrahydropyrrolo[2,3-g]indazole
-
-
6-(ethoxymethyl)-5,6-dihydro-4H-[1,2]oxazolo[5,4-e]indole
-
-
6-(ethoxymethyl)-6H-[1,2]oxazolo[5,4-e]indole
-
-
6-anilino-5,8-quinolinedione
-
-
6H-[1,2,4]oxadiazolo[4,3-d]pyrido[3,2-b][1,4]oxazin-9-one
-
-
8-(4-methoxyphenyl)-4H-[1,2,4]oxadiazolo[3,4-c][1,4]-benzoxazin-1-one
-
-
8-bromo-4H-[1,2,4]oxadiazolo[3,4-c]benzoxazin-1-one
-
NS 2028
8-oxoguanosine triphosphate
-
i.e. oxo8GTP, a potent competitive inhibitor of nitric oxide-stimulated soluble guanylyl cyclase
8-[3-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo[3,4-c]-benzoxazin-1-one
-
-
9-chloro-12-oxo-6,12-dihydroquinazolino[2,3-c][1,4]-benzoxazine
-
-
adenosine-5'-tetraphosphate
-
basal activity of wild-type enzyme is considerably less sensitive than NO-stimulated wild-type activity
ADPbetaS
-
basal activity of wild-type enzyme is considerably less sensitive than NO-stimulated wild-type activity
GDPbetaS
-
basal activity of wild-type enzyme is considerably less sensitive than NO-stimulated wild-type activity
guanosine-5'-tetraphosphate
-
basal activity of wild-type enzyme is considerably less sensitive than NO-stimulated wild-type activity
LY-83583
-
inhibits the enzyme and completely blocks at 5 mM high frequency stimuli at 20 Hz/20 s-induced gLTP in superior cervical ganglia isolated from control rats
LY83583
-
a selective sGC inhibitor
Mg2+ATPgammaS
-
inhibits cyclase activity through a mixed, non-competitive mechanism, only observable under NO stimulation and not under basal conditions
Mg2+GTPgammaS
-
inhibits cyclase activity through a mixed, non-competitive mechanism, only observable under NO stimulation and not under basal conditions
ONE-GC 880MGTTVEPEYFDQVTIYFSDIVG901
-
causes ca. 90% inhibition
ONE-GC 900VGFTTISALSEPIEVVGFLNDL921
-
most effective inhibitor, causes ca. 95% inhibition
XDP
-
basal activity of wild-type enzyme is considerably less sensitive than NO-stimulated wild-type activity
XTP
-
basal activity of wild-type enzyme is considerably less sensitive than NO-stimulated wild-type activity
[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one
-
-
[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
-
-
ATP
-
-
ATP
-
in solubilized membranes ATP exerts an inhibitory role on basal and atrial natriuretic peptide 1-28-induced GC activity
ITP
-
-
ITP
-
basal activity of wild-type enzyme is considerably less sensitive than NO-stimulated wild-type activity
methylene blue
-
-
methylene blue
-
non-specific sGC inhibitor, significantly blocks the capsaicin-induced reduction of mechanical threshold to noxious stimulation of the masseter
methylene blue
in vivo treatment with the sGC inhibitor methylene blue does not decrease plasmatic and jejunal cGMP levels, nor does it influence the change in electrical filed stimulation-induced relaxation
methylene blue
inhibits by oxidation of the enzyme's ferrous heme
additional information
-
the N-terminal heme-bound regulatory domain of the beta1 subunit of soluble guanylate cyclase inhibits the activity of the alphacatbetacat complex in trans, suggesting a domain-scale mechanism of regulation by NO
-
additional information
-
desensitization of the soluble guanylyl cyclase/cGMP pathway by lipopolysaccharide in rat isolated pulmonary artery but not aorta
-
additional information
-
effects of activators and inhibitors on enzyme regulation, overview
-
additional information
-
phosphorylation at Ser64 of the alpha1 subunit inhibits the enzyme
-
additional information
-
12-oxo-6,12-dihydroquinazolino[2,3-c][1,4]benzoxazine, 2-bromo-12-oxo-6,12-dihydroquinazolino[2,3-c][1,4]-benzoxazine, and 8-bromo-2,4-dihydro-1H-[1,2,4]triazolo[3,4-c][1,4]-benzoxazin-1-one do not exhibit an inhibitory effect on sGC
-
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(R)-3',5-dihydroxy-4',7-dimethoxyspiro(2H-1-benzopyran-3(4H)-7'-bicyclo[4.2.0]-octa[1,3,5]-trien)4-one
-
activates the soluble guanylate cyclase exhibiting a vasorelaxing effect on the aortic ring, the compound is isolated from bulbs of South African Hyacinthaceae, i.e. Drimiopsis maculata, Eucomis schiffii, Urginea epigea, Drimia altissima, mass spectrometric identification. The compound counteracts vasocontractory agents, overview
(Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate
-
sGC ferrous-nitrosyl complex adopts two 5-coordinate conformations, a lower activity closed form, which releases NO slowly, and a higher activity open form, which releases NO rapidly
1-benzyl-3-(hydroxymethyl-2-furyl)indazole
-
trivial name YC-1, allosteric activator, synergistically increases the catalytic activity in the presence of NO
2-(N,N-diethylamino)-diazenolate-2-oxide
-
stimulates 4.3fold
2-(N,N-diethylamino)diazenolate-2-oxide
-
the wild type enzyme shows 59fold stimulation of activity at 0.001 mM 2-(N,N-diethylamino)diazenolate-2-oxide
3-(5'-hydroxymethyl-2'-furylf)-1-benzylimdazole
-
activation
3-(5'-hydroxymethyl-3'-furyl)-1-benzylindazole
-
-
4-((4-carboxybutyl){2-[(4-phenethyl-benzyl)oxy]-phenethyl}amino)methyl[benzoic]acid
-
NO- and heme-independent sGC activator, stimulates 15fold, stimulation increases up to 30fold in the presence of 1H-(1,2,4)-oxadiazole-(4,3-a)-quinoxalin-1-one
5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine
-
NO-independent but heme-dependent sGC stimulator, stimulates the enzyme in a concentration-dependent manner
5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
-
the wild type enzyme shows 6fold stimulation of activity at 0.1 mM
A-350619
-
a heme-dependent stimulator of sGC, structurally not related to YC-1, but synergistic to YC-1 and sodium nitroprusside for the binding site
A-778935
-
i.e. cis-3-[2-(2,2-dimethyl-propylsulfanyl)pyridin-3-yl]-N-(3-hydroxycyclohexyl-)acrylamide, derived from the YC-1 structure, activates the enzyme is a synergistic fashion with the NO donor sodium nitroprusside
Activator protein
-
from rat lung
-
adenylylimidophosphate
-
activation
ATP
-
induces a concentration-dependent increase in basal and atrial natriuretic peptide 1-28-stimulated GC activity of glomerular and papillary membranes that is significantly higher in spontaneously hypertensive rats than in age-matched Wistar Kyoto rats
ATPgammaS
-
is more effective than ATP on glomerular and papillary membranes, has little effect on GC activity in solubilized membranes
atrial natriuretic peptide
-
atrial natriuretic peptide 1-28
-
increases GC enzymatic activity of glomerular and papillary membranes in a concentration-dependent manner
-
BAY 41-8543
-
lowers blood pressure in normotensive rats
BAY 58-2667
-
long term treatment causes a slight decrease in systolic blood pressure
BAY 60-2770
-
i.e. 4-([(4-carboxybutyl)[2-(5-fluoro-2-([4'-(trifluoromethyl)biphenyl-4-yl]methoxy)phenyl)ethyl]amino]methyl)benzoic acid, NO-independent activation, the compound attenuates pig serum-induced liver fibrosis in vivo but does not affect blodd pressure in spontaneously hypertensive rats, overview
BaY 63-2521
-
i.e. methyl-4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimindin-5-ylmethylcarbamate, stimulates sGC directly and sensitizes it to NO, causes enzyme upregulation in pulmonary arterial hypertension lungs
brain natriuretic peptide
-
activation of isoforms GC-A and GC-B
-
C-type natriuretic peptide
-
G protein alpha subunit
-
-
-
heat-stable enterotoxin
-
-
-
HMR-1766
-
chronic treatment causes reduced ex-vivo platelet adhesion and in vivo vasodilator-stimulated phosphoprotein phosphorylation
N-(beta-D-glucopyranosyl-N2-acetyl-S-nitroso-D,L-penicillaminamide)
-
NO donor
natriuretic peptide
-
-
-
neurocalcin
-
in the presence of the semimicromolar range of free Ca2+, neurocalcin binds to the catalytic module and stimulates ONE-GC, M880-L921 region of ONE-GC is the Ca2+-dependent neurocalcin binding and the transduction site of ONE-GC
-
neurocalcin sigma
-
dose-dependent stimulation in presence of the 0.01 mM Ca2+, 8fold over the basal value at ca. 0.002 mM
-
nitrosobutane
-
6fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 47fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole
nitrosohexane
-
2fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 33fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole
nitrosooctane
-
2fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 11fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole
nitrosopentane
-
2fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 39fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole
nitrosopropane
-
2fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 45fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole
phenylhydrazine
-
acivation
prostaglandin endoepoxide analogs
-
activation
-
protoporphyrin-IX
-
the wild type enzyme shows 1.9fold stimulation of activity at 0.1 mM and 12fold stimulation at 0.01 mM
S-nitroso-N-acetylpenicillamine
-
the wild type enzyme shows 14.5fold stimulation of activity at 0.1 mM
Triton X-100
-
activation
unsaturated fatty acids
-
activation
-
uroguanylin
-
stimulates ONE-GC through its external domain in a dose-dependent fashion
atrial natriuretic peptide
-
-
-
atrial natriuretic peptide
-
activation of isoforms GC-A and GC-B
-
atrial natriuretic peptide
-
increases cGMP production up to 300fold
-
BAY 41-2272
-
sGC stimulant, relaxes newborn, but not adult bronchial muscle
BAY 41-2272
-
a direct sGC activator
BAY 41-2272
-
an allosteric activator
BAY 41-2272
-
is effective against pulmonary hypertension in a rat model
C-type natriuretic peptide
-
-
-
C-type natriuretic peptide
-
activation of isoforms GC-A and GC-B
-
CO
-
activation
CO
-
2fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 115fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole
nitric oxide
-
nitric oxide
-
nitric oxide binds to its receptor soluble guanylyl cyclase and leads to 3',5'-cyclic-GMP production
NO
-
-
NO
-
binds at beta1 subunit heme, several hundred fold increase in activity
NO
-
127fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 211fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole
NO
-
binds to the heme cofactor in the beta1 subunit, forming a five-coordinate NO complex that activates the enzyme several hundred-fold
NO
-
NO binds to the heme of soluble guanylate cyclase heme, activating the enzyme. In the presence of physiological concentrations of ATP and GTP, NO dissociation from the heme of soluble guanylate cyclase is about 160 times slower than the rate of enzyme deactivation in vitro. Deactivated enzyme still has NO bound to the heme, and full activation requires additional NO. An activation model is proposed where, in the presence of both ATP and GTP, tonic NO forms a stable heme complex with low activity, acute production of NO transiently and fully activates this NO-bound enzyme
NO
-
beta2 homodimer forms a five-coordinate Fe(II)-NO-complex
NO
-
binding of NO to sGC leads to the formation of a five-coordinate ferrous-nitrosyl complex and a several hundred-fold increase in cGMP synthesis, the NO activation of sGC is influenced by GTP and the allosteric activators YC-1 and BAY 41-2272, analysis of the Fe-NO conformation, overview
NO
-
binds and activates the enzyme
NO
-
NO indirectly inhibits 5-lipoxygenase metabolism synthesis via activation of soluble guanylyl cyclase in rat alveolar macrophages
NO
-
physiologic stimulator
NO
-
the sensitivity to NO is increased in case of obesity and high-fat diet
sodium nitroprusside
-
-
sodium nitroprusside
-
activation of the soluble form
sodium nitroprusside
-
NO donor
sodium nitroprusside
-
NO donor, significant higher stimulation of sGC activity in newborns compared with adults
sodium nitroprusside
activates via release of NO
sodium nitroprusside
-
an NO donor
sodium nitroprusside
-
synergistic to YC-1 and A-350619 for the binding site
YC-1
-
sGC stimulant, relaxes newborn, but not adult bronchial muscle
YC-1
-
a non-NO-dependent activator of sGC
YC-1
-
an allosteric activator
YC-1
-
synergistic with NO, blocked by 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one
additional information
-
C-type natriuretic peptide does not stimulate cGMP production
-
additional information
-
guanylin is totally ineffective in stimulating ONE-GC
-
additional information
-
effects of activators and inhibitors on enzyme regulation, overview
-
additional information
soluble GC alpha-1 and beta-1 subunit mRNA levels are increased in the lungs, but not in the aorta in a sepsis model, overview
-
additional information
soluble GC alpha-1 and beta-1 subunit mRNA levels are increased in the lungs, but not in the aorta in a sepsis model, overview
-
additional information
-
tirofiban, which mimics the structure of arginine-glycine-aspartic acid peptides, up-regulates soluble guanylate cyclase beta1 subunit, sGC-beta1, expression in contractile vascular smooth muscle cells and in aorta from rats, and tirofiban reverses the down-regulation of soluble guanylate cyclase content promoted by chronic treatment with NO donors and NO donor tachyphylaxis
-
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Purification and properties of heme-deficient hepatic soluble guanylate cyclase: effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX
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218
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1982
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Zwiller, J.; Basset, P.; Mandel, P.
Rat brain guanylate cyclase. Purification, amphiphilic properties and immunological characterization
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658
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1981
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Characterization of rat testicular guanylate cyclase during development
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587
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Rattus norvegicus
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Purification of soluble guanylate cyclase from rat liver
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Purification of soluble guanylate cyclase from rat lung
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254
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Rattus norvegicus
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Purification of guanylate cyclase from rat liver supernatant
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253
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-
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Purification and properties of guanylate cyclase from the synaptosomal soluble fraction of rat brain
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Properties and subcellular distribution of guanylate cyclase activity in rat renal medulla: correlation with tissue content of guanosine 3 ,5 -monophosphate
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55
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Characterization of particulate and soluble guanylate cyclases from rat lung
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Rattus norvegicus
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Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3 ,5 -monophosphate from guanosine trihosphate
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25
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Characterization of ATP-stimulated guanylate cyclase activation in rat lung membranes
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Waldman, S.A.; Leitman, D.C.; Murad, F.
Immunoaffinity purification of soluble guanylyl cyclase
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Functional Characterization of Nitric Oxide and YC-1 Activation of Soluble Guanylyl Cyclase: Structural Implication for the YC-1 Binding Site?
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Ultracytochemistry as a tool for the study of the cellular and subcellular localization of membrane-bound guanylate cyclase (GC) activity. Applicability to both receptor-activated and receptor-independent GC activity
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Characterization of functional heme domains from soluble guanylate cyclase
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Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domain
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Soluble guanylate cyclase-dependent relaxation is reduced in the adult rat bronchial smooth muscle
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ONE-GC membrane guanylate cyclase, a trimodal odorant signal transducer
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Soluble guanylate cyclase
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Bos taurus, Clostridium botulinum, Homo sapiens, Rattus norvegicus, Caldanaerobacter subterraneus subsp. tengcongensis, Vibrio cholerae serotype O1
brenda
Mueller, D.; Cortes-Dericks, L.; Budnik, L.T.; Brunswig-Spickenheier, B.; Pancratius, M.; Speth, R.C.; Mukhopadhyay, A.K.; Middendorff, R.
Homologous and lysophosphatidic acid-induced desensitization of the atrial natriuretic peptide receptor, guanylyl cyclase-A, in MA-10 leydig cells
Endocrinology
147
2974-2985
2006
Mus musculus, Rattus norvegicus
brenda
Winger, J.A.; Derbyshire, E.R.; Marletta, M.A.
Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs
J. Biol. Chem.
282
897-907
2007
Rattus norvegicus
brenda
Ding, J.D.; Weinberg, R.J.
Localization of soluble guanylyl cyclase in the superficial dorsal horn
J. Comp. Neurol.
495
668-678
2006
Rattus norvegicus
brenda
Pifarre, P.; Garcia, A.; Mengod, G.
Species differences in the localization of soluble guanylyl cyclase subunits in monkey and rat brain
J. Comp. Neurol.
500
942-957
2007
Macaca fascicularis, Rattus norvegicus
brenda
Ding, J.D.; Weinberg, R.J.
Distribution of soluble guanylyl cyclase in rat retina
J. Comp. Neurol.
502
734-745
2007
Rattus norvegicus
brenda
Rothkegel, C.; Schmidt, P.M.; Atkins, D.J.; Hoffmann, L.S.; Schmidt, H.H.; Schroeder, H.; Stasch, J.P.
Dimerization region of soluble guanylate cyclase characterized by bimolecular fluorescence complementation in vivo
Mol. Pharmacol.
72
1181-1190
2007
Rattus norvegicus
brenda
Hodson, C.A.; Ambrogi, I.G.; Scott, R.O.; Mohler, P.J.; Milgram, S.L.
Polarized apical sorting of guanylyl cyclase C is specified by a cytosolic signal
Traffic
7
456-464
2006
Rattus norvegicus
brenda
Cabilla, J.P.; Ronchetti, S.A.; Nudler, S.I.; Miler, E.A.; Quinteros, F.A.; Duvilanski, B.H.
Nitric oxide sensitive-guanylyl cyclase subunits expression changes during estrous cycle in anterior pituitary glands
Am. J. Physiol. Endocrinol. Metab.
296
731-737
2009
Rattus norvegicus
brenda
Jebelovszki, E.; Kiraly, C.; Erdei, N.; Feher, A.; Pasztor, E.T.; Rutkai, I.; Forster, T.; Edes, I.; Koller, A.; Bagi, Z.
High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation
Am. J. Physiol. Heart Circ. Physiol.
294
H2558-H2564
2008
Rattus norvegicus
brenda
Zhou, Z.; Sayed, N.; Pyriochou, A.; Roussos, C.; Fulton, D.; Beuve, A.; Papapetropoulos, A.
Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity
Arterioscler. Thromb. Vasc. Biol.
28
1803-1810
2008
Rattus norvegicus
brenda
Knorr, A.; Hirth-Dietrich, C.; Alonso-Alija, C.; Haerter, M.; Hahn, M.; Keim, Y.; Wunder, F.; Stasch, J.P.
Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis
Arzneimittelforschung
58
71-80
2008
Rattus norvegicus
brenda
Derbyshire, E.R.; Gunn, A.; Ibrahim, M.; Spiro, T.G.; Britt, R.D.; Marletta, M.A.
Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes
Biochemistry
47
3892-3899
2008
Rattus norvegicus
brenda
Coffey, M.J.; Phare, S.M.; Luo, M.; Peters-Golden, M.
Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages
Biochim. Biophys. Acta
1781
299-305
2008
Rattus norvegicus
brenda
El-Awady, M.S.; Smirnov, S.V.; Watson, M.L.
Desensitization of the soluble guanylyl cyclase/cGMP pathway by lipopolysaccharide in rat isolated pulmonary artery but not aorta
Br. J. Pharmacol.
155
1164-1173
2008
Rattus norvegicus
brenda
Hoenicka, M.; Schmid, C.
Cardiovascular effects of modulators of soluble guanylyl cyclase activity
Cardiovasc. Hematol. Agents Med. Chem.
6
287-301
2008
Bos taurus, Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa, Ovis aries (Q8SPV3)
brenda
Ruiz-Torres, M.P.; Griera, M.; Chamorro, A.; Diez-Marques, M.L.; Rodriguez-Puyol, D.; Rodriguez-Puyol, M.
Tirofiban increases soluble guanylate cyclase in rat vascular walls: pharmacological and pathophysiological consequences
Cardiovasc. Res.
82
125-132
2009
Rattus norvegicus
brenda
Schermuly, R.T.; Stasch, J.P.; Pullamsetti, S.S.; Middendorff, R.; Mueller, D.; Schlueter, K.D.; Dingendorf, A.; Hackemack, S.; Kolosionek, E.; Kaulen, C.; Dumitrascu, R.; Weissmann, N.; Mittendorf, J.; Klepetko, W.; Seeger, W.; Ghofrani, H.A.; Grimminger, F.
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
Eur. Respir. J.
32
881-891
2008
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Bolin, C.; Cardozo-Pelaez, F.
Characterization of oxidized guanosine 5-triphosphate as a viable inhibitor of soluble guanylyl cyclase
Free Radic. Biol. Med.
46
828-835
2009
Bos taurus, Rattus norvegicus
brenda
Powers-Martin, K.; Barron, A.M.; Auckland, C.H.; McCooke, J.K.; McKitrick, D.J.; Arnolda, L.F.; Phillips, J.K.
Immunohistochemical assessment of cyclic guanosine monophosphate (cGMP) and soluble guanylate cyclase (sGC) within the rostral ventrolateral medulla
J. Biomed. Sci.
15
801-812
2008
Rattus norvegicus
brenda
Fusi, F.; Ferrara, A.; Koorbanally, C.; Crouch, N.R.; Mulholland, D.A.; Sgaragli, G.
Vascular myorelaxing activity of isolates from South African Hyacinthaceae partly mediated by activation of soluble guanylyl cyclase in rat aortic ring preparations
J. Pharm. Pharmacol.
60
489-497
2008
Rattus norvegicus
brenda
Fernandes, D.; de Sordi, R.; Pacheco, L.K.; Nardi, G.M.; Heckert, B.T.; Villela, C.G.; Lobo, A.R.; Barja-Fidalgo, C.; Assreuy, J.
Late but not early inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model
J. Pharmacol. Exp. Ther.
328
991-999
2008
Rattus norvegicus (P19686), Rattus norvegicus (Q80WY4)
brenda
Alzoubi, K.H.; Alkadhi, K.A.
Calmodulin and guanylyl cyclase inhibitors block the in vivo expression of gLTP in sympathetic ganglia from chronically stressed rats
Neurosci. Res.
63
95-99
2009
Rattus norvegicus
brenda
Abdelalim, E.M.; Masuda, C.; Tooyama, I.
Expression of natriuretic peptide-activated guanylate cyclases by cholinergic and dopaminergic amacrine cells of the rat retina
Peptides
29
622-628
2008
Rattus norvegicus (P16067), Rattus norvegicus (P18910)
brenda
Vanneste, G.; Van Nassauw, L.; Kalfin, R.; Van Colen, I.; Elinck, E.; Van Crombruggen, K.; Timmermans, J.P.; Lefebvre, R.A.
Jejunal cholinergic, nitrergic, and soluble guanylate cyclase activity in postoperative ileus
Surgery
144
410-426
2008
Rattus norvegicus (Q02108), Rattus norvegicus (Q02153)
brenda
Murphy, B.A.; Fakira, K.A.; Song, Z.; Beuve, A.; Routh, V.H.
AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons
Am. J. Physiol. Cell Physiol.
297
C750-C758
2009
Rattus norvegicus
brenda
Spyridonidou, K.; Fousteris, M.; Antonia, M.; Chatzianastasiou, A.; Papapetropoulos, A.; Nikolaropoulos, S.
Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase
Bioorg. Med. Chem. Lett.
19
4810-4813
2009
Rattus norvegicus
brenda
von Wantoch Rekowski, M.; Pyriochou, A.; Papapetropoulos, N.; Stoessel, A.; Papapetropoulos, A.; Giannis, A.
Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase
Bioorg. Med. Chem.
18
1288-1296
2010
Rattus norvegicus
brenda
Ma, X.; Beuve, A.; van den Akker, F.
Crystal structure of the signaling helix coiled-coil domain of the beta1 subunit of the soluble guanylyl cyclase
BMC Struct. Biol.
10
2-2
2010
Rattus norvegicus (P20595)
brenda
Haase, N.; Haase, T.; Kraehling, J.R.; Behrends, S.
Direct fusion of subunits of heterodimeric nitric oxide sensitive guanylyl cyclase leads to functional enzymes with preserved biochemical properties: evidence for isoform specific activation by ciguates
Biochem. Pharmacol.
80
1676-1683
2010
Rattus norvegicus
brenda
Baskaran, P.; Heckler, E.J.; van den Akker, F.; Beuve, A.
Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation
Biochemistry
50
4291-4297
2011
Rattus norvegicus
brenda
Shpakov, A.; Derkach, K.; Chistyakova, O.; Pertseva, M.
Changes in the functional activity of membrane-bound guanylate cyclase forms in tissues of diabetic rats
Dokl. Biochem. Biophys.
433
219-222
2010
Rattus norvegicus
brenda
Baskaran, P.; Heckler, E.J.; van den Akker, F.; Beuve, A.
Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity
PLoS ONE
6
e26976
2011
Rattus norvegicus (P20595)
brenda
Ghosh, A.; Stuehr, D.J.
Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme
Proc. Natl. Acad. Sci. USA
109
12998-13003
2012
Rattus norvegicus
brenda