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1-acylglycerol-3-phosphate o-acyltransferase deficiency
ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield.
Acute Lung Injury
RNase L Is Involved in Liposaccharide-Induced Lung Inflammation.
Adenocarcinoma
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Adenocarcinoma
Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma.
Adenocarcinoma of Lung
Actinomycin D-Activated RNase L Promotes H2A.X/H2B-Mediated DNA Damage and Apoptosis in Lung Cancer Cells.
Adenocarcinoma of Lung
Ribonuclease L mediates the cell-lethal phenotype of the double-stranded RNA editing enzyme ADAR1 in a human cell line.
Adenomatous Polyposis Coli
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Adrenoleukodystrophy
ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis.
Alphavirus Infections
Alphavirus minus-strand synthesis and persistence in mouse embryo fibroblasts derived from mice lacking RNase L and protein kinase R.
Alzheimer Disease
Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.
Alzheimer Disease
Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke.
Alzheimer Disease
Polymorphisms in Glutathione S-Transferase Omega-1 Gene and Increased Risk of Sporadic Alzheimer Disease.
Aortic Coarctation
Prenatal diagnosis and molecular cytogenetic characterization of de novo partial trisomy 12q (12q24.21?qter) and partial monosomy 6q (6q27?qter) associated with coarctation of the aorta, ventriculomegaly and thickened nuchal fold.
Asthenozoospermia
RNASET2 impairs the sperm motility via PKA/PI3K/calcium signal pathways.
Asthenozoospermia
RNASET2 in human spermatozoa and seminal plasma: a novel relevant indicator for asthenozoospermia.
Asthenozoospermia
RNASET2 is required for ROS propagation during oxidative stress-mediated cell death.
Asymptomatic Infections
Effects of PKR/RNase L-dependent and alternative antiviral pathways on alphavirus replication and pathogenesis.
Atherosclerosis
Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression.
Avitaminosis
Hepatic peroxisome proliferation in vitamin A-deficient mice without a simultaneous increase in peroxisomal acyl-CoA oxidase activity.
Bacterial Infections
New insights into the role of RNase L in innate immunity.
Bacterial Infections
Recombinant HvRNASET2 protein induces marked connective tissue remodelling in the invertebrate model Hirudo verbana.
Breast Neoplasms
Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer.
Breast Neoplasms
siRNA?induced ABCE1 silencing inhibits proliferation and invasion of breast cancer cells.
Carcinogenesis
ACTIBIND, an actin-binding fungal T2-RNase with antiangiogenic and anticarcinogenic characteristics.
Carcinogenesis
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Carcinogenesis
FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
Carcinogenesis
Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis.
Carcinogenesis
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.
Carcinogenesis
Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV from 22Rv1 Prostate Carcinoma Cells.
Carcinogenesis
RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth.
Carcinogenesis
RNASET2 as a tumor antagonizing gene in a melanoma cancer model.
Carcinogenesis
Tumor and metastasis suppression by the human RNASET2 gene.
Carcinoid Tumor
New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1?.
Carcinoma
A Cell-Autonomous Oncosuppressive Role of Human RNASET2 Affecting ECM-Mediated Oncogenic Signaling.
Carcinoma
Chromosome 6 Encoded RNaseT2 Protein is a Cell Growth Regulator.
Carcinoma
Induction of the interferon-inducible RNA-degrading enzyme, RNase L, by stress-inducing agents in the human cervical carcinoma cells.
Carcinoma
Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells.
Carcinoma
Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection.
Carcinoma
Rapid RNase L-Driven Arrest of Protein Synthesis in the dsRNA Response without Degradation of Translation Machinery.
Carcinoma
[A comparism between lysosomal enzyme activity in normal ectocervical squamous epithelium and squamous carcinoma of the ectocervix]
Carcinoma, Hepatocellular
Acid ribonuclease activity of hepatoma cells.
Carcinoma, Hepatocellular
Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L.
Carcinoma, Hepatocellular
The ribonuclease L-dependent antiviral roles of human 2',5'-oligoadenylate synthetase family members against hepatitis C virus.
Carcinoma, Neuroendocrine
New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1?.
Carcinoma, Ovarian Epithelial
A Cell-Autonomous Oncosuppressive Role of Human RNASET2 Affecting ECM-Mediated Oncogenic Signaling.
Colonic Neoplasms
Human recombinant RNASET2: A potential anti-cancer drug.
Colorectal Neoplasms
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Coronavirus Infections
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.
COVID-19
Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export.
COVID-19
SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block.
Coxsackievirus Infections
RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection.
Cystic Fibrosis
Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
Cysts
Clinical, radiological and possible pathological overlap of cystic leukoencephalopathy without megalencephaly and Aicardi-Goutières syndrome.
Cysts
RMND1-Related Leukoencephalopathy With Temporal Lobe Cysts and Hearing Loss-Another Mendelian Mimicker of Congenital Cytomegalovirus Infection.
Cysts
rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA.
Cysts
Structure and activity of the only human RNase T2.
Cytomegalovirus Infections
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.
Dementia, Vascular
Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke.
Demyelinating Diseases
New insights into the role of RNase L in innate immunity.
Demyelinating Diseases
RNase L mediated protection from virus induced demyelination.
Dengue
Identification and comparative analysis of hepatitis C virus-host cell protein interactions.
Dengue
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Dengue
Zika Virus Production Is Resistant to RNase L Antiviral Activity.
Dermatitis, Contact
Skin allograft rejection is suppressed in mice lacking the antiviral enzyme, 2',5'-oligoadenylate-dependent RNase L.
Diabetes Mellitus, Type 1
RNase L contributes to experimentally induced type 1 diabetes onset in mice.
double-stranded rna adenine deaminase deficiency
A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency.
Encephalomyelitis
RNase L mediated protection from virus induced demyelination.
Epilepsy
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
Fatigue Syndrome, Chronic
2',5'-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome.
Fatigue Syndrome, Chronic
37-Kilodalton/83-kilodalton RNase L isoform ratio in peripheral blood mononuclear cells: analytical performance and relevance for chronic fatigue syndrome.
Fatigue Syndrome, Chronic
A 37 kDa 2-5A binding protein as a potential biochemical marker for chronic fatigue syndrome.
Fatigue Syndrome, Chronic
Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome.
Fatigue Syndrome, Chronic
Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome.
Fatigue Syndrome, Chronic
Exercise capacity and immune function in male and female patients with chronic fatigue syndrome (CFS).
Fatigue Syndrome, Chronic
Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome.
Fatigue Syndrome, Chronic
Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients.
Fatigue Syndrome, Chronic
RNase L levels in peripheral blood mononuclear cells: 37-kilodalton/83-kilodalton isoform ratio is a potential test for chronic fatigue syndrome.
Fatigue Syndrome, Chronic
Structural and functional features of the 37-kDa 2-5A-dependent RNase L in chronic fatigue syndrome.
Fatigue Syndrome, Chronic
Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance.
Fatigue Syndrome, Chronic
Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome.
Fatigue Syndrome, Chronic
Variability of the RNase L isoform ratio (37 kiloDaltons/83 kiloDaltons) in diagnosis of chronic fatigue syndrome.
Fibrosarcoma
Tumour suppressor function of RNase L in a mouse model.
Flavivirus Infections
RNase L antiviral activity is not a critical component of the Oas1b-mediated flavivirus resistance phenotype.
Flavivirus Infections
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Foot-and-Mouth Disease
Inhibition of Antiviral Innate Immunity by Foot-and-Mouth Disease Virus Lpro through Interaction with the N-Terminal Domain of Swine RNase L.
Glioma
Monitoring activation of ribonuclease L by 2',5'-oligoadenylates using purified recombinant enzyme and intact malignant glioma cells.
Granuloma
Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function.
Granuloma
Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo.
Granuloma
Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response.
Graves Disease
RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
Graves Disease
[Association of RNASET2 gene polymorphisms and haplotypes with Graves disease in Han Chinese population from coastal regions of Shandong].
Hematologic Neoplasms
Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax.
Hepatitis
A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.
Hepatitis
Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
Hepatitis
Antagonism of RNase L is required for murine coronavirus replication in Kupffer cells and liver sinusoidal endothelial cells but not in hepatocytes.
Hepatitis
Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.
Hepatitis
Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation.
Hepatitis
RNase L mediated protection from virus induced demyelination.
Hepatitis
[Clinical significance of interleukin-28B and RNAse L gene polymorphism determination in patients with chronic viral hepatitis C].
Hepatitis B
Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L.
Hepatitis C
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Hepatitis C
Clinical relevance of the 2'-5'-oligoadenylate synthetase/RNase L system for treatment response in chronic hepatitis C.
Hepatitis C
Effect of ribavirin on the frequency of RNase L cleavage sites within the hepatitis C viral genome.
Hepatitis C
Hepatitis C virus RNA: dinucleotide frequencies and cleavage by RNase L.
Hepatitis C
Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a vaccinia virus recombinant.
Hepatitis C
JNJ-4178 (AL-335, Odalasvir, and Simeprevir) for 6 or 8 Weeks in Hepatitis C Virus-infected Patients without Cirrhosis: OMEGA-1.
Hepatitis C
Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs.
Hepatitis C
RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.
Hepatitis C
Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites.
Hepatitis C
The ribonuclease L-dependent antiviral roles of human 2',5'-oligoadenylate synthetase family members against hepatitis C virus.
Hepatitis C, Chronic
Clinical relevance of the 2'-5'-oligoadenylate synthetase/RNase L system for treatment response in chronic hepatitis C.
Hepatitis C, Chronic
Intrahepatic mRNA expression of interferon-inducible antiviral genes in liver diseases: dsRNA-dependent protein kinase overexpression and RNase L inhibitor suppression in chronic hepatitis C.
Hepatitis C, Chronic
JNJ-4178 (AL-335, Odalasvir, and Simeprevir) for 6 or 8 Weeks in Hepatitis C Virus-infected Patients without Cirrhosis: OMEGA-1.
Hepatitis C, Chronic
[Clinical significance of interleukin-28B and RNAse L gene polymorphism determination in patients with chronic viral hepatitis C].
Herpes Simplex
Delivery of Interferon-gamma by an adenovirus vector blocks herpes simplex virus Type 1 reactivation in vitro and in vivo independent of RNase L and double-stranded RNA-dependent protein kinase pathways.
Herpes Simplex
Herpes simplex virus type 2-mediated disease is reduced in mice lacking RNase L.
Herpes Simplex
RNase L activity does not contribute to host RNA degradation induced by herpes simplex virus infection.
Herpes Simplex
The murine double-stranded RNA-dependent protein kinase PKR and the murine 2',5'-oligoadenylate synthetase-dependent RNase L are required for IFN-beta-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture.
HIV Infections
RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells.
Hypertension
Cytochrome P-450 metabolites of arachidonic acid: implications for blood pressure regulation.
Hyperthyroidism
RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
Ileus
[Changes in the activity of lysosomal enzymes in experimental ileus]
Infections
A 2',5'-oligoadenylate analogue inhibits murine hepatitis virus strain 3 (MHV-3) replication in vitro but does not reduce MHV-3-related mortality or induction of procoagulant activity in susceptible mice.
Infections
A mammalian 2-5A system functions as an antiviral pathway in transgenic plants.
Infections
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Infections
Activation and evasion of the antiviral 2'-5' oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA.
Infections
Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs.
Infections
Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
Infections
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.
Infections
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Infections
Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells.
Infections
AIF-1 and RNASET2 Play Complementary Roles in the Innate Immune Response of Medicinal Leech.
Infections
Alphavirus minus-strand synthesis and persistence in mouse embryo fibroblasts derived from mice lacking RNase L and protein kinase R.
Infections
An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes.
Infections
Antagonism of RNase L is required for murine coronavirus replication in Kupffer cells and liver sinusoidal endothelial cells but not in hepatocytes.
Infections
Apoptosis induced by a cytopathic hepatitis A virus is dependent on caspase activation following ribosomal RNA degradation but occurs in the absence of 2'-5' oligoadenylate synthetase.
Infections
Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus.
Infections
Cellular and biochemical differences between two attenuated poxvirus vaccine candidates (MVA and NYVAC) and role of the C7L gene.
Infections
Changes in Two Ribonuclease Isozymes During Rust Infection of Flax Cotyledons.
Infections
Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function.
Infections
Correction for Li et al., Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Infections
Dengue virus replication in infected human keratinocytes leads to activation of antiviral innate immune responses.
Infections
Effect of sodium stibogluconate on hepatic mixed function oxidase system and marker enzymes of golden hamsters during Leishmania donovani infection.
Infections
Enteropathogenic Escherichia coli inhibits type I interferon- and RNase L-mediated host defense to disrupt intestinal epithelial cell barrier function.
Infections
Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1.
Infections
Herpes simplex virus type 2-mediated disease is reduced in mice lacking RNase L.
Infections
ICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cells.
Infections
Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant.
Infections
Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling.
Infections
Inducible expression of the 2-5A synthetase/RNase L system results in inhibition of vaccinia virus replication.
Infections
Influenza A induced cellular signal transduction pathways.
Infections
Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L.
Infections
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.
Infections
Reverse genetics reveals a role of the rotavirus VP3 phosphodiesterase activity in inhibiting RNase L signaling and contributing to intestinal viral replication in vivo.
Infections
Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation.
Infections
Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.
Infections
RMND1-Related Leukoencephalopathy With Temporal Lobe Cysts and Hearing Loss-Another Mendelian Mimicker of Congenital Cytomegalovirus Infection.
Infections
RNase activity prevents the growth of a fungal pathogen in tobacco leaves and increases upon induction of systemic acquired resistance with elicitin.
Infections
RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells.
Infections
RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells.
Infections
RNase L levels in peripheral blood mononuclear cells: 37-kilodalton/83-kilodalton isoform ratio is a potential test for chronic fatigue syndrome.
Infections
RNase L mediated protection from virus induced demyelination.
Infections
RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection.
Infections
RNase L Plays a Role in the Antiviral Response to West Nile Virus.
Infections
RNase L Triggers Autophagy in Response to Viral Infections.
Infections
Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection.
Infections
Rotavirus Controls Activation of the 2'-5'-Oligoadenylate Synthetase/RNase L Pathway Using at Least Two Distinct Mechanisms.
Infections
Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro.
Infections
Suppression of NYVAC Infection in HeLa Cells Requires RNase L but Is Independent of Protein Kinase R Activity.
Infections
The 2-5A system and HIV infection.
Infections
The cytopathic 18f strain of Hepatitis A virus induces RNA degradation in FrhK4 cells.
Infections
The RNase L inhibitor (RLI) is induced by double-stranded RNA.
Infections
The vaccinia virus A18R DNA helicase is a postreplicative negative transcription elongation factor.
Infections
Varicella-zoster virus does not significantly induce cell defence mechanism mediated by the 2-5A/RNase L pathway during its replication cycle.
Infections
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Infections
Zika Virus Production Is Resistant to RNase L Antiviral Activity.
Inflammatory Breast Neoplasms
In Vitro Assessment of the Inflammatory Breast Cancer Cell Line SUM 149: Discovery of 2 Single Nucleotide Polymorphisms in the RNase L Gene.
Influenza, Human
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Influenza, Human
Influenza A induced cellular signal transduction pathways.
Influenza, Human
Novel inhibitor of influenza NS1 blocks multi-cycle replication in an RNase L dependent manner.
Influenza, Human
RNase L activates the NLRP3 inflammasome during viral infections.
Influenza, Human
RNase L limits host and viral protein synthesis via inhibition of mRNA export.
Influenza, Human
RNase L Targets Distinct Sites in Influenza A Virus RNAs.
Influenza, Human
Solid-phase synthesis of 5'-triphosphate 2'-5'-oligoadenylates analogs with 3'-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.
Insulin Resistance
Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people.
Insulin Resistance
RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation.
Intracranial Aneurysm
Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms.
Intracranial Arteriosclerosis
Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression.
Ischemic Stroke
Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population.
Keratitis
Increased severity of HSV-1 keratitis and mortality in mice lacking the 2-5A-dependent RNase L gene.
Leukemia
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Leukemia
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.
Leukemia
Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.
Leukemia
Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.
Leukemia
Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV from 22Rv1 Prostate Carcinoma Cells.
Leukemia
Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer.
Leukemia
Xenotropic murine leukemia virus-related virus is susceptible to AZT.
Leukemia
XMRV Discovery and Prostate Cancer-Related Research.
Leukemia
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
Leukemia
[RNase L, a crucial mediator of innate immunity and other cell functions]
Leukemia, Erythroblastic, Acute
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
2',5'-Oligoadenylate-antisense chimeras cause RNase L to selectively degrade bcr/abl mRNA in chronic myelogenous leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
RNase L and increased endoribonuclease activities in the mononuclear cells of patients with chronic myelogenous leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
The properties of ribonucleases isolated from urine of patients with chronic granulocytic leukemia (CGL). II. Urinary acid ribonuclease.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[The properties of ribonucleases isolated from urine of patients with chronic granulocytic leukemia (CGL). II. Urinary acid ribonuclease (RNase)]
Leukemia, Myeloid
Activities of serum acid ribonuclease in patients with malignant neoplasms or with renal failure.
Leukemia, Myeloid
Serum acid ribonuclease in myelogenous leukemia.
Leukemia, Myeloid, Acute
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
Leukemia, Promyelocytic, Acute
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
Leukoencephalopathies
Clinical, radiological and possible pathological overlap of cystic leukoencephalopathy without megalencephaly and Aicardi-Goutières syndrome.
Leukoencephalopathies
Heterogeneity of PNPT1 neuroimaging: mitochondriopathy, interferonopathy or both?
Leukoencephalopathies
Novel RNASET2 Pathogenic Variants in an East Asian Child with Delayed Psychomotor Development.
Leukoencephalopathies
RMND1-Related Leukoencephalopathy With Temporal Lobe Cysts and Hearing Loss-Another Mendelian Mimicker of Congenital Cytomegalovirus Infection.
Leukoencephalopathies
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
Leukoencephalopathies
rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA.
Leukoencephalopathies
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.
Leukoencephalopathies
RNASET2-deficient leukoencephalopathy mimicking congenital CMV infection and Aicardi-Goutieres syndrome: a case report with a novel pathogenic variant.
Leukoencephalopathies
Structure and activity of the only human RNase T2.
Liver Diseases
Intrahepatic mRNA expression of interferon-inducible antiviral genes in liver diseases: dsRNA-dependent protein kinase overexpression and RNase L inhibitor suppression in chronic hepatitis C.
Lung Neoplasms
Actinomycin D-Activated RNase L Promotes H2A.X/H2B-Mediated DNA Damage and Apoptosis in Lung Cancer Cells.
Lung Neoplasms
IFN-? restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
Lung Neoplasms
The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization.
Lymphoma
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
Lymphoma, Large-Cell, Anaplastic
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
Lymphoma, Non-Hodgkin
Effect of in vitro glucocorticoid treatment on acid ribonuclease activity in P1798 lymphosarcoma cells.
Lymphoma, Non-Hodgkin
Studies on an acid ribonuclease from corticoid-sensitive 9alpha-fluoroprednisolone-treated lymphosarcoma P1798: changes in heat inactivation kinetics of the enzyme due to steroid treatment.
Megalencephaly
Clinical, radiological and possible pathological overlap of cystic leukoencephalopathy without megalencephaly and Aicardi-Goutières syndrome.
Megalencephaly
Novel RNASET2 Pathogenic Variants in an East Asian Child with Delayed Psychomotor Development.
Melanoma
ACTIBIND, a T2 RNase, competes with angiogenin and inhibits human melanoma growth, angiogenesis, and metastasis.
Melanoma
Human recombinant RNASET2: A potential anti-cancer drug.
Melanoma
Intracellular trafficking of RNASET2, a novel component of P-bodies.
Melanoma
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.
Melanoma
RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules.
Melanoma
RNASET2 as a tumor antagonizing gene in a melanoma cancer model.
Melanoma
Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer.
Memory Disorders
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
Mitochondrial Diseases
Heterogeneity of PNPT1 neuroimaging: mitochondriopathy, interferonopathy or both?
Muscle Weakness
Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase and RNase L) in patients with chronic fatigue immune dysfunction syndrome.
Myalgia
Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase and RNase L) in patients with chronic fatigue immune dysfunction syndrome.
Myocardial Infarction
The function of RNase L and its degradation mechanism in cardiac acute ischemic injury.
Neoplasm Metastasis
ACTIBIND, a T2 RNase, competes with angiogenin and inhibits human melanoma growth, angiogenesis, and metastasis.
Neoplasm Metastasis
Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma.
Neoplasm Metastasis
RNase L is a negative regulator of cell migration.
Neoplasm Metastasis
Tumor and metastasis suppression by the human RNASET2 gene.
Neoplasms
A Cell-Autonomous Oncosuppressive Role of Human RNASET2 Affecting ECM-Mediated Oncogenic Signaling.
Neoplasms
A clinical evaluation of serological diagnosis for pancreatic cancer.
Neoplasms
A novel apoptotic pathway of 3'-Ethynylcytidine(ECyd) involving the inhibition of RNA synthesis--the possibility of RNase L activated pathway as a target of ECyd.
Neoplasms
A recombinant human RNASET2 glycoprotein with antitumorigenic and antiangiogenic characteristics: expression, purification, and characterization.
Neoplasms
ACTIBIND, a T2 RNase, competes with angiogenin and inhibits human melanoma growth, angiogenesis, and metastasis.
Neoplasms
ACTIBIND, an actin-binding fungal T2-RNase with antiangiogenic and anticarcinogenic characteristics.
Neoplasms
Actinomycin D-Activated RNase L Promotes H2A.X/H2B-Mediated DNA Damage and Apoptosis in Lung Cancer Cells.
Neoplasms
Activities of serum acid ribonuclease in patients with malignant neoplasms or with renal failure.
Neoplasms
Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
Neoplasms
An apoptotic pathway of 3'-Ethynylcytidine(ECyd) involving the inhibition of RNA synthesis mediated by RNase L.
Neoplasms
Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins.
Neoplasms
Comparison of the baculovirus-insect cell and Pichia pastoris heterologous systems for the expression of the human tumor suppressor protein RNASET2.
Neoplasms
Development and Clinical Validation of a Seven-Gene Prognostic Signature Based on Multiple Machine Learning Algorithms in Kidney Cancer.
Neoplasms
Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax.
Neoplasms
Diverse functions of RNase L and implications in pathology.
Neoplasms
Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer.
Neoplasms
Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect.
Neoplasms
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Neoplasms
Expression and purification of the human tumor suppressor protein RNASET2 in CHO-S cells.
Neoplasms
Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma.
Neoplasms
FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
Neoplasms
Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome.
Neoplasms
Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL.
Neoplasms
Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer.
Neoplasms
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.
Neoplasms
Human recombinant RNASET2: A potential anti-cancer drug.
Neoplasms
Human recombinant truncated RNASET2, devoid of RNase activity; A potential cancer therapeutic agent.
Neoplasms
Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway.
Neoplasms
IFN-? restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
Neoplasms
Induction of the interferon-inducible RNA-degrading enzyme, RNase L, by stress-inducing agents in the human cervical carcinoma cells.
Neoplasms
Innate Immune Response Regulation by the Human RNASET2 Tumor Suppressor Gene.
Neoplasms
Interaction between the androgen receptor and RNase L mediates a cross-talk between the interferon and androgen signaling pathways.
Neoplasms
Intracellular trafficking of RNASET2, a novel component of P-bodies.
Neoplasms
Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer.
Neoplasms
Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis.
Neoplasms
Mammary tumor regression. V. Role of acid ribonuclease and cathepsin.
Neoplasms
Mammary tumor regression. VI. Synthesis and degradation of acid ribonuclease.
Neoplasms
Mapping of the human RNASEL promoter and expression in cancer and normal cells.
Neoplasms
Metabolic fate of omega-1 and omega-2 oxidized N-nitrosodibutylamines in the rat.
Neoplasms
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.
Neoplasms
Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells.
Neoplasms
Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer.
Neoplasms
New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1?.
Neoplasms
New insights into the role of RNase L in innate immunity.
Neoplasms
New Strategies for Expression and Purification of Recombinant Human RNASET2 Protein in Pichia pastoris.
Neoplasms
Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection.
Neoplasms
Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase.
Neoplasms
Promyelocytic leukemia zinc finger triggers ATP-binding cassette subfamily E member 1-mediated growth inhibition in breast cancer cells.
Neoplasms
Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs.
Neoplasms
RNase L and increased endoribonuclease activities in the mononuclear cells of patients with chronic myelogenous leukemia.
Neoplasms
RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1.
Neoplasms
RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth.
Neoplasms
RNase L is a negative regulator of cell migration.
Neoplasms
RNase T2 in Inflammation and Cancer: Immunological and Biological Views.
Neoplasms
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
Neoplasms
RNASET2 as a tumor antagonizing gene in a melanoma cancer model.
Neoplasms
RNASET2 silencing affects miRNAs and target gene expression pattern in a human ovarian cancer cell model.
Neoplasms
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Neoplasms
Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.
Neoplasms
Stress-induced RNASET2 overexpression mediates melanocyte apoptosis via the TRAF2 pathway in vitro.
Neoplasms
Structure and activity of the only human RNase T2.
Neoplasms
T2 Family ribonucleases: ancient enzymes with diverse roles.
Neoplasms
The 1.8 Å crystal structure of ACTIBIND suggests a mode of action for T2 ribonucleases as antitumorigenic agents.
Neoplasms
The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization.
Neoplasms
The biological regulation of ABCE1.
Neoplasms
The human RNASET2 protein affects the polarization pattern of human macrophages in vitro.
Neoplasms
The role of IFN regulatory factor-3 in the cytotoxic activity of NS-9, a polyinosinic-polycytidylic acid/cationic liposome complex, against tumor cells.
Neoplasms
The synergistic cytocidal effect produced by immune interferon and tumor necrosis factor in HT-29 cells is associated with inhibition of rRNA processing and (2',5') oligo (A) activation of RNase L.
Neoplasms
Tumor and metastasis suppression by the human RNASET2 gene.
Neoplasms
Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response.
Neoplasms
Tumour suppressor function of RNase L in a mouse model.
Neoplasms
[Host factors in cancer chemotherapy]
Neuroinflammatory Diseases
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
Ovarian Neoplasms
Caspase-dependent apoptosis by 2',5'-oligoadenylate activation of RNase L is enhanced by IFN-beta.
Ovarian Neoplasms
Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer.
Ovarian Neoplasms
FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
Ovarian Neoplasms
Human recombinant RNASET2-induced inflammatory response and connective tissue remodeling in the medicinal leech.
Ovarian Neoplasms
Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells.
Ovarian Neoplasms
Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase.
Ovarian Neoplasms
RNase L restricts the mobility of engineered retrotransposons in cultured human cells.
Ovarian Neoplasms
RNASET2 as a tumor antagonizing gene in a melanoma cancer model.
Ovarian Neoplasms
RNASET2 silencing affects miRNAs and target gene expression pattern in a human ovarian cancer cell model.
Ovarian Neoplasms
Tumor and metastasis suppression by the human RNASET2 gene.
Pancreatic Neoplasms
A clinical evaluation of serological diagnosis for pancreatic cancer.
Pancreatic Neoplasms
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Pancreatitis
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Pancreatitis
Serum ribonuclease elevations and pancreatic necrosis in acute pancreatitis.
Pancreatitis, Chronic
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Pancreatitis, Chronic
Serum ribonuclease elevations and pancreatic necrosis in acute pancreatitis.
Papillomavirus Infections
Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer.
Paramyxoviridae Infections
Impact of RNase L overexpression on viral and cellular growth and death.
Paramyxoviridae Infections
Small-molecule activators of RNase L with broad-spectrum antiviral activity.
Parasitic Diseases
T2 Family ribonucleases: ancient enzymes with diverse roles.
Parkinson Disease
Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications.
Parkinson Disease
Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.
Persistent Infection
Functionally conserved architecture of hepatitis C virus RNA genomes.
Pneumonia
RNase L Is Involved in Liposaccharide-Induced Lung Inflammation.
Prostatic Hyperplasia
Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer.
Prostatic Neoplasms
A convenient and sensitive fluorescence resonance energy transfer assay for RNase L and 2',5' oligoadenylates.
Prostatic Neoplasms
A scientific journey through the 2-5A/RNase L system.
Prostatic Neoplasms
A Single Nucleotide Polymorphism in Inflammatory Gene RNASEL Predicts Outcome after Radiation Therapy for Localized Prostate Cancer.
Prostatic Neoplasms
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.
Prostatic Neoplasms
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Prostatic Neoplasms
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.
Prostatic Neoplasms
An update analysis of two polymorphisms in encoding ribonuclease L gene and prostate cancer risk: involving 13,372 cases and 11,953 controls.
Prostatic Neoplasms
Arg462Gln and Asp541Glu polymorphisms in ribonuclease L and prostate cancer risk: a meta-analysis.
Prostatic Neoplasms
Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study.
Prostatic Neoplasms
Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.
Prostatic Neoplasms
Diverse functions of RNase L and implications in pathology.
Prostatic Neoplasms
Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates.
Prostatic Neoplasms
Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL.
Prostatic Neoplasms
Genetic analysis of the principal genes related to prostate cancer: A review.
Prostatic Neoplasms
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.
Prostatic Neoplasms
HPC1/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand.
Prostatic Neoplasms
Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant.
Prostatic Neoplasms
Implications for RNase L in prostate cancer biology.
Prostatic Neoplasms
Induction of the interferon-inducible RNA-degrading enzyme, RNase L, by stress-inducing agents in the human cervical carcinoma cells.
Prostatic Neoplasms
Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.
Prostatic Neoplasms
Involvement of the RNAse L gene in prostate cancer.
Prostatic Neoplasms
Mapping of the human RNASEL promoter and expression in cancer and normal cells.
Prostatic Neoplasms
Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV from 22Rv1 Prostate Carcinoma Cells.
Prostatic Neoplasms
Mutation analysis suggests role for ribonuclease L gene in prostate cancer.
Prostatic Neoplasms
Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer.
Prostatic Neoplasms
New advances in our understanding of the "unique" RNase L in host pathogen interaction and immune signaling.
Prostatic Neoplasms
New insights into the role of RNase L in innate immunity.
Prostatic Neoplasms
No association of xenotropic murine leukemia virus-related viruses with prostate cancer.
Prostatic Neoplasms
Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.
Prostatic Neoplasms
RNase L is a negative regulator of cell migration.
Prostatic Neoplasms
RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.
Prostatic Neoplasms
RNASEL 1623A>C variant is associated with the risk of prostate cancer in African descendants.
Prostatic Neoplasms
RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans.
Prostatic Neoplasms
Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells.
Prostatic Neoplasms
Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.
Prostatic Neoplasms
Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer.
Prostatic Neoplasms
Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.
Prostatic Neoplasms
Xenotropic murine leukemia virus-related virus is susceptible to AZT.
Prostatic Neoplasms
XMRV Discovery and Prostate Cancer-Related Research.
Prostatic Neoplasms
[RNase L, a crucial mediator of innate immunity and other cell functions]
Protein Deficiency
Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase and RNase L) in patients with chronic fatigue immune dysfunction syndrome.
Protein-Energy Malnutrition
Nutritionally triggered alterations in the regiospecificity of arachidonic acid oxygenation by rat liver microsomal cytochrome P450.
Psychomotor Disorders
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
Pulmonary Disease, Chronic Obstructive
Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling.
Renal Insufficiency
Activities of serum acid ribonuclease in patients with malignant neoplasms or with renal failure.
Retroviridae Infections
Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.
ribonuclease t2 deficiency
Heterogeneity of PNPT1 neuroimaging: mitochondriopathy, interferonopathy or both?
ribonuclease t2 deficiency
RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response.
ribonuclease t2 deficiency
RNase L mediated protection from virus induced demyelination.
ribonuclease t2 deficiency
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
ribonuclease t2 deficiency
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.
ribonuclease t2 deficiency
Structure and activity of the only human RNase T2.
Schistosomiasis
Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens.
Seizures
Picrotoxin-induced convulsions and lysosomal function in the rat brain.
Starvation
Induction of an Extracellular Ribonuclease in Cultured Tomato Cells upon Phosphate Starvation.
Starvation
Isolation and characterization of a wound-inducible ribonuclease from Nicotiana glutinosa leaves.
Starvation
Molecular characterisation of an S-like RNase of Nicotiana alata that is induced by phosphate starvation.
Starvation
Tissue-specific expression of tomato Ribonuclease LX during phosphate starvation-induced root growth.
Stroke
Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke.
Thyroid Diseases
RNASET2 tag SNP but not CCR6 polymorphisms is associated with autoimmune thyroid diseases in the Chinese Han population.
Urinary Bladder Neoplasms
Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case-control study.
Urinary Bladder Neoplasms
Metabolic fate of omega-1 and omega-2 oxidized N-nitrosodibutylamines in the rat.
Uterine Cervical Neoplasms
Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect.
Uterine Cervical Neoplasms
Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer.
Vaccinia
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.
Vaccinia
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Vaccinia
Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells.
Vaccinia
Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.
Vaccinia
Impact of RNase L overexpression on viral and cellular growth and death.
Vaccinia
Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a vaccinia virus recombinant.
Vesicular Stomatitis
Impact of RNase L overexpression on viral and cellular growth and death.
Vesicular Stomatitis
Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways.
Vesicular Stomatitis
Phosphorothioate analogues of (2'-5')(A)4: agonist and antagonist activities in intact cells.
Vesicular Stomatitis
RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection.
Vesicular Stomatitis
RNase L Triggers Autophagy in Response to Viral Infections.
Virus Diseases
A novel apoptotic pathway of 3'-Ethynylcytidine(ECyd) involving the inhibition of RNA synthesis--the possibility of RNase L activated pathway as a target of ECyd.
Virus Diseases
A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand.
Virus Diseases
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.
Virus Diseases
ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections.
Virus Diseases
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.
Virus Diseases
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Virus Diseases
Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequences.
Virus Diseases
Age-dependent changes are observed in the levels of an enzyme mediator of interferon action: a (2'-5')A(n)-dependent endoribonuclease.
Virus Diseases
An alternative spliced RNASEL variant in peripheral blood leukocytes.
Virus Diseases
Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.
Virus Diseases
Cell-type-specific effects of RNase L on viral induction of beta interferon.
Virus Diseases
Circular RNAs and RNase L in PKR activation and virus infection.
Virus Diseases
Cloning and characterization of a ribonuclease L inhibitor from the silkworm, Bombyx mori.
Virus Diseases
Correction to: Circular RNAs and RNase L in PKR activation and virus infection.
Virus Diseases
CRISPR-Cas9 Mediated RNase L Knockout Regulates Cellular Function of PK-15 Cells and Increases PRV Replication.
Virus Diseases
Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3.
Virus Diseases
Curcumin, a natural antioxidant, acts as a noncompetitive inhibitor of human RNase L in presence of its cofactor 2-5A in vitro.
Virus Diseases
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Virus Diseases
Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.
Virus Diseases
Genetic variation in RNASEL associated with prostate cancer risk and progression.
Virus Diseases
High yield synthesis, purification and characterisation of the RNase L activators 5'-triphosphate 2'-5'-oligoadenylates.
Virus Diseases
ICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cells.
Virus Diseases
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.
Virus Diseases
Induction of the interferon-inducible RNA-degrading enzyme, RNase L, by stress-inducing agents in the human cervical carcinoma cells.
Virus Diseases
Mechanistic insights into RNase L through use of an MDMX-derived multi-functional protein domain.
Virus Diseases
New insights into the role of RNase L in innate immunity.
Virus Diseases
Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L.
Virus Diseases
OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses.
Virus Diseases
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases.
Virus Diseases
PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons.
Virus Diseases
RNase L activates the NLRP3 inflammasome during viral infections.
Virus Diseases
RNase L activity does not contribute to host RNA degradation induced by herpes simplex virus infection.
Virus Diseases
RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules.
Virus Diseases
RNase L and the NLRP3-inflammasome: An old merchant in a new trade.
Virus Diseases
RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1.
Virus Diseases
RNase L contributes to experimentally induced type 1 diabetes onset in mice.
Virus Diseases
RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways.
Virus Diseases
RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entry.
Virus Diseases
RNase L Is Involved in Liposaccharide-Induced Lung Inflammation.
Virus Diseases
RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection.
Virus Diseases
RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.
Virus Diseases
RNase L Triggers Autophagy in Response to Viral Infections.
Virus Diseases
Rotavirus Controls Activation of the 2'-5'-Oligoadenylate Synthetase/RNase L Pathway Using at Least Two Distinct Mechanisms.
Virus Diseases
Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro.
Virus Diseases
Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.
Virus Diseases
Small self-RNA generated by RNase L amplifies antiviral innate immunity.
Virus Diseases
Small-molecule activators of RNase L with broad-spectrum antiviral activity.
Virus Diseases
Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate Immunity.
Virus Diseases
Structural architecture of an RNA that competitively inhibits RNase L.
Virus Diseases
Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity.
Virus Diseases
The 2-5A system in viral infection and apoptosis.
Virus Diseases
The biological regulation of ABCE1.
Virus Diseases
The Endogenous RIG-I Ligand Is Generated in Influenza A-Virus Infected Cells.
Virus Diseases
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Virus Diseases
[Investigation of the role of ribonuclease L gene in the response of tonsil tissues against viral infections]
Vitiligo
Rnaset2 inhibits melanocyte outgrowth possibly through interacting with shootin1.
Vitiligo
RNASET2 is required for ROS propagation during oxidative stress-mediated cell death.
Vitiligo
Role and Mechanism of RNASET2 in the Pathogenesis of Vitiligo.
Vitiligo
Stress-induced RNASET2 overexpression mediates melanocyte apoptosis via the TRAF2 pathway in vitro.
West Nile Fever
PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons.
West Nile Fever
RNase L Plays a Role in the Antiviral Response to West Nile Virus.
West Nile Fever
Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.
Zika Virus Infection
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Zika Virus Infection
Zika Virus Production Is Resistant to RNase L Antiviral Activity.
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4.6.1.19 ribonuclease T2
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
