Disease on EC 4.6.1.18 - pancreatic ribonuclease

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DISEASE
TITLE OF PUBLICATION
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Acidosis
Reversible nephrotoxicity of onconase and effect of lysine pH on renal onconase uptake.
Adenocarcinoma
Altered glycosylation in tumours focused to cancer diagnosis.
Enhanced cellular radiation sensitivity of androgen-independent human prostate tumor cells by onconase.
Glycosylation of human pancreatic ribonuclease: differences between normal and tumor states.
Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1.
Human pancreatic ribonuclease 1: expression and distribution in pancreatic adenocarcinoma.
Necl 4 and RNase 5 Are Important Biomarkers for Gastric and Colon Adenocarcinomas.
Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner.
Tamoxifen in patients with advanced pancreatic adenocarcinoma.
Adenocarcinoma of Lung
Enhanced in vitro cytotoxicity and cytostasis of the combination of onconase with a proteasome inhibitor.
Airway Obstruction
Airway inflammation in smokers with nonobstructive and obstructive chronic bronchitis.
Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients.
Albuminuria
Indirect assessment of eosinophiluria in urinary schistosomiasis using eosinophil cationic protein (ECP) and eosinophil protein X (EPX).
Alopecia
Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase.
Amyotrophic Lateral Sclerosis
Eosinophil-derived neurotoxin is elevated in patients with amyotrophic lateral sclerosis.
Anaphylaxis
Late-onset anaphylaxis to fermented soybeans: the first confirmation of food-induced, late-onset anaphylaxis by provocation test.
Persistent anaphylactic reaction after induction with thiopentone and cisatracurium.
Release of eosinophil cationic protein (ECP) in anaphylactoid anaesthetic reactions in vivo and in vitro.
Anemia
Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children.
Relationship between RNASE1, ANG and RNASE6 gene polymorphism and the values of blood indices in suckling piglets.
Angina Pectoris
[Eosinophilic activation based on measurements of eosinophil cationic protein in patients with acute myocardial infarction and patients with angina pectoris]
Angioedema
Efficacy and Safety of Mepolizumab (Anti-Interleukin-5) Treatment in Gleich's Syndrome.
Angiolymphoid Hyperplasia with Eosinophilia
Angiolymphoid hyperplasia with eosinophilia associated with arteriovenous malformation: a clinicopathological correlation with angiography and serial estimation of serum levels of renin, eosinophil cationic protein and interleukin 5.
Anisakiasis
Measurement of serum levels of eosinophil cationic protein in the diagnosis of acute gastrointestinal anisakiasis.
Appendicitis
Evidence for eosinophil degranulation in acute appendicitis.
Arteriovenous Malformations
Angiolymphoid hyperplasia with eosinophilia associated with arteriovenous malformation: a clinicopathological correlation with angiography and serial estimation of serum levels of renin, eosinophil cationic protein and interleukin 5.
Arteritis
Deposition of eosinophil cationic protein in vascular lesions in temporal arteritis.
Arthritis
Eosinophil cationic protein in inflammatory synovial effusions as evidence of eosinophil involvement.
Mast cell activation in arthritis: detection of alpha- and beta-tryptase, histamine and eosinophil cationic protein in synovial fluid.
Arthritis, Reactive
Eosinophil cationic protein in inflammatory synovial effusions as evidence of eosinophil involvement.
Arthritis, Rheumatoid
Eosinophil involvement in rheumatoid arthritis as reflected by elevated serum levels of eosinophil cationic protein.
Influence of Extracellular RNAs, Released by Rheumatoid Arthritis Synovial Fibroblasts, on Their Adhesive and Invasive Properties.
Mast cell activation in arthritis: detection of alpha- and beta-tryptase, histamine and eosinophil cationic protein in synovial fluid.
Study of eosinophil-endothelial adhesion, production of oxygen radicals and release of eosinophil cationic protein by peripheral blood eosinophils of patients with rheumatoid arthritis.
Ascaridida Infections
Eosinophil-associated inflammation and elaboration of eosinophil-derived proteins in 2 children with raccoon roundworm (Baylisascaris procyonis) encephalitis.
Asthma
"The (1)H, (13)C, (15)N resonance assignment, solution structure and residue level stability of eosinophil cationic protein/rnase 3 determined by NMR spectroscopy"
A heparan sulfate-facilitated and raft-dependent macropinocytosis of eosinophil cationic protein.
A randomized controlled trial on the effect of montelukast on sputum eosinophil cationic protein in children with corticosteroid-dependent asthma.
Absence of airway inflammation in a large proportion of adolescents with asthma.
Absence of association of peripheral blood eosinophilia or increased eosinophil cationic protein with bronchial hyperresponsiveness during asthma remission.
Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma.
Airway Platelet Activation is Associated With Airway Eosinophilic Inflammation in Asthma.
Airway surfactant protein D (SP-D) deficiency in adults with severe asthma.
Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices.
Allergy in marathon runners and effect of Lactobacillus GG supplementation on allergic inflammatory markers.
Analysis of sputum taken from wheezy and asthmatic infants and children, with special reference to respiratory infections.
Applicability of extracellular electrical impedance tomography in monitoring respiratory tract inflammation.
Application of monoclonal antibodies against major basic protein (BMK-13) and eosinophil cationic protein (EG1 and EG2) for quantifying eosinophils in bronchial biopsies from atopic asthma.
Association Between Epithelial Cytokines and Clinical Phenotypes of Elderly Asthma.
Associations between nasal torquetenovirus load and spirometric indices in children with asthma.
Associations between self-rated health, sickness behaviour and inflammatory markers in primary care patients with allergic asthma: a longitudinal study.
Asthma and allergy among schoolchildren in a mountainous, dry, non-polluted area in Norway.
Asthma in children less than 5 years of age: eosinophils and serum levels of the eosinophil proteins ECP and EPX in relation to atopy and symptoms.
Asthma nurse practice--a resource-effective approach in asthma management.
Asthma, bronchial hyperreactivity and mediator release in children with birch pollinosis. ECP and EPX levels are not related to bronchial hyperreactivity.
Blood eosinophil leucocytes and eosinophil cationic protein. Diurnal variation in normal subjects and patients with bronchial asthma.
Blood eosinophil number and activity in relation to lung function in patients with asthma and with eosinophilia.
Blood eosinophil numbers and activity during 24 hours: effects of treatment with budesonide and bambuterol.
Blood Eosinophils, Fraction of Exhaled Nitric Oxide, and Serum Eosinophil Cationic Protein as Surrogate Markers for Sputum Eosinophils in Asthma: Influence of Treatment With Inhaled Corticosteroids.
Bronchial responsiveness and serum eosinophil cationic protein levels in preschool children with recurrent wheezing.
Bronchial responsiveness to methacholine and adenosine 5'-monophosphate in young children with asthma: their relationship with blood eosinophils and serum eosinophil cationic protein.
Bronchoalveolar lavage eosinophil cationic protein and interleukin-8 levels in acute asthma and acute bronchiolitis.
Bronchoalveolar lavage in asthmatic children: evidence of neutrophil activation in mild-to-moderate persistent asthma.
C-reactive protein levels in the serum of asthmatic patients.
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
Cell infiltration, ICAM-1 expression, and eosinophil chemotactic activity in asthmatic sputum.
Changes in serum eotaxin and eosinophil cationic protein levels, and eosinophil count during treatment of childhood asthma.
Chemoattraction of macrophages by secretory molecules derived from cells expressing the signal peptide of eosinophil cationic protein.
Chlorine in breath condensate--a measure of airway affection in pollinosis?
Circulating histamine and eosinophil cationic protein levels in nocturnal asthma.
Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma.
Clinical application of eosinophilic cationic protein in asthma.
Clinical assessment of asthma severity partially corresponds to sputum eosinophilic airway inflammation.
Clinical utility of serum levels of eosinophil cationic protein (ECP) for monitoring and predicting clinical course in childhood asthma.
Clinical value of monitoring eosinophil activity in asthma.
Comparison of basophil histamine release, eosinophil cationic protein and non-specific airway responsiveness between mite-sensitive asthmatic and non-asthmatic children and non-allergic controls.
Comparison of exhaled nitric oxide, serum eosinophilic cationic protein, and soluble interleukin-2 receptor in exacerbations of pediatric asthma.
Comparison of serum eosinophil-derived neurotoxin levels between wheezing and non-wheezing groups in children with respiratory tract infection.
Comparison of sputum and serum eosinophil cationic protein (ECP) levels in nonatopic asthma and chronic obstructive pulmonary disease.
Comparison of the effects of salmeterol and salbutamol on clinical activity and eosinophil cationic protein serum levels during the pollen season in atopic asthmatics.
Contribution of eosinophil-derived mediators in asthma.
Correlation of bronchial eosinophil and mast cell activation with bronchial hyperresponsiveness in children with asthma.
Correlation of eosinophil cationic protein with severity of asthma.
Creola bodies in wheezing infants predict the development of asthma.
Cytokine concentrations in sputum of asthmatic patients.
Decreased serum levels of P-selectin and eosinophil cationic protein in patients with mild asthma after inhaled salbutamol.
Development of a novel enzyme-linked immunosorbent assay for blood and urinary eosinophil-derived neurotoxin: a preliminary study in patients with bronchial asthma.
Differential effects of corticosteroids on serum eosinophil cationic protein and cytokine production in rhinovirus- and respiratory syncytial virus-induced acute exacerbation of childhood asthma.
Does eosinophil cationic protein in sputum and blood reflect bronchial inflammation and obstruction in allergic asthmatics?
Double-blind placebo-controlled study of oxatomide in the treatment of childhood asthma.
Effect of physical and chemical methods of homogenization on inflammatory mediators in sputum of asthma patients.
Effect of suplatast tosilate, a Th2 cytokine inhibitor, on steroid-dependent asthma: a double-blind randomised study. Tokyo Joshi-Idai Asthma Research Group.
Effects of allergen challenge on eosinophils, eosinophil cationic protein, and granulocyte-macrophage colony-stimulating factor in mild asthma.
Effects of different anti-asthmatic agents on induced sputum and eosinophil cationic protein in mild asthmatics.
Effects of PAF, FMLP and opsonized zymosan on the release of ECP, elastase and superoxide from human granulocytes.
Effects of pranlukast hydrate on serum eosinophil cationic protein levels in patients with adult bronchial asthma.
Effects of prednisolone on eosinophils, IL-5, eosinophil cationic protein, EG2+ eosinophils, and nitric oxide metabolites in the sputum of patients with exacerbated asthma.
Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins.
Elevated complement C3a in plasma from patients with severe acute asthma.
Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients.
Elevated serum levels of TNF-?, IL-8, and ECP can be involved in the development and progression of bronchial asthma.
Elevation of serum eosinophil cationic protein, soluble tumor necrosis factor receptors and soluble intercellular adhesion molecule-1 levels in acute bronchial asthma.
Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis.
Eosinophil activity in infants hospitalized for wheezing and risk of persistent childhood asthma.
Eosinophil cationic protein (ECP) and eosinophil protein X (EPX) concentrations in serum and bronchial lavage fluid in asthma. Effect of prednisolone treatment.
Eosinophil cationic protein (ECP) in saliva: a new marker of disease activity in bronchial asthma.
Eosinophil cationic protein (ECP) in school children living in a mountainous area of Norway: a population-based study of ECP as a tool for diagnosing asthma in children with reference values.
Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes.
Eosinophil cationic protein (ECP), histamine and tryptase in peripheral blood before and during inhalation challenge with toluene diisocyanate (TDI) in sensitized subjects.
Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma.
Eosinophil cationic protein and interleukin-8 levels in bronchial lavage fluid from children with asthma and infantile wheeze.
Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma.
Eosinophil cationic protein as a diagnostic marker for asthmatic children treated by immunotherapy.
Eosinophil cationic protein as a serological marker of disease activity in childhood bronchial asthma.
Eosinophil Cationic Protein Concentrations among Crop and Dairy Farmers with Asthma.
Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy.
Eosinophil cationic protein in peripheral blood of pediatric patients with allergic diseases.
Eosinophil cationic protein in serum of corticosteroid-sensitive and resistant bronchial asthma.
Eosinophil cationic protein in sputum is dependent on temperature and time.
Eosinophil cationic protein in the sera of patients with Mycoplasma pneumonia.
Eosinophil cationic protein levels in induced sputum correlate with the severity of bronchial asthma.
Eosinophil cationic protein mRNA expression in children with bronchial asthma.
Eosinophil cationic protein, myeloperoxidase and tryptase in children with asthma and atopic dermatitis.
Eosinophil cationic protein: is it useful in asthma? A systematic review.
Eosinophil chemoattractants in the middle ear of patients with eosinophilic otitis media.
Eosinophil count and eosinophil cationic protein concentration of induced sputum in the diagnosis and assessment of airway inflammation in bronchial asthma.
Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection.
Eosinophil soluble protein levels, eosinophil peroxidase and eosinophil cationic protein in asthmatic patients.
Eosinophil viability-enhancing activity in mite-sensitive bronchial asthma.
Eosinophil-derived neurotoxin in childhood asthma: correlation with disease severity.
Eosinophil-derived neurotoxin: a novel biomarker for diagnosis and monitoring of asthma.
Eosinophilic activity and bronchial hyperresponsiveness within an asthmatic paediatric population.
Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease.
Eosinophilic inflammation in asthma.
Eosinophilic inflammation in cough variant asthma.
Eosinophilic inflammation in stable chronic obstructive pulmonary disease. Relationship with neutrophils and airway function.
Eosinophilic inflammation is associated with elevation of interleukin-5 in the airways of patients with spontaneous symptomatic asthma.
Eosinophils and eosinophil-derived proteins in children with moderate asthma.
Eosinophils in exercise-induced asthma.
Eotaxin in induced sputum of asthmatics: relationship with eosinophils and eosinophil cationic protein in sputum.
Eotaxin in serum of patients with asthma or chronic obstructive pulmonary disease: relationship with eosinophil cationic protein and lung function.
Evaluation of a clinical algorithm involving serum eosinophil cationic protein for guiding the anti-inflammatory treatment of bronchial asthma in childhood.
Evaluation of serum eosinophil cationic protein as a predictive marker for asthma exacerbation in patients with persistent disease.
Evaluation of serum eosinophilic cationic protein as a marker of disease activity in chronic asthma.
Evaluation of the PPAR-? Agonist Pioglitazone in Mild Asthma: A Double-Blind Randomized Controlled Trial.
Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature.
Gene expression of interleukin-3 and granulocyte macrophage colony-stimulating factor in circulating CD4+ T cells in acute severe asthma.
Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects.
Granulocyte proteins in serum in childhood asthma: relation to spirometry and therapy.
Granulocyte-macrophage colony-stimulating factor, eosinophils and eosinophil cationic protein in subjects with and without mild, stable, atopic asthma.
Hepatocyte Growth Factor Suppresses Production of Reactive Oxygen Species and Release of Eosinophil-Derived Neurotoxin from Human Eosinophils.
High eosinophil cationic protein level in asthmatic patients with "heat" Zheng.
High levels of eosinophil cationic protein in wheezing infants predict the development of asthma.
High-resolution computed tomography scan and airway remodeling in children with severe asthma.
High-sensitive C-reactive protein is associated with reduced lung function in young adults.
IL-18 might reflect disease activity in mild and moderate asthma exacerbation.
Increased levels of nitric oxide derivatives in induced sputum in patients with asthma.
Induced sputum eosinophil cationic protein (ECP) measurement in asthma and chronic obstructive airway disease (COAD)
Induced sputum eosinophils and neutrophils and bronchiectasis severity in allergic bronchopulmonary aspergillosis.
Induced sputum in adolescents with severe stable asthma. Safety and the relationship of cell counts and eosinophil cationic protein to clinical severity.
Induced sputum in children: feasibility, repeatability, and relation of findings to asthma severity.
Induced sputum: comparison of postinfectious cough with allergic asthma in children.
Inflammation markers and symptom activity in children with bronchial asthma. Influence of atopy and eczema.
Inflammatory and bronchospastic factors in asthma exacerbations caused by upper respiratory tract infections.
Inflammatory cell number and mediators in bronchoalveolar lavage fluid and peripheral blood in subjects with asthma with increased nocturnal airways narrowing.
Inflammatory markers and Acid-base equilibrium in exhaled breath condensate of stable and unstable asthma patients.
Influence of hyposensitization on soluble interleukin-2 receptor, eosinophil cationic protein, in vitro lymphocyte proliferation, in vitro lymphocyte adhesion, and lymphocyte membrane markers in childhood asthma.
Inhaled fluticasone decreases bronchial but not alveolar nitric oxide output in asthma.
Inhaled salmeterol and albuterol in asthmatic patients receiving high-dose inhaled corticosteroids.
Interleukin-5 messenger RNA expression in peripheral blood CD4+ cells in asthma.
Intranasal heparin reduces eosinophil recruitment after nasal allergen challenge in patients with allergic rhinitis.
IP-10 Is Elevated in Virus-Induced Acute Exacerbations in Childhood Asthma.
Is serum ECP level helpful in determining discontinuation of inhaled corticosteroid therapy in asthmatic children?
Is serum eosinophil cationic protein in bronchiolitis a predictor of asthma?
Is serum or sputum eosinophil cationic protein level adequate for diagnosis of mild asthma?
Lack of relationship between eosinophil cationic protein and eosinophil protein X in nasal lavage and urine and the severity of childhood asthma in a 6-month follow-up study.
Leukocyte counts in hypertonic saline-induced sputum in subjects with occupational asthma.
Lipopolysaccharide amplifies eosinophilic inflammation after segmental challenge with house dust mite in asthmatics.
Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial.
Macrolides for chronic asthma.
Measurement of inflammatory mediators of eosinophils and lymphocytes in blood in acute asthma: serum levels of ECP influence the bronchodilator response.
Molecular Imaging of Heparan Sulfate Expression with Radiolabeled Recombinant Eosinophil Cationic Protein Predicts Allergic Lung Inflammation in a Mouse Model for Asthma.
Monitoring of asthma inflammation by serum measurements of eosinophil cationic protein (ECP). A new clinical approach to asthma management.
Monitoring of serum eosinophil cationic protein (ECP) level and its clinical value in paediatric practice.
Montelukast decreases plasma endothelin-1 and serum eosinophil cationic protein levels in paediatric atopic asthma.
Montelukast Reduces Serum Levels of Eosinophil-Derived Neurotoxin in Preschool Asthma.
Mycoplasma pneumoniae infection in children is a risk factor for developing allergic diseases.
N-Acetyl-Beta-Hexosaminidase Activity in Asthma.
Naturally occurring parainfluenza virus 3 infection in adults induces mild exacerbation of asthma associated with increased sputum concentrations of cysteinyl leukotrienes.
Neutrophilic inflammation in severe persistent asthma.
Nitric oxide metabolites, eosinophils, and eosinophilic cationic protein in patients with asthma: sputum versus blood.
NO in exhaled air is correlated with markers of eosinophilic airway inflammation in corticosteroid-dependent childhood asthma.
No relationship between lung function and high-sensitive C-reactive protein in adolescence.
Noninvasive assessment of airway inflammation in children: induced sputum, exhaled nitric oxide, and breath condensate.
Occupational asthma and rhinitis due to glutaraldehyde: changes in nasal lavage fluid after specific inhalatory challenge test.
Once-daily theophylline reduces serum eosinophil cationic protein and eosinophil levels in induced sputum of asthmatics.
One-year follow-up of young children hospitalized for wheezing: the influence of early anti-inflammatory therapy and risk factors for subsequent wheezing and asthma.
Parental support and cytokine activity in childhood asthma: the role of glucocorticoid sensitivity.
Percentage of eosinophils with surface CD44 and levels of eosinophil cationic protein in the peripheral blood in children with bronchial asthma and their changes after montelukast therapy.
Peripheral blood eosinophils from patients with allergic asthma contain increased intracellular eosinophil-derived neurotoxin.
Persistent airway inflammation and bronchial hyperresponsiveness in patients with totally controlled asthma.
Plasma protein leakage and local secretion of proteins assessed in sputum in asthma and COPD. The effect of inhaled corticosteroids.
Pranlukast, a cysteinyl leukotriene antagonist, reduces serum eosinophil cationic protein levels in patients with asthma.
Predictive capabilities of serum eosinophil cationic protein, percentage of eosinophils and total immunoglobulin E in allergic rhinitis without bronchial asthma.
Predictors of response to therapy with omalizumab in patients with severe allergic asthma - a real life study.
Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
Prevalence of serum IgE antibodies to the Staphylococcus aureus enterotoxins (SAE, SEB, SEC, SED, TSST-1) in patients with persistent allergic rhinitis.
Profiles of proinflammatory cytokines in sputum from different groups of severe asthmatic patients.
Ragweed-specific IgA in nasal lavage fluid of ragweed-sensitive allergic rhinitis patients: increase during the pollen season.
Ratio of eosinophil cationic protein/eosinophil count as a new marker in children with acute asthma.
Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma.
Relationship between activated eosinophils of the bronchial mucosa and serum eosinophil cationic protein in atopic asthma.
Relationship between cough, cough receptor sensitivity and asthma in children.
Relationship between induced sputum cell counts and fluid-phase eosinophil cationic protein and clinical or physiologic profiles in mild asthma.
Relationship between induced sputum eosinophils and the clinical pattern of childhood asthma.
Relationship of asthma, atopy, and bronchial responsiveness to serum eosinophil cationic proteins in early childhood.
Relevance of serum ECP measurements for monitoring acute asthma in children.
Repeated inhalation of low doses of cat allergen that do not induce clinical symptoms increases bronchial hyperresponsiveness and eosinophil cationic protein levels.
Repeated measurement of nasal lavage fluid chemokines in school-age children with asthma.
Role of clinical laboratory in allergy testing.
Role of regular treatment with inhaled corticosteroid or leukotriene receptor antagonist in mild intermittent asthma.
Roles of genotypes of beta2-adrenergic receptor in the relationship between eosinophil counts and lung function in Taiwanese adolescents.
Safety and application of induced sputum analysis in childhood asthma.
Salivary Eosinophil Cationic Protein in Allergic Rhinitis.
Salmeterol decreases eosinophilic cationic protein and rescue medication in patients inhaling beclomethasone dipropionate: preliminary study in mild and moderate asthma in Trinidad, West Indies.
Serum B12 tryptase level as a marker of allergic airway inflammation in asthma.
Serum ECP and MPO are increased during exacerbations of chronic bronchitis with airway obstruction.
Serum ECP levels and methacholine challenge in infants with recurrent wheezing.
Serum eosinophil cationic protein (ECP) and eosinophil protein X (EPX) in childhood asthma: the influence of atopy.
Serum eosinophil cationic protein (ECP) as a marker of disease activity and treatment efficacy in seasonal asthma.
Serum eosinophil cationic protein (ECP) as a mediator of inflammation in acute asthma, during resolution and during the monitoring of stable asthmatic patients treated with inhaled steroids according to a dose reduction schedule.
Serum eosinophil cationic protein (ECP) in chronic asthma. Relationship to spirometry, flow-volume curves, PC20, and exacerbations.
Serum eosinophil cationic protein (ECP) levels in patients with seasonal allergic rhinitis and allergic asthma.
Serum eosinophil cationic protein (sECP) in subjects with a history of asthma symptoms with or without rhinitis.
Serum eosinophil cationic protein and 27 cytokines/chemokines in acute exacerbation of childhood asthma.
Serum eosinophil cationic protein and bronchial responsiveness in pediatric and adolescent asthma patients.
Serum eosinophil cationic protein and interleukin-5 in children with bronchial asthma and acute bronchiolitis.
Serum eosinophil cationic protein as a marker of eosinophilic inflammation in asthma.
Serum eosinophil cationic protein as a predictor of disease activity in acute and chronic asthma.
Serum eosinophil cationic protein during treatment of asthma in children.
Serum eosinophil cationic protein for predicting the prognosis of a step-down in inhaled corticosteroid therapy in adult chronic asthmatics.
Serum eosinophil cationic protein in asthma of farmers.
Serum eosinophil cationic protein in asthma: what does it mean?
Serum eosinophil cationic protein in relation to bronchial asthma in a young Swedish population.
Serum eosinophil cationic protein in the evaluation of asthma severity in children.
Serum Eosinophil Cationic Protein Is a Useful Marker for Assessing the Efficacy of Inhaled Corticosteroid Therapy in Children with Bronchial Asthma.
Serum eosinophil cationic protein levels and bronchodilator responses at acute asthma exacerbation.
Serum eosinophil cationic protein levels measured during exacerbation of asthma: characteristics of patients with low titres.
Serum eosinophil cationic protein measurements in monitoring pulmonary inflammation in asthma.
Serum eosinophil cationic protein measurements in the management of perennial and periodic asthma: a prospective study.
Serum eosinophil-derived neurotoxin (EDN) in diagnosis and evaluation of severity and bronchial hyperresponsiveness in childhood asthma.
Serum eosinophil-derived neurotoxin: correlation with persistent airflow limitation in adults with house-dust mite allergic asthma.
Serum inflammatory markers and effects of age and tobacco smoke exposure in young non-asthmatic children.
Serum levels of eosinophil cationic protein and eosinophil protein x in pollen atopic patients with stable asthma and its relation with bronchial hyperresponsiveness.
Serum levels of eosinophil cationic protein and eosinophils in asthmatic children during a course of prednisolone therapy.
Serum levels of eosinophil cationic protein and IL-5 in patients with asthma without systemic corticosteroids.
Serum Levels of Eosinophil-Derived Neurotoxin: A Biomarker for Asthma Severity in Adult Asthmatics.
Serum levels of soluble CD23 in patients with asthma or rhinitis monosensitive to Parietaria. Its relation to total serum IgE levels and eosinophil cationic protein during and out of the pollen season.
Serum measurement of eosinophil cationic protein in the management of asthma.
Serum measurements of eosinophil cationic protein (ECP) in bronchial asthma.
Serum total IgE and specific IgE to Dermatophagoides pteronyssinus, but not eosinophil cationic protein, are more likely to be elevated in elderly asthmatic patients.
Severity and associated risk factors in adult asthma patients in Turkey.
Signal peptide of eosinophil cationic protein upregulates transforming growth factor-alpha expression in human cells.
Significance of the eosinophil cationic protein/eosinophil count ratio in asthmatic patients: its relationship to disease severity.
Similar RANTES levels in healthy and asthmatic airways by immunoassay and in situ hybridization.
Simultaneously elevated exhaled nitric oxide and serum-ECP relate to recent asthma events in asthmatics in a cross sectional population based study.
Specific IgE antibodies and serum eosinophil cationic protein in children with atopic dermatitis alone.
Sputum eosinophil counts and eosinophil cationic protein levels in cough-variant asthma and in classic asthma, and their relationships to airway hypersensitivity or maximal airway response to methacholine.
Sputum pentraxin 3 as a candidate to assess airway inflammation and remodeling in childhood asthma.
Suppression of airway inflammation by theophylline in adult bronchial asthma.
T cell and eosinophil activation in mild and moderate atopic and nonatopic children's asthma in remission.
The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils--implications for asthma.
The association between allergic rhinitis and otitis media: A national representative sample of in South Korean children.
The content of eosinophil cationic protein in eosinophil leucocytes. Study on normal controls and patients with bronchial asthma.
The effect of cotton-based collection methods on eosinophil cationic protein (ECP) concentrations detected in saliva.
The effect of treatment with montelukast on levels of serum interleukin-10, eosinophil cationic protein, blood eosinophil counts, and clinical parameters in children with asthma.
The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma.
The inflammatory marker serum eosinophil cationic protein (ECP) compared with PEF as a tool to decide inhaled corticosteroid dose in asthmatic patients.
The influence of atopic constitution, the severity and exacerbation of the disease on the serum eosinophil cationic protein (ECP) concentration in patients with bronchial asthma.
The predictive value of eosinophil cationic protein and lactate dehydrogenase in asthma: a comparative study of serum versus sputum.
The presence of eosinophil cationic protein in middle ear effusion.
The promoter polymorphism in the eosinophil cationic protein gene and its influence on the serum eosinophil cationic protein level.
The relationship of eosinophil granule proteins to ions in the sputum of patients with cystic fibrosis.
The relationships among hydrogen peroxide in expired breath condensate, airway inflammation, and asthma severity.
The significance of sputum ECP levels in differential diagnosis of asthma in children.
The use of serum eosinophil cationic protein (ECP) in the management of steroid therapy in chronic asthma.
The usefulness of job relocation and serum eosinophil cationic protein in baker's asthma.
Time-course study of the levels of urinary leukotriene E4, serum thromboxane B2 and serum eosinophil cationic protein in spontaneous asthma attacks in five children.
Total blood eosinophils, serum eosinophil cationic protein and eosinophil protein X in childhood asthma: relation to disease status and therapy.
Total eosinophil cationic protein levels in induced sputum as a marker of changes in eosinophilic inflammation in a patient with allergic asthma.
Toward RNase inhibitors: thermodynamics of 2'-CMP/RNase-A binding in multi-ion buffer.
Tumor necrosis factor-?, interleukin-8 and eosinophil cationic protein as serum markers of glucocorticoid efficacy in the treatment of bronchial asthma.
Update in allergy testing in childhood asthma: how do you know whether you are successfully controlling the patient's inflammation?
Utility of serum eosinophil-derived neurotoxin (EDN) measurement by ELISA in young children with asthma.
Variations of blood eosinophils and eosinophil cationic protein in serum in patients with bronchial asthma. Studies during inhalation challenge test.
Virus detection and cytokine profile in relation to age among acute exacerbations of childhood asthma.
[A basic study on the plasma and serum levels of eosinophil cationic protein (ECP) in bronchial asthma]
[Airway inflammation and peripheral airway function in asthmatic patients with different control levels]
[Bronchial hyperreactivity to histamine and levels of serum eosinophil cationic protein in patients with non-atopic asthma]
[Clinical significance of cytokine and eosinophil cationic protein concentrations in sputum of asthmatic patients]
[Diagnostic significance of serum allergen detection in diagnosis of allergic rhinitis and bronchial asthma]
[Effects of interleukin-1 receptor antagonist on the apoptosis of eosinophil in guinea pig with asthma]
[Eosinophil activation in acute asthma attacks evaluated by electronmicroscopic findings of eosinophils and the concentration of eosinophil cationic protein in sputum]
[Eosinophil cationic protein in patients with bronchial asthma]
[Eosinophil cationic protein in serum from adults with asthma and with chronic obstructive pulmonary disease]
[Flow cytometric analysis for the activation of peripheral immunoregulatory cells from patients with bronchial asthma]
[Fundamental studies on measurement of the eosinophil cationic protein in sputum from patients with bronchial asthma]
[Histopathological changes and hyperresponsiveness in asthmatic airways: relationship to peak expiratory flow]
[Measurement of serum and sputum eosinophil cationic protein concentrations in asthma]
[Measurement of serum eosinophil cationic protein levels in bronchial asthma]
[Measurement of serum eosinophil cationic protein levels in wheezing infants]
[Quantitative assessment of eosinophil cationic protein in blood of patients with bronchial asthma to study individual variants of inflammation pathogenesis and as a monitoring parameter of specific immunotherapy effects in the early periods]
[Relation between serum eosinophil cationic protein (ECP) level and asthma attack in children]
[Sensitivity of sputum eosinophil cationic protein level for monitoring asthmatic patients with normal peak expiratory flow]
[Serum eosinophil cationic protein (ECP) and major basic protein (MBP) levels in patients prepared for asthma attack]
[Serum eosinophil cationic protein, urinary eosinophil protein X and urinary N-methylhistamine during acute asthma in children]
[Serum IgE and eosinophil cationic protein levels in children with cough variant asthma]
[The changes of NO2-./NO3-. level in sputum from patients with asthma and their clinical implications]
[The impact of asthma on nasal function in patient with allergic rhinitis].
[The study of the relationship between serum eosinophil cationic protein and bronchial responsiveness in the patients with bronchial asthma]
[What role does eosinophil cationic protein have in the evaluation of asthma severity?]
Asthma, Exercise-Induced
Changes in blood levels of eosinophil cationic protein and tryptase after exercise challenge in adolescents with exercise-induced asthma.
Eosinophils in exercise-induced asthma.
Roles of eosinophils and catecholamines in pathophysiology of exercise-induced asthma.
[A study on the role of T lymphocytes and eosinophil cationic protein in exercise-induced asthma]
Asthma, Occupational
Diagnosing occupational asthma: use of induced sputum.
Barrett Esophagus
Increased Numbers of Eosinophils, Rather Than Only Etiology, Predict Histologic Changes in Patients With Esophageal Eosinophilia.
Blister
Eosinophil cationic protein levels parallel coagulation activation in the blister fluid of patients with bullous pemphigoid.
Granulocyte activation in bullous diseases: release of granular proteins in bullous pemphigoid and pemphigus vulgaris.
IL-5 levels in the serum and blister fluid of patients with bullous pemphigoid: correlations with eosinophil cationic protein, RANTES, IgE and disease severity.
Breast Neoplasms
A novel fully human anti-NCL immunoRNase for triple-negative breast cancer therapy.
A Novel Ribonuclease from Rana Chensinensis and Its Potential for the Treatment of Human Breast Cancer.
Enhanced in vitro cytotoxicity and cytostasis of the combination of onconase with a proteasome inhibitor.
Rana catesbeiana ribonuclease induces cell apoptosis via the caspase-9/-3 signaling pathway in human glioblastoma DBTRG, GBM8901 and GBM8401 cell lines.
Ribonuclease-Activated Cancer Prodrug.
Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase.
Bronchial Hyperreactivity
Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis.
Changes in High-Sensitivity C-Reactive Protein in Serum and Exhaled Breath Condensate after Intensive Exercise in Patients with Allergic Asthma.
Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma.
Immunoglobulin E Sensitization to Cross-Reactive Carbohydrate Determinants: Epidemiological Study of Clinical Relevance and Role of Alcohol Consumption.
Influence of total IgE and seasonal increase of eosinophil cationic protein on bronchial hyperreactivity in asthmatic grass-sensitized farmers.
RANTES in Exhaled Breath Condensate of Allergic Asthma Patients with Exercise-Induced Bronchoconstriction.
Relationship between the tumor necrosis factor system and the serum interleukin-4, interleukin-5, interleukin-8, eosinophil cationic protein, and immunoglobulin E levels in the bronchial hyperreactivity of adults and their children.
The role of endothelium-derived mediators in exercise-induced bronchoconstriction.
[Bronchial hyperreactivity to histamine and levels of serum eosinophil cationic protein in patients with non-atopic asthma]
[Correlation of ECP levels in sputum and blood with parameters of airflow obstruction and hyperreactivity in patients with irreversible bronchial obstruction due to chronic bronchitis]
[Effect of 16-week use of salmeterol on ECP levels, pulmonary function tests and bronchial hyperreactivity in patients with chronic obstructive lung disease]
Bronchial Spasm
Value of eosinophil cationic protein and tryptase levels in bronchoalveolar lavage fluid for predicting lung function impairment in anaesthetised, asthmatic children.
Bronchiectasis
Evidence for eosinophil activation in bronchiectasis unrelated to cystic fibrosis and bronchopulmonary aspergillosis: discrepancy between blood eosinophil counts and serum eosinophil cationic protein levels.
Bronchiolitis
Bronchoalveolar lavage eosinophil cationic protein and interleukin-8 levels in acute asthma and acute bronchiolitis.
Comparison of serum eosinophil-derived neurotoxin levels between wheezing and non-wheezing groups in children with respiratory tract infection.
Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis.
Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis.
Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing.
Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy.
Eosinophil-derived neurotoxin levels at 3 months post-respiratory syncytial virus bronchiolitis are a predictive biomarker of recurrent wheezing.
Is serum eosinophil cationic protein in bronchiolitis a predictor of asthma?
Nasopharyngeal eosinophil cationic protein in bronchiolitis: relation to viral findings and subsequent wheezing.
Neutrophil but not eosinophil inflammation is related to the severity of a first acute epidemic bronchiolitis in young infants.
Peripheral blood eosinophil counts and eosinophil cationic protein content of respiratory secretions in bronchiolitis: relationship to severity of disease.
Presence of Eosinophils in Nasal Secretion during Acute Respiratory Tract Infection in Young Children Predicts Subsequent Wheezing within Two Months.
Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells.
Serum eosinophil cationic protein and CD23 in acute RSV bronchiolitis.
Serum eosinophil cationic protein and interleukin-5 in children with bronchial asthma and acute bronchiolitis.
Serum eosinophil cationic protein as a predictor of wheezing after bronchiolitis.
The role of leukotrienes and eosinophil cationic protein in acute respiratory syncytial virus bronchiolitis.
Bronchitis
Increased serum inflammatory markers as predictors of airway obstruction.
[A study of airway reactivity and nature of chronic asthmatic bronchitis]
[Levels of eosinophil cationic protein in serum of infants with wheezy bronchitis]
Bronchitis, Chronic
Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid.
The significance of sputum ECP levels in differential diagnosis of asthma in children.
Bronchopulmonary Dysplasia
Eosinophil cationic protein in tracheal aspirates of preterm infants with bronchopulmonary dysplasia.
Burkitt Lymphoma
Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: potential for the treatment of non-Hodgkin lymphoma.
Carcinogenesis
Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray.
Human pancreatic ribonuclease 1: expression and distribution in pancreatic adenocarcinoma.
RNA damage and inhibition of neoplastic endothelial cell growth: effects of human and amphibian ribonucleases.
Carcinoma
Alteration of N-acetylglucosaminyltransferases in pancreatic carcinoma.
Combination of onconase and dihydroartemisinin synergistically suppresses growth and angiogenesis of non-small-cell lung carcinoma and malignant mesothelioma.
Effect of eosinophil cationic protein on human oral squamous carcinoma cell viability.
Effect of ONCONASE +/- tamoxifen on ASPC-1 human pancreatic tumors in nude mice.
Enhanced in vitro cytotoxicity and cytostasis of the combination of onconase with a proteasome inhibitor.
Enhancement of vincristine cytotoxicity in drug-resistant cells by simultaneous treatment with onconase, an antitumor ribonuclease.
Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway.
Highly efficient destruction of squamous carcinoma cells of the head and neck by photochemical internalization of Ranpirnase.
Human pancreatic ribonuclease 1: expression and distribution in pancreatic adenocarcinoma.
In vivo and in vitro growth-inhibitory effect of bovine seminal ribonuclease on a system of rat thyroid epithelial transformed cells and tumors.
MicroRNA drop in the bloodstream and microRNA boost in the tumour caused by treatment with ribonuclease A leads to an attenuation of tumour malignancy.
Seminal ribonuclease inhibits tumor growth and reduces the metastatic potential of Lewis lung carcinoma.
Serum ribonuclease in patients with lung carcinoma.
The 434(G>C) polymorphism in the eosinophil cationic protein gene and its association with tissue eosinophilia in oral squamous cell carcinomas.
Carcinoma, Embryonal
Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway.
Eosinophil cationic protein enhances stabilization of ?-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Carcinoma, Hepatocellular
Rana catesbeiana ribonuclease induces cell apoptosis via the caspase-9/-3 signaling pathway in human glioblastoma DBTRG, GBM8901 and GBM8401 cell lines.
Carcinoma, Lewis Lung
MicroRNA drop in the bloodstream and microRNA boost in the tumour caused by treatment with ribonuclease A leads to an attenuation of tumour malignancy.
Seminal ribonuclease inhibits tumor growth and reduces the metastatic potential of Lewis lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Combination of onconase and dihydroartemisinin synergistically suppresses growth and angiogenesis of non-small-cell lung carcinoma and malignant mesothelioma.
Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase.
Carcinoma, Renal Cell
A phase II trial of weekly intravenous ranpirnase (Onconase), a novel ribonuclease in patients with metastatic kidney cancer.
Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase.
Carcinoma, Squamous Cell
Effect of eosinophil cationic protein on human oral squamous carcinoma cell viability.
Epidermal growth factor receptor-dependent cytotoxicity for human squamous carcinoma cell lines of a conjugate composed of human EGF and RNase 1.
Highly efficient destruction of squamous carcinoma cells of the head and neck by photochemical internalization of Ranpirnase.
The 434(G>C) polymorphism in the eosinophil cationic protein gene and its association with tissue eosinophilia in oral squamous cell carcinomas.
Cardiotoxicity
Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase.
Cardiovascular Diseases
Extracellular Ribonucleic Acids (RNA) Enter the Stage in Cardiovascular Disease.
Chagas Disease
Immunohistochemical detection of deposits of eosinophil-derived neurotoxin and eosinophil peroxidase in the myocardium of patients with Chagas' disease.
Chemical and Drug Induced Liver Injury
Eotaxin expression and eosinophil infiltrate in the liver of patients with drug-induced liver disease.
Cholera
[Effects of G-Protein Regulators and Stylar S-RNase on the Growth and Ca(2+) Concentration of Pyrus pyrifolia Pollen Tube.]
Chronic Urticaria
Blood eosinophils and serum eosinophil cationic protein in patients with acute and chronic urticaria.
Co-existence of Chronic Urticaria and Metabolic Syndrome: Clinical Implications.
Churg-Strauss Syndrome
Allergic granulomatosis and angiitis of Churg-Strauss. A case of high serum level of eosinophil cationic protein.
Churg-Strauss syndrome: serum markers of lymphocyte activation and endothelial damage.
Deposition of eosinophil cationic protein in granulomas in allergic granulomatosis and vasculitis: the Churg-Strauss syndrome.
Eosinophilic Myocarditis due to Churg-Strauss Syndrome With Markedly Elevated Eosinophil Cationic Protein.
Serum eosinophil cationic protein: a marker of disease activity in Churg-Strauss syndrome.
Serum interleukin-5 levels correlate with disease activity of Churg-Strauss syndrome in a patient treated with a leucotriene receptor antagonist, pranlukast, and inhaled corticosteroid.
Urinary eosinophil-derived neurotoxin in Churg-Strauss syndrome.
[Eosinophil cationic protein in a 39-year-old patient with Churg-Strauss syndrome]
Colitis
Antibody to eosinophil cationic protein suppresses dextran sulfate sodium-induced colitis in rats.
Colitis, Collagenous
Evidence of local eosinophil activation and altered mucosal permeability in collagenous colitis.
Fecal eosinophil cationic protein as a marker of active disease and treatment outcome in collagenous colitis: a pilot study.
Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients.
Colitis, Ulcerative
Eosinophil activation in ulcerative colitis: studies on mucosal release and localization of eosinophil granule constituents.
Evaluation of serum eosinophil cationic protein (ECP) level in patients with ulcerative colitis.
In vitro release of eosinophil cationic protein from peripheral eosinophils reflects disease activity in childhood Crohn disease and ulcerative colitis.
Quantification of inflammatory mediators in stool samples of patients with inflammatory bowel disorders and controls.
Serum eosinophil cationic protein in active and quiescent ulcerative colitis.
Colorectal Neoplasms
An essential role of PRMT1-mediated EGFR methylation in EGFR activation by ribonuclease 5.
Common Cold
Allergen challenge-induced acute exudation of IL-8, ECP and alpha2-macroglobulin in human rhinovirus-induced common colds.
Communicable Diseases
Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.
Conjunctival Diseases
Clinical Severity and Tear Biomarkers, Eosinophil Cationic Protein and CCL23, in Chronic Allergic Conjunctival Diseases.
Conjunctivitis
Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases.
[Tear eosinophil cationic protein measurement in patients with seasonal allergic conjunctivitis]
Conjunctivitis, Allergic
Atopy and serum eosinophil cationic protein in 110 white children with vernal keratoconjunctivitis: differences between tarsal and limbal forms.
Effect of lodoxamide and disodium cromoglycate on tear eosinophil cationic protein in vernal keratoconjunctivitis.
Eosinophil cationic protein in tears in allergic conjunctivitis.
Eosinophil cationic protein in tears of normal subjects and patients affected by vernal keratoconjunctivitis.
Expression of ICAM-1 on conjunctival epithelium and ECP in tears and serum from children with allergic conjunctivitis.
Increased serum levels of eosinophil cationic protein and eosinophil-derived neurotoxin (protein X) in vernal keratoconjunctivitis.
Ocular allergic disease.
Tear and serum eosinophil cationic protein levels in seasonal allergic conjunctivitis.
Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases.
The origin of keratopathy in chronic allergic eye disease: a histopathological study.
The role of eosinophil cationic protein (ECP) and histamine in vernal keratoconjunctivitis.
[Tear eosinophil cationic protein measurement in patients with seasonal allergic conjunctivitis]
Conjunctivitis, Bacterial
Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases.
Coronary Artery Disease
Eosinophil cationic protein: A new biomarker of coronary atherosclerosis.
The Correlation of Serum Myeloid-Related Protein-8/14 and Eosinophil Cationic Protein in Patients with Coronary Artery Disease.
Cough
Induced sputum: comparison of postinfectious cough with allergic asthma in children.
Relationship between cough, cough receptor sensitivity and asthma in children.
Serum level of eosinophil cationic protein in patients with chronic cough: relationship to blood eosinophils and airway hyperresponsiveness.
Sputum cell counts and exhaled nitric oxide in patients with gastroesophageal reflux, and cough or asthma.
Sputum ECP levels correlate with parameters of airflow obstruction.
Sputum eosinophilia and bronchial responsiveness in patients with chronic non-productive cough responsive to anti-asthma therapy.
[Serum IgE and eosinophil cationic protein levels in children with cough variant asthma]
Crohn Disease
In vitro release of eosinophil cationic protein from peripheral eosinophils reflects disease activity in childhood Crohn disease and ulcerative colitis.
Quantification of inflammatory mediators in stool samples of patients with inflammatory bowel disorders and controls.
Secretion and tissue content of eosinophil cationic protein in Crohn's disease.
Cryptogenic Organizing Pneumonia
Interleukin 5 and granulocyte-macrophage colony-stimulating factor levels in bronchoalveolar lavage fluid in interstitial lung disease.
Crystal Arthropathies
Eosinophil cationic protein in inflammatory synovial effusions as evidence of eosinophil involvement.
Cystic Fibrosis
Eosinophil cationic protein in sputum from cystic fibrosis patients with Pseudomonas aeruginosa infections.
Eosinophilic activation in cystic fibrosis.
Evidence for eosinophil activation in bronchiectasis unrelated to cystic fibrosis and bronchopulmonary aspergillosis: discrepancy between blood eosinophil counts and serum eosinophil cationic protein levels.
Increased degranulation of eosinophil and neutrophil granulocytes in cystic fibrosis.
Major basic protein, but not eosinophil cationic protein or eosinophil protein X, is related to atopy in cystic fibrosis.
Myeloperoxidase and eosinophil cationic protein in serum and sputum during antibiotic treatment in cystic fibrosis patients with Pseudomonas aeruginosa infection.
Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro.
Relationship between disease severity and inflammatory markers in cystic fibrosis.
Serum eosinophil cationic protein, eosinophil protein X and eosinophil peroxidase in relation to pulmonary function in cystic fibrosis.
[Serum and sputum eosinophil cationic protein levels and clinical status in cystic fibrosis patients]
Cystitis, Interstitial
Chronic interstitial cystitis: increased levels of eosinophil cationic protein in serum and urine and an ameliorating effect of subcutaneous heparin.
Complement C3, eosinophil cationic protein and symptom evaluation in interstitial cystitis.
Determination of eosinophil cationic protein in urine by an enzyme immunoassay.
Pathology and pathophysiology of painful bladder diseases.
Urine eosinophil cationic protein in painful bladder disease.
Dermatitis Herpetiformis
Serum eosinophil cationic protein, myeloperoxidase, tryptase, eotaxin and Th2-L-like cytokines in Dermatitis herpetiformis.
Dermatitis, Atopic
A Double-Blind, Randomized, Crossover Study to Compare the Effectiveness of Montelukast on Atopic Dermatitis in Korean Children.
Atopic eczema, Langerhans cells and allergy.
Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis.
Circulating activation markers of severe atopic dermatitis following ultraviolet A1 cold light phototherapy: eosinophil cationic protein, soluble interleukin-2 receptor and soluble interleukin-4 receptor.
Comparison of severity scoring of atopic dermatitis values and serum levels of eosinophil cationic protein and mast cell tryptase for routine evaluation of atopic dermatitis.
Correlation of eosinophils, eosinophil cationic protein and soluble interleukin-2 receptor with the clinical activity of atopic dermatitis.
Correlations of serum Interleukin-16, total IgE, eosinophil cationic protein and total eosinophil counts with disease activity in children with atopic dermatitis.
Effect and correlation of serum total IgE, eosinophil granule cationic proteins and sensitized allergens in atopic dermatitis patients with or without rhinitis.
Effect of processed foods on serum levels of eosinophil cationic protein among children with atopic dermatitis.
Eosinophil cationic protein (ECP) level and its correlation with eosinophil number or IgE level of peripheral blood in patients with various skin diseases.
Eosinophil cationic protein in atopic eczema.
Eosinophil cationic protein in human milk is associated with development of cow's milk allergy and atopic eczema in breast-fed infants.
Eosinophil cationic protein in peripheral blood of pediatric patients with allergic diseases.
Eosinophil cationic protein in sera of patients with atopic dermatitis.
Eosinophil cationic protein, myeloperoxidase and tryptase in children with asthma and atopic dermatitis.
Eosinophil chemiluminescence response to cytokines and opsonized zymosans in atopic dermatitis.
Eosinophil granule proteins in serum and urine of patients with helminth infections and atopic dermatitis.
Eosinophil involvement in atopic dermatitis as reflected by elevated serum levels of eosinophil cationic protein.
Eosinophil protein X and eosinophil cationic protein as indicators of intestinal inflammation in infants with atopic eczema and food allergy.
Eosinophil-derived neurotoxin as a biomarker for disease severity and relapse in recalcitrant atopic dermatitis.
Eosinophils are neither migrated nor activated in the skin lesions of atopic dermatitis in infants.
Fecal tumor necrosis factor alpha, eosinophil cationic protein and IgE levels in infants with cow's milk allergy and gastrointestinal manifestations.
Genotypic and phenotypic characterization of Staphylococcus aureus strains isolated in subjects with atopic dermatitis. Higher prevalence of exfoliative B toxin production in lesional strains and correlation between the markers of disease intensity and colonization density.
High-dose UVA1 therapy in the treatment of patients with atopic dermatitis.
Interleukin-5 messenger RNA and immunoreactive protein expression by activated eosinophils in lesional atopic dermatitis skin.
Intestinal inflammation in children with atopic eczema: faecal eosinophil cationic protein and tumour necrosis factor-alpha as non-invasive indicators of food allergy.
Modulation of serum eosinophil cationic protein levels by cyclosporin in severe atopic dermatitis.
Monitoring of disease activity by measurement of inflammatory markers in atopic dermatitis in childhood.
Monitoring of inflammation during challenge tests in children.
Monitoring of serologic immune parameters in inflammatory skin diseases.
No association between serum eosinophil cationic protein and atopic dermatitis or allergic rhinitis in an unselected population of children.
Relationships between eosinophil-associated parameters and disease severity in atopic dermatitis.
Role of clinical laboratory in allergy testing.
Serum eosinophil cationic protein (ECP) is a sensitive measure for disease activity in atopic dermatitis.
Serum eosinophil cationic protein in children with atopic dermatitis.
Serum eosinophil cationic protein in patients with atopic dermatitis.
Serum eosinophil derived neurotoxin may reflect more strongly disease severity in childhood atopic dermatitis than eosinophil cationic protein.
Serum eosinophil-derived neurotoxin in childhood atopic dermatitis: a useful marker of disease activity?
Serum levels of eosinophil cationic protein reflect the state of in vitro degranulation of blood hypodense eosinophils in atopic dermatitis.
Serum soluble IL-2 receptor (sIL-2R) and eosinophil cationic protein (ECP) levels in atopic dermatitis.
Soluble E-selectin and eosinophil cationic protein are distinct serum markers that differentially represent clinical features of atopic dermatitis.
Specific IgE antibodies and serum eosinophil cationic protein in children with atopic dermatitis alone.
The relationship between eosinophils, OKT6-positive cells and house dust mite (HDM) antigens in naturally occurring lesions of atopic dermatitis.
The role of eosinophils and eosinophil cationic protein in monitoring oral challenge tests in children with food-sensitive atopic dermatitis.
Urinary eosinophil protein X and serum eosinophil cationic protein in infants and young children with atopic dermatitis: correlation with disease activity.
Urinary Eosinophil-derived Neurotoxin Concentrations in Patients with Atopic Dermatitis: A Useful Clinical Marker for Disease Activity.
Utility of Eosinophil Cationic Protein Levels in the Diagnosis of Intrinsic Atopic Dermatitis.
[Aqueous levels of eosinophil cationic protein and major basic protein in patients with retinal detachment associated with atopic dermatitis]
[Peripheral eosinophil counts relates the improvement of the skin lesions of atopic dermatitis patients more sensitive than serum eosinophil cationic protein levels]
[Serum eosinophil cationic protein (ECP) in patients with perennial rhinitis and atopic dermatitis, allergic to house dust mites]
[The effect of suplatast tosilate on immunological parameters for the patients with atopic dermatitis]
Drug Hypersensitivity
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.
Duodenal Ulcer
[The secretion of pancreatic ribonuclease in patients with duodenal ulcer after surgical treatment (author's transl)]
Dyspnea
Clinical features and airway inflammation in mild asthma versus asymptomatic airway hyperresponsiveness.
Echinococcosis
Eosinophil cationic protein damages protoscoleces in vitro and is present in the hydatid cyst.
[Evaluation of eosinophil cationic protein levels with clinical symptoms and laboratory findings of patients with cystic echinococcosis]
Eczema
Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature.
Orange-induced skin lesions in patients with atopic eczema: evidence for a non-IgE-mediated mechanism.
Serum inflammatory markers and effects of age and tobacco smoke exposure in young non-asthmatic children.
Encephalitis
A comparison of Saint Louis encephalitis and Sindbis virus RNA.
Eosinophil-associated inflammation and elaboration of eosinophil-derived proteins in 2 children with raccoon roundworm (Baylisascaris procyonis) encephalitis.
Encephalitis, Tick-Borne
Ribonuclease treatment of tick-borne encephalitis.
Enterocolitis
Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome.
Eosinophilia
Absence of association of peripheral blood eosinophilia or increased eosinophil cationic protein with bronchial hyperresponsiveness during asthma remission.
Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways.
Angiolymphoid hyperplasia with eosinophilia associated with arteriovenous malformation: a clinicopathological correlation with angiography and serial estimation of serum levels of renin, eosinophil cationic protein and interleukin 5.
Biochemical properties of the eosinophil cationic protein and demonstration of its biosynthesis in vitro in marrow cells from patients with an eosinophilia.
Blood eosinophil number and activity in relation to lung function in patients with asthma and with eosinophilia.
Casein hydrolysate formula-induced liver dysfunction in a neonate with non-immunoglobulin E-mediated cow's milk allergy.
Churg-Strauss Syndrome: The Clinical Features and Long-term Follow-up of 17 Patients.
Comparison of exhaled nitric oxide measurement with conventional tests in steroid-naive asthma patients.
Comparison of the effects of repetitive low-dose and single-dose antigen challenge on airway inflammation.
DRESS syndrome associated with carbamazepine and phenytoin.
Effect of a bronchial provocation test with house-dust mite on blood eosinophilia, eosinophil cationic protein, soluble interleukin-2 receptor, and interleukin-6 in asthmatic children.
Eosinophil-associated inflammation and elaboration of eosinophil-derived proteins in 2 children with raccoon roundworm (Baylisascaris procyonis) encephalitis.
Eosinophilic esophagitis in children with celiac disease.
Evaluation of blood eosinophilia and the eosinophil cationic protein (ECP) in the serum of asthmatic children with varying degree of severity.
House dust mite-specific IgE antibodies in induced sputum are associated with sputum eosinophilia in mite-sensitive asthmatics.
Hypereosinophilic syndrome evolving to acute lymphoblastic leukemia.
Idiopathic eosinophilia associated with portal vein and massive thrombosis: successful thrombolysis with streptokinase.
Inflammatory markers and Acid-base equilibrium in exhaled breath condensate of stable and unstable asthma patients.
Kimura's disease associated with bronchial asthma presenting eosinophilia and hyperimmunoglobulinemia E which were attenuated by suplatast tosilate (IPD-1151T).
Laboratory diagnosis of human toxocariasis.
Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis.
Nasal eosinophilia induced by PAF-acether is accompanied by the release of eosinophil cationic protein.
Non-atopic IgE and eosinophil cationic protein after allogeneic hematopoietic stem cell transplantation in children.
Paragonimiasis westermani with multifocal lesions in lungs and skin.
Plasma eosinophil cationic protein, interleukin-5, and ECP/Eo count ratio in patients with various eosinophilic diseases.
Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children.
Presence of Eosinophils in Nasal Secretion during Acute Respiratory Tract Infection in Young Children Predicts Subsequent Wheezing within Two Months.
Role of Leptin/Osteopontin Axis in the Function of Eosinophils in Allergic Rhinitis with Obesity.
Serum eosinophil cationic protein in the evaluation of asthma severity in children.
Serum IL-5 and IL-13 consistently serve as the best predictors for the blood eosinophilia phenotype in adult asthmatics.
Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib.
T-helper 2 involvement in the pathogenesis of bullous pemphigoid: role of soluble CD30 (sCD30).
The 434(G>C) polymorphism in the eosinophil cationic protein gene and its association with tissue eosinophilia in oral squamous cell carcinomas.
The relationship of IgE, skin-test, eosinophilia, eosinophil cationic protein and tumor necrosis factor production in allergic rhinitis.
The role of endothelium-derived mediators in exercise-induced bronchoconstriction.
[Blood and tissue eosinophilia, mistletoe lectin antibodies and quality of life in a breast cancer patient undergoing intratumoral and subcutaneous mistletoe therapy]
[Diagnostic value of selected eosinophil activity parameters in children with hay fever]
[Inflammatory mediators, cell counts in nasal lavage and computed tomography of the paranasal sinuses in atopic children]
[New concepts about atopic dermatitis]
Eosinophilia-Myalgia Syndrome
1,1'-Ethylidenebis(tryptophan) (Peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: association of eosinophilia-myalgia syndrome with a L-tryptophan contaminant.
Eosinophilic Esophagitis
Marked deposition of eosinophil-derived neurotoxin in adult patients with eosinophilic esophagitis (am j gastroenterol 2010;105:298-307).
Marked deposition of eosinophil-derived neurotoxin in adult patients with eosinophilic esophagitis.
Normalized serum eosinophil peroxidase levels are inversely correlated with esophageal eosinophilia in eosinophilic esophagitis.
Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis.
Serum Eosinophil Cationic Protein is Superior to Mast Cell Tryptase as Marker for Response to Topical Corticosteroid Therapy in Eosinophilic Esophagitis.
Eosinophilic Granuloma
Immunopathological study of eosinophils in eosinophilic granuloma of bone: evidence for release of three cationic proteins and subsequent uptake in macrophages.
Epididymitis
RNase9, an androgen-dependent member of the RNase A family, is specifically expressed in the rat epididymis.
Esophageal Achalasia
Activated Eosinophils are Present in Esophageal Muscle in Patients with Achalasia of the Esophagus.
Eosinophil infiltration in primary esophageal achalasia. A possible pathogenic role.
Familial Mediterranean Fever
Increased serum eosinophil cationic protein levels in familial Mediterranean fever.
Fascioliasis
Eosinophil cationic protein in patients with fascioliasis: its probable effects on symptoms and signs.
Fatigue Syndrome, Chronic
Eosinophil cationic protein serum levels and allergy in chronic fatigue syndrome.
Folliculitis
Eosinophil cationic protein in eosinophilic pustular folliculitis: an immunohistochemical investigation.
Food Hypersensitivity
Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy.
Dynamics of cytokine mRNA expression and fecal biomarkers in school-children undergoing a double-blind placebo-controlled food challenge series.
Effects of Leukotriene Receptor Antagonists on Peripheral Eosinophil Counts and Serum IgE Levels in Children with Food Allergy.
Eosinophil protein X and eosinophil cationic protein as indicators of intestinal inflammation in infants with atopic eczema and food allergy.
Intestinal inflammation in children with atopic eczema: faecal eosinophil cationic protein and tumour necrosis factor-alpha as non-invasive indicators of food allergy.
Quantification of inflammatory mediators in stool samples of patients with inflammatory bowel disorders and controls.
[Eosinophil cationic protein in serum of children with food allergy]
Gastritis
Eosinophil infiltration, gastric juice and serum eosinophil cationic protein levels in Helicobacter pylori-associated chronic gastritis and gastric ulcer.
Gastroesophageal Reflux
Increased Numbers of Eosinophils, Rather Than Only Etiology, Predict Histologic Changes in Patients With Esophageal Eosinophilia.
Gastrointestinal Diseases
Eosinophil cationic protein in feces: reference values in healthy and atopic individuals and patients with digestive diseases.
Giant Cell Arteritis
Deposition of eosinophil cationic protein in vascular lesions in temporal arteritis.
Giardiasis
[Eosinophil cationic protein in serum of children with food allergy]
Glioma
A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity.
Enhanced cellular radiation sensitivity of androgen-independent human prostate tumor cells by onconase.
Recombinant expression, different downstream processing of the disulfide-rich anti-tumor peptide Ranpirnase and its effect on the growth of human glioma cell line SHG-44.
Glomerulonephritis, IGA
Eosinophil cationic protein in Henoch-Schönlein purpura and in IgA nephropathy.
Graft vs Host Disease
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.
Granuloma
Deposition of eosinophil cationic protein in granulomas in allergic granulomatosis and vasculitis: the Churg-Strauss syndrome.
Granulomatosis with Polyangiitis
Inflammatory cells and cellular activation in the lower respiratory tract in Churg-Strauss syndrome.
Graves Disease
Increased serum concentration of eosinophil-derived neurotoxin in patients with Graves' disease.
Head and Neck Neoplasms
A fusogenic dengue virus-derived peptide enhances antitumor efficacy of an antibody-ribonuclease fusion protein targeting the EGF receptor.
Heart Diseases
RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-? in cardiac ischaemia/reperfusion injury.
Heart Failure
Synthesis of interleukin-5 by activated eosinophils in patients with eosinophilic heart diseases.
Helminthiasis
Eosinophil cationic protein as a possible marker of active human Toxocara infection.
Eosinophil granule proteins in serum and urine of patients with helminth infections and atopic dermatitis.
Hematoma, Subdural, Chronic
Expressions of Eotaxin-3, Interleukin-5, and Eosinophil-Derived Neurotoxin in Chronic Subdural Hematoma Fluids.
Hemorrhagic Fever, Ebola
Antiviral effect of ranpirnase against Ebola virus.
Hepatitis B
Adenoviral-vector mediated transfer of HBV-targeted ribonuclease can inhibit HBV replication in vivo.
Hepatitis C
A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus.
Hodgkin Disease
Effect of eosinophil cationic protein (ECP) on Hodgkin lymphoma cell lines.
The serum levels of eosinophil cationic protein (ECP) are related to the infiltration of eosinophils in the tumours of patients with Hodgkin's disease.
Hookworm Infections
Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana.
Hypereosinophilic Syndrome
Familial eosinophilia: a benign disorder?
Purification of human eosinophil-derived neurotoxin.
Synthesis of interleukin-5 by activated eosinophils in patients with eosinophilic heart diseases.
Hypersensitivity
"The (1)H, (13)C, (15)N resonance assignment, solution structure and residue level stability of eosinophil cationic protein/rnase 3 determined by NMR spectroscopy"
Allergy in marathon runners and effect of Lactobacillus GG supplementation on allergic inflammatory markers.
Association of otitis media with effusion and allergy as demonstrated by intradermal skin testing and eosinophil cationic protein levels in both middle ear effusions and mucosal biopsies.
Biochemical assessment of intracellular signal transduction pathways in eosinophils: implications for pharmacotherapy.
Comparison of basophil histamine release, eosinophil cationic protein and non-specific airway responsiveness between mite-sensitive asthmatic and non-asthmatic children and non-allergic controls.
Determination of inflammatory markers in allergic reactions to drugs.
Different cytokine profile and eosinophil activation are involved in rhinovirus- and RS virus-induced acute exacerbation of childhood wheezing.
Effect of processed foods on serum levels of eosinophil cationic protein among children with atopic dermatitis.
Eicosanoid metabolism and eosinophilic inflammation in nasal polyp patients with immune response to Staphylococcus aureus enterotoxins.
Eosinophil cationic protein in mucosal biopsies from patients with allergy and otitis media with effusion.
Eosinophil cationic protein in sera of patients with atopic dermatitis.
Eosinophil cationic protein in the nasal secretions of patients with mite allergic rhinitis.
Eosinophil cationic protein mRNA expression in children with bronchial asthma.
Eosinophil cationic protein serum levels and allergy in chronic fatigue syndrome.
Eosinophil granule proteins in serum and urine of patients with helminth infections and atopic dermatitis.
Eosinophil involvement in atopic dermatitis as reflected by elevated serum levels of eosinophil cationic protein.
Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis.
Exhaled breath condensate, nasal eosinophil cationic protein level and nasal cytology during immunotherapy for cypress allergy.
Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children.
Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature.
In-vivo diagnostic measurements of ocular inflammation.
Lactoferrin, myeloperoxidase, lysozyme and eosinophil cationic protein in exudate in delayed type hypersensitivity.
Levels of eosinophil cationic protein and myeloperoxidase from chronic middle ear effusion in patients with allergy and/or acute infection.
Measurement of serum levels of eosinophil cationic protein to monitor patients with seasonal respiratory allergy induced by Parietaria pollen (treated and untreated with specific immunotherapy).
Nasal indices of eosinophilic and exudative inflammation in bakery-workers.
Nasal lavage fluid examination in diagnostics of occupational allergy to chloramine.
Peripheral blood eosinophils from patients with allergic asthma contain increased intracellular eosinophil-derived neurotoxin.
Prospective longitudinal study of urinary eosinophil protein X in children with asthma and chronic cough.
Role of tryptase, eosinophil cationic protein and histamine in immediate allergic reactions to drugs.
Serum eosinophil cationic protein in relation to bronchial asthma in a young Swedish population.
Sputum eosinophil counts and eosinophil cationic protein levels in cough-variant asthma and in classic asthma, and their relationships to airway hypersensitivity or maximal airway response to methacholine.
The association between allergic rhinitis and otitis media: A national representative sample of in South Korean children.
The distribution of eosinophil cationic protein positive eosinophils in the nasal mucosa of the nasal allergy patients.
Tumour necrosis factor-alpha in nasal allergy.
Urinary leukotriene E(4), eosinophil protein X, and nasal eosinophil cationic protein are not associated with respiratory symptoms in 1-year-old children.
Variations of cationic proteins from eosinophil leukocytes in food intolerance and allergic rhinitis.
Variations of serum eosinophil cationic protein and tryptase, measured in serum and saliva, during the course of immediate allergic reactions to foods.
[Eosinophil cationic protein in persons with contact allergy to disinfectants]
[Eosinophil cationic protein in serum of children with food allergy]
[Eosinophilic cationic protein levels in feces and serum in children with food allergies]
[Experimental study of the allergenic and modulating properties of RNAses]
[Study on eosinophil cationic protein (ECP) and arylsulfatase B in nasal secretions and sera from patients with nasal allergy]
[Tear eosinophil cationic protein measurement in patients with seasonal allergic conjunctivitis]
[The measuring of ECP and IgE in middle ear effusion of patients with otitis media of effusion]
Hypertension, Pulmonary
[Effect of inhaled corticosteroids on serum eosinophil cationic protein and sIL-2R levels in asthmatics pulmonary hypertension]
Idiopathic Pulmonary Fibrosis
Eosinophil activation in patients with pulmonary fibrosis.
The eosinophil component of the alveolitis in idiopathic pulmonary fibrosis. Signs of eosinophil activation in the lung are related to impaired lung function.
Infarction, Middle Cerebral Artery
RNase therapy assessed by magnetic resonance imaging reduces cerebral edema and infarction size in acute stroke.
Infections
A novel RNase 3/ECP peptide for Pseudomonas aeruginosa biofilm eradication. Combining antimicrobial, lipopolysaccharide binding and cell agglutinating activities.
Antimicrobial RNases in Cutaneous Defense.
Antiviral effect of ranpirnase against Ebola virus.
Circulating fibrosis markers, eosinophil cationic protein and eosinophil protein X in patients with Wuchereria bancrofti infection: association with clinical status.
Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall.
Comparison of serum eosinophil-derived neurotoxin levels between wheezing and non-wheezing groups in children with respiratory tract infection.
Correlation between Torque tenovirus infection and serum levels of eosinophil cationic protein in children hospitalized for acute respiratory diseases.
Eosinophil cationic protein as a possible marker of active human Toxocara infection.
Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy.
Eosinophil cationic protein in nasopharyngeal secretions and serum of infants infected with respiratory syncytial virus.
Eosinophil cationic protein in sputum from cystic fibrosis patients with Pseudomonas aeruginosa infections.
Eosinophil cationic protein mRNA expression in children with bronchial asthma.
Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis.
Eosinophil granule proteins in serum and urine of patients with helminth infections and atopic dermatitis.
Eosinophil-associated inflammation and elaboration of eosinophil-derived proteins in 2 children with raccoon roundworm (Baylisascaris procyonis) encephalitis.
Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia.
High levels of eosinophil cationic protein in wheezing infants predict the development of asthma.
Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.
Indirect assessment of eosinophiluria in urinary schistosomiasis using eosinophil cationic protein (ECP) and eosinophil protein X (EPX).
Levels of eosinophil cationic protein and myeloperoxidase from chronic middle ear effusion in patients with allergy and/or acute infection.
Morbidity assessment in urinary schistosomiasis infection through ultrasonography and measurement of eosinophil cationic protein (ECP) in urine.
Myeloperoxidase and eosinophil cationic protein in serum and sputum during antibiotic treatment in cystic fibrosis patients with Pseudomonas aeruginosa infection.
Protein post-translational modification in host defense: the antimicrobial mechanism of action of human eosinophil cationic protein native forms.
Ranpirnase Reduces HIV-1 Infection and Associated Inflammatory Changes in a Human Colorectal Explant Model.
Relationships between cotinine, lower respiratory tract infection, and eosinophil cationic protein in children.
Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response.
RNase1 alleviates the Aeromonas hydrophila-induced oxidative stress in blunt snout bream.
Sequence-specific backbone resonance assignments and microsecond timescale molecular dynamics simulation of human eosinophil-derived neurotoxin.
Serum eosinophil cationic protein (ECP) in human immunodeficiency virus (HIV) infection.
Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariae and schistosomes.
Structural basis for endotoxin neutralization by the eosinophil cationic protein.
The 434(G>C) polymorphism within the coding sequence of Eosinophil Cationic Protein (ECP) correlates with the natural course of Schistosoma mansoni infection.
The antiviral activity of ribosomal polynucleotides against encephalomyocarditis virus infection of mice.
The differential release of eosinophil granule proteins. Studies on patients with acute bacterial and viral infections.
The role of eosinophil cationic protein in patients with Mycoplasma pneumoniae infection.
Towards tricking a pathogen's protease into fighting infection: the 3D structure of a stable circularly permuted onconase variant cleavedby HIV-1 protease.
[Eosinophil cationic protein in serum of children with food allergy]
Inflammatory Bowel Diseases
A new method for the quantification of neutrophil and eosinophil cationic proteins in feces: establishment of normal levels and clinical application in patients with inflammatory bowel disease.
Do serum levels of eosinophil granule-derived protein change in patients undergoing pelvic radiotherapy?
Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed.
Increased fecal eosinophil cationic protein in inflammatory bowel disease.
Influenza, Human
Assembly of influenza ribonucleoprotein in vitro using recombinant nucleoprotein.
Some Properties of Influenza Virus Nucleocapsids.
[Action of hydrolytic enzymes on influenza virus A ribonucleoprotein]
Irritable Bowel Syndrome
Inflammatory bowel disease detection and monitoring by measuring biomarkers in non-invasively collected colorectal mucus.
Joint Diseases
Influence of Extracellular RNAs, Released by Rheumatoid Arthritis Synovial Fibroblasts, on Their Adhesive and Invasive Properties.
Keratitis
Heat Shock Proteins 70kDa, Eosinophil Cationic Protein, and Nitric Oxide During Chronic Superficial Keratitis in Dogs.
Keratoconjunctivitis
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis.
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis.
Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases.
Kidney Diseases
Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis.
Urinary disease in 2 Dogon populations with different exposure to Schistosoma haematobium infection: progression of bladder and kidney diseases in children and adults.
Kidney Failure, Chronic
Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis.
Kidney Neoplasms
A phase II trial of weekly intravenous ranpirnase (Onconase), a novel ribonuclease in patients with metastatic kidney cancer.
Leishmaniasis, Visceral
The genetically determined production of the alarmin eosinophil-derived neurotoxin is reduced in visceral leishmaniasis.
Leukemia
A Humanized Anti-CD22-Onconase Antibody-Drug Conjugate Mediates Highly Potent Destruction of Targeted Tumor Cells.
Bovine seminal ribonuclease attached to nanoparticles made of polylactic acid kills leukemia and lymphoma cell lines in vitro.
Endowing human pancreatic ribonuclease with toxicity for cancer cells.
Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity.
Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues.
Mechanism of RNA primer removal by the RNase H activity of avian myeloblastosis virus reverse transcriptase.
Rana catesbeiana ribonuclease induces cell apoptosis via the caspase-9/-3 signaling pathway in human glioblastoma DBTRG, GBM8901 and GBM8401 cell lines.
RNase inhibition of human immunodeficiency virus infection of H9 cells.
Leukemia, Erythroblastic, Acute
Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein.
Leukocytosis
DRESS syndrome associated with carbamazepine and phenytoin.
Eosinophilic Myocarditis due to Churg-Strauss Syndrome With Markedly Elevated Eosinophil Cationic Protein.
Lung Diseases
Extracellular RNA facilitates hypoxia-induced leukocyte adhesion and infiltration in the lung through TLR3-IFN-?-STAT1 signaling pathway.
Markers of pulmonary inflammation in tracheobronchial fluid of premature infants with respiratory distress syndrome.
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.
Lung Diseases, Obstructive
[Correlation between expressions of myeloperoxidase and eosinophil cationic protein in sputum and clinical features of asthma-chronic obstructive pulmonary disease overlap].
[The significance of inflammatory markers in sputum of asthmatic and chronic obstructive pulmonary diseases patients before and after glucocorticoid treatment]
Lung Neoplasms
Antitumor efficacy of the cytotoxic RNase, ranpirnase, on A549 human lung cancer xenografts of nude mice.
Mechanisms of enhanced tumoricidal efficacy of multiple small dosages of ranpirnase, the novel cytotoxic ribonuclease, on lung cancer.
Possible mechanisms of improved radiation response by cytotoxic RNase, Onconase, on A549 human lung cancer xenografts of nude mice.
Ranpirnase: amphibian ribonuclease A, P-30 protein-alfacell.
Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase.
[Study of mast cell, eosinophil and fibroblast activation in bronchoalveolar lavage fluid in patients with lung cancer]
Lupus Nephritis
Measuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritis.
Lymphoma
A Humanized Anti-CD22-Onconase Antibody-Drug Conjugate Mediates Highly Potent Destruction of Targeted Tumor Cells.
Bovine seminal ribonuclease attached to nanoparticles made of polylactic acid kills leukemia and lymphoma cell lines in vitro.
In vitro cytotoxicity of ranpirnase (onconase) in combination with components of R-CHOP regimen against diffuse large B cell lymphoma (DLBCL) cell line.
Lymphoma, B-Cell
In vitro cytotoxicity of ranpirnase (onconase) in combination with components of R-CHOP regimen against diffuse large B cell lymphoma (DLBCL) cell line.
Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: potential for the treatment of non-Hodgkin lymphoma.
Lymphoma, Large B-Cell, Diffuse
G1 arrest of U937 cells by onconase is associated with suppression of cyclin D3 expression, induction of p16INK4A, p21WAF1/CIP1 and p27KIP and decreased pRb phosphorylation.
Lymphoma, Non-Hodgkin
Anti-CD22 Onconase: preparation and characterization.
Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: potential for the treatment of non-Hodgkin lymphoma.
Lymphoproliferative Disorders
Cytotoxic activity of the amphibian ribonucleases onconase and r-amphinase on tumor cells from B cell lymphoproliferative disorders.
Malaria
Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children.
Mastocytosis
Urine eosinophil cationic protein in painful bladder disease.
Melanoma
Antitumor action of bovine seminal ribonuclease. Cytostatic effect on human melanoma and mouse seminoma.
Antitumor and biological effects of black pine (pinus nigra) pollen nuclease.
Antitumor effects and cytotoxicity of recombinant plant nucleases.
Chemosensitivity of conjunctival melanoma cell lines to target-specific chemotherapeutic agents.
Eosinophil-cationic protein - a novel liquid prognostic biomarker in melanoma.
Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells.
PEG chains increase aspermatogenic and antitumor activity of RNase A and BS-RNase enzymes.
Plant ribonucleases and nucleases as antiproliferative agens targeting human tumors growing in mice.
Polymer conjugated bovine seminal ribonuclease inhibits growth of solid tumors and development of metastases in mice.
Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice.
Poly[N-(2-hydroxypropyl)methacrylamide] conjugates of bovine pancreatic ribonuclease (RNase A) inhibit growth of human melanoma in nude mice.
Mesothelioma
A novel combination: ranpirnase and rosiglitazone induce a synergistic apoptotic effect by down-regulating Fra-1 and Survivin in cancer cells.
Antibody-onconase conjugates: cytotoxicity and intracellular routing.
Antibody-targeted RNase fusion proteins (immunoRNases) for cancer therapy.
Combination of onconase and dihydroartemisinin synergistically suppresses growth and angiogenesis of non-small-cell lung carcinoma and malignant mesothelioma.
Constitutive expression and anticancer potency of a novel immunotoxin onconase-DV3.
Cytostatic and cytotoxic properties of Amphinase: a novel cytotoxic ribonuclease from Rana pipiens oocytes.
Cytotoxicity of bovine seminal ribonuclease: monomer versus dimer.
Designing hybrid onconase nanocarriers for mesothelioma therapy: a Taguchi orthogonal array and multivariate component driven analysis.
Disruption of shape-complementarity markers to create cytotoxic variants of ribonuclease A.
Human mesothelioma cells exhibit tumor cell-specific differences in phosphatidylinositol 3-kinase/AKT activity that predict the efficacy of Onconase.
Interaction of onconase with the human ribonuclease inhibitor protein.
Mild hyperthermia predisposes tumor cells to undergo apoptosis upon treatment with onconase.
Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes.
Onconase mediated NFK? downregulation in malignant pleural mesothelioma.
Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent.
Phase II trial of a single weekly intravenous dose of ranpirnase in patients with unresectable malignant mesothelioma.
Ranpirnase and its potential for the treatment of unresectable malignant mesothelioma.
Ranpirnase as a potential antitumor ribonuclease treatment for mesothelioma and other malignancies.
Ranpirnase Interferes with NF-?B Pathway and MMP9 Activity, Inhibiting Malignant Mesothelioma Cell Invasiveness and Xenograft Growth.
Ranpirnase: amphibian ribonuclease A, P-30 protein-alfacell.
Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines.
Ribonucleases and immunoRNases as anticancer drugs.
Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase.
Ribonucleases as novel chemotherapeutics : the ranpirnase example.
Secretory expression of glycosylated and aglycosylated mutein of onconase from Pichia pastoris using different secretion signals and their purification and characterization.
Three-state thermal unfolding of onconase.
Treatment of Jurkat acute T-lymphocytic leukemia cells by onconase (Ranpirnase) is accompanied by an altered nucleocytoplasmic distribution and reduced expression of transcription factor NF-kappaB.
[Onconase: a ribonuclease with antitumor activity]
Metabolic Syndrome
Co-existence of Chronic Urticaria and Metabolic Syndrome: Clinical Implications.
Milk Hypersensitivity
Casein hydrolysate formula-induced liver dysfunction in a neonate with non-immunoglobulin E-mediated cow's milk allergy.
Diagnostic value of skin-prick and patch tests and serum eosinophil cationic protein and cow's milk-specific IgE in infants with cow's milk allergy.
Eosinophil cationic protein in human milk is associated with development of cow's milk allergy and atopic eczema in breast-fed infants.
Fecal tumor necrosis factor alpha, eosinophil cationic protein and IgE levels in infants with cow's milk allergy and gastrointestinal manifestations.
Higher serum eosinophil cationic protein levels in children with cow's milk allergy.
Intestinal permeability and fecal eosinophil-derived neurotoxin are the best diagnosis tools for digestive non-IgE-mediated cow's milk allergy in toddlers.
Markers of inflammation in the feces of infants with cow's milk allergy.
Mouth Neoplasms
The role of eosinophils and eosinophil cationic protein in oral cancer: A review.
Mucositis
Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase.
Muscular Atrophy
[Eosinophil-derived neurotoxin as a new additional clinical marker in spinal muscular atrophies]
Mycoses
Exploring the mechanisms of action of human secretory RNase 3 and RNase 7 against Candida albicans.
Myocardial Infarction
Allergic Inflammation Is Associated With Coronary Instability and a Worse Clinical Outcome After Acute Myocardial Infarction.
Blood eosinophils and eosinophil cationic protein after acute myocardial infarction or corticosteroid administration.
RNase1 as a potential mediator of remote ischaemic preconditioning for cardioprotection†
RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-? in cardiac ischaemia/reperfusion injury.
[Eosinophilic activation based on measurements of eosinophil cationic protein in patients with acute myocardial infarction and patients with angina pectoris]
Myocarditis
Eosinophilic myocarditis associated with dense deposits of eosinophil cationic protein (ECP) in endomyocardium with high serum ECP.
Eosinophilic Myocarditis due to Churg-Strauss Syndrome With Markedly Elevated Eosinophil Cationic Protein.
Serum levels of eosinophil cationic protein in patients with eosinophilic myocarditis.
Myositis
Eosinophilic myositis with eosinophilic cellulitislike skin lesions. Association with increased serum levels of eosinophil cationic protein and interleukin-5.
Nasal Obstruction
Noninvasive biological evaluation of response to pranlukast treatment in pediatric patients with Japanese cedar pollinosis.
Nasal Polyps
A prospective analysis evaluating tissue biopsy location and its clinical relevance in chronic rhinosinusitis with nasal polyps.
Comparison of Corticosteroids by 3 Approaches to the Treatment of Chronic Rhinosinusitis With Nasal Polyps.
Differentiation of chronic sinus diseases by measurement of inflammatory mediators.
Effect of nasal antifungal therapy on nasal cell activation markers in chronic rhinosinusitis.
Inflammatory mediators and eosinophilia in atopic and non-atopic patients with nasal polyposis.
Localization of human eosinophil granule major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin by immunoelectron microscopy.
Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis.
Pattern of inflammation and impact of Staphylococcus aureus enterotoxins in nasal polyps from southern China.
Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis.
V?1? ??T Cells Are Correlated With Increasing Expression of Eosinophil Cationic Protein and Metalloproteinase-7 in Chronic Rhinosinusitis With Nasal Polyps Inducing the Formation of Edema.
[Study on the role of interleukin-5 and eosinophil cationic protein and the correlation between them in nasal polyp]
Neoplasm Metastasis
Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray.
Polymer conjugated bovine seminal ribonuclease inhibits growth of solid tumors and development of metastases in mice.
Seminal ribonuclease inhibits tumor growth and reduces the metastatic potential of Lewis lung carcinoma.
The systemic tumor response to RNase A treatment affects the expression of genes involved in maintaining cell malignancy.
Neoplasms
A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells.
A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation.
A novel combination: ranpirnase and rosiglitazone induce a synergistic apoptotic effect by down-regulating Fra-1 and Survivin in cancer cells.
A Novel Ribonuclease from Rana Chensinensis and Its Potential for the Treatment of Human Breast Cancer.
A nuclear localization sequence endows human pancreatic ribonuclease with cytotoxic activity.
A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells.
A phase II trial of weekly intravenous ranpirnase (Onconase), a novel ribonuclease in patients with metastatic kidney cancer.
A ribonuclease A variant with low catalytic activity but high cytotoxicity.
A study of the intracellular routing of cytotoxic ribonucleases.
Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase.
Activation of caspases and serine proteases during apoptosis induced by onconase (Ranpirnase).
Altered glycosylation in tumours focused to cancer diagnosis.
An EGF receptor targeting Ranpirnase-diabody fusion protein mediates potent antitumour activity in vitro and in vivo.
An inhaled steroid improves markers of airway inflammation in patients with mild asthma.
Anti-gliomas Effect of Chlorotoxin-Conjugated Onconase at High Dose.
Anti-tumor effect in an in vivo model by human-derived pancreatic RNase with basic fibroblast growth factor insertional fusion protein through antiangiogenic properties.
Anti-tumor ribonuclease, combined with or conjugated to monoclonal antibody MRK16, overcomes multidrug resistance to vincristine in vitro and in vivo.
Antibody-onconase conjugates: cytotoxicity and intracellular routing.
Antitumor action of seminal ribonuclease, its dimeric structure, and its resistance to the cytosolic ribonuclease inhibitor.
Antitumor activity of apoptotic nuclease TBN1 from L. esculentum.
Antitumor activity of ribonuclease multimers created by site-specific covalent tethering.
Antitumor and biological effects of black pine (pinus nigra) pollen nuclease.
Antitumor effects and cytotoxicity of recombinant plant nucleases.
Arginine residues are more effective than lysine residues in eliciting the cellular uptake of onconase.
Bactericidal activity engineered on human pancreatic ribonuclease and onconase.
Binding of bull seminal ribonuclease (AS RNase) to human tumour tissues.
Biological markers in nasal secretions.
Bovine seminal ribonuclease exerts selective cytotoxicity toward neuroblastoma cells both sensitive and resistant to chemotherapeutic drugs.
Bovine seminal ribonuclease induces in vitro concentration dependent apoptosis in stimulated human lymphocytes and cells from human tumor cell lines.
Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.
Bovine seminal ribonuclease selectively kills human multidrug-resistant neuroblastoma cells via induction of apoptosis.
Bovine seminal ribonuclease triggers Beclin1-mediated autophagic cell death in pancreatic cancer cells.
Bovine seminal RNase induces apoptosis in normal proliferating lymphocytes.
Bystander cells and prognosis in Hodgkin lymphoma. Review based on a doctoral thesis.
Cancer chemotherapy--ribonucleases to the rescue.
CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors.
Cell-free protein synthesis of a cytotoxic cancer therapeutic: Onconase production and a just-add-water cell-free system.
Cloning and cytotoxicity of a human pancreatic RNase immunofusion.
Co-existence of Chronic Urticaria and Metabolic Syndrome: Clinical Implications.
Colorectal cancer detection by biomarker quantification in noninvasively collected colorectal mucus: preliminary comparison of 24 protein biomarkers.
Colorectal mucus non-invasively collected from patients with inflammatory bowel disease and its suitability for diagnostic cytology.
Combined effects of onconase and IFN-beta on proliferation, macromolecular syntheses and expression of STAT-1 in JCA-1 cancer cells.
Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology.
Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray.
Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease.
Conformational stability is a determinant of ribonuclease A cytotoxicity.
Constitutive expression and anticancer potency of a novel immunotoxin onconase-DV3.
Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases.
Contribution of active-site residues to the function of onconase, a ribonuclease with antitumoral activity.
Contribution of the C30/C75 disulfide bond to the biological properties of onconase.
Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice.
Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule.
Crystal structure of Onconase at 1.1 Å resolution--insights into substrate binding and collective motion.
Cytokines and eosinophil-derived cationic proteins upregulate intercellular adhesion molecule-1 on human nasal epithelial cells.
Cytotoxic activity of the amphibian ribonucleases onconase and r-amphinase on tumor cells from B cell lymphoproliferative disorders.
Cytotoxicity of bovine seminal ribonuclease: monomer versus dimer.
Design and Characterization of an HIV-Specific Ribonuclease Zymogen.
Detection of in situ activation of transglutaminase during apoptosis: correlation with the cell cycle phase by multiparameter flow and laser scanning cytometry.
Differences in cytokine levels between the nasal polyps of adolescents with local allergic and adolescents with allergic or nonallergic rhinitis.
Differential requirement for the stress-activated protein kinase/c-Jun NH(2)-terminal kinase in RNAdamage-induced apoptosis in primary and in immortalized fibroblasts.
Effect of eosinophil cationic protein (ECP) on Hodgkin lymphoma cell lines.
Effect of eosinophil cationic protein on human oral squamous carcinoma cell viability.
Effect of N-terminal and Met23 mutations on the structure and dynamics of onconase.
Effect of native and modified bull seminal ribonuclease on tumour and testicular cells and phytohaemagglutinin-stimulated pig lymphocytes.
Effect of ONCONASE +/- tamoxifen on ASPC-1 human pancreatic tumors in nude mice.
Effect of Onconase on double-stranded RNA in vitro.
Effect of wheat leaf ribonuclease on tumor cells and tissues.
Effects of a second-generation human anti-ErbB2 ImmunoRNase on trastuzumab-resistant tumors and cardiac cells.
Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD.
Effects of intranasal azelastine on the response to nasal allergen challenge.
Effects of physiologic soluble agonists on leukotriene C4 production and degranulation by human eosinophils.
Elevated serum levels of TNF-?, IL-8, and ECP can be involved in the development and progression of bronchial asthma.
Elevation of serum eosinophil cationic protein, soluble tumor necrosis factor receptors and soluble intercellular adhesion molecule-1 levels in acute bronchial asthma.
Endowing human pancreatic ribonuclease with toxicity for cancer cells.
Engineering the refolding pathway and the quaternary structure of seminal ribonuclease by newly introduced disulfide bridges.
Enhanced cellular radiation sensitivity of androgen-independent human prostate tumor cells by onconase.
Enhanced in vitro cytotoxicity and cytostasis of the combination of onconase with a proteasome inhibitor.
Enhancement of activation-induced apoptosis of lymphocytes by the cytotoxic ribonuclease onconase (Ranpirnase).
Enhancement of vincristine cytotoxicity in drug-resistant cells by simultaneous treatment with onconase, an antitumor ribonuclease.
Eosinophil Cationic Protein in Patients with Differentiated Thyroid Cancer Treated with Radioactive Iodine 131.
Eosinophil cationic protein in peripheral blood of pediatric patients with allergic diseases.
Eosinophils in Cancer: Favourable or Unfavourable?
Evaluation of human pancreatic RNase as effector molecule in a therapeutic antibody platform.
Extracellular RNA Liberates Tumor Necrosis Factor-? to Promote Tumor Cell Trafficking and Progression.
Fecal tumor necrosis factor alpha, eosinophil cationic protein and IgE levels in infants with cow's milk allergy and gastrointestinal manifestations.
G1 arrest of U937 cells by onconase is associated with suppression of cyclin D3 expression, induction of p16INK4A, p21WAF1/CIP1 and p27KIP and decreased pRb phosphorylation.
GENERATION OF NEW CYTOTOXIC HUMAN RIBONUCLEASE VARIANTS DIRECTED TO THE NUCLEUS.
Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity.
Glycosylation of human pancreatic ribonuclease: differences between normal and tumor states.
Glycosylation of onconase increases its conformational stability and toxicity for cancer cells.
Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer.
Human mesothelioma cells exhibit tumor cell-specific differences in phosphatidylinositol 3-kinase/AKT activity that predict the efficacy of Onconase.
Human pancreatic ribonuclease 1: expression and distribution in pancreatic adenocarcinoma.
Immunosuppressive and anticancer effect of a mammalian ribonuclease that targets high-affinity interleukin-2-receptors.
Improving the specific antitumor efficacy of ONC by fusion with N-terminal domain of transferrin.
In vitro studies on selective inhibition of tumor cell growth by seminal ribonuclease.
In vivo and in vitro growth-inhibitory effect of bovine seminal ribonuclease on a system of rat thyroid epithelial transformed cells and tumors.
Induction of differentiation of leukaemic (HL-60) or prostate cancer (LNCaP, JCA-1) cells potentiates apoptosis triggered by onconase.
Infiltrating cells, related cytokines and chemokine receptors in lesional skin of patients with dermatomyositis.
Influence of proinflammatory stimuli on the expression of vascular ribonuclease 1 in endothelial cells.
Inhibition by pancreatic ribonuclease of experimental tumour metastasizing in mice.
Inhibition of tumor cell proliferation by dimerized ribonuclease.
Interferon-gamma activates the cleavage of double-stranded RNA by bovine seminal ribonuclease.
Intestinal inflammation in children with atopic eczema: faecal eosinophil cationic protein and tumour necrosis factor-alpha as non-invasive indicators of food allergy.
Intestinal permeability and fecal eosinophil-derived neurotoxin are the best diagnosis tools for digestive non-IgE-mediated cow's milk allergy in toddlers.
Intranasal mometasone furoate reduces late-phase inflammation after allergen challenge.
Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease.
Mediators and cytokines in persistent allergic rhinitis and nonallergic rhinitis with eosinophilia syndrome.
MicroRNA drop in the bloodstream and microRNA boost in the tumour caused by treatment with ribonuclease A leads to an attenuation of tumour malignancy.
Mild hyperthermia predisposes tumor cells to undergo apoptosis upon treatment with onconase.
Molecular determinants in the plasma clearance and tissue distribution of ribonucleases of the ribonuclease A superfamily.
Mucosal synthesis and release of prostaglandin E2 from activated eosinophils and macrophages in ulcerative colitis.
Mung bean sprout (Phaseolus aureus) nuclease and its biological and antitumor effects.
New, exciting developments in experimental therapies in the early 21st century.
Noncytotoxic ribonuclease, RNase T1, induces tumor cell death via hemagglutinating virus of Japan envelope vector.
On the track of antitumour ribonucleases.
Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes.
Onconase cytotoxicity relies on the distribution of its positive charge.
Onconase dimerization through 3D domain swapping: structural investigations and increase in the apoptotic effect in cancer cells.
Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner.
Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent.
Pattern-recognition receptors in human eosinophils.
Phase-I human clinical-trial of onconase(r) (p-30 protein) administered intravenously on a weekly schedule in cancer-patients with solid tumors.
Plant ribonucleases and nucleases as antiproliferative agens targeting human tumors growing in mice.
Plasma eosinophil cationic protein, interleukin-5, and ECP/Eo count ratio in patients with various eosinophilic diseases.
Polymer conjugated bovine seminal ribonuclease inhibits growth of solid tumors and development of metastases in mice.
Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice.
Poly[N-(2-hydroxypropyl)methacrylamide] conjugates of bovine pancreatic ribonuclease (RNase A) inhibit growth of human melanoma in nude mice.
Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: potential for the treatment of non-Hodgkin lymphoma.
Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer.
Potentiation of tumor necrosis factor induced apoptosis by onconase.
Predictors of histology, tissue eosinophilia and mast cell infiltration in Hodgkin's Lymphoma - a population-based study.
Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants.
Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials.
Probiotics: a novel approach in the management of food allergy.
Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine.
Radioimmunoassay for human pancreatic ribonuclease and measurement of serum immunoreactive pancreatic ribonuclease in patients with malignant tumors.
Rana catesbeiana ribonuclease induces cell apoptosis via the caspase-9/-3 signaling pathway in human glioblastoma DBTRG, GBM8901 and GBM8401 cell lines.
Ranpirnase (frog RNase) targeted with a humanized, internalizing, anti-Trop-2 antibody has potent cytotoxicity against diverse epithelial cancer cells.
Ranpirnase (Onconase), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy.
Ranpirnase and its potential for the treatment of unresectable malignant mesothelioma.
Ranpirnase as a potential antitumor ribonuclease treatment for mesothelioma and other malignancies.
Ranpirnase Interferes with NF-?B Pathway and MMP9 Activity, Inhibiting Malignant Mesothelioma Cell Invasiveness and Xenograft Growth.
Ranpirnase: amphibian ribonuclease A, P-30 protein-alfacell.
Recombinant expression, different downstream processing of the disulfide-rich anti-tumor peptide Ranpirnase and its effect on the growth of human glioma cell line SHG-44.
Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD.
Reductions in eosinophil biomarkers by benralizumab in patients with asthma.
Relationship between the tumor necrosis factor system and the serum interleukin-4, interleukin-5, interleukin-8, eosinophil cationic protein, and immunoglobulin E levels in the bronchial hyperreactivity of adults and their children.
Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines.
Reproducibility of measurements of exhaled NO, and cell count and cytokine concentrations in induced sputum.
Ribonuclease activity of sialic acid-binding lectin from Rana catesbeiana eggs.
Ribonuclease inhibitor as an intracellular sentry.
Ribonucleases and deoxyribonucleases in pancreatic cancer: clinical value and pathophysiological interrelationships.
Ribonucleases and immunoRNases as anticancer drugs.
Ribonucleases and their antitumor activity.
Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase.
Ribonucleases as novel chemotherapeutics : the ranpirnase example.
Ribonucleases as potential modalities in anticancer therapy.
Ribonucleases expressed by human pancreatic adenocarcinoma cell lines.
RNA cleavage and inhibition of protein synthesis by bleomycin.
RNase 3 (ECP) is an extraordinarily stable protein among human pancreatic-type RNases.
RNase inhibition of human immunodeficiency virus infection of H9 cells.
RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-? in cardiac ischaemia/reperfusion injury.
Role of the N terminus in RNase A homologues: differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity.
Selective activity of BS-RNase against anaplastic thyroid cancer.
Seminal ribonuclease inhibits tumor growth and reduces the metastatic potential of Lewis lung carcinoma.
Serum soluble tumor necrosis factor receptor levels in patients with seasonal allergic rhinitis.
Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease: an enzyme tailored to evade ribonuclease protein inhibitor.
Structure-cytotoxicity relationships in bovine seminal ribonuclease: new insights from heat and chemical denaturation studies on variants.
Sustained and cancer cell targeted cytosolic delivery of Onconase results in potent antitumor effects.
Targeted delivery of immuno-RNase may improve cancer therapy.
The antitumor action of seminal ribonuclease tested with the plasmacytoma spleen colonization assay.
The cytotoxic ribonuclease onconase targets RNA interference (siRNA).
The effect of bovine seminal ribonuclease (AS RNase) on cells of Crocker tumour in mice.
The folding pathway of onconase is directed by a conserved intermediate.
The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants.
The interaction of human peripheral blood eosinophils with bacterial lipopolysaccharide is CD14 dependent.
The relationship of IgE, skin-test, eosinophilia, eosinophil cationic protein and tumor necrosis factor production in allergic rhinitis.
The return of pancreatic ribonucleases.
The role of eosinophils and eosinophil cationic protein in oral cancer: A review.
The role of lymphocytes, granulocytes, mast cells and their related cytokines in lesional skin of linear IgA bullous dermatosis.
The serum levels of eosinophil cationic protein (ECP) are related to the infiltration of eosinophils in the tumours of patients with Hodgkin's disease.
The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization.
The systemic tumor response to RNase A treatment affects the expression of genes involved in maintaining cell malignancy.
The therapeutic mechanisms of ranpirnase-induced enhancement of radiation response on A549 human lung cancer.
Treatment of Jurkat acute T-lymphocytic leukemia cells by onconase (Ranpirnase) is accompanied by an altered nucleocytoplasmic distribution and reduced expression of transcription factor NF-kappaB.
Tumor necrosis factor-?, interleukin-8 and eosinophil cationic protein as serum markers of glucocorticoid efficacy in the treatment of bronchial asthma.
Tumoricidal effects of onconase on various tumors.
Tumour necrosis factor-alpha in nasal allergy.
Upregulation of adhesion molecules in the bronchial mucosa of subjects with chronic obstructive bronchitis.
Utility of a Noninvasive Serum Biomarker Panel for Diagnosis and Monitoring of Eosinophilic Esophagitis: A Prospective Study.
X-ray structure of two crystalline forms of a streptomycete ribonuclease with cytotoxic activity.
[Effective expression of ribonuclease-onconase in Escherichia coli and assaying its cytotoxic potential]
[Expression, purification and characterization of recombinant onconase expressed in Pichia pastoris].
[Onconase: a ribonuclease with antitumor activity]
[Relationship between airway remodeling and inflammatory mediators and cytokines in sputum in patients with bronchial asthma]
Nephritis
[Role of mast cells and eosinophil cationic protein in the pathogenesis of Henoch-Schonlein purpura nephritis]
Neuroblastoma
Bovine seminal ribonuclease exerts selective cytotoxicity toward neuroblastoma cells both sensitive and resistant to chemotherapeutic drugs.
Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.
Bovine seminal ribonuclease selectively kills human multidrug-resistant neuroblastoma cells via induction of apoptosis.
Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells.
Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice.
Ranpirnase: amphibian ribonuclease A, P-30 protein-alfacell.
Single amino acid substitutions at the N-terminus of a recombinant cytotoxic ribonuclease markedly influence biochemical and biological properties.
Neurodegenerative Diseases
Structural basis of substrate specificity in porcine RNase 4.
Neutropenia
Lethal adult respiratory distress syndrome after meningococcal septicemia biochemical markers in bronchoalveolar lavage.
Nose Diseases
Azelastine reduces mediators of inflammation in patients with nasal polyps.
Onchocerciasis
Eosinophil granule proteins in serum and urine of patients with helminth infections and atopic dermatitis.
Eosinophils, eosinophil cationic protein and eosinophil-derived neurotoxin in serum and urine of patients with onchocerciasis coinfected with intestinal nematodes and in urinary schistosomiasis.
Osteoarthritis
Mast cell activation in arthritis: detection of alpha- and beta-tryptase, histamine and eosinophil cationic protein in synovial fluid.
Otitis Media
Association of otitis media with effusion and allergy as demonstrated by intradermal skin testing and eosinophil cationic protein levels in both middle ear effusions and mucosal biopsies.
Effect of omalizumab on biomarkers in middle ear effusion in patients with eosinophilic otitis media.
Eosinophil cationic protein in mucosal biopsies from patients with allergy and otitis media with effusion.
Eosinophil-derived neurotoxin, elastase, and cytokine profile in effusion from eosinophilic otitis media.
Eosinophils and neutrophils in biopsies from the middle ear of atopic children with otitis media with effusion.
Levels of eosinophil cationic protein and myeloperoxidase from chronic middle ear effusion in patients with allergy and/or acute infection.
[The measuring of ECP and IgE in middle ear effusion of patients with otitis media of effusion]
Otitis Media with Effusion
Association of otitis media with effusion and allergy as demonstrated by intradermal skin testing and eosinophil cationic protein levels in both middle ear effusions and mucosal biopsies.
Effect of omalizumab on biomarkers in middle ear effusion in patients with eosinophilic otitis media.
Eosinophil cationic protein in mucosal biopsies from patients with allergy and otitis media with effusion.
Eosinophil chemoattractants in the middle ear of patients with eosinophilic otitis media.
Eosinophils and neutrophils in biopsies from the middle ear of atopic children with otitis media with effusion.
Eosinophils are activated in middle ear mucosa and middle ear effusion of patients with intractable otitis media associated with bronchial asthma.
Levels of eosinophil cationic protein and myeloperoxidase from chronic middle ear effusion in patients with allergy and/or acute infection.
The presence of eosinophil cationic protein in middle ear effusion.
[The measuring of ECP and IgE in middle ear effusion of patients with otitis media of effusion]
Otitis Media, Suppurative
Levels of eosinophil cationic protein and myeloperoxidase from chronic middle ear effusion in patients with allergy and/or acute infection.
Ovarian Neoplasms
Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine.
Pancreatic Neoplasms
Bovine seminal ribonuclease triggers Beclin1-mediated autophagic cell death in pancreatic cancer cells.
Immunological assay of pancreatic ribonuclease in serum as an indicator of pancreatic cancer.
Increased N-glycosylation of Asn?? in serum pancreatic ribonuclease 1 is a novel diagnostic marker for pancreatic cancer.
Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner.
Radioimmunoassay for human pancreatic ribonuclease and measurement of serum immunoreactive pancreatic ribonuclease in patients with malignant tumors.
Rana catesbeiana ribonuclease induces cell apoptosis via the caspase-9/-3 signaling pathway in human glioblastoma DBTRG, GBM8901 and GBM8401 cell lines.
Urinary kallikrein excretion in chronic pancreatic diseases.
Pancreatitis
Urinary kallikrein excretion in chronic pancreatic diseases.
[Use of pancreatic ribonuclease in the combined conservative therapy of acute pancreatitis]
[Use of pancreatic ribonuclease in the treatment of acute pancreatitis]
Pancreatitis, Chronic
Human pancreatic ribonuclease 1: expression and distribution in pancreatic adenocarcinoma.
Ribonucleases and deoxyribonucleases in pancreatic cancer: clinical value and pathophysiological interrelationships.
Papilloma
Differential requirement for the stress-activated protein kinase/c-Jun NH(2)-terminal kinase in RNAdamage-induced apoptosis in primary and in immortalized fibroblasts.
Paralysis
Schistosoma mansoni: further studies of the interaction between schistosomula and granulocyte-derived cationic proteins in vitro.
Parasitic Diseases
Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana.
Pemphigoid, Benign Mucous Membrane
Serum eosinophil cationic protein (ECP) in bullous pemphigoid.
Pemphigoid, Bullous
Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome.
Eosinophil cationic protein levels parallel coagulation activation in the blister fluid of patients with bullous pemphigoid.
Granulocyte activation in bullous diseases: release of granular proteins in bullous pemphigoid and pemphigus vulgaris.
IL-5 levels in the serum and blister fluid of patients with bullous pemphigoid: correlations with eosinophil cationic protein, RANTES, IgE and disease severity.
Serum eosinophil cationic protein (ECP) in bullous pemphigoid.
Pemphigus
Elevated serum eosinophil cationic protein and transforming growth factor-? levels in a patient with pemphigus vegetans.
Further support for a role for Th2-like cytokines in blister formation of pemphigus.
Granulocyte activation in bullous diseases: release of granular proteins in bullous pemphigoid and pemphigus vulgaris.
Periodontitis
Eosinophil cationic protein and histamine production by neutrophils from patients with periodontitis.
Eosinophil Cationic Protein and Histamine Production by Neutrophils from Periodontitis Patients.
Peritonitis
Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis.
Plasmacytoma
The antitumor action of seminal ribonuclease tested with the plasmacytoma spleen colonization assay.
Pleural Effusion
High concentrations of eosinophil cationic protein and eosinophil protein X in eosinophilic pleural effusions.
Paragonimiasis westermani with multifocal lesions in lungs and skin.
Pneumonia
A biologically inspired lung-on-a-chip device for the study of protein-induced lung inflammation.
Markers of pulmonary inflammation in tracheobronchial fluid of premature infants with respiratory distress syndrome.
Molecular Imaging of Heparan Sulfate Expression with Radiolabeled Recombinant Eosinophil Cationic Protein Predicts Allergic Lung Inflammation in a Mouse Model for Asthma.
Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A virus infection-induced lung injury.
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.
Serum eosinophil cationic protein measurements in monitoring pulmonary inflammation in asthma.
Pneumonia, Mycoplasma
Eosinophil cationic protein in the sera of patients with Mycoplasma pneumonia.
The role of eosinophil cationic protein in patients with Mycoplasma pneumoniae infection.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Treatment of Jurkat acute T-lymphocytic leukemia cells by onconase (Ranpirnase) is accompanied by an altered nucleocytoplasmic distribution and reduced expression of transcription factor NF-kappaB.
Prostatic Neoplasms
Induction of differentiation of leukaemic (HL-60) or prostate cancer (LNCaP, JCA-1) cells potentiates apoptosis triggered by onconase.
Rana catesbeiana ribonuclease induces cell apoptosis via the caspase-9/-3 signaling pathway in human glioblastoma DBTRG, GBM8901 and GBM8401 cell lines.
Prurigo
CGRP-immunoreactive nerves in prurigo nodularis--an exploration of neurogenic inflammation.
Pruritus
Comparison of different activity parameters in atopic dermatitis: correlation with clinical scores.
Eosinophils, pruritus and psoriasis: effects of treatment with etretinate or cyclosporin-A.
Intranasal mometasone furoate reduces late-phase inflammation after allergen challenge.
Pseudomonas Infections
Eosinophil cationic protein in sputum from cystic fibrosis patients with Pseudomonas aeruginosa infections.
Myeloperoxidase and eosinophil cationic protein in serum and sputum during antibiotic treatment in cystic fibrosis patients with Pseudomonas aeruginosa infection.
Pseudorabies
[Comparative study of the antiviral activity of pancreatic and microbial RNAse]
Psoriasis
Clinical relevance of nerve growth factor serum levels in patients with atopic dermatitis and psoriasis.
Eosinophil cationic protein in sera of patients with atopic dermatitis.
Eosinophils, pruritus and psoriasis: effects of treatment with etretinate or cyclosporin-A.
Monitoring of serologic immune parameters in inflammatory skin diseases.
Patients with psoriasis have elevated levels of serum eosinophil cationic protein and increased numbers of EG2 positive eosinophils in the duodenal stroma.
The eosinophil granulocyte in psoriasis.
Pulmonary Aspergillosis
Evidence for eosinophil activation in bronchiectasis unrelated to cystic fibrosis and bronchopulmonary aspergillosis: discrepancy between blood eosinophil counts and serum eosinophil cationic protein levels.
Pulmonary Disease, Chronic Obstructive
Can hypertonic saline inhalation influence preformed chemokine and mediator release in induced sputum of chronic obstructive pulmonary disease patients? Comparison with isotonic saline.
Comparison of sputum and serum eosinophil cationic protein (ECP) levels in nonatopic asthma and chronic obstructive pulmonary disease.
Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD.
Efficacy of the novel phosphodiesterase-4 inhibitor BAY 19-8004 on lung function and airway inflammation in asthma and chronic obstructive pulmonary disease (COPD).
Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease.
Eosinophilic inflammation in stable chronic obstructive pulmonary disease. Relationship with neutrophils and airway function.
Eotaxin in serum of patients with asthma or chronic obstructive pulmonary disease: relationship with eosinophil cationic protein and lung function.
Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects.
Induced sputum eosinophil cationic protein (ECP) measurement in asthma and chronic obstructive airway disease (COAD)
Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease.
Inhaled nebulised unfractionated heparin improves lung function in moderate to very severe COPD: A pilot study.
Plasma protein leakage and local secretion of proteins assessed in sputum in asthma and COPD. The effect of inhaled corticosteroids.
[Effect of 16-week use of salmeterol on ECP levels, pulmonary function tests and bronchial hyperreactivity in patients with chronic obstructive lung disease]
[Eosinophil cationic protein in serum from adults with asthma and with chronic obstructive pulmonary disease]
[Measurement of serum and sputum eosinophil cationic protein concentrations in asthma]
Pulmonary Embolism
Eosinophilic biomarkers for detection of acute exacerbation of chronic obstructive pulmonary disease with or without pulmonary embolism.
Pulmonary Emphysema
Eosinophilic inflammation in the airway is related to glucocorticoid reversibility in patients with pulmonary emphysema.
Pulmonary Eosinophilia
Eosinophil cationic protein and immunoglobulin levels in bronchoalveolar lavage fluid obtained from patients with chronic eosinophilic pneumonia.
Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia.
Increased urinary leukotriene E4 concentration in patients with eosinophilic pneumonia.
Levels of circulating IL-33 and eosinophil cationic protein in patients with hypereosinophilia or pulmonary eosinophilia.
Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.
[Chronic eosinophilic pneumonia involving eosinophil cationic protein and bone marrow cells]
[Evaluation of tissue eosinophils in eosinophilic pneumonia]
Pulmonary Fibrosis
Eosinophil activation in patients with pulmonary fibrosis.
Purpura
Eosinophil cationic protein in Henoch-Schönlein purpura and in IgA nephropathy.
Eosinophil cationic protein in Henoch-Schönlein purpura.
Purpura, Schoenlein-Henoch
[Role of mast cells and eosinophil cationic protein in the pathogenesis of Henoch-Schonlein purpura nephritis]
Respiratory Distress Syndrome, Adult
Eosinophil activation in the lung is related to lung damage in adult respiratory distress syndrome.
Signs of neutrophil and eosinophil activation in adult respiratory distress syndrome.
Respiratory Hypersensitivity
Creola bodies in wheezing infants predict the development of asthma.
Involvement of IL-10 gene promoter polymorphisms in the susceptibility for childhood asthma.
Respiratory Insufficiency
The Human Host Defense Ribonucleases 1, 3 and 7 Are Elevated in Patients with Sepsis after Major Surgery-A Pilot Study.
Respiratory Tract Infections
Comparison of serum eosinophil-derived neurotoxin levels between wheezing and non-wheezing groups in children with respiratory tract infection.
High levels of eosinophil cationic protein in wheezing infants predict the development of asthma.
Relationships between cotinine, lower respiratory tract infection, and eosinophil cationic protein in children.
Retinal Detachment
[Aqueous levels of eosinophil cationic protein and major basic protein in patients with retinal detachment associated with atopic dermatitis]
Rhabdomyosarcoma
Ranpirnase: amphibian ribonuclease A, P-30 protein-alfacell.
Rhinitis
Applicability of extracellular electrical impedance tomography in monitoring respiratory tract inflammation.
Assessment of the allergic reaction in seasonal rhinitis: acoustic rhinometry is a sensitive and objective method.
Basophil histamine release, IgE, eosinophil counts, ECP, and EPX are related to the severity of symptoms in seasonal allergic rhinitis.
Chemokines in seasonal allergic rhinitis.
Effect and correlation of serum total IgE, eosinophil granule cationic proteins and sensitized allergens in atopic dermatitis patients with or without rhinitis.
Eosinophil cationic protein (ECP) and tryptase in the nasal lavage fluid (NLF) of children with grass pollen rhinitis: levocabastine effect.
Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma.
Eosinophil inflammation of the nasal mucosa in allergic and non-allergic rhinitis measured by eosinophil cationic protein levels in native nasal fluid and serum.
Exhaled Nitric Oxide and Airway Hyperresponsiveness to Adenosine 5'-monophosphate and Methacholine in Children with Asthma.
Inflammatory cell populations and cytokine mRNA expression in the nasal mucosa in aspirin-sensitive rhinitis.
Interleukin-5 and eosinophil cationic protein in nasal lavages of rhinitis patients.
Kinetics of eosinophil cationic protein release in mite-allergic rhinitis after specific nasal provocation.
Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis.
Prevalence of serum IgE antibodies to the Staphylococcus aureus enterotoxins (SAE, SEB, SEC, SED, TSST-1) in patients with persistent allergic rhinitis.
Ragweed-specific IgA in nasal lavage fluid of ragweed-sensitive allergic rhinitis patients: increase during the pollen season.
Repeatability and validity of cell and fluid-phase measurements in nasal fluid: a comparison of two methods of nasal lavage.
Serum eosinophil cationic protein (sECP) in subjects with a history of asthma symptoms with or without rhinitis.
Serum eosinophil cationic protein level and disease activity in childhood rhinitis.
Serum levels of soluble CD23 in patients with asthma or rhinitis monosensitive to Parietaria. Its relation to total serum IgE levels and eosinophil cationic protein during and out of the pollen season.
Steroid sparing effects of intranasal corticosteroids in asthma and allergic rhinitis.
The role of allergic rhinitis in nasal responses to sudden temperature changes.
[Serum eosinophil cationic protein (ECP) in patients with perennial rhinitis and atopic dermatitis, allergic to house dust mites]
Rhinitis, Allergic
Allergic rhinitis in children: effects of flunisolide and disodium cromoglycate on nasal eosinophil cationic protein.
Allergic rhinitis update: Epidemiology and natural history.
Bet v 1-specific IgA increases during the pollen season but not after a single allergen challenge in children with birch pollen-induced intermittent allergic rhinitis.
Chemokines in seasonal allergic rhinitis.
Comparison of serum eosinophil-derived neurotoxin levels between wheezing and non-wheezing groups in children with respiratory tract infection.
Correlation of immunoglobulin E, eosinophil cationic protein, and eosinophil count with the severity of childhood perennial allergic rhinitis.
Effect of immunotherapy on serum levels of eosinophil cationic protein in perennial allergic rhinitis.
Eosinophil and eosinophil cationic protein in allergic rhinitis.
Eosinophil cationic protein and myeloperoxidase in nasal secretion as markers of inflammation in allergic rhinitis.
Eosinophil cationic protein in perennial allergic rhinitis.
Eosinophil cationic protein in the nasal secretions of patients with mite allergic rhinitis.
Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature.
Identification of polymorphisms in the RNase3 gene and the association with allergic rhinitis.
Intranasal heparin reduces eosinophil recruitment after nasal allergen challenge in patients with allergic rhinitis.
Local allergic rhinitis: a new entity, characterization and further studies.
Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis.
Nasal neutrophil activity and mucinous secretory responsiveness in COPD.
Nerve growth factor localization in the nasal mucosa of patients with persistent allergic rhinitis.
No association between serum eosinophil cationic protein and atopic dermatitis or allergic rhinitis in an unselected population of children.
Olfactory dysfunction in allergic rhinitis is related to nasal eosinophilic inflammation.
Predictive capabilities of serum eosinophil cationic protein, percentage of eosinophils and total immunoglobulin E in allergic rhinitis without bronchial asthma.
Relationship between squamous cell carcinoma antigen and the clinical severity of allergic rhinitis caused by Dermatophagoides farinae and Japanese cedar pollen.
Retrospective study on fluticasone propionate aqueous nasal spray efficacy in patients with allergic rhinitis: evaluation of clinical and laboratory parameters.
Salivary Eosinophil Cationic Protein in Allergic Rhinitis.
Serum eosinophil cationic protein level and disease activity in childhood rhinitis.
Serum eosinophil cationic protein level in Chinese subjects with nonallergic and local allergic rhinitis and its relation to the severity of disease.
The association between allergic rhinitis and otitis media: A national representative sample of in South Korean children.
The correlation of serum eosinophil cationic protein level with eosinophil count, and total IgE level in Korean adult allergic rhinitis patients.
The determinants of bronchial hyperresponsiveness in patients with allergic rhinitis.
The effect of immunotherapy on the serum levels of eosinophil cationic protein in seasonal allergic rhinitis.
The relationship of IgE, skin-test, eosinophilia, eosinophil cationic protein and tumor necrosis factor production in allergic rhinitis.
TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis.
Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines, eosinophils, eosinophil cationic protein, and IgE but has no significant effect on IFN-gamma, IL-1beta, TNF-alpha, or neutrophils.
Variations of cationic proteins from eosinophil leukocytes in food intolerance and allergic rhinitis.
[A study of costimulatory molecules in allergic allergic rhinitis patients]
[Blood levels of eosinophil cationic protein in patients with allergic rhinitis. Evolution after treatment with corticoids]
[Correlation of serum eosinophil cationic protein with the severity of allergic rhinitis in childhood].
[Detection of eosinophil cationic protein and E-selectin in serum and nasal lavage fluid in patients with allergic rhinitis]
[Diagnosis of allergic rhinitis by determining of tryptase and eosinophil cationic protein in nasal secretions]
[Diagnostic significance of serum allergen detection in diagnosis of allergic rhinitis and bronchial asthma]
[Levels of interleukin-4, interleukin-5, tryptase and eosinophil cationic protein of nasal lavage fluid in pollen allergic rhinitis]
[Serum ECP levels in patients with allergic rhinitis and chronic rhinosinusitis.]
[The impact of asthma on nasal function in patient with allergic rhinitis].
[The influence of Xuanfeijiedu granules on trace elements, IgE, ECP of allergic rhinitis].
[The significance and application of serum eosinophil cationic proteinand IgG4 antibody in patients with allergic rhinitistreated by allergic specific immunotherapy].
Rhinitis, Allergic, Seasonal
Albumin, bradykinins, and eosinophil cationic protein on the nasal mucosal surface in patients with hay fever during natural allergen exposure.
Alpha2-macroglobulin and eosinophil cationic protein in the allergic airway mucosa in seasonal allergic rhinitis.
Eosinophil cationic protein and prophylactic treatment in pollinosis in natural allergen provocation.
Major basic protein and eosinophil-derived neurotoxin concentrations in nasal-lavage fluid after antigen challenge: effect of systemic corticosteroids and relationship to eosinophil influx.
Major basic protein, eosinophil cationic protein, and arylsulfatase in nasal secretions of patients with Japanese cedar pollinosis.
Measurement of serum levels of eosinophil cationic protein to monitor patients with seasonal respiratory allergy induced by Parietaria pollen (treated and untreated with specific immunotherapy).
Placebo-controlled study with OHIO chamber of prophylactic pranlukast for children with Japanese cedar pollinosis: TOPIC-J III study.
Ragweed-specific IgA in nasal lavage fluid of ragweed-sensitive allergic rhinitis patients: increase during the pollen season.
Seasonal variation in interleukin 4 in patients with hayfever.
Serum eosinophil cationic protein (ECP) levels in patients with seasonal allergic rhinitis and allergic asthma.
Serum eosinophil granule proteins predict asthma risk in allergic rhinitis.
Serum soluble tumor necrosis factor receptor levels in patients with seasonal allergic rhinitis.
The effect of immunotherapy on the serum levels of eosinophil cationic protein in seasonal allergic rhinitis.
[Correlations between plasma levels of IL-18, IL-4, IFN-gamma, IgE and ECP in the patients with seasonal allergic rhinitis and their clinical implications]
[Seasonal changes in serum level of eosinophil-derived neurotoxin, interleukin-18, and interferon-gamma in pollinosis patients]
[The immunological parameters and risk factors for pollen-induced allergic rhinitis and asthma]
Rosacea
Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases.
Sarcoidosis
Eosinophil activation in patients with pulmonary fibrosis.
Sarcoidosis, Pulmonary
IL-18 might reflect disease activity in mild and moderate asthma exacerbation.
Sarcoma, Kaposi
A synthetic peptide derived from the human eosinophil-derived neurotoxin induces apoptosis in Kaposi's sarcoma cells.
Schistosomiasis
Assessing the morbidity of schistosomiasis by measuring eosinophil cationic protein in serum.
Assessment of eosinophil cationic protein as a possible diagnostic marker for female genital schistosomiasis in women living in a Schistosoma haematobium endemic area.
Community-based study of genital schistosomiasis in men from Madagascar.
Diagnosis of female genital schistosomiasis by indirect disease markers: determination of eosinophil cationic protein, neopterin and IgA in vaginal fluid and swab eluates.
Schistosomiasis haematobia
Eosinophil cationic protein, soluble egg antigen, circulating anodic antigen, and egg excretion in male urogenital schistosomiasis.
Eosinophils, eosinophil cationic protein and eosinophil-derived neurotoxin in serum and urine of patients with onchocerciasis coinfected with intestinal nematodes and in urinary schistosomiasis.
Indirect assessment of eosinophiluria in urinary schistosomiasis using eosinophil cationic protein (ECP) and eosinophil protein X (EPX).
Morbidity assessment in urinary schistosomiasis infection through ultrasonography and measurement of eosinophil cationic protein (ECP) in urine.
Schistosomiasis mansoni
The 434(G>C) polymorphism within the coding sequence of Eosinophil Cationic Protein (ECP) correlates with the natural course of Schistosoma mansoni infection.
Scleroderma, Systemic
Eosinophil activation in systemic sclerosis.
Seminoma
Antitumor action of bovine seminal ribonuclease. Cytostatic effect on human melanoma and mouse seminoma.
Sepsis
The Human Host Defense Ribonucleases 1, 3 and 7 Are Elevated in Patients with Sepsis after Major Surgery-A Pilot Study.
Severe Acute Respiratory Syndrome
Ranpirnase: amphibian ribonuclease A, P-30 protein-alfacell.
Sinusitis
Assessment of inflammation in noninfectious chronic maxillary sinusitis.
Local and systemic eosinophil activation in allergic fungal sinusitis.
[A study on the concentration of eosinophil cationic protein in chronic sinusitis]
Skin Diseases
Eosinophil cationic protein (ECP) level and its correlation with eosinophil number or IgE level of peripheral blood in patients with various skin diseases.
Monitoring of serologic immune parameters in inflammatory skin diseases.
[The value of detecting eosinophil cationic protein in various dermatoses]
Sleep Initiation and Maintenance Disorders
Comparison of different activity parameters in atopic dermatitis: correlation with clinical scores.
Spondylitis, Ankylosing
Raised circulating levels of the eosinophil cationic protein in ankylosing spondylitis: relation with the inflammatory activity and the influence of sulphasalazine treatment.
Starvation
Accumulation of nucleotides by starved Escherichia coli cells as a probe for the involvement of ribonucleases in ribonucleic acid degradation.
The involvement of ribonuclease I, ribonuclease II, and polynucleotide phosphorylase in the degradation of stable ribonucleic acid during carbon starvation in Escherichia coli.
Stomach Neoplasms
Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray.
Stomach Ulcer
Eosinophil infiltration, gastric juice and serum eosinophil cationic protein levels in Helicobacter pylori-associated chronic gastritis and gastric ulcer.
[Experimental gastric ulcer from pancreatic ribonuclease.]
[Experimental production of gastric ulcer with pancreatic ribonuclease.]
Stroke
Discovery of New Risk Markers for Ischemic Stroke Using a Novel Targeted Proteomics Chip.
Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke.
Tachypnea
Effects of human eosinophil granule-derived cationic proteins on C-fiber afferents in the rat lung.
Tetanus
Intracellular pathway of Onconase that enables its delivery to the cytosol.
SNARE proteins are critical for regulated exocytosis of ECP from human eosinophils.
Thrombosis
Allergic Inflammation Is Associated With Coronary Instability and a Worse Clinical Outcome After Acute Myocardial Infarction.
Extracellular nucleic acids as novel alarm signals in the vascular system. Mediators of defence and disease.
Extracellular RNA Liberates Tumor Necrosis Factor-? to Promote Tumor Cell Trafficking and Progression.
Idiopathic eosinophilia associated with portal vein and massive thrombosis: successful thrombolysis with streptokinase.
Thyroid Carcinoma, Anaplastic
Selective activity of BS-RNase against anaplastic thyroid cancer.
Thyroid Neoplasms
Eosinophil Cationic Protein in Patients with Differentiated Thyroid Cancer Treated with Radioactive Iodine 131.
Selective activity of BS-RNase against anaplastic thyroid cancer.
Toxocariasis
Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis.
Laboratory diagnosis of human toxocariasis.
Tumor Virus Infections
[RNA fragments, in vivo inhibitors of Shope fibroma and vaccinia virus multiplication]
Uremia
Elevated circulating levels of eosinophil cationic protein in uremia as signs of abnormal eosinophil homeostasis.
Urinary Bladder Diseases
Autorosette inhibition factor: a positive acute phase reactant in interstitial cystitis.
Urinary disease in 2 Dogon populations with different exposure to Schistosoma haematobium infection: progression of bladder and kidney diseases in children and adults.
Urine eosinophil cationic protein in painful bladder disease.
Urinary Bladder Neoplasms
Eosinophil cationic protein in urine in patients with urinary bladder tumors.
Urticaria
Blood eosinophils and serum eosinophil cationic protein in patients with acute and chronic urticaria.
Co-existence of Chronic Urticaria and Metabolic Syndrome: Clinical Implications.
Cold urticaria as a model of mediator release: platelet factor 4, eosinophil cationic protein and histamine.
Serum soluble IL-2 receptor (sIL-2R) and eosinophil cationic protein (ECP) levels in atopic dermatitis.
Uterine Cervical Neoplasms
Rana catesbeiana ribonuclease induces cell apoptosis via the caspase-9/-3 signaling pathway in human glioblastoma DBTRG, GBM8901 and GBM8401 cell lines.
Vaccinia
Capped and polyadenylated low-molecular-weight RNA synthesized by vaccinia virus in vitro.
[RNA fragments, in vivo inhibitors of Shope fibroma and vaccinia virus multiplication]
Vasculitis
Allergic granulomatosis and angiitis of Churg-Strauss. A case of high serum level of eosinophil cationic protein.
Clinicopathological studies of peripheral neuropathy in Churg-Strauss syndrome.
Deposition of eosinophil cationic protein in granulomas in allergic granulomatosis and vasculitis: the Churg-Strauss syndrome.
Usefulness of serum eosinophil cationic protein (ECP) in predicting relapse of Churg and Strauss vasculitis.
Vesicular Stomatitis
Bovine coronavirus genome.
Virus Diseases
Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response.
Warts
Ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a Phase I study.
Whooping Cough
[Effects of G-Protein Regulators and Stylar S-RNase on the Growth and Ca(2+) Concentration of Pyrus pyrifolia Pollen Tube.]