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Information on EC 4.6.1.12 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and Organism(s) Bacillus subtilis and UniProt Accession Q06756

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IUBMB Comments
The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
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Bacillus subtilis
UNIPROT: Q06756
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The taxonomic range for the selected organisms is: Bacillus subtilis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
mecs, mecps, ispdf, 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase, 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase, 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase, 2-methylerythritol 2,4-cyclodiphosphate synthase, ygbb protein, mec synthase, 2-c-methyl-d-erythritol-2,4-cyclodiphosphate synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MECDP-synthase
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MECPS
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SYSTEMATIC NAME
IUBMB Comments
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)
The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
CAS REGISTRY NUMBER
COMMENTARY hide
287480-92-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
a protein complex assembly of 2-C-methyl-D-erythritol-4-phosphatecytidyltransferase (IspD), CDPME kinase (IspE) and IspF, which catalyze three consecutive steps, is not detectable
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
structures of native IspF and in complex with CMP, to 1.99 A resolution
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liu, Z.; Jin, Y.; Tao, Y.; Wang, G.
Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly amongst IspD/IspE/IspF enzymes in the MEP pathway
Biosci. Rep.
38
BSR20171370
2018
Bacillus subtilis (Q06756), Bacillus subtilis 168 (Q06756)
Manually annotated by BRENDA team