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Information on EC 4.6.1.1 - adenylate cyclase and Organism(s) Rattus norvegicus and UniProt Accession P40146

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EC Tree
IUBMB Comments
Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase.
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Rattus norvegicus
UNIPROT: P40146
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
adenylate cyclase, adenylyl cyclase, adenyl cyclase, pituitary adenylate cyclase, edema factor, adenylylcyclase, soluble adenylyl cyclase, adenylate cyclase toxin, adcy5, aciii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
adenylyl cyclase type 8
-
Ca2+-calmodulin stimulated adenylyl cyclase type 8
-
3',5'-cyclic AMP synthetase
-
-
-
-
ACTP10
-
-
-
-
adenyl cyclase
-
-
-
-
adenylate cyclase 1
-
-
adenylate cyclase [ATP pyrophosphate-lyase (cyclizing)]
-
-
Adenylate cyclase, olfactive type
-
-
-
-
adenylyl cyclase
adenylyl cyclase 1
-
-
adenylyl cyclase 2
-
-
adenylyl cyclase 8
-
-
Adenylyl cyclase type 10
-
-
-
-
adenylyl cyclase type 6
-
-
adenylylcyclase
-
-
-
-
ATP pyrophosphate-lyase
-
-
-
-
Ca(2+)-inhibitable adenylyl cyclase
-
-
-
-
Ca(2+)/calmodulin activated adenylyl cyclase
-
-
-
-
Ca2+-dependent adenylyl cyclase
-
-
class III AC
-
-
class III adenylyl cyclase
-
-
cyclase, adenylate
-
-
-
-
Edema factor
-
-
-
-
mAC
-
C2 domain of type II mAC (IIC2)
membrane adenylyl cyclase
-
-
Rutabaga protein
-
-
-
-
soluble adenylate cyclase
-
-
soluble adenylyl cyclase
type II AC
-
-
type V adenylate cyclase
-
type VIII adenylyl cyclase
-
-
xlAC
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
P-O bond cleavage
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-42-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
ATP
3',5'-cAMP + diphosphate
show the reaction diagram
ATP
3',5'-cyclic AMP + diphosphate
show the reaction diagram
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
MgATP2-
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
capacitative Ca2+ entry via plasma membrane pore-forming component Orai1, i.e. Ca2+ release-activated Ca2+ modulator 1 or CRACM1, and stromal interacting molecule 1, STIM1, regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, detailed overview
-
-
?
ATP
3',5'-cyclic AMP + diphosphate
show the reaction diagram
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calmodulin
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
Ca2+ stimulates transmembrane isozyme AC8 via calmodulin, capacitative Ca2+ entry via Orai1 and STIM1 regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, AC8 shows a dis-inhibitory activation mechanism
bicarbonate
-
activates
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2'(3')-O-(N-methylanthraniloyl)-ATP
-
catalytic heterodimer VC1-IIC2
2'(3')-O-(N-methylanthraniloyl)-GTP
-
catalytic heterodimer VC1-IIC2, incompletely defined structure 2'- or 3'-substituted nucleoside triphosphate
2',3'-bis[(2-(N-methylanthraniloyl)amino)ethyl-carbamoyl]-ATP
-
catalytic heterodimer VC1-IIC2
2',3'-di[(2-(N-methylanthraniloyl)amino)ethyl-carbamoyl]-ATP
-
-
2',3'-O-(2,4,6-trinitrophenyl)-ADP
-
catalytic heterodimer VC1-IIC2
2',3'-O-(2,4,6-trinitrophenyl)-AMP
-
catalytic heterodimer VC1-IIC2
2',3'-O-(2,4,6-trinitrophenyl)-ATP
-
catalytic heterodimer VC1-IIC2
2',3'-O-(2,4,6-trinitrophenyl)-CTP
-
catalytic heterodimer VC1-IIC2, incompletely defined structure 2'- or 3'-substituted nucleoside triphosphate
2',3'-O-(2,4,6-trinitrophenyl)-GDP
-
catalytic heterodimer VC1-IIC2
2',3'-O-(2,4,6-trinitrophenyl)-GTP
-
catalytic heterodimer VC1-IIC2
2',3'-O-(2,4,6-trinitrophenyl)-UTP
-
catalytic heterodimer VC1-IIC2
2-(1H-benzo[d]imidazole-2-ylthio)-N'-(5-bromo-2-hydroxybenzylidene) propanehydrazide
-
0.07 mM used in assay conditions
2-hydroxyestradiol
-
0.01 mM used in assay conditions
4-hydroxyestradiol
-
a catechol estrogen and sAC-selective inhibitor
8-[(4-(N-methylanthraniloyl)amino)butyl]amino-ATP
-
catalytic heterodimer VC1-IIC2
8-[(6-(N-methylanthraniloyl)amino)hexyl]-amino-ATP
-
catalytic heterodimer VC1-IIC2
adenosine
-
-
catechol
-
and derivatives
DAMGO
-
a mu-opioid receptor agonist, inhibits the forskolin-activated enzyme, the combined treatment with sufentanil and nimodipine, an L-type Ca2+ channel blocker, increases mu-opioid-mediated inhibition of adenylyl cyclase and switched it to a predominantly PTX-resistant response, overview
epinephrine
-
overexposure to epinephrine inactivates adenylate cyclase
Foscarnet
-
a diphosphate analogue, is able to inhibit adenylate cyclase activity in cardiac myocytes, but does not inhibit activity of recombinant murine isozyme ACVI in virus-infected myocytes
Galphai2G203T
chronic treatment of HEK-293T cells reduces AC5 activity
-
inhibitory G protein
-
-
-
KH7
-
sAC-specific inhibitor
MANT-GTP
-
inhibits the VC1-IIC2 heterodimer
MDL-12,330A
-
-
N6-[6-((N-methylanthraniloyl)amino)hexyl]-ATP
-
catalytic heterodimer VC1-IIC2
noradrenaline
-
adenylate cyclase is almost completely inhibited by 0.5 mM noradrenaline
pertussis toxin
chronic treatment of HEK-293T cells reduces AC5 activity
-
PKC
-
inhibits AC6 activity
-
Ric8a
i.e., resistance to inhibitors of cholinesterase 8 homolog A, AC5 interacts with Ric8a through directly interacting at its N-terminus, selectively suppresses AC5 activity, does not further suppress AC5’s activity in the presence of somatostatin, effectively suppresses the forskolin-stimulated activity of AC5, but not that of AC6. Treating cells with pertussis toxin or expressing a dominant negative Galphai mutant abolishes the suppressive effect, markedly suppresses the activation of AC5 induced by isoprenaline of a Galphas coupled receptor in an isoform-specific manner, while the isoprenaline-evoked activity of AC6 is not affected
-
siRNA
-
selectively reduces heterologous expression of AC6 without impact on the expression of AC2, reduces forskolin-activated AC6 activity, whereby diminishing forskolin-induced arborization
-
SQ22536
sufentanil
-
a mu-opioid receptor agonist, inhibits the forskolin-activated enzyme, the combined treatment with sufentanil and nimodipine, an L-type Ca2+ channel blocker, increases mu-opioid-mediated inhibition of adenylyl cyclase and switched it to a predominantly PTX-resistant response, overview
vitamin D
-
decreases parathyroid-induced stimulation of AC6 and induces a phosphorylation of AC6 in a PKC-dependent manner
WIN55212-2
-
-
Yotiao
-
the A-kinase anchoring protein Yotiao or AKAP9 binds and regulates adenylyl cyclase in brain, it inhibits AC2 and AC3, but has no effect on AC1 or AC9, the N-terminus of isozyme AC2, AC2-NT, acts as a competitive inhibitor of Yotiao-AC2 interactions, recombinantly expressed Yotiao from HEK293 cells
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calmodulin
Ca2+ stimulates transmembrane isozyme AC8 via calmodulin
5-CT
-
h5-HT6/rAC2 cell line highly responsive
5-HT
-
h5-HT6/rAC2 cell line highly responsive
A-77636
-
a dopamine receptor agonist, the activation by can be reversed by D1-receptor antagonists SCH23390, SKF83566, and butaclamol
acetazolamide
-
when apical membrane insertion of the vacuolar proton pumping ATPase is stimulated by treatment with acetazolamide, sAC is also concentrated in the apical membrane of A-intercalated cells
adrenaline
-
stimulates adenylate cyclase activity
alamethicin
-
activation
alpha subunit of the guanine-nucleotide binding regulatory protein
-
activation
-
bicarbonate
bovine serum albumin
-
stimulation
-
Calmodulin
dihydrexidine
-
a dopamine receptor agonist, the activation by can be reversed by D1-receptor antagonists SCH23390, SKF83566, and butaclamol
dopamine
Epidermal growth factor
ethanol
forskolin
G-protein
-
-
-
Galphas
-
Gbetagamma
-
conditionally stimulates ACV and ACVI
-
glucagon-like peptide-1
-
stimulates the enzyme via activation of the specific G protein-coupled receptor GLP-1
-
GSalpha proteins
-
mediate stimulation of the adenylyl cyclase in case of hyperglycemia
-
GTP
-
activation
GTP-gamma-S
-
activation
GTPgammaS
guanosine 5'-(beta,gamma-imido)triphosphate
-
activation
HCO3-
-
50 mM, 5-20fold activation in the presence of Mg2+, 3fold activation in the presence of Mn2+
isoproterenol
-
stimulates AC6 resulting in a significant increase in the arborization process
lisuride
-
h5-HT6/rAC2 cell line highly responsive
Nicotine
-
nicotine treatment in adulthood produces an immediate increase in adenylate cyclase activity in males that disappears upon withdrawal, nicotine increases the activating effect of forskolin, especially in males, overview
phorbol 12-myristate 13-acetate
-
PKC-selective activator, stimulates AC2
pituitary adenylate cyclase activating polypeptide
-
-
-
pituitary adenylate cyclase-activating polypeptide
-
i.e. PACAP, a neurotrophic and neuromodulatory peptide, differentially modulates AMPA receptor-mediated current in CA1 pyramidal neurons by activation of PAC1 and VPAC2 receptors, both involving the cAMP/PKA pathway, mechanism and regulation, overview. It also enhances NMDA receptor-mediated currents
-
serotonin
-
AC2 stimulation followed by cAMP accumulation, no effect on AC5. AC2 co-transfected with Gs protein shows a synergistic effect on both baseline and agonist-stimulated cAMP accumulation. In the combined presence of Golf and AC2, the level of cAMP accumulation is enhanced in the agonist-stimulated cell line to levels equaling those of the AC2-expressing cell line only, with no effect on baseline activity. Similarly, when AC5 is co-expressed with Gs a synergistic effect with this pairing on both baseline and agonist-stimulated cAMP accumulation versus control can be observed. Because baseline activity is so high with the AC5/Gs pairing, the difference between stimulated and non-stimulated treatments is not significant. The AC5/Golf pairing fails to show any enhancement in cAMP accumulation upon serotonin stimulation, and no effect on baseline activity
Sodium fluoride
-
-
stimulating G protein
-
-
-
sumatriptan
-
h5-HT6/rAC2 cell line highly responsive
Vasoactive intestinal peptide
-
activation
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.001 - 1.2
ATP
0.009 - 0.019
MgATP2-
additional information
additional information
-
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0833 - 34
ATP
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000011 - 0.00011
2'(3')-O-(N-methylanthraniloyl)-ATP
0.000014 - 0.00013
2'(3')-O-(N-methylanthraniloyl)-GTP
0.0055
2',3'-bis[(2-(N-methylanthraniloyl)amino)ethyl-carbamoyl]-ATP
-
VC1-IIC2 in the presence of 0.1 mM forskolin
0.0067
2',3'-di[(2-(N-methylanthraniloyl)amino)ethyl-carbamoyl]-ATP
-
VC1-IIC2 in the presence of 0.1 mM forskolin and GTPgammaS-activated Galphas
0.0013 - 0.002
2',3'-O-(2,4,6-trinitrophenyl)-ADP
0.017 - 0.021
2',3'-O-(2,4,6-trinitrophenyl)-AMP
0.000081 - 0.0001
2',3'-O-(2,4,6-trinitrophenyl)-ATP
0.00011 - 0.00031
2',3'-O-(2,4,6-trinitrophenyl)-CTP
0.0081 - 0.0094
2',3'-O-(2,4,6-trinitrophenyl)-GDP
0.000083 - 0.00043
2',3'-O-(2,4,6-trinitrophenyl)-GTP
0.000092
2',3'-O-(2,4,6-trinitrophenyl)-UTP
0.0094 - 0.01
8-[(4-(N-methylanthraniloyl)amino)butyl]amino-ATP
0.058 - 0.1
8-[(6-(N-methylanthraniloyl)amino)hexyl]-amino-ATP
0.0094 - 0.011
N6-[6-((N-methylanthraniloyl)amino)hexyl]-ATP
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
67
-
recombinant C-terminal cytoplasmic domain of type II adenylyl cyclase
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20
-
assay at
35
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
vascular smooth muscle cell line
Manually annotated by BRENDA team
-
of isolated ventricular myocytes
Manually annotated by BRENDA team
epithelial cells, both intercalated cells and principal cells
Manually annotated by BRENDA team
-
AC4 and AC6
Manually annotated by BRENDA team
-
in all intercalated cells, sAC and vacuolar proton pumping ATPase show considerable overlap under basal conditions, but sAC is also found in other cellular locations in the absence of vacuolar proton pumping ATPase. In type A-intercalated cells, both sAC and vacuolar proton pumping ATPase are apically and subapically located, whereas in type B-intercalated cells, significant basolateral colocalization of sAC and the vacuolar proton pumping ATPase is seen
Manually annotated by BRENDA team
-
lumbar spinal cord segments
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
transmembrane AC isozymes, some of which are sensitive to Ca2+
Manually annotated by BRENDA team
AC8 is confined to lipid raft microdomains of the plasma membrane. AC8, Orai1 and STIM1 are co-localized in lipid raft domains of the plasma membrane
Manually annotated by BRENDA team
the soluble isozyme is attached to the cytoskeleton via protein-protein interactions
Manually annotated by BRENDA team
-
apical domain of type A-intercalated cells
Manually annotated by BRENDA team
soluble isozyme, only in its shortened, active form
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
inhibition of adenylyl cyclase in amygdala blocks the effect of audiogenic seizure kindling in genetically epilepsy-prone rats
physiological function
-
the enzyme is involved in the activation of L-type Ca2+ channels in a HCO3--dependent braking pathway that results in elevated intracellular Ca2+ and activation of BK channels
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ADCY8_RAT
1248
10
139823
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
123000
-
AC2, Western immunoblotting
130000
-
immunoblotting
171000
-
x * 171000, immunoblot, full length sAC
187000
191000
-
membrane bound form, sucrose density gradient centrifugation
46000
-
1 * 46000, immunoblot, truncated sAC resulting from alternative splicing
48000
49000
-
gel filtration, recombinant truncated sAC
50000
56000
-
water soluble form, sucrose density gradient centrifugation
69000
-
SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heterodimer
-
-
monomer
-
1 * 46000, immunoblot, truncated sAC resulting from alternative splicing
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
proteolytic modification
the soluble isozyme is processed by proteases to its active form of 48 kDa
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of native soluble AC and of soluble AC in complex with the competitiv substrate analogs beta-L-2',3'-dideoxyadenosine 5'-triphiosphate and adenosine 5'-(alpha-thio)-triphosphate at 2.8-3.0 A
-
crystal structures of catalytic domains VC1-IIC2 bound to 2'(3')-O-(N-methylanthraniloyl)-GTP, 2'(3')-O-(N-methylanthraniloyl)-ATP, and 2',3'-(2,4,6-trinitrophenyl)-ATP, at 2.9 to 3.3 A resolution, inhibitors reside in the same binding pocket in the VC1-IIC2 protein complex, but there are substantial differences in interactions of base, fluorophore, and polyphosphate chain of the inhibitors with mAC
-
VC1-IIC2 heterodimer in complex with ATP analogs
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D396A
-
almost no activity
D396A/D440A
-
no activity
D396A/D440N
-
no activity
D396N
-
almost no activity
D396N/D440A
-
no activity
D396N/D440N
-
no activity
D425A
-
catalytically inactive mutant of isoform AC6, the expression of the mutant is associated with marked reduction in cAMP production
D440A
-
almost no activity
D440N
-
almost no activity
additional information
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
33
-
membrane bound form solubilized with Lubrol-PX
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
by Ni-coupled beads
recombinant C-terminal cytoplasmic domain of type II adenylyl cyclase
-
recombinant soluble AC
-
soluble isozyme
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
overexpression of untagged AC8 and C-terminally HA-tagged AC8 in HEK293 cells, co-expression of HA-tagged AC8, myc-tagged Orai1 and untagged STIM1 in membranes, and co-expression of CFP-tagged AC8, YFP-tagged STIM1 and myc-tagged Orai1 with co-localization at the plasma membrane
chimeras inserted into the mammalian expression vector pCMV-SK, wild-type and chimeric mutants expressed in HEK-293 cells
Escherichia coli BL21 (DE3) transformed with pET11D-AC5N1-215, AC5-myc and HA-Ric8a expressed in HEK-293T cells
expressed in mpkCCDc14 cells
expression in Sf9 cells
-
expression of C-terminal cytoplasmic domain of type II adenylyl cyclase in Escherichia coli
-
expression of full length and C-terminal truncated sAC in HEK293 cells
expression of full length and truncated sAC in HEK293 cells
-
expression of Mus musculus isozyme ACVI with an AU1 tag, a 6-amino acid epitope DTYRY, in rat myocytes using an adenoviral vector leads to increases phosphorylation of phospholamban independently of beta-adrenergic receptor stimulation
-
expression of soluble AC in Escherichia coli
-
expression of transmembrane isozymes in HEK293T cells, expression of His-tagged soluble isozyme
-
h5-HT6 pHTop CHODUKX-A2 cells transiently transfected with human Golf, Gs proteins and rat AC2, AC5 full-length isoforms
-
HEK-293 cells stably transfected with rat AC2 cDNA
-
HEK293 cells transiently transfected with pcDNA3 containing either GFP or Flag-tagged AC1, AC2 and AC5 or AC6 cDNA
-
the testis isozyme is located in the Sacytm1Lex locus, sAC transcripts in brain use an alternate start site than the testis isozyme transcripts
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
isoform AC6 expression is stimulated by forskolin and isoproterenol (0.01 mM)
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression
drug development
-
stable AC2-expressing CHODUKX cell line in which the generation of high expressing GPCR receptor/AC2 lines can retain their functional responsiveness and can provide pharmacological drug comparisons between the same host line for screening purposes and measurement of multiple cellular parameters
medicine
additional information
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kornblihtt, A.R.; Flawia, M.M.; Torres, H.N.
Manganese ion dependent adenylate cyclase activity in rat testes: purification and properties
Biochemistry
20
1262-1267
1981
Rattus norvegicus
Manually annotated by BRENDA team
Rodan, S.B.; Egan, J.J.; Golub, E.E.; Rodan, G.A.
Comparison of bone and osteosarcoma adenylate cyclase. Partial purification of membranes and kinetic properties of enzyme
Biochem. J.
185
617-627
1980
Rattus norvegicus
Manually annotated by BRENDA team
Stengel, D.; Hanoune, J.
Solubilization and physical characterization of the adenylate cyclase from rat-liver plasma membranes
Eur. J. Biochem.
102
21-34
1979
Rattus norvegicus
Manually annotated by BRENDA team
Neer, E.J.
Physical and functional properties of adenylate cyclase from mature rat testis
J. Biol. Chem.
253
5808-5812
1978
Rattus norvegicus
Manually annotated by BRENDA team
Braun, T.
Purification of soluble form of adenylyl cyclase from testes
Methods Enzymol.
195
130-136
1991
Rattus norvegicus
Manually annotated by BRENDA team
Neer, E.J.
The size of adenylate cyclase
J. Biol. Chem.
249
6527-6531
1974
Rattus norvegicus
Manually annotated by BRENDA team
Feinstein, P.G.; Schrader, K.A.; Bakalyar, H.A.; Tang, W-J.; Krupinski, J.; Gilman, A.G.; Reed, R.R.
Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain
Proc. Natl. Acad. Sci. USA
88
10173-10177
1991
Rattus norvegicus
Manually annotated by BRENDA team
Premont, R.T.; Matsuoka, I.; Mattei, M.G.; Pouille, Y.; Defer, N.; Hanoune, J.
Identification and characterization of a widely expressed form of adenylyl cyclase
J. Biol. Chem.
271
13900-13907
1996
Rattus norvegicus, Mus musculus (P51830), Mus musculus
Manually annotated by BRENDA team
Sethi, R.; Dhalla, K.S.; Shah, K.R.; Dhalla, N.S.
Characterization of adenylyl cyclase in heart sarcolemma in the absence or presence of alamethicin
Mol. Cell. Biol.
119
185-193
1993
Rattus norvegicus
Manually annotated by BRENDA team
Plesneva, S.A.; Nalivaeva, N.N.; Zhuravin, I.A.
Adenylate cyclase system of the rat striatum: regulatory properties and the effects of gangliosides
Neurosci. Behav. Physiol.
28
392-396
1998
Rattus norvegicus
Manually annotated by BRENDA team
Enomoto, L.; Takano, M.; Ariyoshi, S.; Asakawa, T.
Mechanism and properties of inhibition of purified rat brain adenylate cyclase by G protein beta gamma-subunits
Jpn. J. Pharmacol.
69
239-250
1995
Rattus norvegicus
Manually annotated by BRENDA team
Pozo, D.; Segura, J.J.; Carrero, I.; Guijarro, L.G.; Prieto, J.C.; Calvo, J.R.
Characterization of adenylyl cyclase stimulated by VIP in rat and mouse peritoneal macrophage membranes
Biochim. Biophys. Acta
1312
249-254
1996
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Nair, B.G.; Patel, T.B.
Inhibition of hepatic adenylate cyclase by NADH
Life Sci.
49
915-923
1991
Rattus norvegicus
Manually annotated by BRENDA team
Defer, N.; Best-Belpomme, M.; Hanoune, J.
Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase
Am. J. Physiol.
279
F400-F416
2000
Gallus gallus, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Jaiswal, B.S.; Conti, M.
Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase
J. Biol. Chem.
276
31698-31708
2001
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Hatley, M.E.; Gilman, A.G.; Sunahara, R.K.
Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases
Methods Enzymol.
345
127-140
2001
Canis lupus familiaris, Rattus norvegicus
Manually annotated by BRENDA team
Buck, J.; Sinclair, M.L.; Schapal, L.; Cann, M.J.; Levin, L.R.
Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals
Proc. Natl. Acad. Sci. USA
96
79-84
1999
Rattus norvegicus (Q9Z286)
Manually annotated by BRENDA team
Tesmer, J.J.G.; Sunahara, R.K.; Johnson, R.A.; Gosselin, G.; Gilman, A.G.; Sprang, S.R.
Two-metal-ion catalysis in adenylyl cyclase
Science
285
756-760
1999
Rattus norvegicus
Manually annotated by BRENDA team
Yoshimura, M.; Pearson, S.; Kadota, Y.; Gonzalez, C.E.
Identification of ethanol responsive domains of adenylyl cyclase
Alcohol. Clin. Exp. Res.
30
1824-1832
2006
Rattus norvegicus (P21932), Rattus norvegicus (P26769), Homo sapiens (P51828)
Manually annotated by BRENDA team
Paunescu, T.G.; Da Silva, N.; Russo, L.M.; McKee, M.; Lu, H.A.; Breton, S.; Brown, D.
Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells
Am. J. Physiol. Renal Physiol.
294
F130-F138
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Wang, S.C.; Lai, H.L.; Chiu, Y.T.; Ou, R.; Huang, C.L.; Chern, Y.
Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor
Biochem. J.
406
383-388
2007
Rattus norvegicus (Q04400)
Manually annotated by BRENDA team
Linder, J.U.
Class III adenylyl cyclases: molecular mechanisms of catalysis and regulation
Cell. Mol. Life Sci.
63
1736-1751
2006
Bacillus anthracis, Bordetella pertussis, Saccharomyces cerevisiae, Caenorhabditis elegans, Chlamydomonas reinhardtii, Chloroflexus aurantiacus, Dictyostelium discoideum, Drosophila melanogaster, Escherichia coli, Euglena gracilis, Mus musculus, Myxococcus xanthus, Pseudomonas aeruginosa, Rattus norvegicus, Sinorhizobium meliloti, Schizosaccharomyces pombe, Arthrospira platensis, Trypanosoma brucei, Ustilago maydis, Yersinia enterocolitica, Mycobacterium tuberculosis (P9WQ35), Nostoc sp. PCC 7120 = FACHB-418 (Q7A2D9), Nostoc sp. PCC 7120 = FACHB-418 (Q8YMH0), Nostoc sp. PCC 7120 = FACHB-418 (Q8YVS0), Mycobacterium tuberculosis H37Rv (P9WQ35)
Manually annotated by BRENDA team
Gros, R.; Ding, Q.; Chorazyczewski, J.; Pickering, J.G.; Limbird, L.E.; Feldman, R.D.
Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization
Circ. Res.
99
845-852
2006
Rattus norvegicus
Manually annotated by BRENDA team
Beazely, M.A.; Watts, V.J.
Regulatory properties of adenylate cyclases type 5 and 6: A progress report
Eur. J. Pharmacol.
535
1-12
2006
Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Gao, X.; Sadana, R.; Dessauer, C.W.; Patel, T.B.
Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits
J. Biol. Chem.
282
294-302
2007
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Nawoschik, S.P.; Olsen, M.; Smith, D.L.; Khawaja, X.
Stable expression of adenylyl cyclase 2 leads to the functional rescue of human 5-HT6 receptor in a CHODUKX cell line
J. Pharmacol. Toxicol. Methods
55
323-331
2007
Rattus norvegicus
Manually annotated by BRENDA team
Watts, V.J.
Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection
Mol. Interv.
7
70-73
2007
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Mou, T.C.; Gille, A.; Suryanarayana, S.; Richter, M.; Seifert, R.; Sprang, S.R.
Broad specificity of mammalian adenylyl cyclase for interaction with 2,3-substituted purine- and pyrimidine nucleotide inhibitors
Mol. Pharmacol.
70
878-886
2006
Canis lupus familiaris, Rattus norvegicus
Manually annotated by BRENDA team
Antoni, F.A.; Wiegand, U.K.; Black, J.; Simpson, J.
Cellular localisation of adenylyl cyclase: a post-genome perspective
Neurochem. Res.
31
287-295
2006
Homo sapiens, Macaca sp., Mus musculus, Rattus norvegicus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Willoughby, D.; Cooper, D.M.
Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains
Physiol. Rev.
87
965-1010
2007
Aplysia sp., Canis lupus familiaris, Oryctolagus cuniculus, Dictyostelium discoideum, Drosophila sp. (in: flies), Homo sapiens, Mus musculus, Paramecium sp., Rattus norvegicus, Tetrahymena sp., Plasmodium sp.
Manually annotated by BRENDA team
Sinha, S.C.; Sprang, S.R.
Structure, mechanism, regulation and evolution of class III nucleotidyl cyclases
Rev. Physiol. Biochem. Pharmacol.
157
105-140
2007
Aeromonas hydrophila, Bacillus anthracis, Prevotella ruminicola, Bordetella pertussis, Canis lupus familiaris, Caulobacter vibrioides, Escherichia sp., Haemophilus sp., Mycobacterium tuberculosis, Yersinia pestis, Pseudomonas sp., Pseudomonas aeruginosa, Rattus norvegicus, Rhizobium etli, Sinorhizobium meliloti, Arthrospira platensis, Trypanosoma brucei, Vibrio parahaemolyticus, Yersinia sp.
Manually annotated by BRENDA team
Li, Y.; Descorbeth, M.; Anand-Srivastava, M.B.
Role of oxidative stress in high glucose-induced decreased expression of Gialpha proteins and adenylyl cyclase signaling in vascular smooth muscle cells
Am. J. Physiol. Heart Circ. Physiol.
294
H2845-H2854
2008
Rattus norvegicus
Manually annotated by BRENDA team
Lee, C.B.; Koh, H.C.
Modification of the cardiovascular response of posterior hypothalamic adenosine A(2A) receptor stimulation by adenylate cyclase and KATP channel blockade in anesthetized rats
Auton. Neurosci.
146
70-75
2009
Rattus norvegicus
Manually annotated by BRENDA team
Slotkin, T.A.; Ryde, I.T.; Mackillop, E.A.; Bodwell, B.E.; Seidler, F.J.
Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects
Brain Res. Bull.
76
522-530
2008
Rattus norvegicus
Manually annotated by BRENDA team
Wann, B.P.; DAnjou, B.; Bah, T.M.; Webster, H.H.; Godbout, R.; Rousseau, G.
Effect of olfactory bulbectomy on adenylyl cyclase activity in the limbic system
Brain Res. Bull.
79
32-36
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Costa, L.; Santangelo, F.; Li Volsi, G.; Ciranna, L.
Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus
Hippocampus
19
99-109
2009
Rattus norvegicus
Manually annotated by BRENDA team
Gao, M.H.; Tang, T.; Guo, T.; Miyanohara, A.; Yajima, T.; Pestonjamasp, K.; Feramisco, J.R.; Hammond, H.K.
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes
J. Biol. Chem.
283
33527-33535
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Hallows, K.R.; Wang, H.; Edinger, R.S.; Butterworth, M.B.; Oyster, N.M.; Li, H.; Buck, J.; Levin, L.R.; Johnson, J.P.; Pastor-Soler, N.M.
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells
J. Biol. Chem.
284
5774-5783
2009
Rattus norvegicus (Q9Z286)
Manually annotated by BRENDA team
Ramos, L.S.; Zippin, J.H.; Kamenetsky, M.; Buck, J.; Levin, L.R.
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells
J. Gen. Physiol.
132
329-338
2008
Rattus norvegicus
Manually annotated by BRENDA team
Schlicker, C.; Rauch, A.; Hess, K.C.; Kachholz, B.; Levin, L.R.; Buck, J.; Steegborn, C.
Structure-based development of novel adenylyl cyclase inhibitors
J. Med. Chem.
51
4456-4464
2008
Rattus norvegicus, Arthrospira platensis (O32393), Homo sapiens (Q96PN6), Homo sapiens
Manually annotated by BRENDA team
Moore, S.W.; Lai Wing Sun, K.; Xie, F.; Barker, P.A.; Conti, M.; Kennedy, T.E.
Soluble adenylyl cyclase is not required for axon guidance to netrin-1
J. Neurosci.
28
3920-3924
2008
Mus musculus (Q8C0T9), Rattus norvegicus (Q9Z286)
Manually annotated by BRENDA team
Moulder, K.L.; Jiang, X.; Chang, C.; Taylor, A.A.; Benz, A.M.; Conti, A.C.; Muglia, L.J.; Mennerick, S.
A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing
J. Neurosci.
28
5159-5168
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Davis-Taber, R.; Baker, S.; Lehto, S.G.; Zhong, C.; Surowy, C.S.; Faltynek, C.R.; Scott, V.E.; Honore, P.
Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states
J. Pain
9
449-456
2008
Rattus norvegicus
Manually annotated by BRENDA team
Vonk, A.; Reinart, R.; Rinken, A.
Modulation of adenylyl cyclase activity in rat striatal homogenate by dopaminergic receptors
J. Pharmacol. Sci.
108
63-70
2008
Rattus norvegicus
Manually annotated by BRENDA team
Gao, J.; Zhang, L.; Wang, Y.; Lu, B.; Cui, H.; Fu, W.; Wang, H.; Yu, Y.; Yu, X.
Antiarrhythmic effect of acupuncture pretreatment in rats subjected to simulative global ischemia and reperfusion - involvement of adenylate cyclase, protein kinase a, and L-type ca(2+) channel
J. Physiol. Sci.
58
389-396
2008
Rattus norvegicus
Manually annotated by BRENDA team
Lomovatskaya, L.A.; Romanenko, A.S.; Filinova, N.V.
Plant adenylate cyclases
J. Recept. Signal Transduct. Res.
28
531-542
2008
Euglena gracilis, Medicago sativa, Nicotiana tabacum, Solanum tuberosum, Bryum argenteum, Rattus norvegicus (Q9Z286)
Manually annotated by BRENDA team
Farrell, S.R.; Howlett, S.E.
The age-related decrease in catecholamine sensitivity is mediated by ss(1)-adrenergic receptors linked to a decrease in adenylate cyclase activity in ventricular myocytes from male Fischer 344 rats
Mech. Ageing Dev.
129
735-744
2008
Rattus norvegicus
Manually annotated by BRENDA team
Martin, A.C.; Willoughby, D.; Ciruela, A.; Ayling, L.J.; Pagano, M.; Wachten, S.; Tengholm, A.; Cooper, D.M.
Capacitative Ca2+ entry via Orai1 and STIM1 regulates adenylyl cyclase type 8
Mol. Pharmacol.
75
830-842
2009
Mus musculus, Rattus norvegicus (P40146)
Manually annotated by BRENDA team
Sanchez, G.; Colettis, N.; Vazquez, P.; Cervenansky, C.; Aguirre, A.; Quillfeldt, J.A.; Jerusalinsky, D.; Kornisiuk, E.
Muscarinic inhibition of hippocampal and striatal adenylyl cyclase is mainly due to the M(4) receptor
Neurochem. Res.
34
1363-1371
2009
Rattus norvegicus
Manually annotated by BRENDA team
Mostany, R.; Diaz, A.; Valdizan, E.M.; Rodriguez-Munoz, M.; Garzon, J.; Hurle, M.A.
Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits
Neuropharmacology
54
989-997
2008
Rattus norvegicus
Manually annotated by BRENDA team
Farrell, J.; Ramos, L.; Tresguerres, M.; Kamenetsky, M.; Levin, L.R.; Buck, J.
Somatic soluble adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex knockout mice
PLoS ONE
3
e3251
2008
Rattus norvegicus
Manually annotated by BRENDA team
Piggott, L.A.; Bauman, A.L.; Scott, J.D.; Dessauer, C.W.
The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain
Proc. Natl. Acad. Sci. USA
105
13835-13840
2008
Rattus norvegicus
Manually annotated by BRENDA team
Bennun, A.
Characterization of the norepinephrine-activation of adenylate cyclase suggests a role in memory affirmation pathways Overexposure to epinephrine inactivates adenylate cyclase, a causal pathway for stress-pathologies
BioSystems
100
87-93
2010
Rattus norvegicus
Manually annotated by BRENDA team
Liou, J.T.; Liu, F.C.; Mao, C.C.; Hsin, S.T.; Lui, P.W.
Adenylate cyclase inhibition attenuates neuropathic pain but lacks pre-emptive effects in rats
Can. J. Anesth.
56
763-769
2009
Rattus norvegicus
Manually annotated by BRENDA team
Latini, S.; Chiarpotto, M.; Muciaccia, B.; Vaccari, S.; Barberi, M.; Guglielmo, M.C.; Stefanini, M.; Cecconi, S.; Canipari, R.
Inhibitory effect of pituitary adenylate cyclase activating polypeptide on the initial stages of rat follicle development
Mol. Cell. Endocrinol.
320
34-44
2010
Rattus norvegicus
Manually annotated by BRENDA team
Mato, S.; Vidal, R.; Castro, E.; Diaz, A.; Pazos, A.; Valdizan, E.M.
Long-term fluoxetine treatment modulates cannabinoid type 1 receptor-mediated inhibition of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine 1A receptor-dependent mechanisms
Mol. Pharmacol.
77
424-434
2010
Rattus norvegicus
Manually annotated by BRENDA team
Tupal, S.; Faingold, C.
Inhibition of adenylyl cyclase in amygdala blocks the effect of audiogenic seizure kindling in genetically epilepsy-prone rats
Neuropharmacology
59
107-111
2010
Rattus norvegicus
Manually annotated by BRENDA team
Gao, M.H.; Tang, T.; Lai, N.C.; Miyanohara, A.; Guo, T.; Tang, R.; Firth, A.L.; Yuan, J.X.; Hammond, H.K.
Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant
Mol. Pharmacol.
79
381-388
2011
Rattus norvegicus
Manually annotated by BRENDA team
Imber, A.N.; Santin, J.M.; Graham, C.D.; Putnam, R.W.
A HCO3--dependent mechanism involving soluble adenylyl cyclase for the activation of Ca2+ currents in locus coeruleus neurons
Biochim. Biophys. Acta
1842
2569-2578
2014
Rattus norvegicus
Manually annotated by BRENDA team
Nikolic, I.; Mitrovic, M.; Zelen, I.; Zaric, M.; Kastratovic, T.; Stanojevic, M.; Nenadovic, M.; Stojanovic, T.
Inhibitory role of monovalent ions on rat brain cortex adenylyl cyclase activity
J. Enzyme Inhib. Med. Chem.
28
1061-1066
2013
Rattus norvegicus
Manually annotated by BRENDA team