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Information on EC 4.4.1.3 - dimethylpropiothetin dethiomethylase
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4.4.1.3 dimethylpropiothetin dethiomethylaseSpecify your search results
Word Map
- 4.4.1.3
- h2s
- dimethylsulfide
-
phytoplankton
- lyases
- hypotaurine
- roseobacter
- o-acetylserine
- ruegeria
- d-cysteine
-
cupin
- rhodobacteraceae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
dmsp lyase, desulfhydrase, dmsp-lyase, dimethylsulfoniopropionate lyase, dddl lyase, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
DddL lyase
dddP
DddQ
DddW
Dddy
desulfhydrase
-
-
-
-
dethiomethylase, dimethylpropiothetin
-
-
-
-
dimethylsulfoniopropionate lyase
DLA
DMSP
DMSP lyase
DMSP-lyase
F963_02809
SL1157_2466
dimethylsulfoniopropionate lyase
-
-
-
-
DMSP lyase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
S,S-dimethyl-beta-propiothetin = dimethyl sulfide + acrylate
-
-
-
-
S,S-dimethyl-beta-propiothetin = dimethyl sulfide + acrylate
mechanism
-
S,S-dimethyl-beta-propiothetin = dimethyl sulfide + acrylate
mechanism
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
elimination
-
-
of RSH, C-S bond cleavage
-
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SYSTEMATIC NAME
IUBMB Comments
S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)
-
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CAS REGISTRY NUMBER
COMMENTARY
9026-85-1
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-(thiolan-1-ium-1-yl)propanoate
thiolane + acrylate
-
-
-
-
?
3-(thiolan-1-ium-1-yl)propanoate
thiolane + acrylate
-
-
-
?
beta-dimethylsulfoniopropanoate
dimethylsulfide + acrylate
-
-
-
?
beta-dimethylsulfoniopropanoate
dimethylsulfide + acrylate
-
-
-
?
beta-dimethylsulfoniopropanoate
dimethylsulfide + acrylate
-
-
-
?
beta-dimethylsulfoniopropanoate
dimethylsulfide + acrylate
-
-
-
?
beta-dimethylsulfoniopropanoate
dimethylsulfide + acrylate
-
-
-
?
beta-dimethylsulfoniopropanoate
dimethylsulfide + acrylate
-
-
-
?
beta-dimethylsulfoniopropanoate
dimethylsulfide + acrylate
D0CY07
-
-
-
?
beta-dimethylsulfoniopropanoate
dimethylsulfide + acrylate
D0CY07
-
-
-
?
beta-dimethylsulfoniopropanoate
dimethylsulfide + acrylate
-
-
-
?
beta-dimethylsulfoniopropanoate
dimethylsulfide + acrylate
-
-
-
?
diethylsulfoniopropionate
diethylsulfide + acrylate
-
-
-
?
dimethylseleniopropionate
dimethylselenide + acrylate
-
-
-
-
?
dimethylseleniopropionate
dimethylselenide + acrylate
-
-
-
?
dimethylseleniopropionate
dimethylselenide + acrylate
-
-
-
?
dimethylsulfoniopropionate
dimethylsulfide + acrylate
-
-
-
-
?
dimethylsulfoniopropionate
dimethylsulfide + acrylate
-
-
-
-
?
dimethylsulfoniopropionate
dimethylsulfide + acrylate
-
-
-
-
?
dimethylsulfoniopropionate
dimethylsulfide + acrylate
-
-
-
-
?
dimethylsulfoniopropionate
dimethylsulfide + acrylate
Roseibium aggregatum IAM 12614
-
-
-
-
?
dimethylsulfoniopropionate
dimethylsulfide + acrylate
-
-
-
?
dimethylsulfoniopropionate
dimethylsulfide + acrylate
-
-
-
?
ethylmethylsulfoniopropionate
ethylmethylsulfide + acrylate
-
-
-
-
?
ethylmethylsulfoniopropionate
ethylmethylsulfide + acrylate
-
-
-
?
ethylmethylsulfoniopropionate
ethylmethylsulfide + acrylate
-
-
-
?
methylpropylsulfoniopropionate
methylpropylsulfide + acrylate
-
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
i.e. , dimethylsulfoniopropionate ?
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
i.e. , dimethylsulfoniopropionate ?
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
-
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium Sulfitobacter EE-36 produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
-
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
i.e. , dimethylsulfoniopropionate ?
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
i.e. , dimethylsulfoniopropionate ?
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
-
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate or dimethylseleniopropionate
-
-
?
additional information
?
-
-
inducible by both acrylate and dimethylsulfoniopropionate
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate, acrylate, acrylamide or methacrylate
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate or dimethylseleniopropionate
-
-
?
additional information
?
-
-
inducible by both acrylate and dimethylsulfoniopropionate
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate, acrylate, acrylamide or methacrylate
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate, choline or glycine betaine
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate or dimethylseleniopropionate
-
-
?
additional information
?
-
-
maximum enzyme production in full-strength seawater or in 50 mM phosphate buffer containing 0.6 M NaCl
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate, dimethyl sulfide, dimethylglycine or glycine betaine
-
-
?
additional information
?
-
-
enzyme is member of the M24B family, which acts on a non-peptide substrate and has no metal cofactor
-
-
?
additional information
?
-
D0CY07
enzyme shows no detectable activity toward the typical substrate (Val-Pro) of M24 peptidases
-
-
?
additional information
?
-
D0CY07
enzyme shows no detectable activity toward the typical substrate (Val-Pro) of M24 peptidases
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium Sulfitobacter EE-36 produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
S,S-dimethyl-beta-propiothetin
dimethyl sulfide + acrylate
-
the alpha-proteobacterium produces the gas dimethylsulfide from dimethylsulfoniopropionate, an abundant antistress molecule made by many marine phytoplankton
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate or dimethylseleniopropionate
-
-
?
additional information
?
-
-
inducible by both acrylate and dimethylsulfoniopropionate
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate, acrylate, acrylamide or methacrylate
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate or dimethylseleniopropionate
-
-
?
additional information
?
-
-
inducible by both acrylate and dimethylsulfoniopropionate
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate, acrylate, acrylamide or methacrylate
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate, choline or glycine betaine
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate or dimethylseleniopropionate
-
-
?
additional information
?
-
-
maximum enzyme production in full-strength seawater or in 50 mM phosphate buffer containing 0.6 M NaCl
-
-
?
additional information
?
-
-
activity is induced by dimethylsulfoniopropionate, dimethyl sulfide, dimethylglycine or glycine betaine
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Cobalt
DddW has the highest affinity for binding Fe(II) at 5 nM, followed by Co(II), Ni(II), and Cu(II) at about 1-3 microM
copper
DddW has the highest affinity for binding Fe(II) at 5 nM, followed by Co(II), Ni(II), and Cu(II) at about 1-3 microM
Iron
Manganese
the presence of Fe(II) or Mn(II) elicits an about 40fold increase in DddW lyase activity compared to the apo-enzyme
Mn2+
Nickel
DddW has the highest affinity for binding Fe(II) at 5 nM, followed by Co(II), Ni(II), and Cu(II) at about 1-3 microM
additional information
-
none of the metals Co, Cu, Mn, Ni or Zn is detected at above background levels
Iron
isolated protein contains 0.5 Fe per subunit. The UV-visible spectrum exhibits a feature at 550 nm, consistent with a tyrosinate-Fe(III) ligand-to-metal charge transfer transition. Both the Fe(III) oxidized and Fe(II) reduced species are active
Iron
the as-isolated enzyme contains 0.2-0.4 equivalents of bound iron. DddW has the highest affinity for binding Fe(II) at 5 nM, followed by Co(II), Ni(II), and Cu(II) at about 1-3 microM, with Mn(II) and Fe(III) exhibiting weaker binding affinities. The presence of Fe(II) or Mn(II) elicits an about 40fold increase in DddW lyase activity compared to the apo-enzyme
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
not inhibitory: EDTA at 25 mM, bipyridyl at 2.5 mM
-
N,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diamine
selectively inhibits all known members of the cupin-DMSP lyases and lyase-like-superfamily that exhibit DMSP lyase activity
N,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diamine
selectively inhibits all known members of the cupin-DMSP lyases and lyase-like-superfamily that exhibit DMSP lyase activity
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
Streptococcus anginosusl-cysteine desulfhydrase gene expression is associated with abscess formation in BALB/c mice.
Dehydration
Hydrogen Sulfide-Mediated Activation of O-Acetylserine (Thiol) Lyase and l/d-Cysteine Desulfhydrase Enhance Dehydration Tolerance in Eruca sativa Mill.
Infections
Coccolithovirus (Phycodnaviridae): characterisation of a new large dsDNA algal virus that infects Emiliana huxleyi.
Vitamin B 6 Deficiency
Increase of serin dehydratase, homoserine dehydratase and cystine (cysteine) desulfhydrase in rat liver due to a high protein diet and the influence of vitamin B6 deficiency.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
5.7
3-(thiolan-1-ium-1-yl)propanoate
30°C, pH not specified in the publication
31.4
3-(thiolan-1-ium-1-yl)propanoate
30°C, pH not specified in the publication
102.6
3-(thiolan-1-ium-1-yl)propanoate
-
30°C, pH not specified in the publication
4.5
beta-dimethylsulfoniopropanoate
presence of Mn2+, pH 8.0, temperature not specified in the publication
8.68
beta-dimethylsulfoniopropanoate
presence of Fe2+, pH 8.0, temperature not specified in the publication
8.2
diethylsulfoniopropionate
30°C, pH not specified in the publication
16.4
diethylsulfoniopropionate
-
30°C, pH not specified in the publication
31.4
diethylsulfoniopropionate
30°C, pH not specified in the publication
4.2
dimethylseleniopropionate
30°C, pH not specified in the publication
18.7
dimethylseleniopropionate
30°C, pH not specified in the publication
21.4
dimethylseleniopropionate
-
30°C, pH not specified in the publication
12.8
dimethylsulfoniopropionate
30°C, pH not specified in the publication
28.6
dimethylsulfoniopropionate
30°C, pH not specified in the publication
34.8
dimethylsulfoniopropionate
-
30°C, pH not specified in the publication
10.7
ethylmethylsulfoniopropionate
30°C, pH not specified in the publication
26.1
ethylmethylsulfoniopropionate
30°C, pH not specified in the publication
33.4
ethylmethylsulfoniopropionate
-
30°C, pH not specified in the publication
8
methylpropylsulfoniopropionate
30°C, pH not specified in the publication
27.8
methylpropylsulfoniopropionate
-
30°C, pH not specified in the publication
35.7
methylpropylsulfoniopropionate
30°C, pH not specified in the publication