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Information on EC 4.4.1.23 - 2-hydroxypropyl-CoM lyase

for references in articles please use BRENDA:EC4.4.1.23

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IUBMB Comments

Requires zinc. Acts on both enantiomers of chiral epoxyalkanes to form the corresponding (R)- and (S)-2-hydroxyalkyl-CoM adducts. The enzyme will function with some other thiols (e.g., 2-sulfanylethanol) as the nucleophile. Uses short-chain epoxyalkanes from C2 (epoxyethane) to C6 (1,2-epoxyhexane). This enzyme forms component I of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.

The enzyme appears in viruses and cellular organisms

Synonyms
eacomt, epoxyalkane:com transferase, epoxyalkane coenzyme m transferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-2-hydroxypropyl-CoM = (R)-1,2-epoxypropane + HS-CoM
show the reaction diagram
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(S)-2-hydroxypropyl-CoM = (S)-1,2-epoxypropane + HS-CoM
show the reaction diagram
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