Reference on EC 4.4.1.20 - leukotriene-C4 synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sala, A.; Garcia, M.; Zarini, S.; Rossi, J.C.; Folco, G.; Durand, T.
14,15-dehydroleukotriene A4: a specific substrate for leukotriene C4 synthase
Biochem. J.
328
225-229
1997
Homo sapiens
-
Manually annotated by BRENDA team
Penrose, J.F.
LTC4 synthase: Enzymology, biochemistry, and molecular characterization
Clin. Rev. Allergy Immunol.
17
133-152
1999
Homo sapiens
Manually annotated by BRENDA team
Penrose, J.F.; Austen, K.F.
The biochemical, molecular, and genomic aspects of leukotriene C4 synthase
Proc. Assoc. Am. Phys.
111
537-546
1999
Cavia porcellus, Homo sapiens, Mus musculus
-
Manually annotated by BRENDA team
Hevko, J.M.; Murphy, R.C.
Formation of murine macrophage-derived 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is catalyzed by leukotriene C4 synthase
J. Biol. Chem.
277
7037-7043
2002
Mus musculus
Manually annotated by BRENDA team
Sjostrom, M.; Jakobsson, P.J.; Juremalm, M.; Ahmed, A.; Nilsson, G.; Macchia, L.; Haeggstrom, J.Z.
Human mast cells express two leukotriene C4 synthase isoenzymes and the CysLT1 receptor
Biochim. Biophys. Acta
1583
53-62
2002
Homo sapiens
Manually annotated by BRENDA team
Gupta, N.; Gresser, M.J.; Ford-Hutchinson, A.W.
Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase
Biochim. Biophys. Acta
1391
157-168
1998
Homo sapiens
Manually annotated by BRENDA team
Söderström, M.; Hammarström, S.; Mannervik, B.
Leukotriene C synthase in mouse mastocytoma cells. An enzyme distinct from cytosolic and microsomal glutathione transferases
Biochem. J.
250
713-718
1988
Mus musculus
Manually annotated by BRENDA team
Christmas, P.; Weber, B.M.; McKee, M.; Brown, D.; Soberman, R.J.
Membrane localization and topology of leukotriene C4 synthase
J. Biol. Chem.
277
28902-28908
2002
Homo sapiens
Manually annotated by BRENDA team
Nicholson, D.W.; Ali, A.; Vaillancourt, J.P.; Calaycay, J.R.; Mumford, R.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.
Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits
Proc. Natl. Acad. Sci. USA
90
2015-2019
1993
Homo sapiens
Manually annotated by BRENDA team
Nicholson, D.W.; Ali, A.; Klemba, M.W.; Munday, N.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.
Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells
J. Biol. Chem.
267
17849-17857
1992
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Abe, M.; Hugli, T.E.
Characterization of leukotriene C4 synthetase in mouse peritoneal exudate cells
Biochim. Biophys. Acta
959
386-398
1988
Mus musculus
Manually annotated by BRENDA team
Soederstroem, M.; Morgenstern, R.; Hammarstroem, S.
Protein-protein interaction affinity chromatography of leukotriene C4 synthase
Protein Expr. Purif.
6
352-356
1995
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Izumi, T.; Honda, Z.; Ohishi, N.; Kitamura, S.; Tsuchida, S.; Sato, K.; Shimizu, T.; Seyama, Y.
Solubilization and partial purification of leukotriene C4 synthase from guinea-pig lung: a microsomal enzyme with high specificity towards 5,6-epoxide leukotriene A4
Biochim. Biophys. Acta
959
305-315
1988
Cavia porcellus, Rattus norvegicus
Manually annotated by BRENDA team
Goppelt-Struebe, M.
Two step purification of human and murine leukotriene C4 synthase
Biochim. Biophys. Acta
1256
257-261
1995
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Söderström, M.; Mannervik, B.; Garkov, V.; Hammarström, S.
On the nature of leukotriene C4 synthase in human platelets
Arch. Biochem. Biophys.
294
70-74
1992
Homo sapiens
Manually annotated by BRENDA team
Lam, B.K.; Frank Austen, K.
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes
Prostaglandins Other Lipid Mediat.
68-69
511-520
2002
Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Yoshimoto, T.; Soberman, R.J.; Lewis, R.A.; Austen, K.F.
Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells
Proc. Natl. Acad. Sci. USA
82
8399-8403
1985
Rattus norvegicus
Manually annotated by BRENDA team
Tornhamre, S.; Sjolinder, M.; Lindberg, A.; Ericsson, I.; Nasman-Glaser, B.; Griffiths, W.J.; Lindgren, J.A.
Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity
Eur. J. Biochem.
251
227-235
1998
Bos taurus, Equus caballus, Homo sapiens, no activity in Sus scrofa, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus
Manually annotated by BRENDA team
Wu, C.
Conversion of leukotrienes A4 to C4 in cell-free systems
Biochem. Biophys. Res. Commun.
134
85-92
1986
Cavia porcellus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Penrose, J.F.; Gagnon, L.; Goppelt-Struebe, M.; Myers, P.; Lam, B.K.; Jack, R.M.; Austen, K.F.; Soberman, R.J.
Purification of human leukotriene C4 synthase
Proc. Natl. Acad. Sci. USA
89
11603-11606
1992
Homo sapiens
Manually annotated by BRENDA team
Nicholson, D.W.; Klemba, M.W.; Rasper, D.M.; Metters, K.M.; Zamboni, R.J.
Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells
Eur. J. Biochem.
209
725-734
1992
Homo sapiens
Manually annotated by BRENDA team
Soberman, R.J.; Yoshimoto, T.
Leukotriene C4 synthase from rat basophilic leukemia cell microsomes
Methods Enzymol.
163
353-357
1988
Rattus norvegicus
Manually annotated by BRENDA team
Soberman, R.J.
Purification and properties of leukotriene C4 synthase from guinea pig lung microsomes
Methods Enzymol.
187
335-337
1990
Cavia porcellus
Manually annotated by BRENDA team
Söderström, M.; Mannervik, B.; Mammarström, S.
Leukotriene C4 synthase: characterization in mouse mastocytoma cells
Methods Enzymol.
187
306-312
1990
Mus musculus
Manually annotated by BRENDA team
Lam, B.K.; Penrose, J.F.; Rokach, J.; Xu, K.; Baldasaro, M.H.; Austen, K.F.
Molecular cloning, expression and characterization of mouse leukotriene C4 synthase
Eur. J. Biochem.
238
606-612
1996
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Bach, M.K.; Brashler, J.R.; Morton, D.R.
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase
Arch. Biochem. Biophys.
230
455-465
1984
Rattus norvegicus
Manually annotated by BRENDA team
Petric, R.; Nicholson, D.W.; Ford-Hutchinson, A.W.
Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis
Biochim. Biophys. Acta
1254
207-215
1995
Rattus norvegicus
Manually annotated by BRENDA team
Schroder, O.; Sjostrom, M.; Qiu, H.; Stein, J.; Jakobsson, P.J.; Haeggstrom, J.Z.
Molecular and catalytic properties of three rat leukotriene C4 synthase homologs
Biochem. Biophys. Res. Commun.
312
271-276
2003
Rattus norvegicus (Q925U2)
Manually annotated by BRENDA team
Svartz, J.; Blomgran, R.; Hammarstrom, S.; Soderstrom, M.
Leukotriene C4 synthase homo-oligomers detected in living cells by bioluminescence resonance energy transfer
Biochim. Biophys. Acta
1633
90-95
2003
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Schroder, O.; Sjostrom, M.; Qiu, H.; Jakobsson, P.J.; Haeggstrom, J.Z.
Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis
Cell. Mol. Life Sci.
62
87-94
2005
Rattus norvegicus
Manually annotated by BRENDA team
Yoshikawa, K.; Matsui, E.; Kaneko, H.; Fukao, T.; Inoue, R.; Teramoto, T.; Shinoda, S.; Fukutomi, O.; Aoki, M.; Kasahara, K.; Kondo, N.
A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases
Int. J. Mol. Med.
16
827-831
2005
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Zaitsu, M.; Hamasaki, Y.; Matsuo, M.; Ichimaru, T.; Fujita, I.; Ishii, E.
Leukotriene synthesis is increased by transcriptional up-regulation of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene C4 synthase in asthmatic children
J. Asthma
40
147-154
2003
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Abe, M.; Shibata, K.; Urata, H.; Sakata, N.; Katsuragi, T.
Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone
J. Cell. Physiol.
196
154-164
2003
Rattus norvegicus
Manually annotated by BRENDA team
Mansour, M.; Tornhamre, S.
Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone
J. Enzyme Inhib. Med. Chem.
19
431-436
2004
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Shimada, A.; Satoh, M.; Chiba, Y.; Saitoh, Y.; Kawamura, N.; Keino, H.; Hosokawa, M.; Shimizu, T.
Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain
Neuroscience
131
683-689
2005
Mus musculus, Mus musculus (Q60860)
Manually annotated by BRENDA team
Mandal, A.K.; Skoch, J.; Bacskai, B.J.; Hyman, B.T.; Christmas, P.; Miller, D.; Yamin, T.t.D.; Xu, S.; Wisniewski, D.; Evans, J.F.; Soberman, R.J.
The membrane organization of leukotriene synthesis
Proc. Natl. Acad. Sci. USA
101
6587-6592
2004
Homo sapiens (Q16873)
Manually annotated by BRENDA team
Lam, B.K.
Leukotriene C4 synthase
Prostaglandins Leukot. Essent. Fatty Acids
69
111-116
2003
Homo sapiens (Q16873)
Manually annotated by BRENDA team
Schmidt-Krey, I.; Kanaoka, Y.; Mills, D.J.; Irikura, D.; Haase, W.; Lam, B.K.; Austen, K.F.; Kuehlbrandt, W.
Human leukotriene C4 synthase at 4.5.ANG. resolution in projection
Structure
12
2009-2014
2004
Homo sapiens (Q16873)
Manually annotated by BRENDA team
Serio, K.J.; Luo, C.; Luo, L.; Mao, J.T.
TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes
Am. J. Physiol.
292
L215-L222
2007
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Serio, K.J.; Luo, C.; Luo, L.; Mao, J.T.
TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes
Am. J. Physiol. Lung Cell Mol. Physiol.
292
L215-L222
2007
Mus musculus, Mus musculus (Q60860)
Manually annotated by BRENDA team
Strid, T.; Soederstroem, M.; Hammarstroem, S.
Leukotriene C4 synthase promoter driven expression of GFP reveals cell specificity
Biochem. Biophys. Res. Commun.
366
80-85
2008
Mus musculus, Mus musculus (Q60860)
Manually annotated by BRENDA team
Yang, S.L.; Lou, Y.J.
Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats
Biochem. Pharmacol.
73
724-735
2007
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Mastalerz, L.; Setkowicz, M.; Sanak, M.; Rybarczyk, H.; Szczeklik, A.
Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant
Br. J. Dermatol.
154
256-260
2006
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Jame, A.J.; Lackie, P.M.; Cazaly, A.M.; Sayers, I.; Penrose, J.F.; Holgate, S.T.; Sampson, A.P.
Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4
Clin. Exp. Allergy
37
880-892
2007
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Svartz, J.; Hallin, E.; Shi, Y.; Soederstroem, M.; Hammarstroem, S.
Identification of regions of leukotriene C4 synthase which direct the enzyme to its nuclear envelope localization
J. Cell. Biochem.
98
1517-1527
2006
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Ago, H.; Kanaoka, Y.; Irikura, D.; Lam, B.K.; Shimamura, T.; Austen, K.F.; Miyano, M.
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
Nature
448
609-612
2007
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Martinez Molina, D.; Wetterholm, A.; Kohl, A.; McCarthy, A.A.; Niegowski, D.; Ohlson, E.; Hammarberg, T.; Eshaghi, S.; Haeggstroem, J.Z.; Nordlund, P.
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase
Nature
448
613-616
2007
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Freiberg, J.J.; Tybjaerg-Hansen, A.; Sillesen, H.; Jensen, G.B.; Nordestgaard, B.G.
Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease
Arterioscler. Thromb. Vasc. Biol.
28
990-996
2008
Homo sapiens
Manually annotated by BRENDA team
Ma, K.; Zhang, Y.; Zhu, D.; Lou, Y.
Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway
Eur. J. Pharmacol.
603
98-107
2009
Rattus norvegicus
Manually annotated by BRENDA team
Sveinbjoernsson, B.; Rasmuson, A.; Baryawno, N.; Wan, M.; Pettersen, I.; Ponthan, F.; Orrego, A.; Haeggstroem, J.Z.; Johnsen, J.I.; Kogner, P.
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy
FASEB J.
22
3525-3536
2008
Homo sapiens
Manually annotated by BRENDA team
Wetterholm, A.; Martinez Molina, D.; Nordlund, P.; Eshaghi, S.; Haeggstroem, J.Z.
High-level expression, purification, and crystallization of recombinant rat leukotriene C4 synthase from the yeast Pichia pastoris
Protein Expr. Purif.
60
1-6
2008
Rattus norvegicus
Manually annotated by BRENDA team
Bevan, S.; Dichgans, M.; Wiechmann, H.E.; Gschwendtner, A.; Meitinger, T.; Markus, H.S.
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations
Stroke
39
1109-1114
2008
Homo sapiens
Manually annotated by BRENDA team
Ma, K.F.; Yang, H.Y.; Chen, Z.; Qi, L.Y.; Zhu, D.Y.; Lou, Y.J.
Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model
World J. Gastroenterol.
14
2748-2756
2008
Rattus norvegicus
Manually annotated by BRENDA team
Strid, T.; Svartz, J.; Franck, N.; Hallin, E.; Ingelsson, B.; Soederstroem, M.; Hammarstroem, S.
Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein
Biochem. Biophys. Res. Commun.
381
518-522
2009
Homo sapiens (Q16873)
Manually annotated by BRENDA team
Westergren, V.S.; Wilson, S.J.; Penrose, J.F.; Howarth, P.H.; Sampson, A.P.
Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis
Clin. Exp. Allergy
39
820-828
2009
Homo sapiens (Q16873)
Manually annotated by BRENDA team
Okubo, M.; Yamanaka, H.; Kobayashi, K.; Noguchi, K.
Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain
Glia
58
599-610
2010
Rattus norvegicus (Q925U2)
Manually annotated by BRENDA team
Steinke, J.W.; Culp, J.A.; Kropf, E.; Borish, L.
Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization
J. Allergy Clin. Immunol.
124
724-730
2009
Homo sapiens (Q16873)
Manually annotated by BRENDA team
Newcomer, M.E.; Gilbert, N.C.
Location, location, location: compartmentalization of early events in leukotriene biosynthesis
J. Biol. Chem.
285
25109-25114
2010
Homo sapiens (Q16873)
Manually annotated by BRENDA team
Sanchez-Borges, M.; Acevedo, N.; Vergara, C.; Jimenez, S.; Zabner-Oziel, P.; Monzon, A.; Caraballo, L.
The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria
J. Investig. Allergol. Clin. Immunol.
19
375-382
2009
Homo sapiens
Manually annotated by BRENDA team
Freiberg, J.J.; Dahl, M.; Tybjaerg-Hansen, A.; Grande, P.; Nordestgaard, B.G.
Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals
J. Mol. Cell. Cardiol.
46
579-586
2009
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Zhao, G.; Johnson, M.C.; Schnell, J.R.; Kanaoka, Y.; Haase, W.; Irikura, D.; Lam, B.K.; Schmidt-Krey, I.
Two-dimensional crystallization conditions of human leukotriene C4 synthase requiring adjustment of a particularly large combination of specific parameters
J. Struct. Biol.
169
450-454
2010
Homo sapiens
Manually annotated by BRENDA team
Esser, J.; Gehrmann, U.; Salvado, M.D.; Wetterholm, A.; Haeggstroem, J.Z.; Samuelsson, B.; Gabrielsson, S.; Scheynius, A.; Radmark, O.
Zymosan suppresses leukotriene C4 synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors
FASEB J.
25
1417-1427
2011
Homo sapiens
Manually annotated by BRENDA team
Rinaldo-Matthis, A.; Wetterholm, A.; Martinez Molina, D.; Holm, J.; Niegowski, D.; Ohlson, E.; Nordlund, P.; Morgenstern, R.; Haeggstroem, J.Z.
Arginine 104 is a key catalytic residue in leukotriene C4 synthase
J. Biol. Chem.
285
40771-40776
2010
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Saino, H.; Ukita, Y.; Ago, H.; Irikura, D.; Nisawa, A.; Ueno, G.; Yamamoto, M.; Kanaoka, Y.; Lam, B.K.; Austen, K.F.; Miyano, M.
The catalytic architecture of leukotriene C4 synthase with two arginine residues
J. Biol. Chem.
286
16392-16401
2011
Homo sapiens (Q16873)
Manually annotated by BRENDA team
Freiberg, J.J.; Tybjaerg-Hansen, A.; Nordestgaard, B.G.
Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals
J. Thromb. Haemost.
8
1694-1701
2010
Homo sapiens
Manually annotated by BRENDA team
Di Gennaro, A.; Wagsaeter, D.; Maeyraenpaeae, M.I.; Gabrielsen, A.; Swedenborg, J.; Hamsten, A.; Samuelsson, B.; Eriksson, P.; Haeggstroem, J.Z.
Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm
Proc. Natl. Acad. Sci. USA
107
21093-21097
2010
Homo sapiens
Manually annotated by BRENDA team
Niegowski, D.; Kleinschmidt, T.; Olsson, U.; Ahmad, S.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism
J. Biol. Chem.
289
5199-5207
2014
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
MacDonald, C.A.; Bushnell, E.A.; Gauld, J.W.; Boyd, R.J.
The catalytic formation of leukotriene C4: a critical step in inflammatory processes
Phys. Chem. Chem. Phys.
16
16284-16289
2014
Homo sapiens
Manually annotated by BRENDA team
Niegowski, D.; Kleinschmidt, T.; Ahmad, S.; Qureshi, A.A.; Marback, M.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
Structure and inhibition of mouse leukotriene C4 synthase
PLoS ONE
9
e96763
2014
Mus musculus, Mus musculus (Q60860)
Manually annotated by BRENDA team
Liening, S.; Scriba, G.K.; Rummler, S.; Weinigel, C.; Kleinschmidt, T.K.; Haeggstroem, J.Z.; Werz, O.; Garscha, U.
Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors
Biochim. Biophys. Acta
1861
1605-1613
2016
Homo sapiens (Q16873)
Manually annotated by BRENDA team
Hong, F.F.; Wang, Y.F.; Liu, H.; Yang, M.W.; Yang, S.L.
V-PYRRO/NO downregulates mRNA expression levels of leukotriene C4 synthase during hepatic ischemia reperfusion injury in rats via inhibition of the nuclear factor-kappaB activation pathway
Biomed. Rep.
4
112-116
2016
Rattus norvegicus (G3V6E6)
Manually annotated by BRENDA team
Ahmad, S.; Ytterberg, A.J.; Thulasingam, M.; Tholander, F.; Bergman, T.; Zubarev, R.; Wetterholm, A.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
Phosphorylation of leukotriene C4 synthase at serine 36 impairs catalytic activity
J. Biol. Chem.
291
18410-18418
2016
Homo sapiens (Q16873)
Manually annotated by BRENDA team
Kleinschmidt, T.K.; Haraldsson, M.; Basavarajappa, D.; Lundeberg, E.; Thulasingam, M.; Ekoff, M.; Fauland, A.; Lehmann, C.; Kahnt, A.S.; Lindbom, L.; Haeggstroem, J.Z.
Tandem benzophenone amino pyridines, potent and selective inhibitors of human leukotriene C4 synthase
J. Pharmacol. Exp. Ther.
355
108-116
2015
Homo sapiens, Homo sapiens (Q16873)
Manually annotated by BRENDA team
Zhang, Z.; Lv, Z.; Wei, Z.; Li, C.; Shao, Y.; Zhang, W.; Zhao, X.; Xiong, J.
Microsomal glutathione transferase 2 modulates LTC4 synthesis and ROS production in Apostichopus japonicus
Mol. Immunol.
91
114-122
2017
Apostichopus japonicus (A0A219VGM9), Apostichopus japonicus
Manually annotated by BRENDA team