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Information on EC 4.4.1.2 - homocysteine desulfhydrase

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IUBMB Comments
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing hydrogen sulfide and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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Synonyms
desulfhydrase, homocysteine, homocysteine desulfurase, Hyc gamma-lyase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-aminobut-2-enoate = 2-iminobutanoate
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spontaneous
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2-iminobutanoate + H2O = 2-oxobutanoate + NH3
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spontaneous
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L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate
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overall reaction
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L-homocysteine = hydrogen sulfide + 2-aminobut-2-enoate
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(1a)
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