Disease on EC 4.4.1.11 - methionine gamma-lyase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
[Glycoproteins associated with metastatic potential of cancer]
Adrenocortical Carcinoma
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.
Amebiasis
Crystallization and preliminary X-ray analysis of L-methionine gamma-lyase 1 from Entamoeba histolytica.
Anaphylaxis
PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates.
Safety and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates.
Arthritis
Anti-inflammatory activity of myricetin-3-O-beta-D-glucuronide and related compounds.
Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats.
Ataxia
Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons.
Atherosclerosis
Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.
Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice.
Autoimmune Diseases
Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45.
Brain Diseases
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats.
Brain Neoplasms
Total Methionine Restriction Treatment of Cancer.
Breast Neoplasms
Influence of L-methioninase targeted to the urokinase receptor on the proliferation and motility of lung and prostate cancer cells.
Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers.
Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons.
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients.
Targeting a methioninase-containing fusion protein to breast cancer urokinase receptors inhibits growth and migration.
Targeting of a novel fusion protein containing methioninase to the urokinase receptor to inhibit breast cancer cell migration and proliferation.
Carcinogenesis
Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms.
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.
Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase.
Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma.
Carcinoma
Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase.
Anticancer efficacy of methioninase in vivo.
Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages.
Evaluation of METase-pemetrexed-loaded PEG-PLGA nanoparticles modified with anti-CD133-scFV for treatment of gastric carcinoma.
Evaluation of rMETase-Loaded Stealth PLGA/Liposomes Modified with Anti-CAGE scFV for Treatment of Gastric Carcinoma.
Initiating activity of eight pyrolysates of carbohydrates in a two-stage mouse skin tumorigenesis model.
Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers.
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase.
Stealth cationic liposomes modified with anti-CAGE single-chain fragment variable deliver recombinant methioninase for gastric carcinoma therapy.
The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma.
Carcinoma, Adenosquamous
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Carcinoma, Hepatocellular
The cyanobacterial oligopeptides microginins induce DNA damage in the human hepatocellular carcinoma (HepG2) cell line.
Carcinoma, Lewis Lung
Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase.
Carcinoma, Squamous Cell
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Cholangitis, Sclerosing
Monoacylglycerol lipase inhibition protects from liver injury in mouse models of sclerosing cholangitis.
Cholesteatoma
Expression of C-type lectin receptor mRNA in chronic otitis media with cholesteatoma.
Colitis, Ulcerative
Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis.
Colonic Neoplasms
Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model.
Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice.
Endosomal escape by photo-activated fusion of liposomes containing a malachite green derivative: a novel class of photoresponsive liposomes for drug delivery vehicles.
MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.
Recombinant Engineering of L-Methioninase Using Two Different Promoter and Expression Systems and in vitro Analysis of Its Anticancer Efficacy on Different Human Cancer Cell Lines.
Colorectal Neoplasms
Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3.
Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer.
The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma.
Communicable Diseases
Methionine gamma-lyase: The unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers.
Cysts
[Evaluation of Giardia lamblia detection method in stool specimens fixed with SAF solution]
Dry Eye Syndromes
Relationships Between Meibomian Gland Loss and Age, Sex, and Dry Eye.
The influence of meibomian gland loss on ocular surface clinical parameters.
Dyslipidemias
Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.
Encephalomyelitis
Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation.
Encephalomyelitis, Autoimmune, Experimental
Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation.
Fibrosarcoma
Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment.
Methioninase Gene Therapy.
Genetic Diseases, Inborn
The DNA methylation machinery as a target for anticancer therapy.
Glaucoma
Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment.
Glioma
Alteration of endocannabinoid system in human gliomas.
Glomerulonephritis, Membranoproliferative
Discriminant analysis in renal histological diagnosis of primary glomerular diseases.
Graft vs Host Disease
Effects of magnesium isoglycyrrhizinate on AST, ALT, and serum levels of Th1 cytokines in patients with allo-HSCT.
Heart Diseases
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
Hematuria
[Idiopathic nephrotic syndrome with diffuse mesangial proliferation]
[Prognosis of nephrosis]
Hepatitis
Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4(+)CD25(-)CD69(+) subset proliferation.
Hepatitis, Autoimmune
Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4(+)CD25(-)CD69(+) subset proliferation.
Hyperalgesia
Inhibition of monoacylglycerol lipase: Another signalling pathway for potential therapeutic targets in migraine?
Hyperglycemia
The impact of glycemic variability on length of stay and mortality in diabetic patients admitted with community-acquired pneumonia or chronic obstructive pulmonary disease.
Hypersensitivity
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment.
Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms.
Hypertension
[Idiopathic nephrotic syndrome with diffuse mesangial proliferation]
Hypoglycemia
The impact of glycemic variability on length of stay and mortality in diabetic patients admitted with community-acquired pneumonia or chronic obstructive pulmonary disease.
Infections
Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry.
Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment.
Methioninase Gene Therapy.
The C-type lectin receptor MGL senses N-acetylgalactosamine on the unique Staphylococcus aureus ST395 wall teichoic acid.
Influenza, Human
Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry.
Insulin Resistance
Flavonoids Fraction of Mespilus Germanica Alleviates Insulin Resistance in Metabolic Syndrome Model of Ovariectomized Rats via Reduction in Tumor Necrosis Factor-?.
Kidney Neoplasms
Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
Leukemia
Glycoproteomic analysis of MGL binding proteins on acute T cell leukemia cells.
Leukemia, T-Cell
Glycoproteomic analysis of MGL binding proteins on acute T cell leukemia cells.
Liposarcoma
Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma.
Liver Diseases
Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption.
Lung Neoplasms
Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1).
Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.
Methioninase Gene Therapy.
Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts.
Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase.
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
Survival efficacy of the combination of the methioninase gene and methioninase in a lung cancer orthotopic model.
Lymphoma
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
Melanoma
Afterword: Oral Methioninase-Answer to Cancer and Fountain of Youth?
Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells In Vitro.
Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma.
Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model.
High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer.
Long exposure of non-cytotoxic concentrations of methylselenol suppresses the invasive potential of B16F10 melanoma.
Methylselenol generated from selenomethionine by methioninase downregulates integrin expression and induces caspase-mediated apoptosis of B16F10 melanoma cells.
Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.
Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy.
Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models.
Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.
methionine gamma-lyase deficiency
Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.
Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic ?-opioid receptor sensitivity.
Multiple Myeloma
A quantitative method for the characterization of lytic metastases of the bone from radiographic images.
Multiple Sclerosis
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.
Neoplasm Metastasis
A quantitative method for the characterization of lytic metastases of the bone from radiographic images.
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Oral Recombinant Methioninase Overcomes Colorectal-cancer Liver Metastasis Resistance to the Combination of 5-Fluorouracil and Oxaliplatinum in a Patient-derived Orthotopic Xenograft Mouse Model.
Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill chemotherapy moves toward the clinic.
Neoplasms
A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension.
Afterword: Oral Methioninase-Answer to Cancer and Fountain of Youth?
Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase.
Anticancer efficacy of methioninase in vivo.
Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells In Vitro.
Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells.
Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5'-phosphate.
Clonostachys rosea demethiolase STR3 controls the conversion of methionine into methanethiol.
Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma.
Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model.
Crystallization and preliminary crystallographic characterization of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane lyase (methioninase).
Development of Recombinant Methioninase for Cancer Treatment.
Dietary Methionine Restriction-Based Cancer Chemotherapy in Rodents.
DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1).
Docking based virtual screening and molecular dynamics study to identify potential monoacylglycerol lipase inhibitors.
Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms.
Effect of the methanolic extract of Glinus lotoides on Dalton's ascitic lymphoma.
Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase.
Effects in Cancer Cells of the Recombinant l-Methionine Gamma-Lyase from Brevibacterium aurantiacum. Encapsulation in Human Erythrocytes for Sustained l-Methionine Elimination.
Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model.
Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review.
Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice.
Enzyme prodrug therapy designed to target L-methioninase to the tumor vasculature.
Evaluation of rMETase-Loaded Stealth PLGA/Liposomes Modified with Anti-CAGE scFV for Treatment of Gastric Carcinoma.
Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis.
Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase.
Gene cloning, characterization, and cytotoxic activity of methionine ?-lyase from Clostridium novyi.
Glycoproteomic analysis of MGL binding proteins on acute T cell leukemia cells.
High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer.
Hyaluronic acid-modified polyamidoamine dendrimer G5-entrapped gold nanoparticles delivering METase gene inhibits gastric tumor growth via targeting CD44+ gastric cancer cells.
In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.
Influence of L-methioninase targeted to the urokinase receptor on the proliferation and motility of lung and prostate cancer cells.
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.
Initiating activity of eight pyrolysates of carbohydrates in a two-stage mouse skin tumorigenesis model.
Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers.
L-methionase: a therapeutic enzyme to treat malignancies.
Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma.
METase promotes cell autophagy via promoting SNHG5 and suppressing miR-20a in gastric cancer.
Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate.
Methioninase Cell-Cycle Trap Cancer Chemotherapy.
Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment.
Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.
Methioninase Gene Therapy.
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.
Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts.
Methionine Gamma Lyase from Clostridium sporogenes Increases the Anticancer Efficacy of Doxorubicin on A549 Cancer Cells In Vitro and Human Cancer Xenografts.
Methionine gamma-lyase: The unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers.
Methionine starvation modulates the efficacy of cisplatin on human breast cancer in nude mice.
Methionine tumor starvation by erythrocyte-encapsulated methionine gamma-lyase activity controlled with per os vitamin B6.
Methods to Study the Role of Methionine-Restricted Diet and Methioninase in Cancer Growth Control.
MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Microbial L-methioninase: production, molecular characterization, and therapeutic applications.
Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma.
Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.
Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma.
Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy.
Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates.
Phosphatidylserine: A cancer cell targeting biomarker.
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.
Polyethylene glycol conjugation of recombinant methioninase for cancer therapy.
Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer.
Protein carboxyl amidation increases the potential extent of protein polyethylene glycol conjugation.
Purification, Characterization of L-Methioninase from Candida tropicalis, and Its Application as an Anticancer.
Recombinant Engineering of L-Methioninase Using Two Different Promoter and Expression Systems and in vitro Analysis of Its Anticancer Efficacy on Different Human Cancer Cell Lines.
Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models.
Recombinant Methioninase as a DNA Demethylation Agent.
Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model.
Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma.
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway.
Safety and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates.
Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity.
Selenomethionine and Methioninase: Selenium Free Radical Anticancer Activity.
Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients.
Soluble and Nanoporous Silica Gel-Entrapped
Survival efficacy of the combination of the methioninase gene and methioninase in a lung cancer orthotopic model.
Targeted enzyme prodrug therapy for metastatic prostate cancer - a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase.
Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.
Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.
Targeting of a novel fusion protein containing methioninase to the urokinase receptor to inhibit breast cancer cell migration and proliferation.
The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL.
The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma.
The DNA methylation machinery as a target for anticancer therapy.
The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions.
The Plasticity of Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin.
The preparation of endotoxin-free L-methionine-alpha-deamino-gamma-mercaptomethane-lyase (L-methioninase) from Pseudomonas putida.
The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes.
Treatment of cancer cells with methioninase produces DNA hypomethylation and increases DNA synthesis.
Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.
Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction.
Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill chemotherapy moves toward the clinic.
[Molecular and biochemical principles of neoplasm enzyme therapy]
[Research development of tumor treatment with methionine gamma-lyase].
Neuralgia
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment.
Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol.
Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model.
Neuroblastoma
Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.
Neurodegenerative Diseases
Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism.
Refined homology model of monoacylglycerol lipase: toward a selective inhibitor.
Non-alcoholic Fatty Liver Disease
Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption.
Prevention of free fatty acid-induced hepatic lipotoxicity in HepG2 cells by magnesium isoglycyrrhizinate in vitro.
Obesity
Erratum: Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity.
Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity.
Investigations of the human endocannabinoid system in two subcutaneous adipose tissue depots in lean subjects and in obese subjects before and after weight loss.
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
Osteosarcoma
Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase.
Methioninase Cell-Cycle Trap Cancer Chemotherapy.
Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma.
Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill chemotherapy moves toward the clinic.
Ovarian Neoplasms
Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment.
Methioninase Gene Therapy.
Recombinant Engineering of L-Methioninase Using Two Different Promoter and Expression Systems and in vitro Analysis of Its Anticancer Efficacy on Different Human Cancer Cell Lines.
Pancreatic Neoplasms
Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.
Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.
Papilloma
Initiating activity of eight pyrolysates of carbohydrates in a two-stage mouse skin tumorigenesis model.
Parkinson Disease
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
Prostatic Neoplasms
Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells.
Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol.
Influence of L-methioninase targeted to the urokinase receptor on the proliferation and motility of lung and prostate cancer cells.
Targeted enzyme prodrug therapy for metastatic prostate cancer - a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase.
Proteinuria
An unusual manifestation in a patient with adult-onset Still's disease: Minimal glomerular lesion.
[Idiopathic nephrotic syndrome with diffuse mesangial proliferation]
[Prognosis of nephrosis]
Retinoblastoma
Activity of Se-allylselenocysteine in the presence of methionine gamma-lyase on cell growth, DNA integrity, apoptosis, and cell-cycle regulatory molecules.
Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms.
Sarcoma
Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase.
Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma.
Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma.
Sarcoma, Ewing
Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model.
High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer.
Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Sarcoma, Synovial
Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model.
Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model.
Sarcoma, Yoshida
Anticancer efficacy of methioninase in vivo.
Seizures
Audiogenic seizure sensitivity in mouse lines genetically selected for high versus low blood magnesium levels.
Sepsis
Hyperglycemia and glycemic variability are associated with the severity of sepsis in nondiabetic subjects.
Starvation
Intestinal monoacylglycerol metabolism: developmental and nutritional regulation of monoacylglycerol lipase and monoacylglycerol acyltransferase.
Methionine tumor starvation by erythrocyte-encapsulated methionine gamma-lyase activity controlled with per os vitamin B6.
Stomach Neoplasms
A novel design of HA-coated nanoparticles co-encapsulating plasmid METase and 5-Fu shows enhanced application in targeting gastric cancer stem cells.
Evaluation of rMETase-Loaded Stealth PLGA/Liposomes Modified with Anti-CAGE scFV for Treatment of Gastric Carcinoma.
Hyaluronic acid-modified polyamidoamine dendrimer G5-entrapped gold nanoparticles delivering METase gene inhibits gastric tumor growth via targeting CD44+ gastric cancer cells.
METase promotes cell autophagy via promoting SNHG5 and suppressing miR-20a in gastric cancer.
METase/lncRNA HULC/FoxM1 reduced cisplatin resistance in gastric cancer by suppressing autophagy.
Methioninase Cell-Cycle Trap Cancer Chemotherapy.
Stealth cationic liposomes modified with anti-CAGE single-chain fragment variable deliver recombinant methioninase for gastric carcinoma therapy.
The mechanism study of lentiviral vector carrying methioninase enhances the sensitivity of drug-resistant gastric cancer cells to Cisplatin.
Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.
Stomach Ulcer
Effect of pyridoxine and magnesium on stress-induced gastric ulcers in mice selected for low or high blood magnesium levels.
Tuberculosis
Complement activation by mycoloyl glycolipids from Mycobacterium tuberculosis and Rhodococcus ruber.
[Culture of mycobacterium tuberculosis of gastric juice collected through different ways in diagnosis of pulmonary tuberculosis in children]
Uterine Cervical Neoplasms
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Virus Diseases
Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry.