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Abscess
Streptococcus anginosusl-cysteine desulfhydrase gene expression is associated with abscess formation in BALB/c mice.
Acquired Immunodeficiency Syndrome
Hepatic gamma-cystathionase deficiency in patients with AIDS.
Acquired Immunodeficiency Syndrome
Sulfur metabolism in AIDS: cystamine as an anti-HIV agent.
Acquired Immunodeficiency Syndrome
Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets.
Acute Lung Injury
Cystathionine-gamma-lyase inhibitor attenuates acute lung injury induced by acute pancreatitis in rats.
Adenocarcinoma, Follicular
Germline PTEN mutations in Cowden syndrome-like families.
Anemia, Hypochromic
Sodium Hydrosulfide Mitigates Cadmium Toxicity by Promoting Cadmium Retention and Inhibiting Its Translocation from Roots to Shoots in Brassica napus.
Asthma
Age-Dependent Allergic Asthma Development and Cystathionine Gamma-Lyase Deficiency.
Astrocytoma
The expression and activity of cystathionine-gamma-lyase and 3-mercaptopyruvate sulfurtransferase in human neoplastic cell lines.
Atherosclerosis
Anti-atherogenic effect of hydrogen sulfide by over-expression of cystathionine gamma-lyase (CSE) gene.
Bradycardia
Hydrogen sulfide as an oxygen sensor in trout gill chemoreceptors.
Breast Neoplasms
Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells.
Breast Neoplasms
Screening for germline phosphatase and tensin homolog-mutations in suspected Cowden syndrome and Cowden syndrome-like families among uterine cancer patients.
Breast Neoplasms
The nutritional phenome of EMT-induced cancer stem-like cells.
Carcinoma
Origin of clear cell carcinoma: nature or nurture?
Carcinoma
Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research.
Carcinoma, Ehrlich Tumor
Nephroprotective effect of cystathionine is due to its diverse action on the kidney and Ehrlich ascites tumor cells.
Cardiovascular Diseases
Norswertianolin Promotes Cystathionine ?-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension.
Cataract
Disorders of nucleotide excision repair.
Chronic Periodontitis
Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme.
Colitis
Rhodanese, but not cystathionine-gamma-lyase, is associated with dextran sulfate sodium-evoked colitis in mice: a sign of impaired colonic sulfide detoxification?
Contracture
Disorders of nucleotide excision repair.
cystathionine gamma-lyase deficiency
Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis.
cystathionine gamma-lyase deficiency
Age-Dependent Allergic Asthma Development and Cystathionine Gamma-Lyase Deficiency.
cystathionine gamma-lyase deficiency
Cystathionase deficiency in fibroblast cultures from a patient with primary cystathioninuria.
cystathionine gamma-lyase deficiency
Cystathionase deficiency: evidence for genetic heterogeneity in primary cystathioninuria.
cystathionine gamma-lyase deficiency
Cystathionase deficiency: the effect of cofactor on the stability of normal and abnormal enzyme from lymphoid cell lines.
cystathionine gamma-lyase deficiency
Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells.
cystathionine gamma-lyase deficiency
Hepatic gamma-cystathionase deficiency in patients with AIDS.
cystathionine gamma-lyase deficiency
L-cysteine and glutathione metabolism are impaired in premature infants due to cystathionase deficiency.
cystathionine gamma-lyase deficiency
Maternal gamma-cystathionase deficiency: absence of both teratogenic effects and pregnancy complications.
Dehydration
Hydrogen sulfide promotes rice drought tolerance via reestablishing redox homeostasis and activation of ABA biosynthesis and signaling.
Dehydration
Hydrogen Sulfide-Mediated Activation of O-Acetylserine (Thiol) Lyase and l/d-Cysteine Desulfhydrase Enhance Dehydration Tolerance in Eruca sativa Mill.
Diabetes Mellitus
CARDIOMYOCYTE DNA CONTENT AND ITS LINK TO CSE/ H2S SYSTEM IN THE HEART OF EXPERIMENTAL DIABETIC RATS.
Endodermal Sinus Tumor
Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors.
Endotoxemia
Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia.
Erectile Dysfunction
[Expressions of CSE and CBS in the corpus cavernosum of spontaneous hypertensive rats].
Erectile Dysfunction
[Expressions of cystathionine-beta-synthase and cystathionine-gamma-lyase in the corpus cavernosum smooth muscle of castrated rats].
Essential Hypertension
Functional promoter polymorphisms direct the expression of cystathionine gamma-lyase gene in mouse models of essential hypertension.
Essential Hypertension
Relationship between cystathionine gamma-lyase gene polymorphism and essential hypertension in Northern Chinese Han population.
Fanconi Anemia
Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair.
Glioma
Cystathionine as a marker for 1p/19q codeleted gliomas by in vivo magnetic resonance spectroscopy.
Glioma
Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells.
Heart Failure
Homocysteine, hydrogen sulfide (H2S) and NMDA-receptor in heart failure.
Hemorrhagic Stroke
A diet rich in taurine, cysteine, folate, B12 and betaine may lessen risk for Alzheimer's disease by boosting brain synthesis of hydrogen sulfide.
Homocystinuria
Homocystinuria: studies on cystathionine beta-synthase, S-adenosylmethionine synthetase and cystathionase activities in skin fibroblasts.
Hyperalgesia
Hydrogen sulfide as a novel nociceptive messenger.
Hypercholesterolemia
THE STATE OF THE CYSTATHIONINE GAMMA-LYASE / H2S SYSTEM IN THE LIVER AND SKELETAL MUSCLES OF RATS WITH HYPERCHOLESTEROLEMIA UNDER SIMVASTATIN ADMINISTRATION.
Hyperhomocysteinemia
Calcium sensing receptor initiating cystathionine-gamma-lyase/hydrogen sulfide pathway to inhibit platelet activation in hyperhomocysteinemia rat.
Hyperhomocysteinemia
H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia.
Hypertension
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.
Hypertension
Norswertianolin Promotes Cystathionine ?-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension.
Hypertension
The importance of MTHFR, MTR, MTRR and CSE expression levels in Caucasian women with preeclampsia.
Hypertension
The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats.
Hypertension
The redox biochemistry of hydrogen sulfide.
Hypertension, Pulmonary
[Interaction between endogenous nitric oxide and hydrogen sulfide in pathogenesis of hypoxic pulmonary hypertension]
Hyperthyroidism
Effects of hypo- and hyperthyroidism on the activity of cystathionase in mammalian parenchymatous organs during early development.
Hypothyroidism
Fetal Hypothyroidism Impairs Aortic Vasorelaxation Responses in Adulthood: Involvement of Hydrogen Sulfide and Nitric Oxide Cross talk.
Hypothyroidism
SULPHUR-CONTAINING AMINO ACIDS METABOLISM IN EXPERIMENTAL HYPER- AND HYPOTHYROIDISM IN RATS.
Infections
Characterization of cysteine-degrading and H2S-releasing enzymes of higher plants - from the field to the test tube and back.
Infections
Methionine transsulfuration is increased during sepsis in rats.
Infections
Sulphur supply and infection with Pyrenopeziza brassicae influence L-cysteine desulphydrase activity in Brassica napus L.
Insulin Resistance
H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells.
Leukemia
L-cyst(e)ine requirements of malignant cells and progress toward depletion therapy.
Leukemia
Reduced gamma-cystathionase protein content in human malignant leukemia cell lines as measured by immunoassay with monoclonal antibody.
Liver Failure
Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury.
Liver Neoplasms
The interaction of disulfiram and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth.
Lung Injury
Inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury.
Melanoma
Cystathionase mediates senescence evasion in melanocytes and melanoma cells.
Melanoma
The expression and activity of cystathionine-gamma-lyase and 3-mercaptopyruvate sulfurtransferase in human neoplastic cell lines.
Motor Neuron Disease
Inhibition of cystathionine-gamma-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS.
Myocardial Ischemia
The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat.
Neoplasms
A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells into S/G2/M-phases.
Neoplasms
Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth.
Neoplasms
Aminotransferase, L-amino acid oxidase and beta-lyase reactions involving L-cysteine S-conjugates found in allium extracts. Relevance to biological activity?
Neoplasms
Anti-CD73 and Anti-OX40 immunotherapy coupled with a novel biocompatible enzyme prodrug system for the treatment of recurrent, metastatic ovarian cancer.
Neoplasms
Antitumor Synergism and Enhanced Survival with a Tumor Vasculature-Targeted Enzyme Prodrug System, Rapamycin, and Cyclophosphamide.
Neoplasms
Basal/HER2 breast carcinomas: integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin).
Neoplasms
Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors.
Neoplasms
CYSTEINE DESULFHYDRASE AND RHODANASE ACTIVITY IN CELLS OF TISSUE CULTURES AND IN TRANSPLANTABLE TUMORS.
Neoplasms
Distinct Alterations in Tricarboxylic Acid Cycle Metabolites Associate with Cancer and Autism Phenotypes in Cowden Syndrome and Bannayan-Riley-Ruvalcaba Syndrome.
Neoplasms
Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes.
Neoplasms
L-cyst(e)ine requirements of malignant cells and progress toward depletion therapy.
Neoplasms
Modulation of resistance to anticancer drugs by inhibition of metallothionein synthesis.
Neoplasms
Nephroprotective effect of cystathionine is due to its diverse action on the kidney and Ehrlich ascites tumor cells.
Neoplasms
Screening for germline phosphatase and tensin homolog-mutations in suspected Cowden syndrome and Cowden syndrome-like families among uterine cancer patients.
Neoplasms
Sensitivity to radiation treatment and changes in metallothionein synthesis in a transplanted murine tumor.
Neoplasms
The nutritional phenome of EMT-induced cancer stem-like cells.
Neoplasms
Transcriptomic Profiling of MDA-MB-231 Cells Exposed to
Neoplasms
Tumor-associated mesenchymal stem cells inhibit naïve T cell expansion by blocking cysteine export from dendritic cells.
Neoplasms
Value of discrepancy of the central scar-like structure between dynamic CT and gadoxetate disodium-enhanced MRI in differentiation of focal nodular hyperplasia and hepatocellular adenoma.
Neuroblastoma
Cystathionine metabolism in neuroblastoma.
Neuroblastoma
The expression and activity of cystathionine-gamma-lyase and 3-mercaptopyruvate sulfurtransferase in human neoplastic cell lines.
Pancreatitis
Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine ?-synthase.
Pancreatitis
Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis.
Pancreatitis
Cystathionine-gamma-lyase inhibitor attenuates acute lung injury induced by acute pancreatitis in rats.
Pancreatitis
Inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury.
Periodontal Pocket
Cystalysin, a 46-kilodalton cysteine desulfhydrase from Treponema denticola, with hemolytic and hemoxidative activities.
Periodontitis
Dimerization and folding processes of Treponema denticola cystalysin: the role of pyridoxal 5'-phosphate.
Periodontitis
Targeting Cystalysin, a Virulence Factor of Treponema denticola-Supported Periodontitis.
Pre-Eclampsia
The importance of rs1021737 and rs482843 polymorphisms of cystathionine gamma-lyase in the etiology of preeclampsia in the Caucasian population.
Pregnancy Complications
Maternal gamma-cystathionase deficiency: absence of both teratogenic effects and pregnancy complications.
Pulmonary Fibrosis
Hydrogen sulfide attenuates epithelial-mesenchymal transition of human alveolar epithelial cells.
Pulmonary Fibrosis
Hydrogen sulfide attenuates the pathogenesis of pulmonary fibrosis induced by bleomycin in rats.
Reperfusion Injury
[Effects of stimulation and blockade of the synthesis of endogenous hydrogen sulfide at myocardial ischemia-reperfusion].
Reperfusion Injury
[Protection of CSE/H2S system in hepatic ischemia reperfusion injury in rats].
Rhinitis, Allergic
[The role of hydrogen sulfide and cystathionine-gamma-lyase in allergic rhinitis guinea pigs]
Root Resorption
Cystathionine gamma lyase aggravates orthodontic root resorption in mice.
Root Resorption
Cystathionine gamma lyase and hydrogen sulfide: new players in orthodontic root resorption.
Scrapie
Endogenous synthesis of 2-aminoacrylate contributes to cysteine sensitivity in Salmonella enterica.
Seminoma
Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors.
Sepsis
Correction: Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.
Sepsis
Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.
Sepsis
Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis*
Starvation
The nutritional phenome of EMT-induced cancer stem-like cells.
Starvation
Transcriptional regulation of Saccharomyces cerevisiae CYS3 encoding cystathionine gamma-lyase.
Stomach Neoplasms
A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells into S/G2/M-phases.
Synostosis
Craniosynostosis in transgenic mice overexpressing Nell-1.
Testicular Neoplasms
Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors.
Thymoma
Accumulation of cystine auxotrophic thymocytes accompanying type C viral leukemogenesis in the mouse.
Thyroid Cancer, Papillary
Diallyl trisulfide, a H2 S donor, inhibits cell growth of human papillary thyroid carcinoma KTC-1 cells through a positive feedback loop between H2 S and cystathionine-gamma-lyase.
Thyroid Cancer, Papillary
Germline compound heterozygous poly-glutamine deletion in USF3 may be involved in predisposition to heritable and sporadic epithelial thyroid carcinoma.
Tuberculosis
Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria.
Ureteral Obstruction
[Change in plasma H2S level and therapeutic effect of H2S supplementation in tubulointerstitial fibrosis among rats with unilateral ureteral obstruction].
Urinary Bladder Neoplasms
Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth.
Uterine Neoplasms
Screening for germline phosphatase and tensin homolog-mutations in suspected Cowden syndrome and Cowden syndrome-like families among uterine cancer patients.
Virus Diseases
Accumulation of cystine auxotrophic thymocytes accompanying type C viral leukemogenesis in the mouse.
Vitamin B 6 Deficiency
Effects of pyridoxine deficiency on the adaptation of rat liver cystathionase to DL-ethionine and to thyroidectomy.
Vitamin B 6 Deficiency
Increase of serin dehydratase, homoserine dehydratase and cystine (cysteine) desulfhydrase in rat liver due to a high protein diet and the influence of vitamin B6 deficiency.
Vitamin B 6 Deficiency
Vitamin B6 deficiency accelerates metabolic turnover of cystathionase in rat liver.
Xeroderma Pigmentosum
Cockayne syndrome pathogenesis: lessons from mouse models.
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4.4.1.1 cystathionine gamma-lyase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
