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BRENDA support

Information on EC 4.3.3.5 - 4'-demethylrebeccamycin synthase

for references in articles please use BRENDA:EC4.3.3.5

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IUBMB Comments

This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a glycosylase, and acts in the reverse direction to that shown. It has a wide substrate range, and was shown to glycosylate several substrates, including the staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin C and indolo-[2,3-a]-carbazole [1,2].

The enzyme appears in viruses and cellular organisms

Synonyms
ngt, RebG, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4'-O-demethylrebeccamycin + H2O = dichloro-arcyriaflavin A + beta-D-glucose
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
rebeccamycin biosynthesis
Highest Expressing Human Cell Lines
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