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(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
-
-
?
L-gamma-glutamyl-L-epsilon-lysine
5-oxoproline + L-lysine
-
-
-
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
(gamma-L-glutamyl)-L-serine
5-oxoproline + L-serine
-
-
-
-
?
5-glutamyl-glutathione
5-oxoproline + glutathione
-
-
-
?
5-L-glutamyl-1-naphthylamide
5-oxoproline + naphthylamine
-
best substrate
-
?
5-L-glutamyl-5-L-glutamyl-4-nitroanilide
5-oxoproline + 5-L-glutamyl-4-nitroanilide
-
-
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
5-L-glutamyl-L-alanine
5-oxoproline + L-alanine
-
low activity compared to glutathione
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
5-L-glutamyl-L-leucine
5-oxoproline + L-leucine
-
-
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
5-L-glutamyl-S-methyl-L-cysteine
5-oxoproline + S-methyl-L-cysteine
D-gamma-glutamyl-O-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]-L-serine
5-oxoproline + O-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]-L-serine
-
-
-
-
?
gamma-glutamyl-L-alanine
5-oxoproline + alanine
-
-
-
?
gamma-L-Glu-epsilon-N-benzyloxycarbonyl-L-Lys
epsilon-N-benzyloxycarbonyl-L-Lys + 5-oxo-L-proline
-
-
-
?
gamma-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
enzyme of L-glutamyl-cycle
-
?
Gln1-containing peptide
pyroglutamyl peptide
-
-
-
-
?
L-gamma-glutamyl-O-[(4-methylumbelliferyl)carbonyl]-L-serine
(2S)-2-amino-3-([[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]carbonyl]oxy)propanoic acid + 5-oxo-L-proline
fluorogenic probe
-
-
?
N5-((S)-1-carboxy-3-(ethyl(((3-oxo-3H-phenoxazin-7-yl)oxy)carbonyl)amino)propyl)-L-glutamine
(2S)-2-amino-4-(ethyl[[(3-oxo-3H-phenoxazin-7-yl)oxy]carbonyl]amino)butanoic acid + 5-oxo-L-proline
fluorogenic probe
-
-
?
additional information
?
-
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
-
-
-
?
(gamma-L-glutamyl)-L-amino acid
5-oxoproline + L-amino acid
-
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
-
-
?
5-L-glutamyl-glycine
5-oxoproline + glycine
-
-
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
best substrate
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
best substrate
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alanine
5-L-oxoproline + L-alanine
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-alpha-aminobutyrate
5-L-oxoproline + L-alpha-aminobutyrate
-
-
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
-
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
stereospecific
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with LD-, DD- and DL-isomers of 5-L-glutamyl-5-L-glutamyl-4-nitroanilide
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamine
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamine
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with: glutathione, i.e. gamma-L-glutamyl-L-cysteinylglycine
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with L-glutamyl-beta-alanine, L-glutamyl-3-aminoisobutyrate
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
highly specific for 5-L-glutamyl peptides
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
preferred substrates: 5-L-glutamyl-5-L-glutamyl-amino acids
-
?
5-L-glutamyl-L-amino acid
5-oxoproline + L-amino acid
-
no activity with: 5-glutamyl-4-nitroanilide
i.e. 2-pyrrolidone-5-carboxylic acid
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
-
-
?
5-L-glutamyl-L-glutamine
5-oxoproline + L-glutamine
-
-
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
poor substrate
-
?
5-L-glutamyl-L-phenylalanine
5-oxoproline + L-phenylalanine
-
poor substrate
-
?
5-L-glutamyl-S-methyl-L-cysteine
5-oxoproline + S-methyl-L-cysteine
-
-
-
?
5-L-glutamyl-S-methyl-L-cysteine
5-oxoproline + S-methyl-L-cysteine
-
-
-
?
additional information
?
-
-
N-terminal pyroglutamate formation is a posttranslational event in the processing of bioactive neuropeptides such as thyrotropin-releasing hormone and neurotensin during their maturation in the secretory pathway. The enzyme also catalyzes N-terminal glutamate cyclization
-
-
?
additional information
?
-
-
no activity with L-Glu-4-nitroanilide
-
-
?
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Asthma
Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population.
Asthma
Association of ADAM33 gene polymorphisms with asthma in Indian children.
Bacterial Infections
RipAY, a Plant Pathogen Effector Protein, Exhibits Robust ?-Glutamyl Cyclotransferase Activity When Stimulated by Eukaryotic Thioredoxins.
Breast Neoplasms
Proteomic profiling of mammary carcinomas identifies C7orf24, a gamma-glutamyl cyclotransferase, as a potential cancer biomarker.
Carcinogenesis
Proteomic profiling of mammary carcinomas identifies C7orf24, a gamma-glutamyl cyclotransferase, as a potential cancer biomarker.
Carcinoma
A novel tumor-related protein, C7orf24, identified by proteome differential display of bladder urothelial carcinoma.
Carcinoma
Proteomic profiling of mammary carcinomas identifies C7orf24, a gamma-glutamyl cyclotransferase, as a potential cancer biomarker.
Glioma
Gamma-glutamylcyclotransferase promotes the growth of human glioma cells by activating Notch-Akt signaling.
Leukemia
The mRNA Distribution of C7orf24, a Gamma-glutamyl Cyclotransferase, in Rat Tissues.
Lung Neoplasms
Prevention of tumor growth by needle-free jet injection of anti-C7orf24 siRNA.
Neoplasms
A novel tumor-related protein, C7orf24, identified by proteome differential display of bladder urothelial carcinoma.
Neoplasms
Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells.
Neoplasms
Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence.
Neoplasms
Depletion of gamma-glutamylcyclotransferase inhibits cancer cell growth by activating the AMPK-FOXO3a-p21 axis.
Neoplasms
Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment.
Neoplasms
Involvement of cancer biomarker C7orf24 in the growth of human osteosarcoma.
Neoplasms
Prevention of tumor growth by needle-free jet injection of anti-C7orf24 siRNA.
Neoplasms
Prohibitin-2 is a novel regulator of p21
Neoplasms
Proteomic profiling of mammary carcinomas identifies C7orf24, a gamma-glutamyl cyclotransferase, as a potential cancer biomarker.
Neoplasms
The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle.
Osteosarcoma
Involvement of cancer biomarker C7orf24 in the growth of human osteosarcoma.
Osteosarcoma
miR-877 inhibits the proliferation, migration, and invasion of osteosarcoma cells by targeting gamma-glutamylcyclotransferase.
Stomach Neoplasms
iTRAQ-Based Quantitative Proteomics Approach Identifies Novel Diagnostic Biomarkers That Were Essential for Glutamine Metabolism and Redox Homeostasis for Gastric Cancer.
Urinary Bladder Neoplasms
A novel tumor-related protein, C7orf24, identified by proteome differential display of bladder urothelial carcinoma.
Urinary Bladder Neoplasms
Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence.
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Orlowski, M.; Richman, P.G.; Meister, A.
Isolation and properties of gamma-L-glutamylcyclotransferase from human brain
Biochemistry
8
1048-1055
1969
Ovis aries, Homo sapiens
brenda
Board, P.G.; Moore, K.A.; Smith, J.E.
Purification and properties of gamma-glutamylcyclotransferase from human erythrocytes
Biochem. J.
173
427-431
1978
Homo sapiens
brenda
York, M.J.; Kuchel, P.W.; Chapman, B.E.
A proton nuclear magnetic resonance study of gamma-glutamyl-amino acid cyclotransferase in human erythrocytes
J. Biol. Chem.
259
15085-15088
1984
Homo sapiens
brenda
Orlowski, M.; Meister, A.
Enzymology of pyrrolidone carboxylic acid
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
123-151
1971
Cavia porcellus, Homo sapiens, Mus musculus, Ovis aries, Rattus norvegicus
-
brenda
Szweczuk, A.; Connell, G.E.
Specificity of gamma-glutamyl cyclotransferase
Can. J. Biochem.
53
706-712
1975
Homo sapiens, Rattus norvegicus, Sus scrofa
brenda
York, M.J.; Crossley, M.J.; Hyslop, S.J.; Fisher, M.L.; Kuchel, P.W.
gamma-Glutamylcyclotransferase: inhibition by D-beta-aminoglutaryl-L-alanine and analysis of the solvent kinetic isotope effect
Eur. J. Biochem.
184
97-101
1989
Homo sapiens
brenda
Korotkina, R.N.; Matskevich, G.N.; Devlikanova, A.S.; Vishnevskii, A.A.; Kunitsyn, A.G.; Karelin, A.A.
Activity of glutathione-metabolizing and antioxidant enzymes in malignant and benign tumors of human lungs
Bull. Exp. Biol. Med.
133
606-608
2002
Homo sapiens
brenda
Schilling, S.; Hoffmann, T.; Manhart, S.; Hoffmann, M.; Demuth, H.U.
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions
FEBS Lett.
563
191-196
2004
Carica papaya, Homo sapiens
brenda
Ren, J.; Mao, Y.; Wang, G.; Wang, X.; Fan, C.; Wang, Z.; Li, J.
Enteral refeeding syndrome after long-term total parenteral nutrition
Chin. Med. J.
119
1856-1860
2006
Homo sapiens
brenda
Oakley, A.J.; Yamada, T.; Liu, D.; Coggan, M.; Clark, A.G.; Board, P.G.
The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle
J. Biol. Chem.
283
22031-22042
2008
Homo sapiens (O75223)
brenda
Oakley, A.J.; Coggan, M.; Board, P.G.
Identification and characterization of {gamma}-glutamylamine cyclotransferase: An enzyme responsible for {gamma}-glutamyl-{epsilon}-lysine catabolism
J. Biol. Chem.
285
9642-9648
2010
Homo sapiens (Q9BVM4)
brenda
Azumi, K.; Ikeda, Y.; Takeuchi, T.; Nomura, T.; Sabau, S.; Hamada, J.; Okada, F.; Hosokawa, M.; Yokosawa, H.
Localization and characterization of gamma-glutamyl cyclotransferase in cancer cells
Mol. Med. Rep.
2
385-391
2009
Rattus norvegicus, Homo sapiens (O75223), Homo sapiens
brenda
Gromov, P.; Gromova, I.; Friis, E.; Timmermans-Wielenga, V.; Rank, F.; Simon, R.; Sauter, G.; Moreira, J.M.
Proteomic profiling of mammary carcinomas identifies C7orf24, a gamma-glutamyl cyclotransferase, as a potential cancer biomarker
J. Proteome Res.
9
3941-3953
2010
Homo sapiens
brenda
Shen, S.H.; Yu, N.; Liu, X.Y.; Tan, G.W.; Wang, Z.X.
Gamma-glutamylcyclotransferase promotes the growth of human glioma cells by activating Notch-Akt signaling
Biochem. Biophys. Res. Commun.
471
616-620
2016
Homo sapiens
brenda
Kageyama, S.; Hanada, E.; Ii, H.; Tomita, K.; Yoshiki, T.; Kawauchi, A.
gamma-Glutamylcyclotransferase: A novel target molecule for cancer diagnosis and treatment
BioMed Res. Int.
2015
345219
2015
Homo sapiens
brenda
Yoshiya, T.; Tsuda, S.; Mochizuki, M.; Hidaka, K.; Tsuda, Y.; Kiso, Y.; Kageyama, S.; Ii, H.; Yoshiki, T.; Nishiuchi, Y.
A fluorogenic probe for gamma-glutamyl cyclotransferase: application of an enzyme-triggered O-to-N acyl migration-type reaction
ChemBioChem
14
2110-2113
2013
Homo sapiens
brenda
Dong, J.; Zhou, Y.; Liao, Z.; Huang, Q.; Feng, S.; Li, Y.
Role of gamma-glutamyl cyclotransferase as a therapeutic target for colorectal cancer based on the lentivirus-mediated system
Anticancer Drugs
27
1011-1020
2016
Homo sapiens (O75223)
brenda
Yoshiya, T.; Ii, H.; Tsuda, S.; Mochizuki, M.; Kageyama, S.; Yoshiki, T.
Design of fluorogenic probes and fluorescent-tagged inhibitors for gamma-glutamyl cyclotransferase
J. Pept. Sci.
23
618-623
2017
Homo sapiens (O75223)
brenda