Information on EC 4.3.2.7 - glutathione-specific gamma-glutamylcyclotransferase

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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.2 Amidine-lyases
                4.3.2.7 glutathione-specific gamma-glutamylcyclotransferase
IUBMB Comments
The enzyme, found in bacteria, fungi and animals, is specific for glutathione (cf. EC 4.3.2.9, gamma-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
CHAC, CHAC1, CHAC2, gamma-GCG, GCG1, RipAY, RSp1022, YER63c, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
glutathione = L-cysteinylglycine + 5-oxo-L-proline
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PATHWAY SOURCE
PATHWAYS
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