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IUBMB Comments The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the terminal γ-L -glutamate of the side chain, releasing it as the cyclic 5-oxo-L -proline.
Synonyms
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gamma-glutamyl cyclotransferase
gamma-glutamylcyclotransferase
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btrG
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gamma-glutamyl cyclotransferase
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gamma-glutamyl cyclotransferase
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GGC
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gamma-L-glutamyl-butirosin B = butirosin B + 5-oxo-L-proline
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MetaCyc
butirosin biosynthesis
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gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase (5-oxoproline producing)
The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the terminal gamma-L-glutamate of the side chain, releasing it as the cyclic 5-oxo-L-proline.
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gamma-L-glutamyl-butirosin B
butirosin B + 5-oxoproline
gamma-L-glutamyl-butirosin B
butirosin B + 5-oxoproline
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Substrates: -
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gamma-L-glutamyl-butirosin B
butirosin B + 5-oxoproline
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Substrates: -
ir, ?
gamma-L-glutamyl-butirosin B
butirosin B + 5-oxoproline
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Substrates: -
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ecotype Col-0
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the expression of isoform GGCT2;1 is concentrated in the primary root tip
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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metabolism
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the enzyme is responsible for the deprotection of the gamma-L-glutamyl-(S)-4-amino-2-hydroxybutyrate side chain following transfer onto ribostamycin
metabolism
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isoform GGCT2;1 mobilizes L-cysteine from glutathione when there is insufficient sulfate for de novo L-cysteine synthesis
metabolism
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the enzyme is responsible for the deprotection of the gamma-L-glutamyl-(S)-4-amino-2-hydroxybutyrate side chain following transfer onto ribostamycin
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BTRG_NIACI
156
0
18061
Swiss-Prot
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18100
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1 * 18100, calculated from amino acid sequence
20093
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1 * 20093, His-tagged enzyme, LC-ESI mass spectrometry
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monomer
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1 * 18100, calculated from amino acid sequence
monomer
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1 * 20093, His-tagged enzyme, LC-ESI mass spectrometry
monomer
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1 * 18100, calculated from amino acid sequence
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monomer
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1 * 20093, His-tagged enzyme, LC-ESI mass spectrometry
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Ni2+-NTA affinity column chromatography
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expressed in Escherichia coli BL21(DE3) cells
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isoform GGCT2;1 is transcriptionally upregulated by starvation for sulfur
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Nudelman, I.; Chen, L.; Llewellyn, N.; Sahraoui, E.; Cherniavsky, M.; Spencer, J.; Baasova, T.
Combined chemical-enzymatic assembly of aminoglycoside derivatives with N-1-AHB side chain
Adv. Synth. Catal.
350
1682-1688
2008
Niallia circulans
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Llewellyn, N.M.; Li, Y.; Spencer, J.B.
Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain
Chem. Biol.
14
379-386
2007
Niallia circulans, Niallia circulans NR3312
brenda
Joshi, N.; Meyer, A.; Bangash, S.; Zheng, Z.; Leustek, T.
Arabidopsis gamma-glutamylcyclotransferase affects glutathione content and root system architecture during sulfur starvation
New Phytol.
221
1387-1397
2019
Arabidopsis thaliana
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