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Information on EC 4.3.2.6 - gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase for references in articles please use BRENDA:EC4.3.2.6Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Bacillus circulans
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gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase
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gamma-L-glutamyl-butirosin B = butirosin B + 5-oxoproline
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butirosin biosynthesis
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Neomycin, kanamycin and gentamicin biosynthesis
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Biosynthesis of antibiotics
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gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase (5-oxoproline producing)
The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the terminal gamma-L-glutamate of the side chain, releasing it as the cyclic 5-oxo-L-proline.
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gamma-glutamyl cyclotransferase
btrG
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gamma-glutamyl cyclotransferase
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gamma-glutamyl cyclotransferase
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GGC
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brenda
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brenda
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metabolism
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the enzyme is responsible for the deprotection of the gamma-L-glutamyl-(S)-4-amino-2-hydroxybutyrate side chain following transfer onto ribostamycin
metabolism
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the enzyme is responsible for the deprotection of the gamma-L-glutamyl-(S)-4-amino-2-hydroxybutyrate side chain following transfer onto ribostamycin
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gamma-L-glutamyl-butirosin B
butirosin B + 5-oxoproline
gamma-L-glutamyl-butirosin B
butirosin B + 5-oxoproline
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gamma-L-glutamyl-butirosin B
butirosin B + 5-oxoproline
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ir
gamma-L-glutamyl-butirosin B
butirosin B + 5-oxoproline
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18100
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1 * 18100, calculated from amino acid sequence
20093
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1 * 20093, His-tagged enzyme, LC-ESI mass spectrometry
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monomer
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1 * 18100, calculated from amino acid sequence; 1 * 20093, His-tagged enzyme, LC-ESI mass spectrometry
monomer
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1 * 18100, calculated from amino acid sequence; 1 * 20093, His-tagged enzyme, LC-ESI mass spectrometry
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Ni2+-NTA affinity column chromatography
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expressed in Escherichia coli BL21(DE3) cells
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BTRG_BACCI
156
18061
Swiss-Prot
A0A1Q2ZB61_9ACTN
180
19580
TrEMBL
A0A1V5VDE1_9BACT
139
16024
TrEMBL
A0A1V5V518_9BACT
143
16433
TrEMBL
A0A2N9BF90_STRCX
138
15070
TrEMBL
A0A0U5LGY8_STRRE
162
17966
TrEMBL
A0A1W6VPJ5_GEOTD
290
32989
TrEMBL
A0A1V4XI32_9DELT
297
34106
TrEMBL
A0A1V5UTX1_9BACT
189
21025
TrEMBL
A0A1Y6B5B8_BACCE
127
14820
TrEMBL
A0A117E8T7_9ACTN
180
19567
TrEMBL
A0A1V5V9A7_9BACT
132
15203
TrEMBL
A0A0G3XX16_9BACI
129
14712
TrEMBL
A0A1C0ATQ0_9PROT
199
23767
TrEMBL
A0A0N1KGG1_9BACI
129
14654
TrEMBL
A0A1J5TF47_9ZZZZ
119
13451
TrEMBL
A0A0K6N3E5_BACIU
127
14912
TrEMBL
A0A1Y2P292_STRFR
146
15469
TrEMBL
A0A164QGF4_BACCE
126
14596
TrEMBL
A0A1V2MX49_9ACTN
166
17700
TrEMBL
A0A1D8FZX0_9ACTN
146
15397
TrEMBL
A0A2K8PLZ4_STRLA
149
16075
TrEMBL
A0A2P9F5M7_9ACTN
142
15588
TrEMBL
A0A1Y6B0R8_BACCE
127
14857
TrEMBL
A0A1Y6AIN6_BACCE
127
14864
TrEMBL
A0A1X9MBA6_9BACI
126
14625
TrEMBL
A0A1Y2MQU6_STRPT
146
15524
TrEMBL
A0A2S9XVQ5_9BACI
127
14912
TrEMBL
A0A177HF11_9ACTN
135
14473
TrEMBL
A0A117EE55_STRSC
146
15930
TrEMBL
A0A0K6J5G4_BACCE
127
14938
TrEMBL
A0A1V5V5S0_9BACT
137
15643
TrEMBL
A0A1B9ES96_9ACTN
152
16275
TrEMBL
A0A0N7J908_9BURK
131
14477
TrEMBL
A0A0P0MIQ2_9BURK
147
16408
TrEMBL
A0A0P8WVY2_9CLOT
135
15358
TrEMBL
A0A143BAE5_9DELT
143
16361
TrEMBL
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Nudelman, I.; Chen, L.; Llewellyn, N.; Sahraoui, E.; Cherniavsky, M.; Spencer, J.; Baasova, T.
Combined chemical-enzymatic assembly of aminoglycoside derivatives with N-1-AHB side chain
Adv. Synth. Catal.
350
1682-1688
2008
Bacillus circulans
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brenda
Llewellyn, N.M.; Li, Y.; Spencer, J.B.
Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain
Chem. Biol.
14
379-386
2007
Bacillus circulans, Bacillus circulans NR3312
brenda
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