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Information on EC 4.3.2.5 - peptidylamidoglycolate lyase

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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.2 Amidine-lyases
                4.3.2.5 peptidylamidoglycolate lyase
IUBMB Comments
Requires zinc. The enzyme acts on the product of the reaction catalysed by EC 1.14.17.3 peptidylglycine monooxygenase, thus removing a terminal glycine residue and leaving a des-glycine peptide amide. In mammals, the two activities are part of a bifunctional protein.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
alpha-AE, alpha-hydroxyglycine amidating dealkylase, bifunctional peptidylglycine alpha-amidating enzyme, dPAL1 gene product, dPAL2 gene product, HGAD, lyase, peptidyl-alpha hydroxyglycine, PAL, PAL2, peptidyl-alpha-hydroxyglycine alpha-amidating lyase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[peptide]-(2S)-2-hydroxyglycine = [peptide]-amide + glyoxylate
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