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Information on EC 4.3.2.2 - adenylosuccinate lyase and Organism(s) Staphylococcus aureus and UniProt Accession Q7A0G9

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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.2 Amidine-lyases
                4.3.2.2 adenylosuccinate lyase
IUBMB Comments
Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole.
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This record set is specific for:
Staphylococcus aureus
UNIPROT: Q7A0G9
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Word Map
The taxonomic range for the selected organisms is: Staphylococcus aureus
The enzyme appears in selected viruses and cellular organisms
Synonyms
adenylosuccinate lyase, asase, adenylosuccinase, succino-amp lyase, amps lyase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
adenylosuccinase
-
-
-
-
AMPS lyase
-
-
-
-
ASASE
-
-
-
-
ASL
-
-
-
-
Glutamyl-tRNA synthetase regulatory factor
-
-
-
-
lyase, adenylosuccinate
-
-
-
-
succino AMP-lyase
-
-
-
-
succino-AMP lyase
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-81-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
49600
4 * 49600, calculated. Enzyme forms a dimer of dimers, crystallization data
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
4 * 49600, calculated. Enzyme forms a dimer of dimers, crystallization data
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with AMP, at 2.5 A resolution, and modeling of oxalate in the active site. Comparisons with the enzyme from Escherichia coli and with human PurB show close similarity of the active sites, but differences in the way that the subunits are assembled into dimers
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fyfe, P.K.; Dawson, A.; Hutchison, M.T.; Cameron, S.; Hunter, W.N.
Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery
Acta Crystallogr. Sect. D
66
881-888
2010
Staphylococcus aureus (Q7A0G9), Staphylococcus aureus
Manually annotated by BRENDA team