Mycobacterium marinum Streptomyces coeruleorubidus
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IUBMB Comments The enzyme, found in some actinobacterial species, participates in the biosynthesis of isonitrile-containing lipopeptides. It catalyses the formation of (3R )-3-[(carboxylmethyl)amino]fatty acid by the addition of glycine and the release of the product from the acyl-carrier protein.
Reaction Schemes
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a (2E)-unsaturated fatty acyl-[acyl-carrier protein]
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Synonyms mmaD , scoD ,
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mmaD
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scoD
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(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein] = a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
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MetaCyc
(3R)-N-[(2S)-1-hydroxy-6-[(3R)-3-isocyanobutanamido]hexan-2-yl]-3-isocyanobutanamide biosynthesis
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(3R)-3-[(carboxylmethyl)amino]fatty acid glycine-lyase ((2E)-unsaturated fatty acyl-[acyl-carrier protein]-forming)
The enzyme, found in some actinobacterial species, participates in the biosynthesis of isonitrile-containing lipopeptides. It catalyses the formation of (3R)-3-[(carboxylmethyl)amino]fatty acid by the addition of glycine and the release of the product from the acyl-carrier protein.
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(2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
(2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
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Substrates: -
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(2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
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Substrates: -
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(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
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Substrates: the enzyme is involved in isonitrile lipopeptide biosynthesis
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(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
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Substrates: -
?
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
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Substrates: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
(2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
-
Substrates: -
?
(2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
-
Substrates: -
?
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
-
Substrates: the enzyme is involved in isonitrile lipopeptide biosynthesis
?
(3R)-3-[(carboxylmethyl)amino]fatty acid + an [acyl-carrier protein]
a (2E)-unsaturated fatty acyl-[acyl-carrier protein] + glycine + H2O
-
Substrates: -
?
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Highest Expressing Human Cell Lines
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physiological function
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the enzyme is involved in the isonitrile lipopeptide biosynthetic pathway
physiological function
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the enzyme participates in the biosynthesis of isonitrile-containing lipopeptides
physiological function
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the enzyme is involved in isonitrile lipopeptide biosynthesis
physiological function
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the enzyme participates in the biosynthesis of isonitrile-containing lipopeptides
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expression in Escherichia coli
expression in Escherichia coli
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expression in Escherichia coli
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Harris, N.; Born, D.; Cai, W.; Huang, Y.; Martin, J.; Khalaf, R.; Drennan, C.; Zhang, W.
Isonitrile formation by a non-heme iron(II)-dependent oxidase/decarboxylase
Angew. Chem. Int. Ed. Engl.
57
9707-9710
2018
Streptomyces coeruleorubidus
brenda
Del Rio Flores, A.; Kastner, D.; Du, Y.; Narayanamoorthy, M.; Shen, Y.; Cai, W.; Vennelakanti, V.; Zill, N.; Dell, L.; Zhai, R.; Kulik, H.; Zhang, W.
Probing the mechanism of isonitrile formation by a non-heme iron(II)-dependent oxidase/decarboxylase
J. Am. Chem. Soc.
144
5893-5901
2022
Mycobacterium marinum, Streptomyces coeruleorubidus
brenda
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