We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments The reaction has only been demonstrated in the direction of addition of ammonia.
The enzyme appears in viruses and cellular organisms
Synonyms
ACL, ammonia-lyase, beta-alanyl coenzyme A, beta-alanyl coenzyme A ammonia-lyase, beta-alanyl-CoA:ammonia lyase 2,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ammonia-lyase, beta-alanyl coenzyme A
-
-
-
-
beta-alanyl coenzyme A ammonia-lyase
-
-
-
-
beta-alanyl-CoA:ammonia lyase 2
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
beta-alanyl-CoA = acryloyl-CoA + NH3
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)
The reaction has only been demonstrated in the direction of addition of ammonia.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
acryloyl-CoA + NH3
beta-alanyl-CoA
-
-
-
r
acrylyl-CoA + NH3
beta-alanyl-CoA
-
-
-
ir
additional information
?
-
additional information
?
-
-
the enzyme may play a role as precursor in the biosynthesis of beta-alanyl peptides such as anserine and carnosine
-
-
?
additional information
?
-
enzyme is induced by beta-alanine. The enzyme is needed to bind acryloyl-CoA, in order to keep the toxic free form at a very low level
-
-
?
additional information
?
-
-
enzyme is induced by beta-alanine. The enzyme is needed to bind acryloyl-CoA, in order to keep the toxic free form at a very low level
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
?
-
additional information
?
-
-
the enzyme may play a role as precursor in the biosynthesis of beta-alanyl peptides such as anserine and carnosine
-
-
?
additional information
?
-
enzyme is induced by beta-alanine. The enzyme is needed to bind acryloyl-CoA, in order to keep the toxic free form at a very low level
-
-
?
additional information
?
-
-
enzyme is induced by beta-alanine. The enzyme is needed to bind acryloyl-CoA, in order to keep the toxic free form at a very low level
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NH4+
100 mM, 70% inhibition of NH3 elimination
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.023
acryloyl-CoA
pH 7.5
0.21
beta-alanyl-CoA
pH 7.0
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
25
beta-alanyl-CoA
pH 7.0
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
SwissProt
brenda
DSM 1682
SwissProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
E6PCI0_9ZZZZ
132
0
14383
TrEMBL
Mitochondrion (Reliability: 5 )
C3JBK8_POREA
Porphyromonas endodontalis (strain ATCC 35406 / BCRC 14492 / JCM 8526 / NCTC 13058 / HG 370)
130
0
14206
TrEMBL
-
D4CSU1_9FUSO
120
0
12898
TrEMBL
-
G8S6N0_ACTS5
Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
121
0
12766
TrEMBL
-
Q1D465_MYXXD
Myxococcus xanthus (strain DK1622)
132
0
14250
TrEMBL
-
E6Q635_9ZZZZ
132
0
14351
TrEMBL
Mitochondrion (Reliability: 4 )
F9EQ71_FUSNU
128
0
13948
TrEMBL
-
D5RCQ8_FUSN2
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 23726 / VPI 4351)
128
0
13960
TrEMBL
-
E3FCM6_STIAD
Stigmatella aurantiaca (strain DW4/3-1)
130
0
14342
TrEMBL
-
E5BF15_9FUSO
127
0
13891
TrEMBL
-
C2M973_9PORP
130
0
14037
TrEMBL
-
C6JK85_FUSVA
127
0
13867
TrEMBL
-
Q6KC22_ANAPI
144
0
16005
TrEMBL
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
15999
5 * 15999, MALDI-TOF MS
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
homohexamer
three dimers combine to a homohexamer
pentamer
5 * 15999, MALDI-TOF MS
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
crystal structure of Acl in its apo-form at a resolution of 0.97 A as well as in complex with CoA at a resolution of 1.59 A. The structures reveal that the enyzme belongs to a superfamily of proteins exhibiting a so called "hot dog fold" which is characterized by a five-stranded antiparallel beta-sheet with a long alpha-helix packed against it
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Stadtman, E.R.
The enzymatic synthesis of beta-alanyl coenzyme A
J. Am. Chem. Soc.
77
5765-5766
1955
Anaerotignum propionicum
-
brenda
Herrmann, G.; Selmer, T.; Jessen, H.J.; Gokarn, R.R.; Selifonova, O.; Gort, S.J.; Buckel, W.
Two beta-alanyl-CoA:ammonia lyases in Clostridium propionicum
FEBS J.
272
813-821
2005
Anaerotignum propionicum (Q6KC22), Anaerotignum propionicum
brenda
Heine, A.; Herrmann, G.; Selmer, T.; Terwesten, F.; Buckel, W.; Reuter, K.
High resolution crystal structure of Clostridium propionicum beta-alanyl-CoA: Ammonia lyase, a new member of the "hot dog fold" protein superfamily
Proteins
82
2041-2053
2014
Anaerotignum propionicum (Q6KC22)
brenda
Select items on the left to see more content.
html completed