Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 4.3.1.32 - 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase

for references in articles please use BRENDA:EC4.3.1.32

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

The enzyme produces the 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) precursor of the redox cofactor coenzyme F420, which is found in methanogens and in various actinobacteria. FO is also produced by some cyanobacteria and eukaryotes. The enzyme, which forms a complex with EC 2.5.1.147, 5-amino-6-(D-ribitylamino)uracil—L-tyrosine 4-hydroxyphenyl transferase, is a radical SAM enzyme that uses the 5′-deoxyadenosyl radical to catalyse the condensation reaction.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
cofG, EC 2.5.1.77, fbiC, FO synthase, MjCofG, MSMEG_5126, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
3PG-factor 420 biosynthesis, factor 420 biosynthesis I (archaea), factor 420 biosynthesis II (mycobacteria)
Highest Expressing Human Cell Lines
Cell Line Links Gene Links