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Information on EC - histidine ammonia-lyase

for references in articles please use BRENDA:EC4.3.1.3
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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
       histidine ammonia-lyase
IUBMB Comments
This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC (tyrosine ammonia-lyase), EC (phenylalanine ammonia-lyase) and EC (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family . This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine . This enzyme catalyses the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate [2,3].
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
ammonia-lyase, histidine, HAL, HAL1, Hal2, histidase, histidase, Hut, histidinase, histidinase-2, histidine alpha-deaminase, histidine ammonia lyase, more
L-histidine = urocanate + NH3
show the reaction diagram
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