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Information on EC 4.3.1.20 - erythro-3-hydroxy-L-aspartate ammonia-lyase

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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.20 erythro-3-hydroxy-L-aspartate ammonia-lyase
IUBMB Comments
A pyridoxal-phosphate protein. The enzyme, which was characterized from the bacterium Paracoccus denitrificans NCIMB 8944, is highly specific for the L-isomer of erythro-3-hydroxyaspartate. Different from EC 4.3.1.16, threo-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.27, threo-3-hydroxy-D-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Mg2+, and Ca2+.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
3-Hydroxyaspartate dehydratase, Dehydratase, 3-hydroxyaspartate, EC 4.2.1.38, Erythro-3-hydroxyaspartate hydro-lyase (deaminating), Erythro-beta-hydroxyaspartate dehydratase, Hydroxyaspartate dehydratase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
erythro-3-hydroxy-L-aspartate = oxaloacetate + NH3
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A pyridoxal-phosphate protein.; A pyridoxal-phosphate protein. The reaction catalysed probably involves initial elimination of water, hence the enzyme's original classification as EC 4.2.1.38, erythro-3-hydroxyaspartate dehydratase, followed by isomerization and hydrolysis of the product with C-N bond breakage
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PATHWAY SOURCE
PATHWAYS
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