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Disease on EC 4.3.1.17 - L-serine ammonia-lyase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
Enzymatically active Peptostreptococcus magnus: association with site of infection.
Acidosis
Downregulation in the expression of the serine dehydratase in the rat liver during chronic metabolic acidosis.
Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney.
Carcinoma
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Carcinoma, Hepatocellular
Effect of B6 deficiency on hepatoma 7794A growth rate: activities of tyrosine transaminase and serine dehydratase before and after induction by hydrocortisone.
Effect of pyridoxine availability on the activity of serine dehydratase of normal liver, host liver, and three Morris hepatomas.
Expression of only one of two types of mRNA transcribed from the serine dehydratase gene is repressed in hepatoma cells.
Hormonal and nutritional effects on the binding of 125I-labeled anti-serine dehydratase Fab' to rat tissue polysomes.
Metabolic adaptations in rat hepatomas: altered regulation of serine dehydratase synthesis by glucose and amino acids in hepatocellular carcinomas.
Dehydration
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Crystal structure of serine dehydratase from rat liver.
Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Unique Conformational and Chemical Transformations Occurring upon [4Fe-4S] Cluster Binding in the Type 2 l-Serine Dehydratase from Legionella pneumophila.
Diabetes Mellitus
Periportal expression of the serine dehydratase gene in rat liver.
Regulation of the expression of the serine dehydratase gene in the kidney and liver of the rat.
Diabetic Foot
Enzymatically active Peptostreptococcus magnus: association with site of infection.
Fragile X Syndrome
Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo.
Hepatitis
[The activity of serine dehydratase enzyme of liver tissue in experimental murine infection with mouse hepatitis virus 3]
Hyperinsulinism
Effects of insulin, epinephrine, and glucose on regulation of transcription of the serine dehydratase gene in newborn dogs.
Hypersensitivity
Nutritional regulation and tissue-specific expression of the serine dehydratase gene in rat.
Threonine deaminase from Escherichia coli: feedback-hypersensitive enzyme from a genetic regulatory mutant.
Infections
Enzymatically active Peptostreptococcus magnus: association with site of infection.
[The activity of serine dehydratase enzyme of liver tissue in experimental murine infection with mouse hepatitis virus 3]
Intellectual Disability
Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo.
Leukemia
L-Threonine deaminase as a possible antitumor agent.
Neoplasms
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Enzymes of serine metabolism in normal and neoplastic rat tissues.
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Induction of enzymes by glucagon, glucose repression, adenosine 3',5'-monophosphate concentration during carcinogenesis and in Morris 6918A hepatoma.
Sarcoma
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Starvation
Amino acid metabolism enzyme activities in the obese Zucker rat.
Control of hepatic utilization of serine, glycine and threonine in fed and starved rats.
Distribution of amino acids and amino-acid enzymes in whole kidney and renal cortex. Effect of 24-h starvation.
Effects of glucose, insulin, and cAMP on transcription of the serine dehydratase gene in rat liver.
Regulation of the expression of the serine dehydratase gene in the kidney and liver of the rat.
Serine dehydratase and tyrosine aminotransferase activities increased by long-term starvation and recovery by refeeding in rainbow trout (Oncorhynchus mykiss).
Synthesis of inducible enzyme in Escherichia coli recovering from prolonged energy starvation.
The regulation of serine dehydratase and glucose-6-phosphatase in hyperplastic nodules of rat liver during diethylnitrosamine and N-2-fluorenylacetamide feeding.
Tuberculosis
Kinetic Evidence of a Noncatalytic Substrate Binding Site That Regulates Activity in Legionella pneumophilal-Serine Dehydratase.
Kinetic, mutagenic, and structural homology analysis of L-serine dehydratase from Legionella pneumophila.
Loop-mediated isothermal amplification as alternative to PCR for the diagnosis of extra-pulmonary tuberculosis.
Structure of L-serine dehydratase from Legionella pneumophila: novel use of the C-terminal cysteine as an intrinsic competitive inhibitor.
Vitamin B 12 Deficiency
Vitamin B12 deficiency results in the abnormal regulation of serine dehydratase and tyrosine aminotransferase activities correlated with impairment of the adenylyl cyclase system in rat liver.