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EC unknown
The expected taxonomic range for this enzyme is: Mycobacterium tuberculosis
Synonyms Rv3378c, more
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Rv3378c
-
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(-)-ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate
(-)-ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate
products of Mycobacterium tuberculosis gene product Rv3378c are 22% (-)-ent-copalol, 8% ent-13-epi-manool plus 42% ent-manool. Enzyme catalyzes the removal reaction of the diphosphate moiety, followed by addition of water to the generated cation
(-)-ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate
products of Mycobacterium tuberculosis gene product Rv3378c are 22% (-)-ent-copalol, 8% ent-13-epi-manool plus 42% ent-manool. Enzyme catalyzes the removal reaction of the diphosphate moiety, followed by addition of water to the generated cation
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(-)-ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate
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-
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-
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(-)-ent-copalyl diphosphate diphosphate-lyase ((-)-ent-copalol-forming)
-
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(-)-ent-copalyl diphosphate + H2O
(-)-ent-copalol + diphosphate
(-)-ent-copalyl diphosphate + H2O
(-)-ent-copalol + diphosphate
Substrates: - Products: products of Mycobacterium tuberculosis gene product Rv3378c are 40% (+)-copalool, 12% manool, 15% 13-epi-manool
?
(-)-ent-copalyl diphosphate + H2O
(-)-ent-copalol + diphosphate
Substrates: - Products: products of Mycobacterium tuberculosis gene product Rv3378c are 40% (+)-copalool, 12% manool, 15% 13-epi-manool
?
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Mg2+
essentially required
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putative
UniProt
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putative
UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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TUBAT_MYCTU
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
296
0
34031
Swiss-Prot
Secretory Pathway (Reliability: 2 )
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expression in Escherichia coli
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Hoshino, T.; Nakano, C.; Ootsuka, T.; Shinohara, Y.; Hara, T.
Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis
Org. Biomol. Chem.
9
2156-2165
2011
Mycobacterium tuberculosis (P9WJ61), Mycobacterium tuberculosis H37Rv (P9WJ61)
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