Information on EC 4.2.3.92 - (+)-gamma-cadinene synthase

for references in articles please use BRENDA:EC4.2.3.92
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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
4.2.3.92
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RECOMMENDED NAME
GeneOntology No.
(+)-gamma-cadinene synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate = (+)-gamma-cadinene + diphosphate
show the reaction diagram
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-
-
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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-gamma-cadinene-forming]
The cloned enzyme from the melon, Cucumis melo, gave mainly delta- and gamma-cadinene with traces of several other sesquiterpenoids cf. EC 4.2.3.62 (-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]; EC 4.2.3.13 (+)-delta-cadinene synthase.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
cultivar Noy Yizre'el
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-
Manually annotated by BRENDA team
no activity in Ocimum basilicum
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-
-
Manually annotated by BRENDA team
sweet basil, cultivar SW
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-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
(+)-gamma-cadinene + diphosphate
show the reaction diagram
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-
-
-
?
(2E,6E)-farnesyl diphosphate
gamma-cadinene + delta-cadinene + diphosphate
show the reaction diagram
-
the recombinant enzyme catalyzes the formation of three sesquiterpenes from farnesyl diphosphate: delta-cadinene, gamma-cadinene and lower levels of alpha-copaene
gamma-cadinene and delta-cadinene are the main products post harvest and in mature fruit stage, respectively (about 60% yield each)
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?
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
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expressed in Escherichia coli BL21(DE3) cells
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LINKS TO OTHER DATABASES (specific for EC-Number 4.2.3.92)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)