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Information on EC 4.2.3.84 - 10-epi-gamma-eudesmol synthase
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The expected taxonomic range for this enzyme is: Zingiber zerumbet
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EC NUMBER 
COMMENTARY 
4.2.3.84
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RECOMMENDED NAME
GeneOntology No.
10-epi-gamma-eudesmol synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate + H2O = 10-epi-gamma-eudesmol + diphosphate
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (10-epi-gamma-eudesmol-forming)
The recombinant enzyme from ginger (Zingiber zerumbet) gives 62.6% beta-eudesmol, 16.8% 10-epi-gamma-eudesmol, 10% alpha-eudesmol, and 5.6% aristolene. cf. EC 4.2.3.68 (beta-eudesmol synthase) and EC 4.2.3.85 (alpha-eudesmol synthase)
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + H2O
10-epi-gamma-eudesmol + diphosphate
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products are 62.6% beta-eudesmol, 16.8% 10-epi-gamma-eudesmol, 10% alpha-eudesmol, and 5.6% aristolene
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?
(2E,6E)-farnesyl diphosphate + H2O
10-epi-gamma-eudesmol + diphosphate
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products are 62.6% beta-eudesmol, 16.8% 10-epi-gamma-eudesmol, 10% alpha-eudesmol, and 5.6% aristolene
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?
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
strong expression, transcript levels increase rapidly in summer, peak in early August and decline significantly in fall and winter
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strong expression, transcript levels increase rapidly in summer, peak in early August and decline significantly in fall and winter
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
introduction of a gene cluster encoding six enzymes of the mevalonate pathway into Escherichia coli and coexpression with ZSS2. When supplemented with mevalonate, the engineered Escherichia coli produces a similar sesquiterpene profile to that produced in the in vitro enzyme assay, and the yield of beta-eudesmol reaches 100 mg/l
additional information
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introduction of a gene cluster encoding six enzymes of the mevalonate pathway into Escherichia coli and coexpression with ZSS2. When supplemented with mevalonate, the engineered Escherichia coli produces a similar sesquiterpene profile to that produced in the in vitro enzyme assay, and the yield of beta-eudesmol reaches 100 mg/l
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
synthesis
synthesis
introduction of a gene cluster encoding six enzymes of the mevalonate pathway into Escherichia coli and coexpression with ZSS2. When supplemented with mevalonate, the engineered Escherichia coli produces a similar sesquiterpene profile to that produced in the in vitro enzyme assay, and the yield of beta-eudesmol reaches 100 mg/l
synthesis
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introduction of a gene cluster encoding six enzymes of the mevalonate pathway into Escherichia coli and coexpression with ZSS2. When supplemented with mevalonate, the engineered Escherichia coli produces a similar sesquiterpene profile to that produced in the in vitro enzyme assay, and the yield of beta-eudesmol reaches 100 mg/l
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LINKS TO OTHER DATABASES (specific for EC-Number 4.2.3.84)
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