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Information on EC 4.2.3.5 - chorismate synthase and Organism(s) Aquifex aeolicus and UniProt Accession O66493

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.5 chorismate synthase
IUBMB Comments
Requires FMN. The reaction goes via a radical mechanism that involves reduced FMN and its semiquinone (FMNH(.)). Shikimate is numbered so that the double-bond is between C-1 and C-2, but some earlier papers numbered the ring in the reverse direction.
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This record set is specific for:
Aquifex aeolicus
UNIPROT: O66493
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Word Map
The taxonomic range for the selected organisms is: Aquifex aeolicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
chorismate synthase, chorismate synthetase, vlaro2, 5-enolpyruvylshikimate-3-phosphate phospholyase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5-enolpyruvylshikimate-3-phosphate phospholyase
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chorismate synthetase
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VEG216
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Vegetative protein 216
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SYSTEMATIC NAME
IUBMB Comments
5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)
Requires FMN. The reaction goes via a radical mechanism that involves reduced FMN and its semiquinone (FMNH(.)). Shikimate is numbered so that the double-bond is between C-1 and C-2, but some earlier papers numbered the ring in the reverse direction.
CAS REGISTRY NUMBER
COMMENTARY hide
9077-07-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
O5-(1-carboxyvinyl)-3-phosphoshikimate
chorismate + phosphate
show the reaction diagram
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Uniprot
Manually annotated by BRENDA team
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of the enzyme reveals a novel beta alpha beta sandwich topology
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Viola, C.M.; Saridakis, V.; Christendat, D.
Crystal structure of chorismate synthase from Aquifex aeolicus reveals a novel beta alpha beta sandwich topology
Proteins Struct. Funct. Bioinform.
54
166-169
2003
Aquifex aeolicus (O66493)
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Manually annotated by BRENDA team