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EC Tree
IUBMB Comments A multifunctional enzyme with EC 2.5.1.29 farnesyltranstransferase activity.
The enzyme appears in viruses and cellular organisms
Synonyms
fusicoccadiene synthase, PaDC4, PaFS,
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fusicoccadiene synthase
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fusicoccadiene synthase
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fusicoccadiene synthase
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fusicoccadiene synthase
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fusicoccadiene synthase
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fusicoccadiene synthase
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PaFS
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geranylgeranyl diphosphate = fusicocca-2,10(14)-diene + diphosphate
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geranylgeranyl diphosphate-lyase (fusicocca-2,10(14)-diene-forming)
A multifunctional enzyme with EC 2.5.1.29 farnesyltranstransferase activity.
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(2E,6E)-farnesyl diphosphate
(E,E)-farnesol + (E)-nerolidol + farnesene + diphosphate
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geranyl diphosphate
geraniol + linalool + diphosphate
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?
geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
geranylgeranyl diphosphate
fusicocca-2,10(14-diene) + diphosphate
geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
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geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
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geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
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geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
the enzyme contains two domains, an N-terminal terpene cyclase domain and a C-terminal prenyltransferase domain, and converts isoprene units sequentially into geranylgeranyl diphosphate and then into fusicocca-2,10 (14)-diene
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geranylgeranyl diphosphate
fusicocca-2,10(14-diene) + diphosphate
multifunctional enzyme: geranylgeranyl diphosphate formation from isopentenyl diphosphate and dimethylallyl diphosphate
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geranylgeranyl diphosphate
fusicocca-2,10(14-diene) + diphosphate
multifunctional enzyme: geranylgeranyl diphosphate formation from isopentenyl diphosphate and dimethylallyl diphosphate
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geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
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geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
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?
geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
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?
geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
the enzyme contains two domains, an N-terminal terpene cyclase domain and a C-terminal prenyltransferase domain, and converts isoprene units sequentially into geranylgeranyl diphosphate and then into fusicocca-2,10 (14)-diene
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?
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0.00014
(2E,6E)-farnesyl diphosphate
pH and temperature not specified in the publication
0.0092
geranyl diphosphate
pH and temperature not specified in the publication
0.00063
geranylgeranyl diphosphate
0.00063
geranylgeranyl diphosphate
pH and temperature not specified in the publication
0.00063
geranylgeranyl diphosphate
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pH and temperature not specified in the publication
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0.027
(2E,6E)-farnesyl diphosphate
pH and temperature not specified in the publication
0.036
geranyl diphosphate
pH and temperature not specified in the publication
0.021
geranylgeranyl diphosphate
0.021
geranylgeranyl diphosphate
pH and temperature not specified in the publication
0.021
geranylgeranyl diphosphate
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pH and temperature not specified in the publication
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190
(2E,6E)-farnesyl diphosphate
pH and temperature not specified in the publication
3.9
geranyl diphosphate
pH and temperature not specified in the publication
33
geranylgeranyl diphosphate
33
geranylgeranyl diphosphate
pH and temperature not specified in the publication
33
geranylgeranyl diphosphate
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pH and temperature not specified in the publication
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brenda
strain ATCC96836
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brenda
strain ATCC96836
UniProt
brenda
strain ATCC96836
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brenda
strain ATCC96836
UniProt
brenda
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UniProt
brenda
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brenda
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brenda
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FC1_PHOAM
719
0
81614
Swiss-Prot
other Location (Reliability: 1 )
BSC8_ALTBR
697
0
78573
Swiss-Prot
other Location (Reliability: 1 )
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homohexamer
small-angle X-ray scattering
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sitting drop vapor diffusion method
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D474A
partially inactivated mutant
D92A
the mutant enzxme does not generate any cyclic products yet retains geranylgeranyl diphosphate synthase activity
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expressed in Escherichia coli
expressed in Escherichia coli BL21(DE3)RIL-CodonPlus cells
expressed in Saccharomyces cerevisiae
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heterologous expression of PaFS alone results in the accumulation of fusicocca-2,10 (14)-diene in Escherichia coli cells
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Toyomasu, T.; Tsukahara, M.; Kaneko, A.; Niida, R.; Mitsuhashi, W.; Dairi, T.; Kato, N.; Sassa, T.
Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi
Proc. Natl. Acad. Sci. USA
104
3084-3088
2007
Diaporthe amygdali (A2PZA5), Diaporthe amygdali
brenda
Hashimoto, M.; Higuchi, Y.; Takahashi, S.; Osada, H.; Sakaki, T.; Toyomasu, T.; Sassa, T.; Kato, N.; Dairi, T.
Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis
Bioorg. Med. Chem. Lett.
19
5640-5643
2009
Alternaria brassicicola, Alternaria brassicicola ATCC 96836
brenda
Minami, A.; Tajima, N.; Higuchi, Y.; Toyomasu, T.; Sassa, T.; Kato, N.; Dairi, T.
Identification and functional analysis of brassicicene C biosynthetic gene cluster in Alternaria brassicicola
Bioorg. Med. Chem. Lett.
19
870-874
2009
Alternaria brassicicola (C9K2Q3), Alternaria brassicicola, Alternaria brassicicola ATCC 96836 (C9K2Q3)
brenda
Chen, M.; Chou, W.K.; Toyomasu, T.; Cane, D.E.; Christianson, D.W.
Structure and function of fusicoccadiene synthase, a hexameric bifunctional diterpene synthase
ACS Chem. Biol.
11
889-899
2016
Diaporthe amygdali (A2PZA5), Diaporthe amygdali
brenda
Pemberton, T.A.; Chen, M.; Harris, G.G.; Chou, W.K.; Duan, L.; Koeksal, M.; Genshaft, A.S.; Cane, D.E.; Christianson, D.W.
Exploring the influence of domain architecture on the catalytic function of diterpene synthases
Biochemistry
56
2010-2023
2017
Diaporthe amygdali
brenda
Pathak, R.; Taj, G.; Pandey, D.; Kasana, V.; Baunthiyal, M.; Kumar, A.
Molecular modeling and docking studies of phytoalexin(s) with pathogenic protein(s) as molecular targets for designing the derivatives with anti-fungal action on Alternaria spp. of Brassica
Plant OMICS
9
172-182
2016
Alternaria brassicicola
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brenda
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4.2.3.43 fusicocca-2,10(14)-diene synthase
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