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IUBMB Comments This sesquiterpenoid enzyme is constitutively expressed in the root, hydathodes and stigma of the plant Arabidopsis thaliana . If the leaves of the plant are wounded, e.g. by cutting, the enzyme is also induced close to the wound site. The sesquiterpenoids (E )-nerolidol and α-bisabolol are also produced by this enzyme as minor products.
Synonyms
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(Z)-gamma-bisabolene synthase K11
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(Z)-gamma-bisabolene synthase K7
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(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate
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(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming]
This sesquiterpenoid enzyme is constitutively expressed in the root, hydathodes and stigma of the plant Arabidopsis thaliana. If the leaves of the plant are wounded, e.g. by cutting, the enzyme is also induced close to the wound site. The sesquiterpenoids (E)-nerolidol and alpha-bisabolol are also produced by this enzyme as minor products.
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(2E,6E)-farnesyl diphosphate
(Z)-gamma-bisabolene + diphosphate
additional information
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(2E,6E)-farnesyl diphosphate
(Z)-gamma-bisabolene + diphosphate
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Substrates: -
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(2E,6E)-farnesyl diphosphate
(Z)-gamma-bisabolene + diphosphate
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Substrates: product identification by GC-MS, additional minor products are E-nerolidol and alpha-bisabolol, overview
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(2E,6E)-farnesyl diphosphate
(Z)-gamma-bisabolene + diphosphate
Substrates: -
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(2E,6E)-farnesyl diphosphate
(Z)-gamma-bisabolene + diphosphate
Substrates: -
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additional information
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Substrates: NMR spectroscopy product analysis
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additional information
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Substrates: NMR spectroscopy product analysis
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(2E,6E)-farnesyl diphosphate
(Z)-gamma-bisabolene + diphosphate
(2E,6E)-farnesyl diphosphate
(Z)-gamma-bisabolene + diphosphate
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Substrates: -
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(2E,6E)-farnesyl diphosphate
(Z)-gamma-bisabolene + diphosphate
Substrates: -
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additional information
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wound-inducible (Z)-gamma-bisabolene synthase, mechanical wounding of leaves induces local expression of At4g13280 and At4g13300
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ecotype Ler, root-specific genes At4g13280 and At4g13300 encoding isozymes TPS12 and TPS13
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UniProt
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UniProt
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young rosette leaves, enzyme induction by mechanical wounding
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root-specific (Z)-gamma-bisabolene synthase, in cortex and sub-epidermal layers
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identification of two bisabolene synthases from linear glandular trichomes of sunflower that produce (Z)gamma-bisabolene
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additional information
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enzyme tissue localization study
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Highest Expressing Human Cell Lines
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Gene Links
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physiological function
the initial step in the biosynthesis of a variety of bisabolene-type sesquiterpenes, that accumulate in trichomes of leaves, stems and flowering parts, from its precursor farnesyl diphosphate is catalyzed by two bisabolene synthases identified in the RNA pool of linear glandular trichomes of sunflower
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GBIS1_ARATH
554
0
63851
Swiss-Prot
other Location (Reliability: 2 )
GBIS2_ARATH
554
0
64145
Swiss-Prot
other Location (Reliability: 2 )
TPS14_SOLLC
568
0
66548
Swiss-Prot
other Location (Reliability: 2 )
A0A125S8N1_HELAN
565
0
66487
TrEMBL
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A0A125S8N2_HELAN
565
0
66528
TrEMBL
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Q0J7R9_ORYSJ
323
0
37693
TrEMBL
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L405V
products are 1.9% 7-epi-sesquithujene, 8.1% (E)-alpha-bergamotene, 8.9% sesquiabinene A, 23.9% (E)-beta-farnesene, 0% gamma-curcumene, 9.7% zingiberene, 12.0% beta-bisabolene, 26.6% beta-sesquiphellandrene, 8.9% (E)-gamma-bisabolene
L405V/Y373S
products are 1.2% 7-epi-sesquithujene, 23.6% (E)-alpha-bergamotene, 17.7% sesquiabinene A, 53.0% (E)-beta-farnesene, 0% gamma-curcumene, 0.6% zingiberene, 1.3% beta-bisabolene, 2.6% beta-sesquiphellandrene, 0% (E)-gamma-bisabolene
Y373S
products are 7.6% 7-epi-sesquithujene, 24.8% (E)-alpha-bergamotene, 18.2% sesquiabinene A, 38.5% (E)-beta-farnesene, 0% gamma-curcumene, 4.7% zingiberene, 2.5% beta-bisabolene, 3.7% beta-sesquiphellandrene, 0% (E)-gamma-bisabolene
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gene TPS12_K7, cloning of two isozymes of bisabolene synthases from RNA, DNA and amino acid sequence determination and analysis, the sequences contain the typical motifs of sesquiterpene synthases, sequence comparisons, functional recombinant expression in yeast
root-specific genes At4g13280 and At4g13300 show constitutive promoter activities in the cortex and sub-epidermal layers of Arabidopsis thaliana roots, hierarchical cluster analysis of terpene synthases TPS gene expression, expression analysis, microarray profiling, overview. Expression in Escherichia coli strain BL21
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Ro, D.K.; Ehlting, J.; Keeling, C.I.; Lin, R.; Mattheus, N.; Bohlmann, J.
Microarray expression profiling and functional characterization of AtTPS genes: duplicated Arabidopsis thaliana sesquiterpene synthase genes At4g13280 and At4g13300 encode root-specific and wound-inducible (Z)-gamma-bisabolene synthases
Arch. Biochem. Biophys.
448
104-116
2006
Arabidopsis thaliana
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Zhuang, X.; Koellner, T.G.; Zhao, N.; Li, G.; Jiang, Y.; Zhu, L.; Ma, J.; Degenhardt, J.; Chen, F.
Dynamic evolution of herbivore-induced sesquiterpene biosynthesis in Sorghum and related grass crops
Plant J.
69
70-80
2012
Oryza sativa (Q0J7R9)
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Aschenbrenner, A.K.; Kwon, M.; Conrad, J.; Ro, D.K.; Spring, O.
Identification and characterization of two bisabolene synthases from linear glandular trichomes of sunflower (Helianthus annuus L., Asteraceae)
Phytochemistry
124
29-37
2016
Helianthus annuus (A0A125S8N1), Helianthus annuus (A0A125S8N2)
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