show all | hide all No of entries

Information on EC 4.2.3.38 - alpha-bisabolene synthase

for references in articles please use BRENDA:EC4.2.3.38
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.38 alpha-bisabolene synthase
IUBMB Comments
This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC 4.2.3.20, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding.
Specify your search results
Select one or more organisms in this record:
Word Map
  • 4.2.3.38
  • sesquiterpene
  • terpene
  • terpenoids
  • herbivores
  • conifer
  • abies
  • monoterpene
The enzyme appears in viruses and cellular organisms
Synonyms
bisabolene synthase, (e)-alpha-bisabolene synthase, e-alpha-bisabolene synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate
show the reaction diagram
Select items on the left to see more content.