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Information on EC - alpha-bisabolene synthase

for references in articles please use BRENDA:EC4.2.3.38
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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
       alpha-bisabolene synthase
IUBMB Comments
This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding.
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Word Map
The enzyme appears in viruses and cellular organisms
(E)-alpha-bisabolene synthase, apha-bisabolene synthase, beta-bisabolene synthase, BIS, bisabolene synthase, E-alpha-bisabolene synthase, GbTPS2, More, TPS2, TPS3, more
(2E,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate
show the reaction diagram
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