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Information on EC 4.2.3.36 - terpentetriene synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.36 terpentetriene synthase
IUBMB Comments
Requires Mg2+ for maximal activity but can use Mn2+, Fe2+ or Co2+ to a lesser extent . Following on from EC 5.5.1.15, terpentedienyl-diphosphate synthase, this enzyme completes the transformation of geranylgeranyl diphosphate (GGDP) into terpentetriene, which is a precursor of the diterpenoid antibiotic terpentecin. Farnesyl diphosphate can also act as a substrate.
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The expected taxonomic range for this enzyme is: Kitasatospora griseola
Synonyms
Cyc2, diterpene cyclase-2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
terpentedienyl diphosphate = terpentetriene + diphosphate
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