Reference on EC 4.2.3.24 - amorpha-4,11-diene synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mercke, P.; Bengtsson, M.; Bouwmeester, H.J.; Posthumus, M.A.; Brodelius, P.E.
Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L.
Arch. Biochem. Biophys.
381
173-180
2000
Artemisia annua
Chang, Y.J.; Song, S.H.; Park, S.H.; Kim, S.U.
Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis
Arch. Biochem. Biophys.
383
178-184
2000
Artemisia annua (Q9AR04), Artemisia annua
Picaud, S.; Olofsson, L.; Brodelius, M.; Brodelius, P.E.
Expression, purification, and characterization of recombinant amorpha-4,11-diene synthase from Artemisia annua L
Arch. Biochem. Biophys.
436
215-226
2005
Artemisia annua
Picaud, S.; Mercke, P.; He, X.; Sterner, O.; Brodelius, M.; Cane, D.E.; Brodelius, P.E.
Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate
Arch. Biochem. Biophys.
448
150-155
2006
Artemisia annua
Kim, S.H.; Heo, K.; Chang, Y.J.; Park, S.H.; Rhee, S.K.; Kim, S.U.
Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis
J. Nat. Prod.
69
758-762
2006
Artemisia annua
Martin, V.J.; Pitera, D.J.; Withers, S.T.; Newman, J.D.; Keasling, J.D.
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
Nat. Biotechnol.
21
796-802
2003
Artemisia annua
Bouwmeester, H.J.; Wallaart, T.E.; Janssen, M.H.A.; Van Loo, B.; Jansen, B.J.M.; Posthumus, M.A.; Schmidt, C.O.; De Kraker, J.W.; Konig, W.A.; Franssen, M.C.R.
Amorpha-4,11-diene synthase catalyzes the first probable step in artemisinin biosynthesis
Phytochemistry
52
843-854
1999
Artemisia annua
Wallaart, T.E.; Bouwmeester, H.J.; Hille, J.; Poppinga, L.; Maijers, N.C.A.
Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin
Planta
212
460-465
2001
Artemisia annua (Q9AR04), Artemisia annua
Lindahl, A.L.; Olsson, M.E.; Mercke, P.; Tollbom, O.; Schelin, J.; Brodelius, M.; Brodelius, P.E.
Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae
Biotechnol. Lett.
28
571-580
2006
Artemisia annua (Q9AR04), Artemisia annua
Li, Z.; Liu, Y.; Liu, B.; Wang, H.; Ye, H.; Li, G.
Cloning, E. coli expression and molecular analysis of amorpha-4,11-diene synthase from a high-yield strain of Artemisia annua L
J. Integr. Plant Biol.
48
1486-1492
2006
Artemisia annua
-
Kim, S.H.; Chang, Y.J.; Kim, S.U.
Tissue specificity and developmental pattern of amorpha-4,11-diene synthase (ADS) proved by ADS promoter-driven GUS expression in the heterologous plant, Arabidopsis thaliana
Planta Med.
74
188-193
2008
Artemisia annua
Picaud, S.; Olsson, M.E.; Brodelius, P.E.
Improved conditions for production of recombinant plant sesquiterpene synthases in Escherichia coli
Protein Expr. Purif.
51
71-79
2007
Artemisia annua (Q9AR04), Artemisia annua
Jiang-Qiang, K.; Wei, W.; Li-Na, W.; Xiao-Dong, Z.; Ke-Di, C.; Ping, Z.
The improvement of amorpha-4,11-diene production by a yeast-conform variant
J. Appl. Microbiol.
106
941-951
2009
Artemisia annua (Q9AR04), Artemisia annua
Lubertozzi, D.; Keasling, J.D.
Expression of a synthetic Artemesia annua amorphadiene synthase in Aspergillus nidulans yields altered product distribution
J. Ind. Microbiol. Biotechnol.
35
1191-1198
2008
Artemisia annua
Anthony, J.R.; Anthony, L.C.; Nowroozi, F.; Kwon, G.; Newman, J.D.; Keasling, J.D.
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene
Metab. Eng.
11
13-19
2008
Artemisia annua
Olsson, M.E.; Olofsson, L.M.; Lindahl, A.L.; Lundgren, A.; Brodelius, M.; Brodelius, P.E.
Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L
Phytochemistry
70
1123-1128
2009
Artemisia annua
Ma, D.; Pu, G.; Lei, C.; Ma, L.; Wang, H.; Guo, Y.; Chen, J.; Du, Z.; Wang, H.; Li, G.; Ye, H.; Liu, B.
Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesis
Plant Cell Physiol.
50
2146-2161
2009
Artemisia annua
Pu, G.B.; Ma, D.M.; Chen, J.L.; Ma, L.Q.; Wang, H.; Li, G.F.; Ye, H.C.; Liu, B.Y.
Salicylic acid activates artemisinin biosynthesis in Artemisia annua L
Plant Cell Rep.
28
1127-1135
2009
Artemisia annua
Alam, P.; Kiran, U.; Ahmad, M.M.; Kamaluddin, M.M.; Khan, M.A.; Jhanwar, S.; Abdin, M.
Isolation, characterization and structural studies of amorpha - 4, 11-diene synthase (ADS(3963)) from Artemisia annua L
Bioinformation
4
421-429
2010
Artemisia annua (Q9AR04), Artemisia annua
Alam, P.; Abdin, M.Z.
Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content
Plant Cell Rep.
30
1919-1928
2011
Artemisia annua (C5HG79), Artemisia annua, Artemisia annua L. (C5HG79)
Alejos-Gonzalez, F.; Qu, G.; Zhou, L.L.; Saravitz, C.H.; Shurtleff, J.L.; Xie, D.Y.
Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants
Planta
234
685-697
2011
Artemisia annua
Pu, G.; Ma, D.; Wang, H.; Ye, H.; Liu, B.
Expression and localization of amorpha-4,11-diene synthase in Artemisia annua L.
Plant Mol. Biol. Rep.
31
32-37
2013
Artemisia annua
-
Muangphrom, P.; Seki, H.; Suzuki, M.; Komori, A.; Nishiwaki, M.; Mikawa, R.; Fukushima, E.O.; Muranaka, T.
Functional analysis of amorpha-4,11-diene synthase (ADS) homologs from non-artemisinin-producing artemisia species the discovery of novel koidzumiol and (+)-alpha-bisabolol synthases
Plant Cell Physiol.
57
1678-1688
2016
Artemisia annua (Q9AR04), Artemisia annua
Chen, X.; Zhang, C.; Zou, R.; Stephanopoulos, G.; Too, H.P.
In vitro metabolic engineering of amorpha-4,11-diene biosynthesis at enhanced rate and specific yield of production
ACS Synth. Biol.
6
1691-1700
2017
Artemisia annua
Fang, X.; Li, J.X.; Huang, J.Q.; Xiao, Y.L.; Zhang, P.; Chen, X.Y.
Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase
Biochem. J.
474
2191-2202
2017
Artemisia annua
Li, Z.; Gao, R.; Hao, Q.; Zhao, H.; Cheng, L.; He, F.; Liu, L.; Liu, X.; Chou, W.K.; Zhu, H.; Cane, D.E.
The T296V mutant of amorpha-4,11-diene synthase is defective in allylic diphosphate isomerization but retains the ability to cyclize the intermediate (3R)-nerolidyl diphosphate to amorpha-4,11-diene
Biochemistry
55
6599-6604
2016
Artemisia annua (Q9AR04)
Catania, T.M.; Branigan, C.A.; Stawniak, N.; Hodson, J.; Harvey, D.; Larson, T.R.; Czechowski, T.; Graham, I.A.
Silencing amorpha-4,11-diene synthase genes in Artemisia annua leads to FPP accumulation
Front. Plant Sci.
9
547
2018
Artemisia annua
Eslami, H.; Mohtashami, S.K.; Basmanj, M.T.; Rahati, M.; Rahimi, H.
An in-silico insight into the substrate binding characteristics of the active site of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis
J. Mol. Model.
23
202
2017
Artemisia annua (A2TEY7), Artemisia annua
Abdallah, I.I.; Czepnik, M.; van Merkerk, R.; Quax, W.J.
Insights into the three-dimensional structure of amorpha-4,11-diene synthase and probing of plasticity residues
J. Nat. Prod.
79
2455-2463
2016
Artemisia annua
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