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IUBMB CommentsA diterpene synthase isolated from the bacterium Streptantibioticus cattleyicolor.
The expected taxonomic range for this enzyme is: Streptantibioticus cattleyicolor
Synonyms
CyS, more
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CyS
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geranylgeranyl diphosphate = cattleyene + diphosphate
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geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, cattleyene-formimg)
A diterpene synthase isolated from the bacterium Streptantibioticus cattleyicolor.
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geranylgeranyl diphosphate
cattleyene + diphosphate
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additional information
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Substrates: geranyl diphosphate, farnesyl diphosphate, and geranylfarnesyl diphosphate are not converted by the enzyme
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geranylgeranyl diphosphate
cattleyene + diphosphate
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Products: -
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Mg2+
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contains two Mg2+ ions
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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CYS_STREN
Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)
367
0
40678
Swiss-Prot
other Location (Reliability: 2)
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apoenzyme and enzyme complexed with geranylgeranyl diphosphate and Mg2+, hanging drop vapor diffusion method
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A190G
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besides cattleyene, the variation causes the formation of an additional product
A191G
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besides cattleyene, the variation causes the formation of an additional product
C59A
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the variant exhibits an increased production of cattleyene and other diterpenes with diverse skeletons
F62A
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the enzyme variant shows a substantially decreased or completely abolished production of cattleyene
F86A
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the mutation results in decreased levels of cattleyene with simultaneous production of several new compounds
W160A
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the mutation results in decreased levels of cattleyene with simultaneous production of several new compounds
W318A
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the enzyme variant shows a substantially decreased or completely abolished production of cattleyene
W81A
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the variant produces minor amounts of cattleyene
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expressed in Escherichia coli
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Rinkel, J.; Steiner, S.; Dickschat, J.
Diterpene biosynthesis in actinomycetes Studies on cattleyene synthase and phomopsene synthase
Angew. Chem. Int. Ed. Engl.
58
9230-9233
2019
Streptantibioticus cattleyicolor
brenda
Xing, B.; Xu, H.; Li, A.; Lou, T.; Xu, M.; Wang, K.; Xu, Z.; Dickschat, J.S.; Yang, D.; Ma, M.
Crystal structure based mutagenesis of cattleyene synthase leads to the generation of rearranged polycyclic diterpenes
Angew. Chem. Int. Ed. Engl.
61
e202209785
2022
Streptantibioticus cattleyicolor
brenda
Gong, K.; Yong, D.; Fu, J.; Li, A.; Zhang, Y.; Li, R.
Diterpenoids from Streptomyces Structures, biosyntheses and bioactivities
ChemBioChem
23
e202200231
2022
Streptantibioticus cattleyicolor
brenda
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