Aspergillus fumigatus Aspergillus fumigatus ATCC MYA-4609
M4VQY9
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IUBMB Comments The enzyme, characterized from the mold Aspergillus fumigatus , participates in the biosynthesis of the meroterpenoid fumagillin.
Synonyms af520 ,
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af520
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(2E,6E)-farnesyl diphosphate = (+)-exo-beta-bergamotene + diphosphate
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(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-exo-beta-bergamotene-forming]
The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin.
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(2E,6E)-farnesyl diphosphate
(+)-exo-beta-bergamotene + diphosphate
(2E,6E)-farnesyl diphosphate
(+)-exo-beta-bergamotene + diphosphate
Substrates: -
?
(2E,6E)-farnesyl diphosphate
(+)-exo-beta-bergamotene + diphosphate
Substrates: -
?
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UniProt
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UniProt
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integral membrane protein
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integral membrane protein
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Highest Expressing Human Cell Lines
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physiological function
a deletion mutant loses the ability to produce fumagillin. Expression of the af520 gene product in yeast leads to synthesis of (+)-exo-beta-bergamotene
physiological function
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a deletion mutant loses the ability to produce fumagillin. Expression of the af520 gene product in yeast leads to synthesis of (+)-exo-beta-bergamotene
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FMAA_ASPFU
Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
289
0
31676
Swiss-Prot
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Lin, H.; Chooi, Y.; Dhingra, S.; Xu, W.; Calvo, A.; Tang, Y.
The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of beta-trans-bergamotene
J. Am. Chem. Soc.
135
4616-4619
2013
Aspergillus fumigatus (M4VQY9), Aspergillus fumigatus ATCC MYA-4609 (M4VQY9)
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