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IUBMB CommentsThe enzyme, characterized from the fungi Hericium erinaceus and Cyathus africanus, requires Mg2+ for activity.
The expected taxonomic range for this enzyme is: Agaricomycetes
Synonyms
CyaTC, eriG, more
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CyaTC
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eriG
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geranylgeranyl diphosphate = (-)-cyatha-3,12-diene + diphosphate
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geranylgeranyl diphosphate-lyase [(-)-cyatha-3,12-diene-forming]
The enzyme, characterized from the fungi Hericium erinaceus and Cyathus africanus, requires Mg2+ for activity.
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geranylgeranyl diphosphate
(-)-cyatha-3,12-diene + diphosphate
geranylgeranyl diphosphate
(-)-cyatha-3,12-diene + diphosphate
Substrates: -
Products: -
?
geranylgeranyl diphosphate
(-)-cyatha-3,12-diene + diphosphate
Substrates: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
geranylgeranyl diphosphate
(-)-cyatha-3,12-diene + diphosphate
geranylgeranyl diphosphate
(-)-cyatha-3,12-diene + diphosphate
Substrates: -
Products: -
?
geranylgeranyl diphosphate
(-)-cyatha-3,12-diene + diphosphate
Substrates: -
Products: -
?
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Mg2+
activity of EriG is strictly dependent on the presence of Mg2+
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EDTA
2.5 mM, complete loss of activity
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0.0996
geranylgeranyl diphosphate
pH not specified in the publication, temperature not specified in the publication
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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physiological function
enzyme is a diterpene cyclase involved in the biosynthesis of the cyathane skeleton
physiological function
enzyme is a diterpene cyclase involved in the biosynthesis of the cyathane skeleton
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ERIG_HERER
306
0
33916
Swiss-Prot
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A0A1V0QSF7_9AGAR
304
0
34283
TrEMBL
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expression in Escherichia coli
expression in Escherichia coli
expression in Escherichia coli
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Yang, Y.; Zhang, S.; Ma, K.; Xu, Y.; Tao, Q.; Chen, Y.; Chen, J.; Guo, S.; Ren, J.; Wang, W.; Tao, Y.; Yin, W.; Liu, H.
Discovery and characterization of a new family of diterpene cyclases in bacteria and fungi
Angew. Chem. Int. Ed. Engl.
56
4749-4752
2017
Cyathus africanus (A0A1V0QSF7), Hericium erinaceus (A0A1V0QSF1)
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