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Information on EC 4.2.3.194 - (-)-drimenol synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.194 (-)-drimenol synthase
IUBMB Comments
Isolated from the plants Valeriana officinalis (valerian) and Persicaria hydropiper (water pepper). The enzyme does not act on farnesol or drimenol diphosphate. Using 18-oxygen labelled water 18-oxygen was incorporated suggesting involvement of a stabilised carbocation or an equivalent species.
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Word Map
  • 4.2.3.194
  • sumo
  • sumo-specific
  • ubiquitin-like
  • senps
  • desumoylation
  • fission
  • mitosis
  • sentrin-specific
  • deconjugation
  • osteosarcoma
  • dynamin
  • nucleoli
  • cytokinesis
  • ubiquitin-related
  • isopeptidase
The enzyme appears in viruses and cellular organisms
Synonyms
2E,6E-farnesyl pyrophosphate:drimenol cyclase, drimenol synthase, farnesyl pyrophosphate:drimenol cyclase, FPP:drimenol cyclase, sesquiterpene synthase 3, TPS3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate + H2O = (-)-drimenol + diphosphate
show the reaction diagram
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