Reference on EC 4.2.3.19 - ent-kaurene synthase
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Fall, R.R.; West, C.A.
Purification and properties of kaurene synthetase from Fusarium moniliforme
J. Biol. Chem.
246
6913-6928
1971
Fusarium verticillioides
Yamaguchi, S.; Saito, T.; Abe, H.; Yamane, H.; Murofushi, N.; Kamiya, Y.
Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme ent-kaurene synthase B from pumpkin (Cucurbita maxima L.)
Plant J.
10
203-213
1996
Cucurbita maxima
Kawaide, H.; Imai, R.; Sassa, T.; Kamiya, Y.
ent-Kaurene synthetase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis
J. Biol. Chem.
272
21706-21712
1997
Phaeosphaeria sp. (O13284), Phaeosphaeria sp., Phaeosphaeria sp. L487 (O13284)
Toyomasu, T.; Kawaide, H.; Ishizaki, A.; Shinoda, S.; Otsuka, M.; Mitsuhashi, W.; Sassa, T.
Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase
Biosci. Biotechnol. Biochem.
64
660-664
2000
Fusarium fujikuroi (Q9UVY5), Fusarium fujikuroi
Frost, R.G.; West, C.A.
Properties of kaurene synthetase from Marah macrocarpus
Plant Physiol.
59
22-29
1977
Marah macrocarpa
Duncan, J.D.; West, C.A.
Properties of kaurene synthetase from Marah macrocarpus endosperm: evidence for the participation of separate but interacting enzymes
Plant Physiol.
68
1128-1134
1981
Marah macrocarpa
Shen-Miller, J.; West, C.A.
Kaurene synthetase activity in Helianthus annuus. Increases in enzyme activity after storage of seedlings in liquid nitrogen
Plant Physiol.
74
439-441
1984
Helianthus annuus, Marah macrocarpa
Shen-Miller, J.; West, C.A.
Distribution and ent-kaurene synthetase in Helianthus annuus and Marah macrocarpus
Phytochemistry
24
461-464
1985
Helianthus annuus, Marah macrocarpa
-
Aach, H.; Boese, G.; Graebe, J.E.
ent-Kaurene biosynthesis in a cell-free system from wheat (Triticum aestivum L.) seedlings and the localization of ent-kaurene synthetase in plastids of three species
Planta
197
333-342
1995
Cucurbita maxima, Pisum sativum, Triticum aestivum
-
Saito, T.; Abe, H.; Yamane, H.; Sakurai, A.; Murofushi, N.; Takio, K.; Takahashi, N.; Kamiya, Y.
Purification and properties of ent-kaurene synthase B from immature seeds of pumpkin
Plant Physiol.
109
1239-1245
1995
Cucurbita maxima
Saito, T.; Yamane, H.; Sakurai, A.; Murofushi, N.; Takahashi, N.; Kamiya, Y.
Inhibition of ent-kaurene synthase by quaternary ammonium growth retardants
Biosci. Biotechnol. Biochem.
60
1040-1042
1996
Cucurbita maxima, Fusarium fujikuroi
-
Aach, H.; Bode, H.; Robinson, D.G.; Graebe, J.E.
ent-Kaurene synthase is located in proplastids of meristematic shoot tissues
Planta
202
211-219
1997
Pisum sativum, Triticum aestivum
-
Kawaide, H.; Sassa, T.; Kamiya, Y.
Functional analysis of the two interacting cyclase domains in ent-kaurene synthase from the fungus Phaeosphaeria sp. L487 and a comparison with cyclases from higher plants
J. Biol. Chem.
275
2276-2280
2000
Phaeosphaeria sp. (O13284), Phaeosphaeria sp., Phaeosphaeria sp. L487 (O13284)
Sakamoto, T.; Miura, K.; Itoh, H.; Tatsumi, T.; Ueguchi-Tanaka, M.; Ishiyama, K.; Kobayashi, M.; Agrawal, G.K.; Takeda, S.; Abe, K.; Miyao, A.; Hirochika, H.; Kitano, H.; Ashikari, M.; Matsuoka, M.
An overview of gibberellin metabolism enzyme genes and their related mutants in rice
Plant Physiol.
134
1642-1653
2004
Oryza sativa
Fleet, C.M.; Yamaguchi, S.; Hanada, A.; Kawaide, H.; David, C.J.; Kamiya, Y.; Sun, T.P.
Overexpression of AtCPS and AtKS in Arabidopsis confers increased ent-kaurene production but no increase in bioactive gibberellins
Plant Physiol.
132
830-839
2003
Arabidopsis thaliana
Hayashi, K.; Kawaide, H.; Notomi, M.; Sakigi, Y.; Matsuo, A.; Nozaki, H.
Identification and functional analysis of bifunctional ent-kaurene synthase from the moss Physcomitrella patens
FEBS Lett.
580
6175-6181
2006
Physcomitrium patens (A5A8G0), Physcomitrium patens
Roy, A.; Roberts, F.G.; Wilderman, P.R.; Zhou, K.; Peters, R.J.; Coates, R.M.
16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana
J. Am. Chem. Soc.
129
12453-12460
2007
Arabidopsis thaliana (Q9SAK2), Arabidopsis thaliana
Boemke, C.; Rojas, M.C.; Gong, F.; Hedden, P.; Tudzynski, B.
Isolation and characterization of the gibberellin biosynthetic gene cluster in Sphaceloma manihoticola
Appl. Environ. Microbiol.
74
5325-5339
2008
Sphaceloma manihoticola (B5DBY7), Sphaceloma manihoticola, Sphaceloma manihoticola Lu949 (B5DBY7)
Hayashi, Y.; Toyomasu, T.; Hirose, Y.; Onodera, Y.; Mitsuhashi, W.; Yamane, H.; Sassa, T.; Dairi, T.
Comparison of the enzymatic properties of ent-copalyl diphosphate-synthases in the biosynthesis of phytoalexins and gibberellins in rice
Biosci. Biotechnol. Biochem.
72
523-530
2008
Oryza sativa
Morrone, D.; Chambers, J.; Lowry, L.; Kim, G.; Anterola, A.; Bender, K.; Peters, R.J.
Gibberellin biosynthesis in bacteria: separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum
FEBS Lett.
583
475-480
2009
Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 110
Hayashi, K.I.; Horie, K.; Hiwatashi, Y.; Kawaide, H.; Yamaguchi, S.; Hanada, A.; Nakashima, T.; Nakajima, M.; Mander, L.N.; Yamane, H.; Hasebe, M.; Nozaki, H.
Endogenous diterpenes derived from ent-kaurene, a common gibberellin precursor, regulate protonema differentiation of the moss Physcomitrella patens
Plant Physiol.
153
1085-1097
2010
Physcomitrium patens, Picea glauca (D2X8G1), Picea sitchensis (D2X8G3)
Anterola, A.; Shanle, E.; Mansouri, K.; Schuette, S.; Renzaglia, K.
Gibberellin precursor is involved in spore germination in the moss Physcomitrella patens
Planta
229
1003-1007
2009
Physcomitrium patens
Pugliesi, C.; Fambrini, M.; Salvini, M.
Molecular cloning and expression profile analysis of three sunflower (Helianthus annuus) diterpene synthase genes
Biochem. Genet.
49
46-62
2011
Helianthus annuus (D4IIJ0), Helianthus annuus (D4IIJ1)
Kawaide, H.; Hayashi, K.; Kawanabe, R.; Sakigi, Y.; Matsuo, A.; Natsume, M.; Nozaki, H.
Identification of the single amino acid involved in quenching the ent-kauranyl cation by a water molecule in ent-kaurene synthase of Physcomitrella patens
FEBS J.
278
123-133
2011
Liochlaena subulata, Physcomitrium patens (A5A8G0), Physcomitrium patens
Albermann, S.; Linnemannstoens, P.; Tudzynski, B.
Strategies for strain improvement in Fusarium fujikuroi: overexpression and localization of key enzymes of the isoprenoid pathway and their impact on gibberellin biosynthesis
Appl. Microbiol. Biotechnol.
97
2979-2995
2013
Fusarium fujikuroi
Shimane, M.; Ueno, Y.; Morisaki, K.; Oogami, S.; Natsume, M.; Hayashi, K.I.; Nozaki, H.; Kawaide, H.
Molecular evolution of the substrate specificity of ent-kaurene synthases to adapt to gibberellin biosynthesis in land plants
Biochem. J.
462
539-546
2014
Selaginella moellendorffii (A0A077JGG8), Selaginella moellendorffii
Jackson, A.J.; Hershey, D.M.; Chesnut, T.; Xu, M.; Peters, R.J.
Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization
Phytochemistry
103
13-21
2014
Ricinus communis (B9T625), Ricinus communis
Zerbe, P.; Chiang, A.; Bohlmann, J.
Mutational analysis of white spruce (Picea glauca) ent-kaurene synthase (PgKS) reveals common and distinct mechanisms of conifer diterpene synthases of general and specialized metabolism
Phytochemistry
74
30-39
2012
Picea glauca
Zhou, K.; Xu, M.; Tiernan, M.; Xie, Q.; Toyomasu, T.; Sugawara, C.; Oku, M.; Usui, M.; Mitsuhashi, W.; Chono, M.; Chandler, P.M.; Peters, R.J.
Functional characterization of wheat ent-kaurene(-like) synthases indicates continuing evolution of labdane-related diterpenoid metabolism in the cereals
Phytochemistry
84
47-55
2012
Hordeum vulgare, Triticum aestivum (G9M5S9)
Zerbe, P.; Rodriguez, S.M.; Mafu, S.; Chiang, A.; Sandhu, H.K.; ONeil-Johnson, M.; Starks, C.M.; Bohlmann, J.
Exploring diterpene metabolism in non-model species transcriptome-enabled discovery and functional characterization of labda-7,13E-dienyl diphosphate synthase from Grindelia robusta
Plant J.
83
783-793
2015
Grindelia hirsutula (A0A0H4SPM5), Grindelia hirsutula
Yamamura, Y.; Taguchi, Y.; Ichitani, K.; Umebara, I.; Ohshita, A.; Kurosaki, F.; Lee, J.B.
Characterization of ent-kaurene synthase and kaurene oxidase involved in gibberellin biosynthesis from Scoparia dulcis
J. Nat. Med.
72
456-463
2018
Scoparia dulcis (F6M9X0), Scoparia dulcis
Su, P.; Tong, Y.; Cheng, Q.; Hu, Y.; Zhang, M.; Yang, J.; Teng, Z.; Gao, W.; Huang, L.
Functional characterization of ent-copalyl diphosphate synthase, kaurene synthase and kaurene oxidase in the Salvia miltiorrhiza gibberellin biosynthetic pathway
Sci. Rep.
6
23057
2016
Salvia miltiorrhiza (A0A0U4CDK4), Salvia miltiorrhiza
Mukherjee, A.
Computational study of a bifunctional ent-kaurene synthase from Physcomitrella patens (Hedw.) Bruch and Schimp. An insight into the origin of terpenoid biosynthesis in plants
Acta Bot. Gallica
162
139-152
2015
Physcomitrium patens
-
Tezuka, D.; Ito, A.; Mitsuhashi, W.; Toyomasu, T.; Imai, R.
The rice ent-kaurene synthase like 2 encodes a functional ent-beyerene synthase
Biochem. Biophys. Res. Commun.
460
766-771
2015
Oryza sativa
Mafu, S.; Potter, K.C.; Hillwig, M.L.; Schulte, S.; Criswell, J.; Peters, R.J.
Efficient heterocyclisation by (di)terpene synthases
Chem. Commun. (Camb.)
51
13485-13487
2015
Arabidopsis thaliana, Oryza sativa, Physcomitrium patens, Physcomitrium patens (A5A8G0), Sinorhizobium fredii, Fusarium fujikuroi (S0EA85), Fusarium fujikuroi CBS 195.34 / IMI 58289 / NRRL A-6831 (S0EA85)
Jia, M.; Peters, R.J.
Extending a single residue switch for abbreviating catalysis in plant ent-kaurene synthases
Front. Plant Sci.
7
1765
2016
Selaginella moellendorffii (A0A077JGG8), Marchantia polymorpha subsp. ruderalis (A0A176VPW0), Physcomitrium patens (A5A8G0), Picea glauca (D2XEB3), Oryza sativa Japonica Group (Q0JA82), Arabidopsis thaliana (Q9SAK2)
Kong, M.K.; Kang, H.J.; Kim, J.H.; Oh, S.H.; Lee, P.C.
Metabolic engineering of the Stevia rebaudiana ent-kaurene biosynthetic pathway in recombinant Escherichia coli
J. Biotechnol.
214
95-102
2015
Stevia rebaudiana, Stevia rebaudiana (Q9XEH9)
Jackson, A.; Hershey, D.; Chesnut, T.; Xu, M.; Peters, R.
Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization
Phytochemistry
103
13
2014
Ricinus communis (B9SIL7), Ricinus communis
Zhan, X.; Bach, S.S.; Hansen, N.L.; Lunde, C.; Simonsen, H.T.
Additional diterpenes from Physcomitrella patens synthesized by copalyl diphosphate/kaurene synthase (PpCPS/KS)
Plant Physiol. Biochem.
96
110-114
2015
Physcomitrium patens (A5A8G0), Physcomitrium patens
Miyazaki, S.; Toyoshima, H.; Natsume, M.; Nakajima, M.; Kawaide, H.
Blue-light irradiation up-regulates the ent-kaurene synthase gene and affects the avoidance response of protonemal growth in Physcomitrella patens
Planta
240
117-124
2014
Physcomitrium patens (A5A8G0), Physcomitrium patens
Liu, W.; Feng, X.; Zheng, Y.; Huang, C.H.; Nakano, C.; Hoshino, T.; Bogue, S.; Ko, T.P.; Chen, C.C.; Cui, Y.; Li, J.; Wang, I.; Hsu, S.T.; Oldfield, E.; Guo, R.T.
Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum
Sci. Rep.
4
6214
2014
Bradyrhizobium diazoefficiens (Q45222), Bradyrhizobium diazoefficiens JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110 (Q45222)
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