Isolated from the bacterium Kitasatospora setae. The stereochemistry suggests the farnesyl diphosphate rearranges to nerolidyl diphosphate or an equivalent intermediate before cyclization. See also EC 4.2.3.174 (2E,6E)-hedycaryol synthase.
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The expected taxonomic range for this enzyme is: Kitasatospora setae
Isolated from the bacterium Kitasatospora setae. The stereochemistry suggests the farnesyl diphosphate rearranges to nerolidyl diphosphate or an equivalent intermediate before cyclization. See also EC 4.2.3.174 (2E,6E)-hedycaryol synthase.
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
structure in complex with nerolidol shows the key carbonyl oxygen of Val179, a highly conserved helix break (G1/2) and its corresponding helix dipole acting in . stabilisation of the carbocation at the substrate's C1 position and catalyzing 1,10 ring closure, thereby exclusively generating the anti-Markovnikov product
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History
Enzyme Nomenclature
4.2.3.187 (2Z,6E)-hedycaryol synthase
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