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ent-copalyl diphosphate
ent-atiserene + diphosphate
ent-copalyl diphosphate
ent-atiserene + diphosphate
Substrates: -
Products: -
?
ent-copalyl diphosphate
ent-atiserene + diphosphate
-
Substrates: -
Products: -
?
ent-copalyl diphosphate
ent-atiserene + diphosphate
Substrates: -
Products: -
?
ent-copalyl diphosphate
ent-atiserene + diphosphate
Substrates: -
Products: -
?
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physiological function
a gene deletion strain completely fails to produce platencin, instead produces only platensimycin
physiological function
CPS1, CPS2s, KSL1, KSL2-1, KSL2-2, and KSL3-1 are responsible for biosynthesis of all the known C20 diterpenoid alkaloids in Aconitum carmichaelii
physiological function
-
CPS1, CPS2, CPS4, and CPS5 can combine with KSL1 to form the C20 diterpene alkaloid precursor ent-atiserene, even though CPS5 is not an ent-CPP synthase
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Jin, B.; Cui, G.; Guo, J.; Tang, J.; Duan, L.; Lin, H.; Shen, Y.; Chen, T.; Zhang, H.; Huang, L.
Functional diversification of kaurene synthase-like genes in Isodon rubescens
Plant Physiol.
174
943-955
2017
Isodon rubescens (A0A1Z3GBK8)
brenda
Smanski, M.; Yu, Z.; Casper, J.; Lin, S.; Peterson, R.; Chen, Y.; Wendt-Pienkowski, E.; Rajski, S.; Shen, B.
Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis
Proc. Natl. Acad. Sci. USA
108
13498-13503
2011
Streptomyces platensis (D8L2U4)
brenda
Mao, L.; Jin, B.; Chen, L.; Tian, M.; Ma, R.; Yin, B.; Zhang, H.; Guo, J.; Tang, J.; Chen, T.; Lai, C.; Cui, G.; Huang, L.
Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii
Acta Pharm. Sin. B
11
3310-3321
2021
Aconitum carmichaelii (A0A8E8P2S0), Aconitum carmichaelii (A0A8E8NZX3)
brenda
Chen, L.; Tian, M.; Jin, B.; Yin, B.; Chen, T.; Guo, J.; Tang, J.; Cui, G.; Huang, L.
Integrating metabolomics and transcriptomics to unveil atisine biosynthesis in Aconitum gymnandrum Maxim
Int. J. Mol. Sci.
23
13463
2022
Gymnaconitum gymnandrum
brenda
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