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Information on EC 4.2.3.182 - pristinol synthase and Organism(s) Streptomyces pristinaespiralis and UniProt Accession B5H7H3

for references in articles please use BRENDA:EC4.2.3.182
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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.182 pristinol synthase
IUBMB Comments
Isolated from the bacterium Streptomyces pristinaespiralis.
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This record set is specific for:
Streptomyces pristinaespiralis
UNIPROT: B5H7H3
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The taxonomic range for the selected organisms is: Streptomyces pristinaespiralis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
pentalenene synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-(2S,3R,9R)-pristinol-forming]
Isolated from the bacterium Streptomyces pristinaespiralis.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + H2O
(+)-(2S,3R,9R)-pristinol + diphosphate
show the reaction diagram
-
-
-
?
additional information
?
-
possible reaction mechanisms start with the cyclization of farnesyl diphosphate to the humulyl cation, a 1,2-hydride shift, and capture with water to (R)-hyemalol. No substrates: geranyl diphosphate and geranylgeranyl diphosphate
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + H2O
(+)-(2S,3R,9R)-pristinol + diphosphate
show the reaction diagram
-
-
-
?
additional information
?
-
possible reaction mechanisms start with the cyclization of farnesyl diphosphate to the humulyl cation, a 1,2-hydride shift, and capture with water to (R)-hyemalol. No substrates: geranyl diphosphate and geranylgeranyl diphosphate
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Klapschinski, T.A.; Rabe, P.; Dickschat, J.S.
Pristinol, a sesquiterpene alcohol with an unusual skeleton from Streptomyces pristinaespiralis
Angew. Chem. Int. Ed. Engl.
55
10141-10144
2016
Streptomyces pristinaespiralis (B5H7H3), Streptomyces pristinaespiralis ATCC 25 486 (B5H7H3)
Manually annotated by BRENDA team