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EC Tree
IUBMB Comments Isolated from the plant Inula hupehensis. The enzyme also gives 10-epi-juneol and traces of other terpenoids, see EC 4.2.3.172, 10-epi-juneol synthase. It has also been isolated from the plants maize (Zea mays) and lavender (Lavandula angustifolia).
The enzyme appears in viruses and cellular organisms
Synonyms
cadinol synthase, CADS, TPS1, Tps7,
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(2E,6E)-farnesyl diphosphate + H2O = tau-cadinol + diphosphate
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(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, tau-cadinol-forming)
Isolated from the plant Inula hupehensis. The enzyme also gives 10-epi-juneol and traces of other terpenoids, see EC 4.2.3.172, 10-epi-juneol synthase. It has also been isolated from the plants maize (Zea mays) and lavender (Lavandula angustifolia).
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(2E,6E)-farnesyl diphosphate + H2O
10-epi-junenol + diphosphate
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-
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?
(2E,6E)-farnesyl diphosphate + H2O
10beta-cadin-4-en-10-ol + diphosphate
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-
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?
(2E,6E)-farnesyl diphosphate + H2O
tau-cadinol + diphosphate
additional information
?
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no substrate: geranylgeranyl diphosphate
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-
?
(2E,6E)-farnesyl diphosphate + H2O
tau-cadinol + diphosphate
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-
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?
(2E,6E)-farnesyl diphosphate + H2O
tau-cadinol + diphosphate
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?
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(2E,6E)-farnesyl diphosphate + H2O
10-epi-junenol + diphosphate
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-
-
?
(2E,6E)-farnesyl diphosphate + H2O
10beta-cadin-4-en-10-ol + diphosphate
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-
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?
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Mg2+
favorite metal cofactor, assay in presence of 10 mM
additional information
sequence contains the highly conserved aspartate-rich DDxxD motif required for Mg2+ or Mn2+ binding
additional information
a divalent cation is required
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0.0065
(2E,6E)-farnesyl diphosphate
pH 7.0, 30°C
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0.0014
(2E,6E)-farnesyl diphosphate
pH 7.0, 30°C
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UniProt
brenda
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UniProt
brenda
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UniProt
brenda
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additional information
constitutively expressed in aerial tissue
brenda
-
brenda
poor expression compared to leaf
brenda
highest expression rate
brenda
high expression rate
brenda
-
brenda
trace amounts of transcript
brenda
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physiological function
anti-fungal activity of tau-cadinol is not physiologically relevant
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TPS1_INUHU
563
0
65177
Swiss-Prot
other Location (Reliability: 4 )
CADS_LAVAN
555
0
64576
Swiss-Prot
Mitochondrion (Reliability: 5 )
TPS7_MAIZE
548
0
62575
Swiss-Prot
other Location (Reliability: 2 )
C5YL52_SORBI
540
0
62358
TrEMBL
other Location (Reliability: 2 )
K4A837_SETIT
543
0
62727
TrEMBL
other Location (Reliability: 3 )
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homology modeling. Instead of a unique amino-acid, the electrostatic properties and solvent accessibility of the whole active site may explain the stabilization of the cadinyl cation intermediate
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D532G
mutation does not change product distribution
D533G
mutation does not change product distribution
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expression in Escherichia coli
expression in Escherichia coli and Nicotiana tabacum
expression in Escherichia coli
expression in Escherichia coli
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expression is induced by methyl jasmonate in leaves, while exogenous abscisic acid induces expression dramatically in roots
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Jullien, F.; Moja, S.; Bony, A.; Legrand, S.; Petit, C.; Benabdelkader, T.; Poirot, K.; Fiorucci, S.; Guitton, Y.; Nicole, F.; Baudino, S.; Magnard, J.L.
Isolation and functional characterization of a tau-cadinol synthase, a new sesquiterpene synthase from Lavandula angustifolia
Plant Mol. Biol.
84
227-241
2014
Lavandula angustifolia (U3LW50)
brenda
Gou, J.; Li, Z.; Li, C.; Chen, F.; Lv, S.; Zhang, Y.
Molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis
Plant Physiol. Biochem.
106
288-294
2016
Inula hupehensis (A0A1L2D3T3)
brenda
Ren, F.; Mao, H.; Liang, J.; Liu, J.; Shu, K.; Wang, Q.
Functional characterization of ZmTPS7 reveals a maize tau-cadinol synthase involved in stress response
Planta
244
1065-1074
2016
Zea mays (Q5GJ59)
brenda
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4.2.3.173 tau-cadinol synthase
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