Information on EC 4.2.3.167 - dolabella-3,7-dien-18-ol synthase

for references in articles please use BRENDA:EC4.2.3.167
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The expected taxonomic range for this enzyme is: Arabidopsis thaliana

EC NUMBER
COMMENTARY hide
4.2.3.167
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RECOMMENDED NAME
GeneOntology No.
dolabella-3,7-dien-18-ol synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
dolabella-3,7-dien-18-ol synthase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
bifunctional dolabella-3,7-dien-18-ol synthase/dolathalia-3,7,11-triene synthase, reactions of EC 4.2.3.167 and EC 4.2.3.168, respectively
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the primary TPS20 diterpene products retard the growth of the root rot pathogen Pythium irregulare but only at concentrations exceeding those in planta
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
geranylgeranyl diphosphate + H2O
(3E,7E)-dolabella-3,7-dien-18-ol + diphosphate
show the reaction diagram
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?
additional information
?
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reaction presumably proceeds via dephosphorylation of geranylgeranyl diphosphate and the formation of a dolabelanyl carbocation, which is then converted to dolathaliatriene by a Wagner-Meerwein rearrangement, reaction of EC 4.2.3.168, and deprotonation or directly to dolabelladienol by quenching with water
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
geranylgeranyl diphosphate + H2O
(3E,7E)-dolabella-3,7-dien-18-ol + diphosphate
show the reaction diagram
A0A178U9Y5
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0063
geranylgeranyl diphosphate
pH not specified in the publication, temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.83
geranylgeranyl diphosphate
pH not specified in the publication, temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
130
geranylgeranyl diphosphate
pH not specified in the publication, temperature not specified in the publication
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
TPS20 compounds occur in all tissues of ecotype Cvi but are absent in the Col ecotype because of deletion and substitution mutations in the Col TPS20 sequence
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE