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Enzyme Nomenclature
Information on EC 4.2.3.166 - (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase
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The expected taxonomic range for this enzyme is: Streptomyces pratensis
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EC NUMBER 
COMMENTARY 
4.2.3.166
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RECOMMENDED NAME
GeneOntology No.
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase
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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol-forming]
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + H2O
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + H2O
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate
the enzyme is specific for (2E,6E)-farnesyl diphosphate: No activity with geranyl diphosphate and geranylgeranyl diphosphate
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol i.e. (1S,2E,6E,10R)-3,7-dimethyl-10-(propan-2-yl)cyclodeca-2,6-dien-1-ol. The product exists in different well-defined conformers that are observable by NMR at low temperatures
-
?
(2E,6E)-farnesyl diphosphate + H2O
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + H2O
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate
the enzyme is specific for (2E,6E)-farnesyl diphosphate: No activity with geranyl diphosphate and geranylgeranyl diphosphate
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol i.e. (1S,2E,6E,10R)-3,7-dimethyl-10-(propan-2-yl)cyclodeca-2,6-dien-1-ol. The product exists in different well-defined conformers that are observable by NMR at low temperatures
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + H2O
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate
E8W6C7
-
-
-
?
(2E,6E)-farnesyl diphosphate + H2O
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate
E8W6C7
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-
-
?
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LINKS TO OTHER DATABASES (specific for EC-Number 4.2.3.166)
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