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Information on EC 4.2.3.165 - (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.165 (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase
IUBMB Comments
The original enzyme (STC5) from the fungus Fusarium fujikuroi is inactive because of a critically naturally occuring mutation that leads to an asparagine to lysine exchange in the NSE (Asn-Ser-Glu) triad, a highly conserved motif of type I terpene cyclases. Sequence correction by site-directed mutagenesis (K288N) restores activity.
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The expected taxonomic range for this enzyme is: Fusarium fujikuroi species complex
Synonyms
STC5, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
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