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IUBMB Comments The enzyme, characterized from the cyanobacterium Nostoc punctiforme PCC 73102, is involved in the biosynthesis of the sunscreen compound shinorine. It requires a divalent metal ion (Zn2+ 2+ + cf . EC 4.2.3.152 , 2-epi -5-epi -valiolone synthase and EC 4.2.3.155 , 2-epi -valiolone synthase.
Synonyms
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desmethyl-4-deoxygadusol synthase
DDGS
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desmethyl-4-deoxygadusol synthase
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desmethyl-4-deoxygadusol synthase
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D-sedoheptulose 7-phosphate = demethyl-4-deoxygadusol + phosphate + H2O
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MetaCyc
shinorine biosynthesis
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D-sedoheptulose-7-phosphate phosphate-lyase (cyclizing; demethyl-4-deoxygadusol-forming)
The enzyme, characterized from the cyanobacterium Nostoc punctiforme PCC 73102, is involved in the biosynthesis of the sunscreen compound shinorine. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. cf. EC 4.2.3.152, 2-epi-5-epi-valiolone synthase and EC 4.2.3.155, 2-epi-valiolone synthase.
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D-sedoheptulose 7-phosphate
demethyl-4-deoxygadusol + phosphate + H2O
D-sedoheptulose 7-phosphate
demethyl-4-deoxygadusol + phosphate + H2O
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Substrates: the enzyme is involved in the biosynthesis of the sunscreen compound shinorine
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D-sedoheptulose 7-phosphate
demethyl-4-deoxygadusol + phosphate + H2O
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Substrates: -
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D-sedoheptulose 7-phosphate
demethyl-4-deoxygadusol + phosphate + H2O
Substrates: the enzyme is involved in the biosynthesis of the sunscreen compound shinorine
?
D-sedoheptulose 7-phosphate
demethyl-4-deoxygadusol + phosphate + H2O
Substrates: -
?
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D-sedoheptulose 7-phosphate
demethyl-4-deoxygadusol + phosphate + H2O
D-sedoheptulose 7-phosphate
demethyl-4-deoxygadusol + phosphate + H2O
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Substrates: the enzyme is involved in the biosynthesis of the sunscreen compound shinorine
?
D-sedoheptulose 7-phosphate
demethyl-4-deoxygadusol + phosphate + H2O
Substrates: the enzyme is involved in the biosynthesis of the sunscreen compound shinorine
?
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NAD+
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the enzyme requires a NAD+ cofactor, which is transiently reduced during the reaction
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Co2+
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the enzyme requires a divalent metal ion (Zn2+ or Co2+)
Zn2+
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the enzyme requires a divalent metal ion (Zn2+ or Co2+)
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0.0216 - 0.0651
D-sedoheptulose 7-phosphate
0.0216
D-sedoheptulose 7-phosphate
pH 7.4, 25°C
0.0651
D-sedoheptulose 7-phosphate
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pH 7.4, 25°C
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0.0533 - 0.0833
D-sedoheptulose 7-phosphate
0.0533
D-sedoheptulose 7-phosphate
pH 7.4, 25°C
0.0833
D-sedoheptulose 7-phosphate
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pH 7.4, 25°C
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1.2 - 2.47
D-sedoheptulose 7-phosphate
1.2
D-sedoheptulose 7-phosphate
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pH 7.4, 25°C
2.47
D-sedoheptulose 7-phosphate
pH 7.4, 25°C
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7.4
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assay at
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25
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assay at
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brenda
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SwissProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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metabolism
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the enzyme is involved in the biosynthesis of the sunscreen compound shinorine
metabolism
the enzyme is involved in the biosynthesis of the sunscreen compound shinorine
metabolism
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the enzyme is involved in the biosynthesis of the sunscreen compound shinorine
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expression in Escherichia coli
expression in Escherichia coli
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expression in Escherichia coli
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Asamizu, S.; Xie, P.; Brumsted, C.J.; Flatt, P.M.; Mahmud, T.
Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products
J. Am. Chem. Soc.
134
12219-12229
2012
Nostoc punctiforme, Trichormus variabilis (Q3M6C3)
brenda
Balskus, E.P.; Walsh, C.T.
The genetic and molecular basis for sunscreen biosynthesis in cyanobacteria
Science
329
1653-1656
2010
Nostoc punctiforme
brenda
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