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DtcycA
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DtcycA
gene name. Two isozymes with this activity are isolated from the bacterium Streptomyces sp. SANK 60404. The enzyme encoded by the DtcycA gene also produces cembrene C (see EC 4.2.3.148, cembrene C synthase), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151 (pentamethylcyclopentadecatrienol synthase))
DtcycA
gene name. Two isozymes with this activity are isolated from the bacterium Streptomyces sp. SANK 60404. The enzyme encoded by the DtcycA gene also produces cembrene C (see EC 4.2.3.148, cembrene C synthase), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151 (pentamethylcyclopentadecatrienol synthase))
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DtcycB
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DtcycB
gene name. The trifunctional enzyme also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151 (pentamethylcyclopentadecatrienol synthase))
DtcycB
gene name. The trifunctional enzyme also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151 (pentamethylcyclopentadecatrienol synthase))
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geranylgeranyl-diphosphate diphosphate-lyase [(R)-nephthenol-forming]
Requires Mg2+. Two isozymes with this activity were isolated from the bacterium Streptomyces sp. SANK 60404. The enzyme encoded by the DtcycA gene also produces cembrene C (see EC 4.2.3.148, cembrene C synthase), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase).
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geranylgeranyl diphosphate
(R)-nephthenol + diphosphate
geranylgeranyl diphosphate
(R)-nephthenol + diphosphate
Substrates: -
Products: -
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geranylgeranyl diphosphate
(R)-nephthenol + diphosphate
Substrates: the bifunctional enzyme also produces cembrene C (see EC 4.2.3.148, cembrene C synthase)
Products: (R)-nephthenol i.e. 2-[(1R,3E,7E,11E)-4,8,12-trimethyltetradeca-3,7,11-trien-1-yl]propan-2-ol
?
geranylgeranyl diphosphate
(R)-nephthenol + diphosphate
Substrates: the enzyme also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase)
Products: (R)-nephthenol i.e. 2-[(1R,3E,7E,11E)-4,8,12-trimethyltetradeca-3,7,11-trien-1-yl]propan-2-ol
?
geranylgeranyl diphosphate
(R)-nephthenol + diphosphate
Substrates: -
Products: -
?
geranylgeranyl diphosphate
(R)-nephthenol + diphosphate
Substrates: the bifunctional enzyme also produces cembrene C (see EC 4.2.3.148, cembrene C synthase)
Products: (R)-nephthenol i.e. 2-[(1R,3E,7E,11E)-4,8,12-trimethyltetradeca-3,7,11-trien-1-yl]propan-2-ol
?
geranylgeranyl diphosphate
(R)-nephthenol + diphosphate
Substrates: the enzyme also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase)
Products: (R)-nephthenol i.e. 2-[(1R,3E,7E,11E)-4,8,12-trimethyltetradeca-3,7,11-trien-1-yl]propan-2-ol
?
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Meguro, A.; Tomita, T.; Nishiyama, M.; Kuzuyama, T.
Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton
ChemBioChem
14
316-321
2013
Streptomyces sp. (M1V9Q0), Streptomyces sp. (M1VDX3), Streptomyces sp. SANK 60404 (M1V9Q0), Streptomyces sp. SANK 60404 (M1VDX3)
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