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Information on EC 4.2.3.132 - neoabietadiene synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.132 neoabietadiene synthase
IUBMB Comments
Isolated from Abies grandis (grand fir) . This class I enzyme forms about equal proportions of abietadiene, levopimaradiene and neoabietadiene. See also EC 4.2.3.18, abieta-7,13-diene synthase and EC 4.2.3.32, levopimaradiene synthase. An X-ray study of this multifunctional enzyme showed that the class I activity is in the alpha domain, while (+)-copalyl diphosphate synthase activity (EC 5.5.1.12, a class II activity) is in the beta and gamma domains . In Pinus taeda (loblolly pine) the major product is levopimaradiene, with less abietadiene and neoabietadiene .
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The enzyme appears in viruses and cellular organisms
Synonyms
abietadiene synthase, abietadiene/levopimaradiene synthase, AGAS, NAS, PtTPS-LAS, TPS-LAS, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(+)-copalyl diphosphate = neoabietadiene + diphosphate
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